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spelling Giugliani, RobertoFederhen, AndressaRojas, Maria Verônica MuñozVieira, TaianeArtigalás, OsvaldoPinto, Louise LapagesseAzevedo, Ana CecíliaAcosta, AngelinaBonfim, CarmenLourenço, Charles MarquesKim, Chong AeHorovitz, Dafne Dain GandelmanBonfim, DenizeNorato, DeniseMarinho, DianePalhares, DurvalSantos, Emerson SantanaRibeiro, ErlaneValadares, EugêniaGuarany, FábioLucca, Gisele Rosone dePimentel, HelenaSouza, Isabel Neves deNeto, Jordão CorreaFraga, José CarlosGoes, José EduardoCabral, José MariaSimionato, JoséLlerena Junior, Juan ClintonJardim, LauraGiuliani, LianeSilva, Luiz Carlos Santana daSantos, Mara L.Moreira, Maria AngelaKerstenetzky, MarceloRibeiro, MárciaRuas, NicoleBarrios, PatriciaAranda, PauloHonjo, RachelBoy, RaquelCosta, RonaldoSouza, CarolinaAlcantara, Flavio F.Avilla, Silvio Gilberto A.Fagondes, SimoneMartins, Ana Maria2015-10-06T11:59:37Z2015-10-06T11:59:37Z2010GIUGLIANI, Roberto et al. Mucopolysaccharidosis I, II, and VI: brief review and guidelines for treatment. Genetics and Molecular Biology, Ribeirão Preto, v. 33, n. 4, p. 589-604, 2010.1678-4685https://www.arca.fiocruz.br/handle/icict/1187810.1590/S1415-47572010005000093engSociedade Brasileira de GenéticaMucopolysaccharidosis I, II, and VI brief review and guidelines for treatmentinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleRede MPS Brasil. Porto Alegre, RS, Brasil / Hospital de Clínicas de Porto Alegre. Serviço de Genética Médica. Porto Alegre, RS, Brasil.Rede MPS Brasil. Porto Alegre, RS, Brasil / Hospital de Clínicas de Porto Alegre. Serviço de Genética Médica. Porto Alegre, RS, Brasil.Hospital de Clínicas de Porto Alegre. Serviço de Genética Médica. Porto Alegre, RS, Brasil.Hospital de Clínicas de Porto Alegre. Serviço de Genética Médica. Porto Alegre, RS, Brasil.Grupo Hospitalar Conceição. Porto Alegre, RS, Brasil.Rede MPS Brasil. Porto Alegre, RS, Brasil / Hospital de Clínicas de Porto Alegre. Serviço de Genética Médica. Porto Alegre, RS, Brasil.Hospital de Clínicas de Porto Alegre. Serviço de Genética Médica. Porto Alegre, RS, Brasil.Universidade Federal da Bahia. Salvador, BA, Brasil.Universidade Federal do Paraná. Hospital das Clínicas. Curitiba, PR, Brasil.Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Hospital de Clínicas. Instituto da Criança. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Universidade de Brasília. Hospital Universitário. Brasília, DF, Brasil.Pontifícia Universidade Católicade Campinas. Campinas, SP, Brasil.Hospital de Clínicas de Porto Alegre. Serviço de Oftalmologia. Porto Alegre, RS, Brasil.Universidade Federal do Mato Grosso do Sul. Campo Grande, MS, Brasil.Universidade Estadual de Ciências da Saúde. Maceió, AL, Brasil.Hospital Geral Albert Sabin. Fortaleza, CE, Brasil.Universidade Federal de Minas Gerais. Escola de Medicina. Belo Horizonte, MG, Brasil.Hospital de Clínicas de Porto Alegre. Serviço de Fisiatria e Reabilitação. Porto Alegre, RS, Brasil.Hospital Infantil Joana de Gusmão. Florianópolis, SC, Brasil.Associação de Pais e Amigos dos Excepcionais. Salvador, BA, Brasil.Universidade Federal do Pará. Belém, PA, Brasil.Pontifícia Universidade Católica de Campinas. Campinas, SP, Brasil.Universidade Federal do Rio Grande do Sul. Faculdade de Medicina. Porto Alegre, RS, Brasil.Hospital Infantil Joana de Gusmão. Florianópolis, SC, Brasil.Universidade Federal do Amazonas. Manaus, AM, Brasil.Hospital Infantil. