Meta-Analysis of HTLV-1-Infected Patients Identifies CD40LG and GBP2 as Markers of ATLL and HAM/TSP Clinical Status: Two Genes Beat as One
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/37826 |
Resumo: | Inova Fiocruz (Project number VPPIS-001-FIO18). |
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Fukutani, Eduardo RochaRamos, Pablo Ivan PereiraKasprzykowski, José IraheAzevedo, Lucas GentilRodrigues, Moreno Magalhães de SouzaLima, João Victor de Oliveira PimentaAraújo Junior, Helton Fábio Santos deFukutani, Kiyoshi FerreiraQueiroz, Artur Trancoso Lopo de2019-12-10T18:38:38Z2019-12-10T18:38:38Z2019FUKUTANI, Eduardo Rocha et al. Meta-Analysis of HTLV-1-Infected Patients Identifies CD40LG and GBP2 as Markers of ATLL and HAM/TSP Clinical Status: Two Genes Beat as One. Frontiers in Genetics, v. 10, p. 1-9, Nov. 2019.1664-8021https://www.arca.fiocruz.br/handle/icict/3782610.3389/fgene.2019.01056Inova Fiocruz (Project number VPPIS-001-FIO18).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Laboratório de Análise e Visualização de Dados. Porto Velho, RO, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brazil / Faculdade de Tecnologia e Ciências. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.Human T-lymphotropic virus 1 (HTLV-1) was the first recognized human retrovirus. Infection can lead to two main symptomatologies: adult T-cell lymphoma/leukemia (ATLL) and HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). Each manifestation is associated with distinct characteristics, as ATLL presents as a leukemia-like disease, while HAM/TSP presents as severe inflammation in the central nervous system, leading to paraparesis. Previous studies have identified molecules associated with disease development, e.g., the downregulation of Foxp3 in Treg cells was associated with increased risk of HAM/TSP. In addition, elevated levels of CXCL10, CXCL9, and Neopterin in cerebrospinal fluid also present increased risk. However, these molecules were only associated with specific patient groups or viral strains. Furthermore, the majority of studies did not jointly compare all clinical manifestations, and robust analysis entails the inclusion of both ATLL and HAM/TSP. The low numbers of samples also pose difficulties in conducting gene expression analysis to identify specific molecular relationships. To address these limitations and increase the power of manifestation-specific gene associations, meta-analysis was performed using publicly available gene expression data. The application of supervised learning techniques identified alterations in two genes observed to act in tandem as potential biomarkers: GBP2 was associated with HAM/TSP, and CD40LG with ATLL. Together, both molecules demonstrated high sample-classification accuracy (AUC values: 0.88 and 1.0, respectively). Next, other genes with expression correlated to these genes were identified, and we attempted to relate the enriched pathways identified with the characteristic of each clinical manifestation. The present findings contribute to knowledge surrounding viral progression and suggest a potentially powerful new tool for the molecular classification of HTLV-associated diseases.engFrontiers MediaVírus linfotrópico T humano 1BioinformáticaBiomarcadoresLinfoma / leucemia de células T adulto,HTLV-1 mielopatia associada / paraparesia espástica tropicalMetanáliseHuman T-lymphotropic virus 1BioinformaticsBiomarkersAdult T-cell lymphoma/leukemia,HTLV-1 associated myelopathy/tropical spastic paraparesis, meta-analysis mielopatia associada / paraparesia espástica tropicalMetanáliseMeta-Analysis of HTLV-1-Infected Patients Identifies CD40LG and GBP2 as Markers of ATLL and HAM/TSP Clinical Status: Two Genes Beat as Oneinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/37826/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALFukutani, E.R.Meta analysis....pdfFukutani, E.R.Meta analysis....pdfapplication/pdf1817867https://www.arca.fiocruz.br/bitstream/icict/37826/2/Fukutani%2c%20E.R.Meta%20analysis....pdf5a2e6b11ba42324f371b71b14efd91a1MD52TEXTFukutani, E.R.Meta analysis....pdf.txtFukutani, E.R.Meta analysis....pdf.txtExtracted texttext/plain50087https://www.arca.fiocruz.br/bitstream/icict/37826/3/Fukutani%2c%20E.R.Meta%20analysis....pdf.txt79d36241504d4eac599cdbe15b4dd640MD53icict/378262023-03-15 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| dc.title.pt_BR.fl_str_mv |
Meta-Analysis of HTLV-1-Infected Patients Identifies CD40LG and GBP2 as Markers of ATLL and HAM/TSP Clinical Status: Two Genes Beat as One |
| title |
Meta-Analysis of HTLV-1-Infected Patients Identifies CD40LG and GBP2 as Markers of ATLL and HAM/TSP Clinical Status: Two Genes Beat as One |
