Treatment of Disseminated Leishmaniasis With Liposomal Amphotericin B
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/20542 |
Resumo: | Carvalho Filho, Edgar Marcelino de “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
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Machado, Paulo Roberto LimaRosa, Maria Elisa AlvesGuimarães, Luís Henrique SantosPrates, Fernanda Ventim de OliveiraQueiroz, AdrianoSchriefer, AlbertCarvalho Filho, Edgar Marcelino2017-08-08T17:20:42Z2017-08-08T17:20:42Z2015MACHADO, P. R. L. et al. Treatment of Disseminated Leishmaniasis With Liposomal Amphotericin B. Clinical Infectious Diseases, v. 61, p. 945-949, 2015.1058-4838https://www.arca.fiocruz.br/handle/icict/2054210.1093/cid/civ416Carvalho Filho, Edgar Marcelino de “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.Ministry of Health of Brazil (MS) and the National Council of Scientific and Technological Development (CNPq) [Edital MS-SCIET-DECIT/CNPq No 69/2010].Universidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilDisseminated leishmaniasis (DL) is a severe and emerging form of American tegumentary leishmaniasis, associated primarily with infection by Leishmania brasiliensis. DL is defined by the presence of ≥10 mixed-type lesions such as inflammatory papules and ulcers, located in ≥2 body parts. Most patients have hundreds of lesions all over the body, and mucosal involvement is detected in up to 44% of cases. DL is a difficult to cure disease and pentavalent antimony (Sb(v)) is used as standard treatment, its highest dosage being 20 mg/kg/day, for 30 days. However, less than 25% of DL cases will be cured after standard therapy, and the majority of cases will require more than one course of Sb(v) for a cure. In this context, new therapies are needed that offer a higher cure rate and a better safety profile, with convenience in drug administration. Methods. We have evaluated liposomal amphotericin B in 20 patients with DL in an open clinical trial. The total dose ranged from 17 to 37 mg/kg, used in 7 to 14 days of treatment. Results. Cure rate at 3 months after therapy was 70%. One relapse was documented 4 months after treatment, producing a final cure rate of 65%. Although liposomal amphotericin B was considered well tolerated, mild adverse events were documented in 75% of the patients. Conclusions. Liposomal amphotericin B is an effective therapy for DL, with a higher final cure rate of 75% observed when used in a total dose above 30 mg/kg.engOxfor University PressLeishmaniose tegumentar americanaLeishmanioseAnfotericina BAmerican tegumentary leishmaniasisDisseminated leishmaniasisLiposomal amphotericin BTreatment of Disseminated Leishmaniasis With Liposomal Amphotericin Binfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/20542/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMachado PRL Treatment of dissemination....pdfMachado PRL Treatment of 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dc.title.pt_BR.fl_str_mv |
Treatment of Disseminated Leishmaniasis With Liposomal Amphotericin B |
title |
Treatment of Disseminated Leishmaniasis With Liposomal Amphotericin B |
spellingShingle |
Treatment of Disseminated Leishmaniasis With Liposomal Amphotericin B Machado, Paulo Roberto Lima Leishmaniose tegumentar americana Leishmaniose Anfotericina B American tegumentary leishmaniasis Disseminated leishmaniasis Liposomal amphotericin B |
title_short |
Treatment of Disseminated Leishmaniasis With Liposomal Amphotericin B |
title_full |
Treatment of Disseminated Leishmaniasis With Liposomal Amphotericin B |
title_fullStr |
Treatment of Disseminated Leishmaniasis With Liposomal Amphotericin B |
title_full_unstemmed |
Treatment of Disseminated Leishmaniasis With Liposomal Amphotericin B |
title_sort |
Treatment of Disseminated Leishmaniasis With Liposomal Amphotericin B |
author |
Machado, Paulo Roberto Lima |
author_facet |
Machado, Paulo Roberto Lima Rosa, Maria Elisa Alves Guimarães, Luís Henrique Santos Prates, Fernanda Ventim de Oliveira Queiroz, Adriano Schriefer, Albert Carvalho Filho, Edgar Marcelino |
author_role |
author |
author2 |
Rosa, Maria Elisa Alves Guimarães, Luís Henrique Santos Prates, Fernanda Ventim de Oliveira Queiroz, Adriano Schriefer, Albert Carvalho Filho, Edgar Marcelino |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Machado, Paulo Roberto Lima Rosa, Maria Elisa Alves Guimarães, Luís Henrique Santos Prates, Fernanda Ventim de Oliveira Queiroz, Adriano Schriefer, Albert Carvalho Filho, Edgar Marcelino |
dc.subject.other.pt_BR.fl_str_mv |
Leishmaniose tegumentar americana Leishmaniose Anfotericina B |
topic |
Leishmaniose tegumentar americana Leishmaniose Anfotericina B American tegumentary leishmaniasis Disseminated leishmaniasis Liposomal amphotericin B |
dc.subject.en.pt_BR.fl_str_mv |
American tegumentary leishmaniasis Disseminated leishmaniasis Liposomal amphotericin B |
description |
Carvalho Filho, Edgar Marcelino de “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015 |
dc.date.accessioned.fl_str_mv |
2017-08-08T17:20:42Z |
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2017-08-08T17:20:42Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
MACHADO, P. R. L. et al. Treatment of Disseminated Leishmaniasis With Liposomal Amphotericin B. Clinical Infectious Diseases, v. 61, p. 945-949, 2015. |
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https://www.arca.fiocruz.br/handle/icict/20542 |
dc.identifier.issn.pt_BR.fl_str_mv |
1058-4838 |
dc.identifier.doi.none.fl_str_mv |
10.1093/cid/civ416 |
identifier_str_mv |
MACHADO, P. R. L. et al. Treatment of Disseminated Leishmaniasis With Liposomal Amphotericin B. Clinical Infectious Diseases, v. 61, p. 945-949, 2015. 1058-4838 10.1093/cid/civ416 |
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https://www.arca.fiocruz.br/handle/icict/20542 |
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Oxfor University Press |
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Oxfor University Press |
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