Trends in HCV prevalence, risk factors and distribution of viral genotypes in injecting drug users: findings from two cross-sectional studies

Detalhes bibliográficos
Autor(a) principal: Oliveira, Maria de Lourdes Aguiar
Data de Publicação: 2009
Outros Autores: Yoshida, Clara Fumiko Tachibana, Dias, Paulo Roberto Telles Pires, Vilas-Boas Hacker, Mariana de Andrea, Oliveira, Sabrina Alberti Nóbrega de, Miguel, Juliana Custódio, Ó, Kycia Maria Rodrigues do, Bastos, Francisco Inácio Pinkusfeld Monteiro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/1275
Resumo: This paper is based on data from two cross-sectional studies: Projeto Brasil, a multicentre study carried out from 1994–1997 to estimate prevalence of HIV and viral hepatitis in five Brazilian cities and the WHO Drug Injection Study Phase II – a project, coordinated and sponsored by the World Health Organization and implemented by the WHO Phase II Drug Injection Collaborative Study Group. The authors alone are responsible for the views expressed in this paper, which do not necessarily represent those of the other investigators participating in the WHO Drug Injection Study Phase II nor the views or policy of the World Health Organization. The Brazilian component of the study was sponsored by WHO, as well as by the Coordenac¸ a˜ o Geral de Laborato´ rios, National Health Foundation, SVS, Ministry of Health, Brazil and Conselho Nacional de Desenvolvimento Cientı´ - fico e Tecnolo´ gico, CNPq, Grant no. 475668/03. We are grateful to Genomic Platform-DNA Sequencing (PDTIS-Fiocruz) for DNA sequencing of samples included in this study.
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spelling Oliveira, Maria de Lourdes AguiarYoshida, Clara Fumiko TachibanaDias, Paulo Roberto Telles PiresVilas-Boas Hacker, Mariana de AndreaOliveira, Sabrina Alberti Nóbrega deMiguel, Juliana CustódioÓ, Kycia Maria Rodrigues doBastos, Francisco Inácio Pinkusfeld Monteiro2010-11-05T17:00:06Z2010-11-05T17:00:06Z2009Epidemiol. Infect. 137, 970–979, 200914694409https://www.arca.fiocruz.br/handle/icict/127510.1017/S0950268808001970This paper is based on data from two cross-sectional studies: Projeto Brasil, a multicentre study carried out from 1994–1997 to estimate prevalence of HIV and viral hepatitis in five Brazilian cities and the WHO Drug Injection Study Phase II – a project, coordinated and sponsored by the World Health Organization and implemented by the WHO Phase II Drug Injection Collaborative Study Group. The authors alone are responsible for the views expressed in this paper, which do not necessarily represent those of the other investigators participating in the WHO Drug Injection Study Phase II nor the views or policy of the World Health Organization. The Brazilian component of the study was sponsored by WHO, as well as by the Coordenac¸ a˜ o Geral de Laborato´ rios, National Health Foundation, SVS, Ministry of Health, Brazil and Conselho Nacional de Desenvolvimento Cientı´ - fico e Tecnolo´ gico, CNPq, Grant no. 475668/03. We are grateful to Genomic Platform-DNA Sequencing (PDTIS-Fiocruz) for DNA sequencing of samples included in this study.National Reference Laboratory for Viral Hepatitis and National Reference Laboratory for Influenza and Exanthematic Diseases, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilNational Reference Laboratory for Viral Hepatitis, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilCenter for Drug Abuse Treatment and Research (NEPAD), State University of Rio de Janeiro, Rio de Janeiro, BrazilLaboratory of Leprosy, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilNational Reference Laboratory for Viral Hepatitis, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilNational Reference Laboratory for Viral Hepatitis, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilNational Reference Laboratory for Viral Hepatitis, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilDepartment of Health Information, Center for Information on Science and Technology, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilIn the last decade, a declining prevalence of HCV infection has been described in injecting drug users (IDUs) in different countries. This study is the first to assess temporal trends in druginjecting patterns, HCV infection rates and viral genotype distribution in 770 Brazilian IDUs, recruited by two cross-sectional studies (1994–1997 and 1999–2001). A substantial decline in the prevalence of HCV infection was found over the years (75% in 1994 vs. 20 . 