Plasmodium berghei ANKA infection induces thymocyte apoptosis and thymocyte depletion in CBA mice

Detalhes bibliográficos
Autor(a) principal: Carvalho,Leonardo JM
Data de Publicação: 2006
Outros Autores: Ferreira-da-Cruz,Maria F, Daniel-Ribeiro,Claudio T, Pelajo-Machado,Marcelo, Lenzi,Henrique L
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762006000500007
Resumo: Immune responses to malaria infections are characterized by strong T and B cell activation, which, in addition of potentially causing immunopathology, are of poor efficacy against the infection. It is possible that the thymus is involved in the origin of immunopathological reactions and a target during malaria infections. This work was developed in an attempt to further clarify these points. We studied the sequential changes in the thymus of CBA mice infected with Plasmodium berghei ANKA, a model in which 60-90% of the infected animals develop cerebral malaria. During the acute phase of infection, different degrees of thymocyte apoptosis were recorded: (1) starry-sky pattern of diffuse apoptosis with maintenance of cortical-medullary structure; (2) intense apoptosis with cortical atrophy, with absence of large cells; (3) severe cortical thymocyte depletion, resulting in cortical-medullary inversion. In the latter, only residual clusters of small thymocytes were observed within the framework of epithelial cells. The intensity of thymus alterations could not be associated with the degree of parasitemia, the expression of clinical signs of cerebral malaria or intensity of brain lesions. The implications of these events for malaria immunity and pathology are discussed.
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spelling Plasmodium berghei ANKA infection induces thymocyte apoptosis and thymocyte depletion in CBA micemalariathymusPlasmodium bergheimiceImmune responses to malaria infections are characterized by strong T and B cell activation, which, in addition of potentially causing immunopathology, are of poor efficacy against the infection. It is possible that the thymus is involved in the origin of immunopathological reactions and a target during malaria infections. This work was developed in an attempt to further clarify these points. We studied the sequential changes in the thymus of CBA mice infected with Plasmodium berghei ANKA, a model in which 60-90% of the infected animals develop cerebral malaria. During the acute phase of infection, different degrees of thymocyte apoptosis were recorded: (1) starry-sky pattern of diffuse apoptosis with maintenance of cortical-medullary structure; (2) intense apoptosis with cortical atrophy, with absence of large cells; (3) severe cortical thymocyte depletion, resulting in cortical-medullary inversion. In the latter, only residual clusters of small thymocytes were observed within the framework of epithelial cells. The intensity of thymus alterations could not be associated with the degree of parasitemia, the expression of clinical signs of cerebral malaria or intensity of brain lesions. The implications of these events for malaria immunity and pathology are discussed.Instituto Oswaldo Cruz, Ministério da Saúde2006-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762006000500007Memórias do Instituto Oswaldo Cruz v.101 n.5 2006reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762006000500007info:eu-repo/semantics/openAccessCarvalho,Leonardo JMFerreira-da-Cruz,Maria FDaniel-Ribeiro,Claudio TPelajo-Machado,MarceloLenzi,Henrique Leng2020-04-25T17:49:36Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:13:53.829Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Plasmodium berghei ANKA infection induces thymocyte apoptosis and thymocyte depletion in CBA mice
title Plasmodium berghei ANKA infection induces thymocyte apoptosis and thymocyte depletion in CBA mice
spellingShingle Plasmodium berghei ANKA infection induces thymocyte apoptosis and thymocyte depletion in CBA mice
Carvalho,Leonardo JM
malaria
thymus
Plasmodium berghei
mice
title_short Plasmodium berghei ANKA infection induces thymocyte apoptosis and thymocyte depletion in CBA mice
title_full Plasmodium berghei ANKA infection induces thymocyte apoptosis and thymocyte depletion in CBA mice
title_fullStr Plasmodium berghei ANKA infection induces thymocyte apoptosis and thymocyte depletion in CBA mice
title_full_unstemmed Plasmodium berghei ANKA infection induces thymocyte apoptosis and thymocyte depletion in CBA mice
title_sort Plasmodium berghei ANKA infection induces thymocyte apoptosis and thymocyte depletion in CBA mice
author Carvalho,Leonardo JM
author_facet Carvalho,Leonardo JM
Ferreira-da-Cruz,Maria F
Daniel-Ribeiro,Claudio T
Pelajo-Machado,Marcelo
Lenzi,Henrique L
author_role author
author2 Ferreira-da-Cruz,Maria F
Daniel-Ribeiro,Claudio T
Pelajo-Machado,Marcelo
Lenzi,Henrique L
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Carvalho,Leonardo JM
Ferreira-da-Cruz,Maria F
Daniel-Ribeiro,Claudio T
Pelajo-Machado,Marcelo
Lenzi,Henrique L
dc.subject.por.fl_str_mv malaria
thymus
Plasmodium berghei
mice
topic malaria
thymus
Plasmodium berghei
mice
dc.description.none.fl_txt_mv Immune responses to malaria infections are characterized by strong T and B cell activation, which, in addition of potentially causing immunopathology, are of poor efficacy against the infection. It is possible that the thymus is involved in the origin of immunopathological reactions and a target during malaria infections. This work was developed in an attempt to further clarify these points. We studied the sequential changes in the thymus of CBA mice infected with Plasmodium berghei ANKA, a model in which 60-90% of the infected animals develop cerebral malaria. During the acute phase of infection, different degrees of thymocyte apoptosis were recorded: (1) starry-sky pattern of diffuse apoptosis with maintenance of cortical-medullary structure; (2) intense apoptosis with cortical atrophy, with absence of large cells; (3) severe cortical thymocyte depletion, resulting in cortical-medullary inversion. In the latter, only residual clusters of small thymocytes were observed within the framework of epithelial cells. The intensity of thymus alterations could not be associated with the degree of parasitemia, the expression of clinical signs of cerebral malaria or intensity of brain lesions. The implications of these events for malaria immunity and pathology are discussed.
description Immune responses to malaria infections are characterized by strong T and B cell activation, which, in addition of potentially causing immunopathology, are of poor efficacy against the infection. It is possible that the thymus is involved in the origin of immunopathological reactions and a target during malaria infections. This work was developed in an attempt to further clarify these points. We studied the sequential changes in the thymus of CBA mice infected with Plasmodium berghei ANKA, a model in which 60-90% of the infected animals develop cerebral malaria. During the acute phase of infection, different degrees of thymocyte apoptosis were recorded: (1) starry-sky pattern of diffuse apoptosis with maintenance of cortical-medullary structure; (2) intense apoptosis with cortical atrophy, with absence of large cells; (3) severe cortical thymocyte depletion, resulting in cortical-medullary inversion. In the latter, only residual clusters of small thymocytes were observed within the framework of epithelial cells. The intensity of thymus alterations could not be associated with the degree of parasitemia, the expression of clinical signs of cerebral malaria or intensity of brain lesions. The implications of these events for malaria immunity and pathology are discussed.
publishDate 2006
dc.date.none.fl_str_mv 2006-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762006000500007
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762006000500007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02762006000500007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.101 n.5 2006
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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