Role of the renin-angiotensin system in the development of severe COVID-19 in hypertensive patients
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1152/ajplung.00286.2020 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/45485 |
Resumo: | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. |
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Silva Junior, Rodrigo PachecoPeruchetti, Diogo BarrosRocco, Patricia Tieken MacedoSchmaier, Alvin H.Silva, Patrícia Machado Rodrigues eMartins, Marco AurélioCarvalho, Vinícius FriasPinheiro, Ana Acácia SáNeves, Celso Caruso2021-01-01T19:55:32Z2021-01-01T19:55:32Z2020AGUIAR, Rodrigo Pacheco Silva et al. Role of the renin-angiostensin system in the development and SARS-CoV-2 infection. American Journal of Physiology. Lung Cellular and Molecular Physiology, v. 319, p. L596-L602, 2020.1040-0605https://www.arca.fiocruz.br/handle/icict/4548510.1152/ajplung.00286.2020engAmerican Physiological SocietyCOVID-19SARS-CoV-2Angiotensin IIHypertensionSistema renina-angiotensinaCOVID-19SARS-CoV-2Angiotensin IIHypertensionRenin-angiotensin systemRole of the renin-angiotensin system in the development of severe COVID-19 in hypertensive patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia de Medicina Reginerativa. Rio de Janeiro, RJ, Brasil / Fundação Carlos Chagas Filho de Amparo à Pesquisa. do Rio de Janeiro. Rede do Rio de Jjaneiro em Inovação em Nanosistemas para a Saúde - NanoSAÚDE. Rio de Janeiro, RJ, Brasil.Case Western Reserve University. Cleveland, Ohio, USA / University Hospitals Cleveland Medical Center. Cleveland, Ohio, USA.Fundação Carlos Chagas Filho de Amparo à Pesquisa. do Rio de Janeiro. Rede do Rio de Jjaneiro em Inovação em Nanosistemas para a Saúde - NamoSAÚDE. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Fundação Carlos Chagas Filho de Amparo à Pesquisa. do Rio de Janeiro. Rede do Rio de Jjaneiro em Inovação em Nanosistemas para a Saúde - NamoSAÚDE. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Fundação Carlos Chagas Filho de Amparo à Pesquisa. do Rio de Janeiro. Rede do Rio de Jjaneiro em Inovação em Nanosistemas para a Saúde - NamoSAÚDE. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Fundação Carlos Chagas Filho de Amparo à Pesquisa. do Rio de Janeiro. Rede do Rio de Jjaneiro em Inovação em Nanosistemas para a Saúde - NanoSAÚDE. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia de Medicina Reginerativa. Rio de Janeiro, RJ, Brasil / Fundação Carlos Chagas Filho de Amparo à Pesquisa. do Rio de Janeiro. Rede do Rio de Jjaneiro em Inovação em Nanosistemas para a Saúde - NanoSAÚDE. Rio de Janeiro, RJ, Brasil.A new form of severe acute respiratory syndrome (SARS) caused by SARS-coronavirus 2 (CoV-2), called COVID-19, has become a global threat in 2020. The mortality rate from COVID-19 is high in hypertensive patients, making this association especially dangerous. There appears to be a consensus, despite the lack of experimental data, that angiotensin II (ANG II) is linked to the pathogenesis of COVID-19. This process may occur due to acquired deficiency of angiotensin-converting enzyme 2 (ACE2), resulting in reduced degradation of ANG II. Furthermore, ANG II has a critical role in the genesis and worsening of hypertension. In this context, the idea that there is a surge in the level of ANG II with COVID-19 infection, causing multiple organ injuries in hypertensive patients becomes attractive. However, the role of other components of the renin angiotensin system (RAS) in this scenario requires elucidation. The identification of other RAS components in COVID-19 hypertension may provide both diagnostic and therapeutic benefits. Here, we summarize the pathophysiologic contributions of different components of RAS in hypertension and their possible correlation with poor outcome observed in hypertensive patients with COVID-19.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/45485/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALVinicusCarvalho_PatriciaTSIlva_etal_IOC_2020.pdfVinicusCarvalho_PatriciaTSIlva_etal_IOC_2020.pdfapplication/pdf303154https://www.arca.fiocruz.br/bitstream/icict/45485/2/VinicusCarvalho_PatriciaTSIlva_etal_IOC_2020.pdfdcfc282d164f6b38f04c25da94f02104MD52TEXTVinicusCarvalho_PatriciaTSIlva_etal_IOC_2020.pdf.txtVinicusCarvalho_PatriciaTSIlva_etal_IOC_2020.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Role of the renin-angiotensin system in the development of severe COVID-19 in hypertensive patients |
