Hepatitis A virus subgenotypes dissemination during a community outbreak in a surrounding region of Rio de Janeiro
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/32374 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico. Rio de Janeiro, RJ, Brasil. |
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Santos, Débora Regina Lopes dosVillar, Livia MeloPaula, Vanessa Salete deLima, Gerson Silva deGaspar, Ana Maria Coimbra2019-04-04T15:58:58Z2019-04-04T15:58:58Z2008SANTOS, Débora Regina Lopes dos et al. Hepatitis A virus subgenotypes dissemination during a community outbreak in a surrounding region of Rio de Janeiro. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 103, n. 3, p. 254-258, May 2008.0074-0276https://www.arca.fiocruz.br/handle/icict/3237410.1590/S0074-027620080003000051678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzVírus da Hepatite AEpidemiologia molecularCo-circulação dos subgenótipos IA e IBHepatitis A virusMolecular epidemiologyCo-circulation of subgenotypes IA and IBHepatitis A virus subgenotypes dissemination during a community outbreak in a surrounding region of Rio de Janeiroinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Departamento de Reativos para Diagnóstico Setor de Bactérias e Recombinantes. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico. Rio de Janeiro, RJ, Brasil.From December 1999 to December 2001, many cases of hepatitis A were notified in the county of Belford Roxo involving individuals aged 0 to 79 years. Serum samples were collected to evaluate the prevalence of anti-hepatitis A virus (HAV) antibodies, to detect HAV-RNA and to correlate with possible risk factors of HAV infection. Serum samples were screened by commercial IgM and total anti-HAV antibody ELISA and HAV-RNA was isolated and subsequently amplified by reverse transcription-polymerase chain reaction (RT-PCR) at VP1/2A region, sequenced and analyzed. Total anti-HAV prevalence was 87.9% (203/231) and IgM anti-HAV prevalence was 38.7% (89/231). Multivariate analysis showed that individuals under 20 years old are risks groups to acquire the infection suggesting that hygienic habits of young subjects are the principal factor of transmission and so they could be the target for vaccine programs. HAV-RNA was amplified from 29 (32.5%) IgM anti-HAV positive patients and 26 samples were sequenced and classified into subgenotypes IB (8 isolates) and IA (18 isolates). Isolates classified into subgenotype IB were identical representing one distinct strain. We could observe both subgenotypes circulating during the study which suggests different sources of infection. Prophylactic measures as vaccination strategies added to improvements in hygienic and sanitary conditions would be highly effective to reduction of infection.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/32374/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALLiviaM_Villar_etal_IOC_2008.pdfLiviaM_Villar_etal_IOC_2008.pdfapplication/pdf664308https://www.arca.fiocruz.br/bitstream/icict/32374/2/LiviaM_Villar_etal_IOC_2008.pdf0a19974ef7d1ec825cf09a6d93f9e322MD52TEXTLiviaM_Villar_etal_IOC_2008.pdf.txtLiviaM_Villar_etal_IOC_2008.pdf.txtExtracted texttext/plain24817https://www.arca.fiocruz.br/bitstream/icict/32374/3/LiviaM_Villar_etal_IOC_2008.pdf.txt4d398f878e22278b73c581a3c410124eMD53icict/323742019-04-10 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dc.title.pt_BR.fl_str_mv |
Hepatitis A virus subgenotypes dissemination during a community outbreak in a surrounding region of Rio de Janeiro |
title |
Hepatitis A virus subgenotypes dissemination during a community outbreak in a surrounding region of Rio de Janeiro |
spellingShingle |
Hepatitis A virus subgenotypes dissemination during a community outbreak in a surrounding region of Rio de Janeiro Santos, Débora Regina Lopes dos Vírus da Hepatite A Epidemiologia molecular Co-circulação dos subgenótipos IA e IB Hepatitis A virus Molecular epidemiology Co-circulation of subgenotypes IA and IB |
title_short |
Hepatitis A virus subgenotypes dissemination during a community outbreak in a surrounding region of Rio de Janeiro |
title_full |
Hepatitis A virus subgenotypes dissemination during a community outbreak in a surrounding region of Rio de Janeiro |
title_fullStr |
Hepatitis A virus subgenotypes dissemination during a community outbreak in a surrounding region of Rio de Janeiro |
title_full_unstemmed |
Hepatitis A virus subgenotypes dissemination during a community outbreak in a surrounding region of Rio de Janeiro |
title_sort |
Hepatitis A virus subgenotypes dissemination during a community outbreak in a surrounding region of Rio de Janeiro |
author |
Santos, Débora Regina Lopes dos |
author_facet |
Santos, Débora Regina Lopes dos Villar, Livia Melo Paula, Vanessa Salete de Lima, Gerson Silva de Gaspar, Ana Maria Coimbra |
author_role |
author |
author2 |
Villar, Livia Melo Paula, Vanessa Salete de Lima, Gerson Silva de Gaspar, Ana Maria Coimbra |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Santos, Débora Regina Lopes dos Villar, Livia Melo Paula, Vanessa Salete de Lima, Gerson Silva de Gaspar, Ana Maria Coimbra |
dc.subject.other.pt_BR.fl_str_mv |
Vírus da Hepatite A Epidemiologia molecular Co-circulação dos subgenótipos IA e IB |
topic |
Vírus da Hepatite A Epidemiologia molecular Co-circulação dos subgenótipos IA e IB Hepatitis A virus Molecular epidemiology Co-circulation of subgenotypes IA and IB |
dc.subject.en.pt_BR.fl_str_mv |
Hepatitis A virus Molecular epidemiology Co-circulation of subgenotypes IA and IB |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico. Rio de Janeiro, RJ, Brasil. |
publishDate |
2008 |
dc.date.issued.fl_str_mv |
2008 |
dc.date.accessioned.fl_str_mv |
2019-04-04T15:58:58Z |
dc.date.available.fl_str_mv |
2019-04-04T15:58:58Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SANTOS, Débora Regina Lopes dos et al. Hepatitis A virus subgenotypes dissemination during a community outbreak in a surrounding region of Rio de Janeiro. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 103, n. 3, p. 254-258, May 2008. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/32374 |
dc.identifier.issn.pt_BR.fl_str_mv |
0074-0276 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.1590/S0074-02762008000300005 |
dc.identifier.eissn.none.fl_str_mv |
1678-8060 |
identifier_str_mv |
SANTOS, Débora Regina Lopes dos et al. Hepatitis A virus subgenotypes dissemination during a community outbreak in a surrounding region of Rio de Janeiro. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 103, n. 3, p. 254-258, May 2008. 0074-0276 10.1590/S0074-02762008000300005 1678-8060 |
url |
https://www.arca.fiocruz.br/handle/icict/32374 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz |
publisher.none.fl_str_mv |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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Fundação Oswaldo Cruz (FIOCRUZ) |
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FIOCRUZ |
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FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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Repositório Institucional da FIOCRUZ (ARCA) |
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