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Hospital de Clínicas de Porto Alegre. Serviço de Genética Médica. Porto Alegre, RS, Brasil.Universidade Federal do Mato Grosso do Sul. Departamento de Pediatria. Campo Grande, MS, Brasil.Universidade Federal do Pará. Belém, PA, Brasil.Hospital Infantil Pequeno Príncipe. Curitiba, PR, Brasil.Hospital de Clínicas. Unidade de Fisiologia Pulmonar. Porto Alegre, RS, Brasil.Hospital da Restauração. Recife, PE, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Pediatria de Puericultura Martagão Gesteira. Rio de Janeiro, RJ, Brasil.Hospital de Clínicas de Porto Alegre. Serviço de Fisiatria e Reabilitação. Porto Alegre, RS, Brasil.Hospital de Clínicas de Porto Alegre. Serviço de Cardiologia. Cardiologista Infantil. Porto Alegre, RS, Brasil.Hospital Evangélico. Londrina, PR, Brasil.Universidade de São Paulo. Hospital de Clínicas. Instituto da Criança. São Paulo, SP, Brasil.Universidade Estadual do Rio de Janeiro. Rio de Janeiro, RJ, Brazil.Hospital de Clínicas de Porto Alegre. Serviço de Anestesiologia e Medicina Perioperativa. Porto Alegre, RS, Brasil.Sociedade Brasileira de Genética Médica. São Paulo, SP, Brasil.Sociedade Brasileira de Patologia Clínica. Medicina Laboratorial. Rio de Janeiro, RJ, Brasil.Associação Brasileira de Cirurgia Pediátrica. São Paulo, SP, Brasil.Sociedade Brasileira de Pneumologia e Tisiologia. Brasília, DF, Brasil.Universidade Federal de São Paulo. Departamento de Pediatria. São Paulo, SP, Brasil.Mucopolysaccharidoses (MPS) are rare genetic diseases caused by the deficiency of one of the lysosomal enzymes involved in the glycosaminoglycan (GAG) breakdown pathway. This metabolic block leads to the accumulation of GAG in various organs and tissues of the affected patients, resulting in a multisystemic clinical picture, sometimes including cognitive impairment. Until the beginning of the XXI century, treatment was mainly supportive. Bone marrow transplantation improved the natural course of the disease in some types of MPS, but the morbidity and mortality restricted its use to selected cases. The identification of the genes involved, the new molecular biology tools and the availability of animal models made it possible to develop specific enzyme replacement therapies (ERT) for these diseases. At present, a great number of Brazilian medical centers from all regions of the country have experience with ERT for MPS I, II, and VI, acquired not only through patient treatment but also in clinical trials. Taking the three types of MPS together, over 200 patients have been treated with ERT in our country. This document summarizes the experience of the professionals involved, along with the data available in the international literature, bringing together and harmonizing the information available on the management of these severe and progressive diseases, thus disclosing new prospects for Brazilian patients affected by these conditions.MucopolisaccharidosesHurler SyndromeHunter SyndromeMaroteaux-Lamy SyndromeEnzyme Replacement TherapyTreatment GuidelinesMucopolissacaridose IPicnodisostoseTerapia de Reposição de EnzimasTerapêuticainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82354https://www.arca.fiocruz.br/bitstream/icict/11878/1/license.txt8b4c200b4e10021c5683c6ccaba07169MD51ORIGINALMucopolysaccharidosis I, II, and VI Brief review and guidelines