The Leishmania metaphylome: A comprehensive survey of Leishmania protein phylogenetic relationships

Detalhes bibliográficos
Autor(a) principal: Rodríguez, Hugo Oswaldo Valdivia
Data de Publicação: 2015
Outros Autores: Scholte, Larissa Lopes Silva, Oliveira, Guilherme Corrêa de, Gabaldón, Toni, Bartholomeu, Daniella Castanheira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/13442
Resumo: Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Imunologia e Genômica de Parasitos. Belo Horizonte, MG, Brasil/Department of Parasitology, U.S. Naval Medical Research Unit No. 6. Lima, Peru/Centro de Investigaciones Tecnológicas, Biomédicas y Medioambientales. Lima, Peru.
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spelling Rodríguez, Hugo Oswaldo ValdiviaScholte, Larissa Lopes SilvaOliveira, Guilherme Corrêa deGabaldón, ToniBartholomeu, Daniella Castanheira2016-04-01T19:15:38Z2016-04-01T19:15:38Z2015RODRÍGUEZ, Hugo Oswaldo Valdivia et al. The Leishmania metaphylome: A comprehensive survey of Leishmania protein phylogenetic relationships. BMC Genomics, vol. 16, p. 887, 20151471-2164https://www.arca.fiocruz.br/handle/icict/1344210.1186/s12864-015-2091-2engBioMed CentralThe Leishmania metaphylome: A comprehensive survey of Leishmania protein phylogenetic relationshipsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Imunologia e Genômica de Parasitos. Belo Horizonte, MG, Brasil/Department of Parasitology, U.S. Naval Medical Research Unit No. 6. Lima, Peru/Centro de Investigaciones Tecnológicas, Biomédicas y Medioambientales. Lima, Peru.Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Grupo de Genomica e Biologia Computacional. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Grupo de Genomica e Biologia Computacional. Belo Horizonte, MG, Brasil/Instituto Tecnológico Vale. Belém, PA, Brasil.Centre for Genomic Regulation. Bioinformatics and Genomics Programme. Barcelona, Spain/Universitat Pompeu Fabra. Barcelona, Spain/Institució Catalana de Recerca i Estudis Avançats. Barcelona, SpainUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Imunologia e Genômica de Parasitos. Belo Horizonte, MG, Brasil/Centro de Investigaciones Tecnológicas, Biomédicas y Medioambientales. Lima, Peru.Background: Leishmaniasis is a neglected parasitic disease with diverse clinical manifestations and a complex epidemiology. It has been shown that its parasite-related traits vary between species and that they modulate infectivity, pathogenicity, and virulence. However, understanding of the species-specific adaptations responsible for these features and their evolutionary background is limited. To improve our knowledge regarding the parasite biology and adaptation mechanisms of different Leishmania species, we conducted a proteome-wide phylogenomic analysis to gain insights into Leishmania evolution. Results: The analysis of the reconstructed phylomes (totaling 45,918 phylogenies) allowed us to detect genes that are shared in pathogenic Leishmania species, such as calpain-like cysteine peptidases and 3'a2rel-related proteins, or genes that could be associated with visceral or cutaneous development. This analysis also established the phylogenetic relationship of several hypothetical proteins whose roles remain to be characterized. Our findings demonstrated that gene duplication constitutes an important evolutionary force in Leishmania, acting on protein families that mediate host-parasite interactions, such as amastins, GP63 metallopeptidases, cathepsin L-like proteases, and our methods permitted a deeper analysis of their phylogenetic relationships. Conclusions: Our results highlight the importance of proteome wide phylogenetic analyses to detect adaptation and evolutionary processes in different organisms and underscore the need to characterize the role of expanded and species-specific proteins in the context of Leishmania evolution by providing a framework for the phylogenetic relationships of Leishmania proteins.PhylogenomicsLeishmaniaHomologypredictioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13442/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALThe Leishmania.pdfThe Leishmania.pdfapplication/pdf1256045https://www.arca.fiocruz.br/bitstream/icict/13442/2/The%20Leishmania.pdfa3ad4bb7840276251cdd5bd04a8fbf43MD52TEXTThe Leishmania.pdf.txtThe Leishmania.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv The Leishmania metaphylome: A comprehensive survey of Leishmania protein phylogenetic relationships
title The Leishmania metaphylome: A comprehensive survey of Leishmania protein phylogenetic relationships
spellingShingle The Leishmania metaphylome: A comprehensive survey of Leishmania protein phylogenetic relationships
Rodríguez, Hugo Oswaldo Valdivia
Phylogenomics
Leishmania
Homology
prediction
title_short The Leishmania metaphylome: A comprehensive survey of Leishmania protein phylogenetic relationships
title_full The Leishmania metaphylome: A comprehensive survey of Leishmania protein phylogenetic relationships
title_fullStr The Leishmania metaphylome: A comprehensive survey of Leishmania protein phylogenetic relationships
title_full_unstemmed The Leishmania metaphylome: A comprehensive survey of Leishmania protein phylogenetic relationships
title_sort The Leishmania metaphylome: A comprehensive survey of Leishmania protein phylogenetic relationships
author Rodríguez, Hugo Oswaldo Valdivia
author_facet Rodríguez, Hugo Oswaldo Valdivia
Scholte, Larissa Lopes Silva
Oliveira, Guilherme Corrêa de
Gabaldón, Toni
Bartholomeu, Daniella Castanheira
author_role author
author2 Scholte, Larissa Lopes Silva
Oliveira, Guilherme Corrêa de
Gabaldón, Toni
Bartholomeu, Daniella Castanheira
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Rodríguez, Hugo Oswaldo Valdivia
Scholte, Larissa Lopes Silva
Oliveira, Guilherme Corrêa de
Gabaldón, Toni
Bartholomeu, Daniella Castanheira
dc.subject.en.pt_BR.fl_str_mv Phylogenomics
Leishmania
Homology
prediction
topic Phylogenomics
Leishmania
Homology
prediction
description Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Imunologia e Genômica de Parasitos. Belo Horizonte, MG, Brasil/Department of Parasitology, U.S. Naval Medical Research Unit No. 6. Lima, Peru/Centro de Investigaciones Tecnológicas, Biomédicas y Medioambientales. Lima, Peru.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-04-01T19:15:38Z
dc.date.available.fl_str_mv 2016-04-01T19:15:38Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv RODRÍGUEZ, Hugo Oswaldo Valdivia et al. The Leishmania metaphylome: A comprehensive survey of Leishmania protein phylogenetic relationships. BMC Genomics, vol. 16, p. 887, 2015
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/13442
dc.identifier.issn.none.fl_str_mv 1471-2164
dc.identifier.doi.none.fl_str_mv 10.1186/s12864-015-2091-2
identifier_str_mv RODRÍGUEZ, Hugo Oswaldo Valdivia et al. The Leishmania metaphylome: A comprehensive survey of Leishmania protein phylogenetic relationships. BMC Genomics, vol. 16, p. 887, 2015
1471-2164
10.1186/s12864-015-2091-2
url https://www.arca.fiocruz.br/handle/icict/13442
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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