Epidemiological and genetic analyses of Hepatitis C virus transmission among young/short- and long-term injecting drug users from Rio de Janeiro, Brazil

Detalhes bibliográficos
Autor(a) principal: Oliveira, Maria de Lourdes Aguiar
Data de Publicação: 2009
Outros Autores: Bastos, Francisco Inácio Pinkusfeld Monteiro, Dias, Paulo Roberto Telles Pires, Vilas-Boas Hacker, Mariana de Andrea, Oliveira, Sabrina Alberti Nóbrega de, Miguel, Juliana Custódio, Yoshida, Clara Fumiko Tachibana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/1261
Resumo: This paper is based on the data and experience obtained during the WHO Drug Injection Study Phase II—a project, coordinated and sponsored by the World Health Organization and implemented by the WHO Phase II Drug Injection Collaborative Study Group. The authors alone are responsible for the views expressed in this paper, which do not necessarily represent those of the other investigators participating in the WHO Drug Injection Study Phase II nor the views or policy of the World Health Organization. We are grateful to the Harm Reduction Program team for the fieldwork with such hard-to-reach and population; to Aline Santos Moreira, from the Genomic Platform-DNA Sequencing (PDTISFiocruz) for DNA sequencing of samples included in this study and to Dr. José Paulo Leite, Dr.Milton Moraes, Mrs. Marcia Paschoal, and Dr. Elisabeth Lampe, for their helpful suggestions.
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spelling Oliveira, Maria de Lourdes AguiarBastos, Francisco Inácio Pinkusfeld MonteiroDias, Paulo Roberto Telles PiresVilas-Boas Hacker, Mariana de AndreaOliveira, Sabrina Alberti Nóbrega deMiguel, Juliana CustódioYoshida, Clara Fumiko Tachibana2010-11-04T18:25:04Z2010-11-04T18:25:04Z2009Journal of Clinical Virology 44 (2009) 200–2061386-6532https://www.arca.fiocruz.br/handle/icict/1261This paper is based on the data and experience obtained during the WHO Drug Injection Study Phase II—a project, coordinated and sponsored by the World Health Organization and implemented by the WHO Phase II Drug Injection Collaborative Study Group. The authors alone are responsible for the views expressed in this paper, which do not necessarily represent those of the other investigators participating in the WHO Drug Injection Study Phase II nor the views or policy of the World Health Organization. We are grateful to the Harm Reduction Program team for the fieldwork with such hard-to-reach and population; to Aline Santos Moreira, from the Genomic Platform-DNA Sequencing (PDTISFiocruz) for DNA sequencing of samples included in this study and to Dr. José Paulo Leite, Dr.Milton Moraes, Mrs. Marcia Paschoal, and Dr. Elisabeth Lampe, for their helpful suggestions.The Brazilian component of the study was sponsored by WHO, as well as by the Coordenac¸ ão Geral de Laboratórios, National Health Foundation, SVS, Ministry of Health and Conselho Nacional de Desenvolvimento Científico e Tecnológico, CNPq, Grant no. 475668/03.National Reference Laboratory for Viral Hepatitis & National Reference Laboratory for Influenza and Exanthematic Diseases, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilOswaldo Cruz Foundation. Department of Health Information. Rio de Janeiro, RJ, Brazil.Harm Reduction Initiative (NEPAD), State University of Rio de Janeiro, Rio de Janeiro, BrazilLaboratory of Leprosy, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilNational Reference Laboratory for Viral Hepatitis, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilNational Reference Laboratory for Viral Hepatitis, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilNational Reference Laboratory for Viral Hepatitis, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilBackground: Injecting drug users (IDU) have a key role in Hepatitis C Virus (HCV) epidemiology. Young/short-term IDUs constitute a target group for preventive/harm reduction interventions. Objectives: To investigate HCV transmission among young/short-term (ST) and long-term (LT) IDUs, from the perspective of epidemiology and molecular biology. Study design: Cross-sectional study assessing the prevalence of HCV infection/genotypes, as well as risk behaviours/practices among IDUs from Rio de Janeiro. Phylogenetic analyses were performed and the extent of segregation between sequences was quantified by the Association Index. Results: ST were more likely to engage into needle-sharing (p = .021) and LT to attend Needle Exchange Programs (p = .006). HCV prevalence was 10.1% vs. 23.4% among initiates and LT, respectively (p < .001). Older age vs. imprisonment and longer duration of IDU career were independent predictors for HCV infection among ST and LT, respectively. Among the latter, NEP attendance was inversely associated with viral infection. HCV3a infectionswere the most prevalent. A moderate extent of phylogenetic