An experimental approach to the pathogenesis of "pipestem" fibrosis (Symmers' fibrosis of the liver)
Autor(a) principal: | |
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Data de Publicação: | 1997 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/5673 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
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Andrade, Zilton de AraújoSilva, Luciana Menezes daSouza, Márcia Maria de2012-10-16T19:00:30Z2012-10-16T19:00:30Z1997ANDRADE, Z.A.; SILVA, L.M.; de SOUZA, M.M. An experimental approach to the pathogenesis of "pipestem" fibrosis (Symmers' fibrosis of the liver). Memórias do Instituto Oswaldo Cruz, v. 92, n. 5, p. 699-706, sep.-oct. 1997.0074-0276https://www.arca.fiocruz.br/handle/icict/5673engAn experimental approach to the pathogenesis of "pipestem" fibrosis (Symmers' fibrosis of the liver)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilPathogenesis of schistosomal hepatic fibrosis ("pipestem" fibrosis of the liver) was investigated by means of the murine model. Although worm load appears as the main pathogenetic factor, alone it is not sufficient to produce that characteristic lesion. By comparing the findings in animals with heavy and prolonged Schistosoma mansoni infection, which developed or not "pipestem" fibrosis, it was observed that the lesion was more frequent in intact animals than in the splenectomized one. However, the size of the spleen, the number of recovered worms, the number of eggs per gram of liver tissue, the level of serum idiotype and anti-idiotype antibodies, the size and volume of periovular granulomas formed in the liver, all that failed to show statistically significant differences between the two groups. After analysing all these data, other factors, that apparently have been hitherto negleted, rested to explain the findings. Among them, the timing and sequence of the egg-induced intrahepatic vascular changes seemed crucial. The sequential development of intrahepatic portal vein obstruction, followed by the opening of periportal collateral veins and the continous arrival of schistosome eggs going to be lodged into the latter, appeared as essential steps in the pathogenesis of "pipestem" fibrosis.Schistosoma mansoniPipestem fibrosisPathogenesisCirrose Hepática/parasitologiaSchistosoma mansoniAnimaisGranulomaCamundongosContagem de Ovos de Parasitas/estatística & dados numéricosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALAndrade ZA An experimental approach....pdfAndrade ZA An experimental approach....pdfapplication/pdf593503https://www.arca.fiocruz.br/bitstream/icict/5673/1/Andrade%20ZA%20An%20experimental%20approach....pdf66f67b29667d850aed40940d70c208fcMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5673/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXTAndrade ZA An experimental approach....pdf.txtAndrade ZA An experimental approach....pdf.txtExtracted texttext/plain24745https://www.arca.fiocruz.br/bitstream/icict/5673/5/Andrade%20ZA%20An%20experimental%20approach....pdf.txt021364571dc3b393cee6d21b672eac16MD55THUMBNAILAndrade ZA An experimental approach....pdf.jpgAndrade ZA An experimental approach....pdf.jpgGenerated Thumbnailimage/jpeg2448https://www.arca.fiocruz.br/bitstream/icict/5673/4/Andrade%20ZA%20An%20experimental%20approach....pdf.jpg0e1383232c10dd702e4571ef03a65f7bMD54icict/56732023-03-15 14:33:01.594oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:01Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
An experimental approach to the pathogenesis of "pipestem" fibrosis (Symmers' fibrosis of the liver) |
title |
An experimental approach to the pathogenesis of "pipestem" fibrosis (Symmers' fibrosis of the liver) |
spellingShingle |
An experimental approach to the pathogenesis of "pipestem" fibrosis (Symmers' fibrosis of the liver) Andrade, Zilton de Araújo Schistosoma mansoni Pipestem fibrosis Pathogenesis Cirrose Hepática/parasitologia Schistosoma mansoni Animais Granuloma Camundongos Contagem de Ovos de Parasitas/estatística & dados numéricos |
title_short |
An experimental approach to the pathogenesis of "pipestem" fibrosis (Symmers' fibrosis of the liver) |
title_full |
An experimental approach to the pathogenesis of "pipestem" fibrosis (Symmers' fibrosis of the liver) |
title_fullStr |
An experimental approach to the pathogenesis of "pipestem" fibrosis (Symmers' fibrosis of the liver) |
title_full_unstemmed |
An experimental approach to the pathogenesis of "pipestem" fibrosis (Symmers' fibrosis of the liver) |
title_sort |
An experimental approach to the pathogenesis of "pipestem" fibrosis (Symmers' fibrosis of the liver) |
author |
Andrade, Zilton de Araújo |
author_facet |
Andrade, Zilton de Araújo Silva, Luciana Menezes da Souza, Márcia Maria de |
author_role |
author |
author2 |
Silva, Luciana Menezes da Souza, Márcia Maria de |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Andrade, Zilton de Araújo Silva, Luciana Menezes da Souza, Márcia Maria de |
dc.subject.en.pt_BR.fl_str_mv |
Schistosoma mansoni Pipestem fibrosis Pathogenesis |
topic |
Schistosoma mansoni Pipestem fibrosis Pathogenesis Cirrose Hepática/parasitologia Schistosoma mansoni Animais Granuloma Camundongos Contagem de Ovos de Parasitas/estatística & dados numéricos |
dc.subject.decs.pt_BR.fl_str_mv |
Cirrose Hepática/parasitologia Schistosoma mansoni Animais Granuloma Camundongos Contagem de Ovos de Parasitas/estatística & dados numéricos |
description |
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
publishDate |
1997 |
dc.date.issued.fl_str_mv |
1997 |
dc.date.accessioned.fl_str_mv |
2012-10-16T19:00:30Z |
dc.date.available.fl_str_mv |
2012-10-16T19:00:30Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ANDRADE, Z.A.; SILVA, L.M.; de SOUZA, M.M. An experimental approach to the pathogenesis of "pipestem" fibrosis (Symmers' fibrosis of the liver). Memórias do Instituto Oswaldo Cruz, v. 92, n. 5, p. 699-706, sep.-oct. 1997. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/5673 |
dc.identifier.issn.none.fl_str_mv |
0074-0276 |
identifier_str_mv |
ANDRADE, Z.A.; SILVA, L.M.; de SOUZA, M.M. An experimental approach to the pathogenesis of "pipestem" fibrosis (Symmers' fibrosis of the liver). Memórias do Instituto Oswaldo Cruz, v. 92, n. 5, p. 699-706, sep.-oct. 1997. 0074-0276 |
url |
https://www.arca.fiocruz.br/handle/icict/5673 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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