for treatment.pdfMucopolysaccharidosis I, II, and VI Brief review and guidelines for treatment.pdfapplication/pdf140337https://www.arca.fiocruz.br/bitstream/icict/11878/2/Mucopolysaccharidosis%20I%2c%20II%2c%20and%20VI%20Brief%20review%20and%20guidelines%20for%20treatment.pdf8178891b23f375cc4f7fd8a9dca6b4aeMD52TEXTMucopolysaccharidosis I, II, and VI Brief review and guidelines for treatment.pdf.txtMucopolysaccharidosis I, II, and VI Brief review and guidelines for treatment.pdf.txtExtracted texttext/plain88707https://www.arca.fiocruz.br/bitstream/icict/11878/3/Mucopolysaccharidosis%20I%2c%20II%2c%20and%20VI%20Brief%20review%20and%20guidelines%20for%20treatment.pdf.txtdbc6572bb304f5b437d0999bb24530b1MD53icict/118782020-05-12 13:37:26.197oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352020-05-12T16:37:26Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.pt_BR.fl_str_mv Mucopolysaccharidosis I, II, and VI brief review and guidelines for treatment
title Mucopolysaccharidosis I, II, and VI brief review and guidelines for treatment
spellingShingle Mucopolysaccharidosis I, II, and VI brief review and guidelines for treatment
Giugliani, Roberto
Mucopolisaccharidoses
Hurler Syndrome
Hunter Syndrome
Maroteaux-Lamy Syndrome
Enzyme Replacement Therapy
Treatment Guidelines
Mucopolissacaridose I
Picnodisostose
Terapia de Reposição de Enzimas
Terapêutica
title_short Mucopolysaccharidosis I, II, and VI brief review and guidelines for treatment
title_full Mucopolysaccharidosis I, II, and VI brief review and guidelines for treatment
title_fullStr Mucopolysaccharidosis I, II, and VI brief review and guidelines for treatment
title_full_unstemmed Mucopolysaccharidosis I, II, and VI brief review and guidelines for treatment
title_sort Mucopolysaccharidosis I, II, and VI brief review and guidelines for treatment
author Giugliani, Roberto
author_facet Giugliani, Roberto
Federhen, Andressa
Rojas, Maria Verônica Muñoz
Vieira, Taiane
Artigalás, Osvaldo
Pinto, Louise Lapagesse
Azevedo, Ana Cecília
Acosta, Angelina
Bonfim, Carmen
Lourenço, Charles Marques
Kim, Chong Ae
Horovitz, Dafne Dain Gandelman
Bonfim, Denize
Norato, Denise
Marinho, Diane
Palhares, Durval
Santos, Emerson Santana
Ribeiro, Erlane
Valadares, Eugênia
Guarany, Fábio
Lucca, Gisele Rosone de
Pimentel, Helena
Souza, Isabel Neves de
Neto, Jordão Correa
Fraga, José Carlos
Goes, José Eduardo
Cabral, José Maria
Simionato, José
Llerena Junior, Juan Clinton
Jardim, Laura
Giuliani, Liane
Silva, Luiz Carlos Santana da
Santos, Mara L.
Moreira, Maria Angela
Kerstenetzky, Marcelo
Ribeiro, Márcia
Ruas, Nicole
Barrios, Patricia
Aranda, Paulo
Honjo, Rachel
Boy, Raquel
Costa, Ronaldo
Souza, Carolina
Alcantara, Flavio F.
Avilla, Silvio Gilberto A.
Fagondes, Simone
Martins, Ana Maria
author_role author
author2 Federhen, Andressa
Rojas, Maria Verônica Muñoz
Vieira, Taiane
Artigalás, Osvaldo
Pinto, Louise Lapagesse
Azevedo, Ana Cecília
Acosta, Angelina
Bonfim, Carmen
Lourenço, Charles Marques
Kim, Chong Ae
Horovitz, Dafne Dain Gandelman
Bonfim, Denize
Norato, Denise
Marinho, Diane
Palhares, Durval
Santos, Emerson Santana
Ribeiro, Erlane
Valadares, Eugênia
Guarany, Fábio
Lucca, Gisele Rosone de
Pimentel, Helena
Souza, Isabel Neves de
Neto, Jordão Correa
Fraga, José Carlos
Goes, José Eduardo
Cabral, José Maria
Simionato, José
Llerena Junior, Juan Clinton
Jardim, Laura
Giuliani, Liane
Silva, Luiz Carlos Santana da
Santos, Mara L.