6% in 2001, P<0.001) that may be a consequence of the significant reduction in the overall frequencies of drug injection and needle-sharing, as well as the participation of IDUs in initiatives aimed at reducing drug-related harm. No trend was found in terms of viral genotype distribution. Despite the favourable scenario, preventive measures must be maintained, especially in vulnerable subgroups such as young or new injectors, where risky behaviours through direct and indirect sharing practices remain common.engCambridge University PressTrends in HCV prevalence, risk factors and distribution of viral genotypes in injecting drug users: findings from two cross-sectional studiesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHepatitis Cinfectious disease epidemiologyinjecting drug usemolecular epidemiologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALBastos_Trends in HCV.pdfBastos_Trends in HCV.pdfapplication/pdf119187https://www.arca.fiocruz.br/bitstream/icict/1275/1/Bastos_Trends%20in%20HCV.pdf26e5dfab50d8704b10a6228887fd42d8MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://www.arca.fiocruz.br/bitstream/icict/1275/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTBastos_Trends in HCV.pdf.txtBastos_Trends in HCV.pdf.txtExtracted texttext/plain37718https://www.arca.fiocruz.br/bitstream/icict/1275/5/Bastos_Trends%20in%20HCV.pdf.txtaa7fd42ba3fb7129e306bd72f3c40653MD55THUMBNAILBastos_Trends in HCV.pdf.jpgBastos_Trends in HCV.pdf.jpgGenerated Thumbnailimage/jpeg2180https://www.arca.fiocruz.br/bitstream/icict/1275/4/Bastos_Trends%20in%20HCV.pdf.jpgbd275db090a33a8353d1f9432e4d42f5MD54icict/12752023-08-23 15:29:32.326oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-08-23T18:29:32Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Trends in HCV prevalence, risk factors and distribution of viral genotypes in injecting drug users: findings from two cross-sectional studies
title Trends in HCV prevalence, risk factors and distribution of viral genotypes in injecting drug users: findings from two cross-sectional studies
spellingShingle Trends in HCV prevalence, risk factors and distribution of viral genotypes in injecting drug users: findings from two cross-sectional studies
Oliveira, Maria de Lourdes Aguiar
Hepatitis C
infectious disease epidemiology
injecting drug use
molecular epidemiology
title_short Trends in HCV prevalence, risk factors and distribution of viral genotypes in injecting drug users: findings from two cross-sectional studies
title_full Trends in HCV prevalence, risk factors and distribution of viral genotypes in injecting drug users: findings from two cross-sectional studies
title_fullStr Trends in HCV prevalence, risk factors and distribution of viral genotypes in injecting drug users: findings from two cross-sectional studies
title_full_unstemmed Trends in HCV prevalence, risk factors and distribution of viral genotypes in injecting drug users: findings from two cross-sectional studies
title_sort Trends in HCV prevalence, risk factors and distribution of viral genotypes in injecting drug users: findings from two cross-sectional studies
author Oliveira, Maria de Lourdes Aguiar
author_facet Oliveira, Maria de Lourdes Aguiar
Yoshida, Clara Fumiko Tachibana
Dias, Paulo Roberto Telles Pires
Vilas-Boas Hacker, Mariana de Andrea
Oliveira, Sabrina Alberti Nóbrega de
Miguel, Juliana Custódio
Ó, Kycia Maria Rodrigues do
Bastos, Francisco Inácio Pinkusfeld Monteiro
author_role author
author2 Yoshida, Clara Fumiko Tachibana
Dias, Paulo Roberto Telles Pires
Vilas-Boas Hacker, Mariana de Andrea
Oliveira, Sabrina Alberti Nóbrega de
Miguel, Juliana Custódio
Ó, Kycia Maria Rodrigues do
Bastos, Francisco Inácio Pinkusfeld Monteiro
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira, Maria de Lourdes Aguiar
Yoshida, Clara Fumiko Tachibana
Dias, Paulo Roberto Telles Pires
Vilas-Boas Hacker, Mariana de Andrea
Oliveira, Sabrina Alberti Nóbrega de
Miguel, Juliana Custódio
Ó, Kycia Maria Rodrigues do
Bastos, Francisco Inácio Pinkusfeld Monteiro
dc.subject.en.pt_BR.fl_str_mv Hepatitis C
infectious disease epidemiology
injecting drug use
molecular epidemiology
topic Hepatitis C
infectious disease epidemiology
injecting drug use
molecular epidemiology
description This paper is based on data from two cross-sectional studies: Projeto Brasil, a multicentre study carried out from 1994–1997 to estimate prevalence of HIV and viral hepatitis in five Brazilian cities and the WHO Drug Injection Study Phase II – a project, coordinated and sponsored by the World Health Organization and implemented by the WHO Phase II Drug Injection Collaborative Study Group. The authors alone are responsible for the views expressed in this paper, which do not necessarily represent those of the other investigators participating in the WHO Drug Injection Study Phase II nor the views or policy of the World Health Organization. The Brazilian component of the study was sponsored by WHO, as well as by the Coordenac¸ a˜ o Geral de Laborato´ rios, National Health Foundation, SVS, Ministry of Health, Brazil and Conselho Nacional de Desenvolvimento Cientı´ - fico e Tecnolo´ gico, CNPq, Grant no. 475668/03. We are grateful to Genomic Platform-DNA Sequencing (PDTIS-Fiocruz) for DNA sequencing of samples included in this study.
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2010-11-05T17:00:06Z
dc.date.available.fl_str_mv 2010-11-05T17:00:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv Epidemiol. Infect. 137, 970–979, 2009
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/1275
dc.identifier.issn.none.fl_str_mv 14694409
dc.identifier.doi.none.fl_str_mv 10.1017/S0950268808001970
identifier_str_mv Epidemiol. Infect. 137, 970–979, 2009
14694409
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url https://www.arca.fiocruz.br/handle/icict/1275
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dc.publisher.none.fl_str_mv Cambridge University Press
publisher.none.fl_str_mv Cambridge University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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