The Comparative Genomics and Phylogenomics of Leishmania amazonensis Parasite

Tschoeke, Diogo A; Nunes, Gisele L; Jardim, Rodrigo; Lima, Joana; Dumaresq, Aline S. R; Gomes, Monete R; Pereira, Leandro de Mattos; Loureiro, Daniel R; Stoco, Patrícia Hermes; Guedes, Herbert Leonel de Matos; Miranda, Antonio Basilio de; Ruiz, Jeronimo; Pitaluga, André; Silva Jr, Floriano P; Probst, Christian M; Dickens, Nicholas J; Mottram, Jeremy C; Grisard, Edmundo C; Dávila, Alberto M. R.

The Comparative Genomics and Phylogenomics of Leishmania amazonensis Parasite

Bibliographic Details
Main Author:	Tschoeke, Diogo A
Publication Date:	2014
Other Authors:	Nunes, Gisele L, Jardim, Rodrigo, Lima, Joana, Dumaresq, Aline S. R, Gomes, Monete R, Pereira, Leandro de Mattos, Loureiro, Daniel R, Stoco, Patrícia Hermes, Guedes, Herbert Leonel de Matos, Miranda, Antonio Basilio de, Ruiz, Jeronimo, Pitaluga, André, Silva Jr, Floriano P, Probst, Christian M, Dickens, Nicholas J, Mottram, Jeremy C, Grisard, Edmundo C, Dávila, Alberto M. R.
Format:	Article
Language:	eng
Source:	Repositório Institucional da FIOCRUZ (ARCA)
Download full:	https://www.arca.fiocruz.br/handle/icict/10106
Summary:	Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Pólo de Biologia Computacional e Sistemas. Laboratório de Biologia Computacional e Sistemas. Rio de Janeiro, RJ, Brasil.