Moreira, Maria Angela
Kerstenetzky, Marcelo
Ribeiro, Márcia
Ruas, Nicole
Barrios, Patricia
Aranda, Paulo
Honjo, Rachel
Boy, Raquel
Costa, Ronaldo
Souza, Carolina
Alcantara, Flavio F.
Avilla, Silvio Gilberto A.
Fagondes, Simone
Martins, Ana Maria
author2_role author
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author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Giugliani, Roberto
Federhen, Andressa
Rojas, Maria Verônica Muñoz
Vieira, Taiane
Artigalás, Osvaldo
Pinto, Louise Lapagesse
Azevedo, Ana Cecília
Acosta, Angelina
Bonfim, Carmen
Lourenço, Charles Marques
Kim, Chong Ae
Horovitz, Dafne Dain Gandelman
Bonfim, Denize
Norato, Denise
Marinho, Diane
Palhares, Durval
Santos, Emerson Santana
Ribeiro, Erlane
Valadares, Eugênia
Guarany, Fábio
Lucca, Gisele Rosone de
Pimentel, Helena
Souza, Isabel Neves de
Neto, Jordão Correa
Fraga, José Carlos
Goes, José Eduardo
Cabral, José Maria
Simionato, José
Llerena Junior, Juan Clinton
Jardim, Laura
Giuliani, Liane
Silva, Luiz Carlos Santana da
Santos, Mara L.
Moreira, Maria Angela
Kerstenetzky, Marcelo
Ribeiro, Márcia
Ruas, Nicole
Barrios, Patricia
Aranda, Paulo
Honjo, Rachel
Boy, Raquel
Costa, Ronaldo
Souza, Carolina
Alcantara, Flavio F.
Avilla, Silvio Gilberto A.
Fagondes, Simone
Martins, Ana Maria
dc.subject.en.pt_BR.fl_str_mv Mucopolisaccharidoses
Hurler Syndrome
Hunter Syndrome
Maroteaux-Lamy Syndrome
Enzyme Replacement Therapy
Treatment Guidelines
topic Mucopolisaccharidoses
Hurler Syndrome
Hunter Syndrome
Maroteaux-Lamy Syndrome
Enzyme Replacement Therapy
Treatment Guidelines
Mucopolissacaridose I
Picnodisostose
Terapia de Reposição de Enzimas
Terapêutica
dc.subject.decs.pt_BR.fl_str_mv Mucopolissacaridose I
Picnodisostose
Terapia de Reposição de Enzimas
Terapêutica
description Rede MPS Brasil. Porto Alegre, RS, Brasil / Hospital de Clínicas de Porto Alegre. Serviço de Genética Médica. Porto Alegre, RS, Brasil.
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2015-10-06T11:59:37Z
dc.date.available.fl_str_mv 2015-10-06T11:59:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GIUGLIANI, Roberto et al. Mucopolysaccharidosis I, II, and VI: brief review and guidelines for treatment. Genetics and Molecular Biology, Ribeirão Preto, v. 33, n. 4, p. 589-604, 2010.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/11878
dc.identifier.issn.none.fl_str_mv 1678-4685
dc.identifier.doi.pt_BR.fl_str_mv 10.1590/S1415-47572010005000093
identifier_str_mv GIUGLIANI, Roberto et al. Mucopolysaccharidosis I, II, and VI: brief review and guidelines for treatment. Genetics and Molecular Biology, Ribeirão Preto, v. 33, n. 4, p. 589-604, 2010.
1678-4685
10.1590/S1415-47572010005000093
url https://www.arca.fiocruz.br/handle/icict/11878
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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