Hepatitis A virus subgenotypes dissemination during a community outbreak in a surrounding region of Rio de Janeiro

Detalhes bibliográficos
Autor(a) principal: Santos, Débora Regina Lopes dos
Data de Publicação: 2008
Outros Autores: Villar, Livia Melo, Paula, Vanessa Salete de, Lima, Gerson Silva de, Gaspar, Ana Maria Coimbra
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/32374
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico. Rio de Janeiro, RJ, Brasil.
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spelling Santos, Débora Regina Lopes dosVillar, Livia MeloPaula, Vanessa Salete deLima, Gerson Silva deGaspar, Ana Maria Coimbra2019-04-04T15:58:58Z2019-04-04T15:58:58Z2008SANTOS, Débora Regina Lopes dos et al. Hepatitis A virus subgenotypes dissemination during a community outbreak in a surrounding region of Rio de Janeiro. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 103, n. 3, p. 254-258, May 2008.0074-0276https://www.arca.fiocruz.br/handle/icict/3237410.1590/S0074-027620080003000051678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzVírus da Hepatite AEpidemiologia molecularCo-circulação dos subgenótipos IA e IBHepatitis A virusMolecular epidemiologyCo-circulation of subgenotypes IA and IBHepatitis A virus subgenotypes dissemination during a community outbreak in a surrounding region of Rio de Janeiroinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Departamento de Reativos para Diagnóstico Setor de Bactérias e Recombinantes. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico. Rio de Janeiro, RJ, Brasil.From December 1999 to December 2001, many cases of hepatitis A were notified in the county of Belford Roxo involving individuals aged 0 to 79 years. Serum samples were collected to evaluate the prevalence of anti-hepatitis A virus (HAV) antibodies, to detect HAV-RNA and to correlate with possible risk factors of HAV infection. Serum samples were screened by commercial IgM and total anti-HAV antibody ELISA and HAV-RNA was isolated and subsequently amplified by reverse transcription-polymerase chain reaction (RT-PCR) at VP1/2A region, sequenced and analyzed. Total anti-HAV prevalence was 87.9% (203/231) and IgM anti-HAV prevalence was 38.7% (89/231). Multivariate analysis showed that individuals under 20 years old are risks groups to acquire the infection suggesting that hygienic habits of young subjects are the principal factor of transmission and so they could be the target for vaccine programs. HAV-RNA was amplified from 29 (32.5%) IgM anti-HAV positive patients and 26 samples were sequenced and classified into subgenotypes IB (8 isolates) and IA (18 isolates). Isolates classified into subgenotype IB were identical representing one distinct strain. We could observe both subgenotypes circulating during the study which suggests different sources of infection. Prophylactic measures as vaccination strategies added to improvements in hygienic and sanitary conditions would be highly effective to reduction of infection.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/32374/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALLiviaM_Villar_etal_IOC_2008.pdfLiviaM_Villar_etal_IOC_2008.pdfapplication/pdf664308https://www.arca.fiocruz.br/bitstream/icict/32374/2/LiviaM_Villar_etal_IOC_2008.pdf0a19974ef7d1ec825cf09a6d93f9e322MD52TEXTLiviaM_Villar_etal_IOC_2008.pdf.txtLiviaM_Villar_etal_IOC_2008.pdf.txtExtracted texttext/plain24817https://www.arca.fiocruz.br/bitstream/icict/32374/3/LiviaM_Villar_etal_IOC_2008.pdf.txt4d398f878e22278b73c581a3c410124eMD53icict/323742019-04-10 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dc.title.pt_BR.fl_str_mv Hepatitis A virus subgenotypes dissemination during a community outbreak in a surrounding region of Rio de Janeiro
title Hepatitis A virus subgenotypes dissemination during a community outbreak in a surrounding region of Rio de Janeiro
spellingShingle Hepatitis A virus subgenotypes dissemination during a community outbreak in a surrounding region of Rio de Janeiro
Santos, Débora Regina Lopes dos
Vírus da Hepatite A
Epidemiologia molecular
Co-circulação dos subgenótipos IA e IB
Hepatitis A virus
Molecular epidemiology
Co-circulation of subgenotypes IA and IB
title_short Hepatitis A virus subgenotypes dissemination during a community outbreak in a surrounding region of Rio de Janeiro
title_full Hepatitis A virus subgenotypes dissemination during a community outbreak in a surrounding region of Rio de Janeiro
title_fullStr Hepatitis A virus subgenotypes dissemination during a community outbreak in a surrounding region of Rio de Janeiro
title_full_unstemmed Hepatitis A virus subgenotypes dissemination during a community outbreak in a surrounding region of Rio de Janeiro
title_sort Hepatitis A virus subgenotypes dissemination during a community outbreak in a surrounding region of Rio de Janeiro
author Santos, Débora Regina Lopes dos
author_facet Santos, Débora Regina Lopes dos
Villar, Livia Melo
Paula, Vanessa Salete de
Lima, Gerson Silva de
Gaspar, Ana Maria Coimbra
author_role author
author2 Villar, Livia Melo
Paula, Vanessa Salete de
Lima, Gerson Silva de
Gaspar, Ana Maria Coimbra
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Santos, Débora Regina Lopes dos
Villar, Livia Melo
Paula, Vanessa Salete de
Lima, Gerson Silva de
Gaspar, Ana Maria Coimbra
dc.subject.other.pt_BR.fl_str_mv Vírus da Hepatite A
Epidemiologia molecular
Co-circulação dos subgenótipos IA e IB
topic Vírus da Hepatite A
Epidemiologia molecular
Co-circulação dos subgenótipos IA e IB
Hepatitis A virus
Molecular epidemiology
Co-circulation of subgenotypes IA and IB
dc.subject.en.pt_BR.fl_str_mv Hepatitis A virus
Molecular epidemiology
Co-circulation of subgenotypes IA and IB
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico. Rio de Janeiro, RJ, Brasil.
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2019-04-04T15:58:58Z
dc.date.available.fl_str_mv 2019-04-04T15:58:58Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SANTOS, Débora Regina Lopes dos et al. Hepatitis A virus subgenotypes dissemination during a community outbreak in a surrounding region of Rio de Janeiro. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 103, n. 3, p. 254-258, May 2008.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/32374
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.pt_BR.fl_str_mv 10.1590/S0074-02762008000300005
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv SANTOS, Débora Regina Lopes dos et al. Hepatitis A virus subgenotypes dissemination during a community outbreak in a surrounding region of Rio de Janeiro. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 103, n. 3, p. 254-258, May 2008.
0074-0276
10.1590/S0074-02762008000300005
1678-8060
url https://www.arca.fiocruz.br/handle/icict/32374
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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