Mice rescued from severe malaria are protected against renal injury during a second kidney insult

Detalhes bibliográficos
Autor(a) principal: Abreu, Thiago P.
Data de Publicação: 2014
Outros Autores: Silva, Leandro S., Takiya, Christina M., Souza, Mariana C., Henriques, Maria G., Pinheiro, Ana Acacia S., Caruso-Neves, Celso
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/59384
Resumo: Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brazil.
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spelling Abreu, Thiago P.Silva, Leandro S.Takiya, Christina M.Souza, Mariana C.Henriques, Maria G.Pinheiro, Ana Acacia S.Caruso-Neves, Celso2023-07-03T22:13:08Z2023-07-03T22:13:08Z2014ABREU, Thiago P. et al. Mice rescued from severe malaria are protected against renal injury during a second kidney insult. PLoS ONE, v. 9, n. 4, p. 1-10, Apr. 2014.1932-6203https://www.arca.fiocruz.br/handle/icict/5938410.1371/JOURNAL.PONE.00936341932-6203engPublic Library of ScienceAcute Kidney InjuryAnimalsAntimalarialsCollagenDisease Models, AnimalKidney CortexKidney GlomerulusMalariaMaleMiceParasitemiaPlasmodium bergheiProtective AgentsMalariaPlasmodium falciparumSepsisRenal injuryMiceSecond kidney insultMice rescued from severe malaria are protected against renal injury during a second kidney insultinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brazil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brazil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos - Farmanguinhos. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos - Farmanguinhos. Rio de Janeiro, RJ, Brazil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brazil / Conselho Nacional de Desenvolvimento Científico e Tecnológico. Instituto Nacional Para Pesquisa Translacional em Saúde e Ambiente na Região Amazônica. Brasília, DF, Brazil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brazil / Conselho Nacional de Desenvolvimento Científico e Tecnológico. Instituto Nacional Para Pesquisa Translacional em Saúde e Ambiente na Região Amazônica. Brasília, DF, Brazil.Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil.Malaria is a worldwide disease that leads to 1 million deaths per year. Plasmodium falciparum is the species responsible for the most severe form of malaria leading to different complications. Beyond the development of cerebral malaria, impairment of renal function is a mortality indicator in infected patients. Treatment with antimalarial drugs can increase survival, however the long-term effects of malaria on renal disease, even after treatment with antimalarials, are unknown. The aim of this study was to evaluate the effect of antimalarial drug treatment on renal function in a murine model of severe malaria and then evaluate kidney susceptibility to a second renal insult. Initially, mice infected with Plasmodium berghei ANKA achieved 20% parasitemia on day 5 post infection, which was completely abolished after treatment with 25 mg/kg artesunate and 40 mg/kg mefloquine. The treatment also decreased plasma creatinine levels by 43% and partially reversed the reduction in the glomerular filtration rate induced by infection. The urinary protein/creatinine ratio, collagen deposition, and size of the interstitial space decreased by 75%, 40%, and 20%, respectively, with drugs compared with untreated infected animals. In infected-treated mice that underwent a second renal insult, the plasma creatinine level decreased by 60% and the glomerular filtration rate increased compared with infected animals treated only with antimalarials. The number of glomerular cells, collagen deposition and the size of the interstitial space decreased by 20%, 39.4%, and 41.3%, respectively, in the infected group that underwent a second renal insult compared with the infected-treated groups. These functional and structural data show that renal injury observed in a murine model of severe malaria is partially reversed after antimalarial drug treatment, making the kidney less susceptible to a second renal insult.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/59384/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINAL10.1371_journal.pone.0093634.pdfapplication/pdf3489793https://www.arca.fiocruz.br/bitstream/icict/59384/2/10.1371_journal.pone.0093634.pdfb5dfe15ba3dce2af5b8dfbb8c4e8ce0fMD52icict/593842023-07-03 20:58:32.466oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-07-03T23:58:32Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Mice rescued from severe malaria are protected against renal injury during a second kidney insult
title Mice rescued from severe malaria are protected against renal injury during a second kidney insult
spellingShingle Mice rescued from severe malaria are protected against renal injury during a second kidney insult
Abreu, Thiago P.
Acute Kidney Injury
Animals
Antimalarials
Collagen
Disease Models, Animal
Kidney Cortex
Kidney Glomerulus
Malaria
Male
Mice
Parasitemia
Plasmodium berghei
Protective Agents
Malaria
Plasmodium falciparum
Sepsis
Renal injury
Mice
Second kidney insult
title_short Mice rescued from severe malaria are protected against renal injury during a second kidney insult
title_full Mice rescued from severe malaria are protected against renal injury during a second kidney insult
title_fullStr Mice rescued from severe malaria are protected against renal injury during a second kidney insult
title_full_unstemmed Mice rescued from severe malaria are protected against renal injury during a second kidney insult
title_sort Mice rescued from severe malaria are protected against renal injury during a second kidney insult
author Abreu, Thiago P.
author_facet Abreu, Thiago P.
Silva, Leandro S.
Takiya, Christina M.
Souza, Mariana C.
Henriques, Maria G.
Pinheiro, Ana Acacia S.
Caruso-Neves, Celso
author_role author
author2 Silva, Leandro S.
Takiya, Christina M.
Souza, Mariana C.
Henriques, Maria G.
Pinheiro, Ana Acacia S.
Caruso-Neves, Celso
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Abreu, Thiago P.
Silva, Leandro S.
Takiya, Christina M.
Souza, Mariana C.
Henriques, Maria G.
Pinheiro, Ana Acacia S.
Caruso-Neves, Celso
dc.subject.mesh.en_US.fl_str_mv Acute Kidney Injury
Animals
Antimalarials
Collagen
Disease Models, Animal
Kidney Cortex
Kidney Glomerulus
Malaria
Male
Mice
Parasitemia
Plasmodium berghei
Protective Agents
topic Acute Kidney Injury
Animals
Antimalarials
Collagen
Disease Models, Animal
Kidney Cortex
Kidney Glomerulus
Malaria
Male
Mice
Parasitemia
Plasmodium berghei
Protective Agents
Malaria
Plasmodium falciparum
Sepsis
Renal injury
Mice
Second kidney insult
dc.subject.en.en_US.fl_str_mv Malaria
Plasmodium falciparum
Sepsis
Renal injury
Mice
Second kidney insult
description Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brazil.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2023-07-03T22:13:08Z
dc.date.available.fl_str_mv 2023-07-03T22:13:08Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ABREU, Thiago P. et al. Mice rescued from severe malaria are protected against renal injury during a second kidney insult. PLoS ONE, v. 9, n. 4, p. 1-10, Apr. 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/59384
dc.identifier.issn.en_US.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/JOURNAL.PONE.0093634
dc.identifier.eissn.none.fl_str_mv 1932-6203
identifier_str_mv ABREU, Thiago P. et al. Mice rescued from severe malaria are protected against renal injury during a second kidney insult. PLoS ONE, v. 9, n. 4, p. 1-10, Apr. 2014.
1932-6203
10.1371/JOURNAL.PONE.0093634
url https://www.arca.fiocruz.br/handle/icict/59384
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dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/59384/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/59384/2/10.1371_journal.pone.0093634.pdf
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