| title |
Role of the renin-angiotensin system in the development of severe COVID-19 in hypertensive patients |
| spellingShingle |
Role of the renin-angiotensin system in the development of severe COVID-19 in hypertensive patients Silva Junior, Rodrigo Pacheco COVID-19 SARS-CoV-2 Angiotensin II Hypertension Sistema renina-angiotensina COVID-19 SARS-CoV-2 Angiotensin II Hypertension Renin-angiotensin system |
| title_short |
Role of the renin-angiotensin system in the development of severe COVID-19 in hypertensive patients |
| title_full |
Role of the renin-angiotensin system in the development of severe COVID-19 in hypertensive patients |
| title_fullStr |
Role of the renin-angiotensin system in the development of severe COVID-19 in hypertensive patients |
| title_full_unstemmed |
Role of the renin-angiotensin system in the development of severe COVID-19 in hypertensive patients |
| title_sort |
Role of the renin-angiotensin system in the development of severe COVID-19 in hypertensive patients |
| author |
Silva Junior, Rodrigo Pacheco |
| author_facet |
Silva Junior, Rodrigo Pacheco Peruchetti, Diogo Barros Rocco, Patricia Tieken Macedo Schmaier, Alvin H. Silva, Patrícia Machado Rodrigues e Martins, Marco Aurélio Carvalho, Vinícius Frias Pinheiro, Ana Acácia Sá Neves, Celso Caruso |
| author_role |
author |
| author2 |
Peruchetti, Diogo Barros Rocco, Patricia Tieken Macedo Schmaier, Alvin H. Silva, Patrícia Machado Rodrigues e Martins, Marco Aurélio Carvalho, Vinícius Frias Pinheiro, Ana Acácia Sá Neves, Celso Caruso |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Silva Junior, Rodrigo Pacheco Peruchetti, Diogo Barros Rocco, Patricia Tieken Macedo Schmaier, Alvin H. Silva, Patrícia Machado Rodrigues e Martins, Marco Aurélio Carvalho, Vinícius Frias Pinheiro, Ana Acácia Sá Neves, Celso Caruso |
| dc.subject.other.pt_BR.fl_str_mv |
COVID-19 SARS-CoV-2 Angiotensin II Hypertension Sistema renina-angiotensina |
| topic |
COVID-19 SARS-CoV-2 Angiotensin II Hypertension Sistema renina-angiotensina COVID-19 SARS-CoV-2 Angiotensin II Hypertension Renin-angiotensin system |
| dc.subject.en.pt_BR.fl_str_mv |
COVID-19 SARS-CoV-2 Angiotensin II Hypertension Renin-angiotensin system |
| description |
Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. |
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2020 |
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2020 |
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2021-01-01T19:55:32Z |
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2021-01-01T19:55:32Z |
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AGUIAR, Rodrigo Pacheco Silva et al. Role of the renin-angiostensin system in the development and SARS-CoV-2 infection. American Journal of Physiology. Lung Cellular and Molecular Physiology, v. 319, p. L596-L602, 2020. |
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1040-0605 |
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10.1152/ajplung.00286.2020 |
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AGUIAR, Rodrigo Pacheco Silva et al. Role of the renin-angiostensin system in the development and SARS-CoV-2 infection. American Journal of Physiology. Lung Cellular and Molecular Physiology, v. 319, p. L596-L602, 2020. 1040-0605 10.1152/ajplung.00286.2020 |
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