Item metadata

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network_acronym_str	CRUZ
network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str	2135
spelling	Tschoeke, Diogo ANunes, Gisele LJardim, RodrigoLima, JoanaDumaresq, Aline S. RGomes, Monete RPereira, Leandro de MattosLoureiro, Daniel RStoco, Patrícia HermesGuedes, Herbert Leonel de MatosMiranda, Antonio Basilio deRuiz, JeronimoPitaluga, AndréSilva Jr, Floriano PProbst, Christian MDickens, Nicholas JMottram, Jeremy CGrisard, Edmundo CDávila, Alberto M. R.2015-04-22T14:23:10Z2015-04-22T14:23:10Z2014TSCHOEKE, Diogo A et al. The Comparative Genomics and Phylogenomics of Leishmania amazonensis Parasite. Evolutionary Bioinformatics, n.10. p.131-153, 2014.1176-9343https://www.arca.fiocruz.br/handle/icict/1010610.4137/EBO.S13759engLibertas AcademicaThe Comparative Genomics and Phylogenomics of Leishmania amazonensis Parasiteinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Pólo de Biologia Computacional e Sistemas. Laboratório de Biologia Computacional e Sistemas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Computacional e Sistemas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Pólo de Biologia Computacional e Sistemas. Laboratório de Biologia Computacional e Sistemas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Computacional e Sistemas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Computacional e Sistemas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Computacional e Sistemas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Computacional e Sistemas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Pólo de Biologia Computacional e Sistemas. Rio de Janeiro, RJ, Brasil.Universidade Federal de Santa Catarina. Laboratório de Protozoologia. Florianópolis, SC, BrazilUniversidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil / University of Glasgow.University of Glasgow. Institute of Immunity, Infection and Inflammation. College of MVLS. Wellcome Trust Centre for Molecular Parasitology. Glasgow, UK.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Pólo de Biologia Computacional e Sistemas. Laboratório de Biologia Computacional e Sistemas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Pólo de Biologia Computacional e Sistemas. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Pólo de Biologia Computacional e Sistemas. Laboratório de Biologia Computacional e Sistemas. 8Laboratório de Bioquímica de Proteínas e Peptídeos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Pólo de Biologia Computacional e Sistemas. Rio de Janeiro, RJ, Brasil. Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, BrasilUniversity of Glasgow. Institute of Immunity, Infection and Inflammation. College of MVLS. Wellcome Trust Centre for Molecular Parasitology. Glasgow, UK.University of Glasgow. Institute of Immunity, Infection and Inflammation. College of MVLS. Wellcome Trust Centre for Molecular Parasitology. Glasgow, UK.Universidade Federal de Santa Catarina. Laboratório de Protozoologia. Florianópolis, SC, BrazilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Pólo de Biologia Computacional e Sistemas. Laboratório de Biologia Computacional e Sistemas. Rio de Janeiro, RJ, Brasil.Leishmaniasis is an infectious disease caused by Leishmania species. Leishmania amazonensis is a New World Leishmania species belonging to the Mexicana complex, which is able to cause all types of leishmaniasis infections. The L. amazonensis reference strain MHOM/BR/1973/M2269 was sequenced identifying 8,802 codifying sequences (CDS), most of them of hypothetical function. Comparative analysis using six Leishmania species showed a core set of 7,016 orthologs. L. amazonensis and Leishmania mexicana share the largest number of distinct orthologs, while Leishmania braziliensis presented the largest number of inparalogs. Additionally, phylogenomic analysis confirmed the taxonomic position for L. amazonensis within the “Mexicana complex”, reinforcing understanding of the split of New and Old World Leishmania. Potential non-homologous isofunctional enzymes (NISE) were identified between L. amazonensis and Homo sapiens that could provide new drug targets for development.Leishmania amazonensisComparative genomicsPhylogenomicsLeishmanioseGênomicainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/10106/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALdiogo_tschoekeetal_IOC_2014.pdfapplication/pdf6323985https://www.arca.fiocruz.br/bitstream/icict/10106/2/diogo_tschoekeetal_IOC_2014.pdf44a3173ca9f8361e11ee797c79334655MD52TEXTdiogo_tschoekeetal_IOC_2014.pdf.txtdiogo_tschoekeetal_IOC_2014.pdf.txtExtracted texttext/plain105612https://www.arca.fiocruz.br/bitstream/icict/10106/3/diogo_tschoekeetal_IOC_2014.pdf.txta363a254ba9865ef2b9c1f068e208438MD53icict/101062022-06-24 13:12:33.162oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T16:12:33Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv	The Comparative Genomics and Phylogenomics of Leishmania amazonensis Parasite
title	The Comparative Genomics and Phylogenomics of Leishmania amazonensis Parasite
spellingShingle	The Comparative Genomics and Phylogenomics of Leishmania amazonensis Parasite Tschoeke, Diogo A Leishmania amazonensis Comparative genomics Phylogenomics Leishmaniose Gênomica
title_short	The Comparative Genomics and Phylogenomics of Leishmania amazonensis Parasite
title_full	The Comparative Genomics and Phylogenomics of Leishmania amazonensis Parasite
title_fullStr	The Comparative Genomics and Phylogenomics of Leishmania amazonensis Parasite
title_full_unstemmed	The Comparative Genomics and Phylogenomics of Leishmania amazonensis Parasite
title_sort	The Comparative Genomics and Phylogenomics of Leishmania amazonensis Parasite
author	Tschoeke, Diogo A
author_facet	Tschoeke, Diogo A Nunes, Gisele L Jardim, Rodrigo Lima, Joana Dumaresq, Aline S. R Gomes, Monete R Pereira, Leandro de Mattos Loureiro, Daniel R Stoco, Patrícia Hermes Guedes, Herbert Leonel de Matos Miranda, Antonio Basilio de Ruiz, Jeronimo Pitaluga, André Silva Jr, Floriano P Probst, Christian M Dickens, Nicholas J Mottram, Jeremy C Grisard, Edmundo C Dávila, Alberto M. R.
author_role	author
author2	Nunes, Gisele L Jardim, Rodrigo Lima, Joana Dumaresq, Aline S. R Gomes, Monete R Pereira, Leandro de Mattos Loureiro, Daniel R Stoco, Patrícia Hermes Guedes, Herbert Leonel de Matos Miranda, Antonio Basilio de Ruiz, Jeronimo Pitaluga, André Silva Jr, Floriano P Probst, Christian M Dickens, Nicholas J Mottram, Jeremy C Grisard, Edmundo C Dávila, Alberto M. R.
author2_role	author author author author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Tschoeke, Diogo A Nunes, Gisele L Jardim, Rodrigo Lima, Joana Dumaresq, Aline S. R Gomes, Monete R Pereira, Leandro de Mattos Loureiro, Daniel R Stoco, Patrícia Hermes Guedes, Herbert Leonel de Matos Miranda, Antonio Basilio de Ruiz, Jeronimo Pitaluga, André Silva Jr, Floriano P Probst, Christian M Dickens, Nicholas J Mottram, Jeremy C Grisard, Edmundo C Dávila, Alberto M. R.
dc.subject.en.pt_BR.fl_str_mv	Leishmania amazonensis Comparative genomics Phylogenomics
topic	Leishmania amazonensis Comparative genomics Phylogenomics Leishmaniose Gênomica
dc.subject.decs.pt_BR.fl_str_mv	Leishmaniose Gênomica
description	Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Pólo de Biologia Computacional e Sistemas. Laboratório de Biologia Computacional e Sistemas. Rio de Janeiro, RJ, Brasil.
publishDate	2014
dc.date.issued.fl_str_mv	2014
dc.date.accessioned.fl_str_mv	2015-04-22T14:23:10Z
dc.date.available.fl_str_mv	2015-04-22T14:23:10Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	TSCHOEKE, Diogo A et al. The Comparative Genomics and Phylogenomics of Leishmania amazonensis Parasite. Evolutionary Bioinformatics, n.10. p.131-153, 2014.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/10106
dc.identifier.issn.pt_BR.fl_str_mv	1176-9343
dc.identifier.doi.pt_BR.fl_str_mv	10.4137/EBO.S13759
identifier_str_mv	TSCHOEKE, Diogo A et al. The Comparative Genomics and Phylogenomics of Leishmania amazonensis Parasite. Evolutionary Bioinformatics, n.10. p.131-153, 2014. 1176-9343 10.4137/EBO.S13759
url	https://www.arca.fiocruz.br/handle/icict/10106
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Libertas Academica
publisher.none.fl_str_mv	Libertas Academica
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/10106/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/10106/2/diogo_tschoekeetal_IOC_2014.pdf https://www.arca.fiocruz.br/bitstream/icict/10106/3/diogo_tschoekeetal_IOC_2014.pdf.txt
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bitstream.checksumAlgorithm.fl_str_mv	MD5 MD5 MD5
repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
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The Comparative Genomics and Phylogenomics of Leishmania amazonensis Parasite

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