| spellingShingle |
Meta-Analysis of HTLV-1-Infected Patients Identifies CD40LG and GBP2 as Markers of ATLL and HAM/TSP Clinical Status: Two Genes Beat as One Fukutani, Eduardo Rocha Vírus linfotrópico T humano 1 Bioinformática Biomarcadores Linfoma / leucemia de células T adulto, HTLV-1 mielopatia associada / paraparesia espástica tropical Metanálise Human T-lymphotropic virus 1 Bioinformatics Biomarkers Adult T-cell lymphoma/leukemia, HTLV-1 associated myelopathy/tropical spastic paraparesis, meta-analysis mielopatia associada / paraparesia espástica tropical Metanálise |
| title_short |
Meta-Analysis of HTLV-1-Infected Patients Identifies CD40LG and GBP2 as Markers of ATLL and HAM/TSP Clinical Status: Two Genes Beat as One |
| title_full |
Meta-Analysis of HTLV-1-Infected Patients Identifies CD40LG and GBP2 as Markers of ATLL and HAM/TSP Clinical Status: Two Genes Beat as One |
| title_fullStr |
Meta-Analysis of HTLV-1-Infected Patients Identifies CD40LG and GBP2 as Markers of ATLL and HAM/TSP Clinical Status: Two Genes Beat as One |
| title_full_unstemmed |
Meta-Analysis of HTLV-1-Infected Patients Identifies CD40LG and GBP2 as Markers of ATLL and HAM/TSP Clinical Status: Two Genes Beat as One |
| title_sort |
Meta-Analysis of HTLV-1-Infected Patients Identifies CD40LG and GBP2 as Markers of ATLL and HAM/TSP Clinical Status: Two Genes Beat as One |
| author |
Fukutani, Eduardo Rocha |
| author_facet |
Fukutani, Eduardo Rocha Ramos, Pablo Ivan Pereira Kasprzykowski, José Irahe Azevedo, Lucas Gentil Rodrigues, Moreno Magalhães de Souza Lima, João Victor de Oliveira Pimenta Araújo Junior, Helton Fábio Santos de Fukutani, Kiyoshi Ferreira Queiroz, Artur Trancoso Lopo de |
| author_role |
author |
| author2 |
Ramos, Pablo Ivan Pereira Kasprzykowski, José Irahe Azevedo, Lucas Gentil Rodrigues, Moreno Magalhães de Souza Lima, João Victor de Oliveira Pimenta Araújo Junior, Helton Fábio Santos de Fukutani, Kiyoshi Ferreira Queiroz, Artur Trancoso Lopo de |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Fukutani, Eduardo Rocha Ramos, Pablo Ivan Pereira Kasprzykowski, José Irahe Azevedo, Lucas Gentil Rodrigues, Moreno Magalhães de Souza Lima, João Victor de Oliveira Pimenta Araújo Junior, Helton Fábio Santos de Fukutani, Kiyoshi Ferreira Queiroz, Artur Trancoso Lopo de |
| dc.subject.other.pt_BR.fl_str_mv |
Vírus linfotrópico T humano 1 Bioinformática Biomarcadores Linfoma / leucemia de células T adulto, HTLV-1 mielopatia associada / paraparesia espástica tropical Metanálise |
| topic |
Vírus linfotrópico T humano 1 Bioinformática Biomarcadores Linfoma / leucemia de células T adulto, HTLV-1 mielopatia associada / paraparesia espástica tropical Metanálise Human T-lymphotropic virus 1 Bioinformatics Biomarkers Adult T-cell lymphoma/leukemia, HTLV-1 associated myelopathy/tropical spastic paraparesis, meta-analysis mielopatia associada / paraparesia espástica tropical Metanálise |
| dc.subject.en.pt_BR.fl_str_mv |
Human T-lymphotropic virus 1 Bioinformatics Biomarkers Adult T-cell lymphoma/leukemia, HTLV-1 associated myelopathy/tropical spastic paraparesis, meta-analysis mielopatia associada / paraparesia espástica tropical Metanálise |
| description |
Inova Fiocruz (Project number VPPIS-001-FIO18). |
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2019 |
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2019-12-10T18:38:38Z |
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2019-12-10T18:38:38Z |
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2019 |
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info:eu-repo/semantics/article |
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FUKUTANI, Eduardo Rocha et al. Meta-Analysis of HTLV-1-Infected Patients Identifies CD40LG and GBP2 as Markers of ATLL and HAM/TSP Clinical Status: Two Genes Beat as One. Frontiers in Genetics, v. 10, p. 1-9, Nov. 2019. |
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https://www.arca.fiocruz.br/handle/icict/37826 |
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1664-8021 |
| dc.identifier.doi.none.fl_str_mv |
10.3389/fgene.2019.01056 |
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FUKUTANI, Eduardo Rocha et al. Meta-Analysis of HTLV-1-Infected Patients Identifies CD40LG and GBP2 as Markers of ATLL and HAM/TSP Clinical Status: Two Genes Beat as One. Frontiers in Genetics, v. 10, p. 1-9, Nov. 2019. 1664-8021 10.3389/fgene.2019.01056 |
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Frontiers Media |
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Frontiers Media |
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