In silico predicted epitopes from the COOH-terminal extension of cysteine proteinase B inducing distinct immune responses during Leishmania (Leishmania) amazonensis experimental murine infection
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/16209 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil. |
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Pereira, Bernardo A. S.Silva, Franklin S.Rebello, Karina M.Marín-Villa, Marcel.Traub-Cseko, Yara M.Andrade, Thereza C. B.Bertho, Álvaro L.Caffarena, Ernesto R.Alves, Carlos R.2016-10-13T12:46:45Z2016-10-13T12:46:45Z2011PEREIRA, Bernardo A. S. et al. In silico predicted epitopes from the COOHterminal extension of cysteine proteinase B inducing distinct immune responses during Leishmania (Leishmania) amazonensis experimental murine infection. BMC Immunology, v.12, n.44, 12p, Aug. 2011.1471-2172https://www.arca.fiocruz.br/handle/icict/1620910.1186/1471-2172-12-44engBioMed CentralLeishmania amazonensisinfecção murinaB proteinase cisteínaRespostas imunesLeishmania (Leishmania) amazonensisCPB COOH-terminal extensionmurine infectionimmune responsesIn silico predicted epitopes from the COOH-terminal extension of cysteine proteinase B inducing distinct immune responses during Leishmania (Leishmania) amazonensis experimental murine infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.Leishmania parasites have been reported to interfere and even subvert their host immune responses to enhance their chances of survival and proliferation. Experimental Leishmania infection in mice has been widely used in the identification of specific parasite virulence factors involved in the interaction with the host immune system. Cysteine-proteinase B (CPB) is an important virulence factor in parasites from the Leishmania (Leishmania) mexicana complex: it inhibits lymphocytes Th1 and/or promotes Th2 responses either through proteolytic activity or through epitopes derived from its COOH-terminal extension. In the present study we analyzed the effects of Leishmania (Leishmania) amazonensis CPB COOH-terminal extension-derived peptides on cell cultures from murine strains with distinct levels of susceptibility to infection: BALB/c, highly susceptible, and CBA, mildly resistant.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16209/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALkarina_rebello_etal_IOC_2011.pdfkarina_rebello_etal_IOC_2011.pdfapplication/pdf405753https://www.arca.fiocruz.br/bitstream/icict/16209/2/karina_rebello_etal_IOC_2011.pdf611592036d0d7722155910fee51d9dbfMD52TEXTkarina_rebello_etal_IOC_2011.pdf.txtkarina_rebello_etal_IOC_2011.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
In silico predicted epitopes from the COOH-terminal extension of cysteine proteinase B inducing distinct immune responses during Leishmania (Leishmania) amazonensis experimental murine infection |
| title |
In silico predicted epitopes from the COOH-terminal extension of cysteine proteinase B inducing distinct immune responses during Leishmania (Leishmania) amazonensis experimental murine infection |
| spellingShingle |
In silico predicted epitopes from the COOH-terminal extension of cysteine proteinase B inducing distinct immune responses during Leishmania (Leishmania) amazonensis experimental murine infection Pereira, Bernardo A. S. Leishmania amazonensis infecção murina B proteinase cisteína Respostas imunes Leishmania (Leishmania) amazonensis CPB COOH-terminal extension murine infection immune responses |
| title_short |
In silico predicted epitopes from the COOH-terminal extension of cysteine proteinase B inducing distinct immune responses during Leishmania (Leishmania) amazonensis experimental murine infection |
| title_full |
In silico predicted epitopes from the COOH-terminal extension of cysteine proteinase B inducing distinct immune responses during Leishmania (Leishmania) amazonensis experimental murine infection |
| title_fullStr |
In silico predicted epitopes from the COOH-terminal extension of cysteine proteinase B inducing distinct immune responses during Leishmania (Leishmania) amazonensis experimental murine infection |
| title_full_unstemmed |
In silico predicted epitopes from the COOH-terminal extension of cysteine proteinase B inducing distinct immune responses during Leishmania (Leishmania) amazonensis experimental murine infection |
| title_sort |
In silico predicted epitopes from the COOH-terminal extension of cysteine proteinase B inducing distinct immune responses during Leishmania (Leishmania) amazonensis experimental murine infection |
| author |
Pereira, Bernardo A. S. |
| author_facet |
Pereira, Bernardo A. S. Silva, Franklin S. Rebello, Karina M. Marín-Villa, Marcel. Traub-Cseko, Yara M. Andrade, Thereza C. B. Bertho, Álvaro L. Caffarena, Ernesto R. Alves, Carlos R. |
| author_role |
author |
| author2 |
Silva, Franklin S. Rebello, Karina M. Marín-Villa, Marcel. Traub-Cseko, Yara M. Andrade, Thereza C. B. Bertho, Álvaro L. Caffarena, Ernesto R. Alves, Carlos R. |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Pereira, Bernardo A. S. Silva, Franklin S. Rebello, Karina M. Marín-Villa, Marcel. Traub-Cseko, Yara M. Andrade, Thereza C. B. Bertho, Álvaro L. Caffarena, Ernesto R. Alves, Carlos R. |
| dc.subject.other.pt_BR.fl_str_mv |
Leishmania amazonensis infecção murina B proteinase cisteína Respostas imunes |
| topic |
Leishmania amazonensis infecção murina B proteinase cisteína Respostas imunes Leishmania (Leishmania) amazonensis CPB COOH-terminal extension murine infection immune responses |
| dc.subject.en.pt_BR.fl_str_mv |
Leishmania (Leishmania) amazonensis CPB COOH-terminal extension murine infection immune responses |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil. |
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2011 |
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2011 |
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2016-10-13T12:46:45Z |
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2016-10-13T12:46:45Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
PEREIRA, Bernardo A. S. et al. In silico predicted epitopes from the COOHterminal extension of cysteine proteinase B inducing distinct immune responses during Leishmania (Leishmania) amazonensis experimental murine infection. BMC Immunology, v.12, n.44, 12p, Aug. 2011. |
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https://www.arca.fiocruz.br/handle/icict/16209 |
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1471-2172 |
| dc.identifier.doi.none.fl_str_mv |
10.1186/1471-2172-12-44 |
| identifier_str_mv |
PEREIRA, Bernardo A. S. et al. In silico predicted epitopes from the COOHterminal extension of cysteine proteinase B inducing distinct immune responses during Leishmania (Leishmania) amazonensis experimental murine infection. BMC Immunology, v.12, n.44, 12p, Aug. 2011. 1471-2172 10.1186/1471-2172-12-44 |
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