segregation between sequences was found, suggestive of transmission between IDU subgroups. Conclusions: The lower HCV prevalence among young/short-term IDUs cannot be viewed with complacency, due to their frequent engagement into direct/indirect sharing practices and the ongoing transmission between IDU subsets. To avert new infections, preventive/harm reduction policies must be tailored to empirical findings.engElsevier B.V.Epidemiological and genetic analyses of Hepatitis C virus transmission among young/short- and long-term injecting drug users from Rio de Janeiro, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInjecting drug useSubstance abuseHepatitis C virusHCV epidemiologyHCV subtypesPhylogenetic analysisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALBastos_. Epidemiological and genetic.pdfBastos_. 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dc.title.pt_BR.fl_str_mv Epidemiological and genetic analyses of Hepatitis C virus transmission among young/short- and long-term injecting drug users from Rio de Janeiro, Brazil
title Epidemiological and genetic analyses of Hepatitis C virus transmission among young/short- and long-term injecting drug users from Rio de Janeiro, Brazil
spellingShingle Epidemiological and genetic analyses of Hepatitis C virus transmission among young/short- and long-term injecting drug users from Rio de Janeiro, Brazil
Oliveira, Maria de Lourdes Aguiar
Injecting drug use
Substance abuse
Hepatitis C virus
HCV epidemiology
HCV subtypes
Phylogenetic analysis
title_short Epidemiological and genetic analyses of Hepatitis C virus transmission among young/short- and long-term injecting drug users from Rio de Janeiro, Brazil
title_full Epidemiological and genetic analyses of Hepatitis C virus transmission among young/short- and long-term injecting drug users from Rio de Janeiro, Brazil
title_fullStr Epidemiological and genetic analyses of Hepatitis C virus transmission among young/short- and long-term injecting drug users from Rio de Janeiro, Brazil
title_full_unstemmed Epidemiological and genetic analyses of Hepatitis C virus transmission among young/short- and long-term injecting drug users from Rio de Janeiro, Brazil
title_sort Epidemiological and genetic analyses of Hepatitis C virus transmission among young/short- and long-term injecting drug users from Rio de Janeiro, Brazil
author Oliveira, Maria de Lourdes Aguiar
author_facet Oliveira, Maria de Lourdes Aguiar
Bastos, Francisco Inácio Pinkusfeld Monteiro
Dias, Paulo Roberto Telles Pires
Vilas-Boas Hacker, Mariana de Andrea
Oliveira, Sabrina Alberti Nóbrega de
Miguel, Juliana Custódio
Yoshida, Clara Fumiko Tachibana
author_role author
author2 Bastos, Francisco Inácio Pinkusfeld Monteiro
Dias, Paulo Roberto Telles Pires
Vilas-Boas Hacker, Mariana de Andrea
Oliveira, Sabrina Alberti Nóbrega de
Miguel, Juliana Custódio
Yoshida, Clara Fumiko Tachibana
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira, Maria de Lourdes Aguiar
Bastos, Francisco Inácio Pinkusfeld Monteiro
Dias, Paulo Roberto Telles Pires
Vilas-Boas Hacker, Mariana de Andrea
Oliveira, Sabrina Alberti Nóbrega de
Miguel, Juliana Custódio
Yoshida, Clara Fumiko Tachibana
dc.subject.en.pt_BR.fl_str_mv Injecting drug use
Substance abuse
Hepatitis C virus
HCV epidemiology
HCV subtypes
Phylogenetic analysis
topic Injecting drug use
Substance abuse
Hepatitis C virus
HCV epidemiology
HCV subtypes
Phylogenetic analysis
description This paper is based on the data and experience obtained during the WHO Drug Injection Study Phase II—a project, coordinated and sponsored by the World Health Organization and implemented by the WHO Phase II Drug Injection Collaborative Study Group. The authors alone are responsible for the views expressed in this paper, which do not necessarily represent those of the other investigators participating in the WHO Drug Injection Study Phase II nor the views or policy of the World Health Organization. We are grateful to the Harm Reduction Program team for the fieldwork with such hard-to-reach and population; to Aline Santos Moreira, from the Genomic Platform-DNA Sequencing (PDTISFiocruz) for DNA sequencing of samples included in this study and to Dr. José Paulo Leite, Dr.Milton Moraes, Mrs. Marcia Paschoal, and Dr. Elisabeth Lampe, for their helpful suggestions.
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2010-11-04T18:25:04Z
dc.date.available.fl_str_mv 2010-11-04T18:25:04Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.citation.fl_str_mv Journal of Clinical Virology 44 (2009) 200–206
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/1261
dc.identifier.issn.none.fl_str_mv 1386-6532
identifier_str_mv Journal of Clinical Virology 44 (2009) 200–206
1386-6532
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dc.publisher.none.fl_str_mv Elsevier B.V.
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