An experimental approach to the pathogenesis of "pipestem" fibrosis (Symmers' fibrosis of the liver)

Detalhes bibliográficos
Autor(a) principal: Andrade, Zilton de Araújo
Data de Publicação: 1997
Outros Autores: Silva, Luciana Menezes da, Souza, Márcia Maria de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/5673
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Andrade, Zilton de AraújoSilva, Luciana Menezes daSouza, Márcia Maria de2012-10-16T19:00:30Z2012-10-16T19:00:30Z1997ANDRADE, Z.A.; SILVA, L.M.; de SOUZA, M.M. An experimental approach to the pathogenesis of "pipestem" fibrosis (Symmers' fibrosis of the liver). Memórias do Instituto Oswaldo Cruz, v. 92, n. 5, p. 699-706, sep.-oct. 1997.0074-0276https://www.arca.fiocruz.br/handle/icict/5673engAn experimental approach to the pathogenesis of "pipestem" fibrosis (Symmers' fibrosis of the liver)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilPathogenesis of schistosomal hepatic fibrosis ("pipestem" fibrosis of the liver) was investigated by means of the murine model. Although worm load appears as the main pathogenetic factor, alone it is not sufficient to produce that characteristic lesion. By comparing the findings in animals with heavy and prolonged Schistosoma mansoni infection, which developed or not "pipestem" fibrosis, it was observed that the lesion was more frequent in intact animals than in the splenectomized one. However, the size of the spleen, the number of recovered worms, the number of eggs per gram of liver tissue, the level of serum idiotype and anti-idiotype antibodies, the size and volume of periovular granulomas formed in the liver, all that failed to show statistically significant differences between the two groups. After analysing all these data, other factors, that apparently have been hitherto negleted, rested to explain the findings. Among them, the timing and sequence of the egg-induced intrahepatic vascular changes seemed crucial. The sequential development of intrahepatic portal vein obstruction, followed by the opening of periportal collateral veins and the continous arrival of schistosome eggs going to be lodged into the latter, appeared as essential steps in the pathogenesis of "pipestem" fibrosis.Schistosoma mansoniPipestem fibrosisPathogenesisCirrose Hepática/parasitologiaSchistosoma mansoniAnimaisGranulomaCamundongosContagem de Ovos de Parasitas/estatística & dados numéricosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALAndrade ZA An experimental approach....pdfAndrade ZA An experimental approach....pdfapplication/pdf593503https://www.arca.fiocruz.br/bitstream/icict/5673/1/Andrade%20ZA%20An%20experimental%20approach....pdf66f67b29667d850aed40940d70c208fcMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5673/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXTAndrade ZA An experimental approach....pdf.txtAndrade ZA An experimental approach....pdf.txtExtracted texttext/plain24745https://www.arca.fiocruz.br/bitstream/icict/5673/5/Andrade%20ZA%20An%20experimental%20approach....pdf.txt021364571dc3b393cee6d21b672eac16MD55THUMBNAILAndrade ZA An experimental approach....pdf.jpgAndrade ZA An experimental approach....pdf.jpgGenerated Thumbnailimage/jpeg2448https://www.arca.fiocruz.br/bitstream/icict/5673/4/Andrade%20ZA%20An%20experimental%20approach....pdf.jpg0e1383232c10dd702e4571ef03a65f7bMD54icict/56732023-03-15 14:33:01.594oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:01Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv An experimental approach to the pathogenesis of "pipestem" fibrosis (Symmers' fibrosis of the liver)
title An experimental approach to the pathogenesis of "pipestem" fibrosis (Symmers' fibrosis of the liver)
spellingShingle An experimental approach to the pathogenesis of "pipestem" fibrosis (Symmers' fibrosis of the liver)
Andrade, Zilton de Araújo
Schistosoma mansoni
Pipestem fibrosis
Pathogenesis
Cirrose Hepática/parasitologia
Schistosoma mansoni
Animais
Granuloma
Camundongos
Contagem de Ovos de Parasitas/estatística & dados numéricos
title_short An experimental approach to the pathogenesis of "pipestem" fibrosis (Symmers' fibrosis of the liver)
title_full An experimental approach to the pathogenesis of "pipestem" fibrosis (Symmers' fibrosis of the liver)
title_fullStr An experimental approach to the pathogenesis of "pipestem" fibrosis (Symmers' fibrosis of the liver)
title_full_unstemmed An experimental approach to the pathogenesis of "pipestem" fibrosis (Symmers' fibrosis of the liver)
title_sort An experimental approach to the pathogenesis of "pipestem" fibrosis (Symmers' fibrosis of the liver)
author Andrade, Zilton de Araújo
author_facet Andrade, Zilton de Araújo
Silva, Luciana Menezes da
Souza, Márcia Maria de
author_role author
author2 Silva, Luciana Menezes da
Souza, Márcia Maria de
author2_role author
author
dc.contributor.author.fl_str_mv Andrade, Zilton de Araújo
Silva, Luciana Menezes da
Souza, Márcia Maria de
dc.subject.en.pt_BR.fl_str_mv Schistosoma mansoni
Pipestem fibrosis
Pathogenesis
topic Schistosoma mansoni
Pipestem fibrosis
Pathogenesis
Cirrose Hepática/parasitologia
Schistosoma mansoni
Animais
Granuloma
Camundongos
Contagem de Ovos de Parasitas/estatística & dados numéricos
dc.subject.decs.pt_BR.fl_str_mv Cirrose Hepática/parasitologia
Schistosoma mansoni
Animais
Granuloma
Camundongos
Contagem de Ovos de Parasitas/estatística & dados numéricos
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 1997
dc.date.issued.fl_str_mv 1997
dc.date.accessioned.fl_str_mv 2012-10-16T19:00:30Z
dc.date.available.fl_str_mv 2012-10-16T19:00:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ANDRADE, Z.A.; SILVA, L.M.; de SOUZA, M.M. An experimental approach to the pathogenesis of "pipestem" fibrosis (Symmers' fibrosis of the liver). Memórias do Instituto Oswaldo Cruz, v. 92, n. 5, p. 699-706, sep.-oct. 1997.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/5673
dc.identifier.issn.none.fl_str_mv 0074-0276
identifier_str_mv ANDRADE, Z.A.; SILVA, L.M.; de SOUZA, M.M. An experimental approach to the pathogenesis of "pipestem" fibrosis (Symmers' fibrosis of the liver). Memórias do Instituto Oswaldo Cruz, v. 92, n. 5, p. 699-706, sep.-oct. 1997.
0074-0276
url https://www.arca.fiocruz.br/handle/icict/5673
dc.language.iso.fl_str_mv eng
language eng
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dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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