Epidemiological and genetic analyses of Hepatitis C virus transmission among young/short- and long-term injecting drug users from Rio de Janeiro, Brazil
Autor(a) principal: | |
---|---|
Data de Publicação: | 2009 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/1261 |
Resumo: | This paper is based on the data and experience obtained during the WHO Drug Injection Study Phase II—a project, coordinated and sponsored by the World Health Organization and implemented by the WHO Phase II Drug Injection Collaborative Study Group. The authors alone are responsible for the views expressed in this paper, which do not necessarily represent those of the other investigators participating in the WHO Drug Injection Study Phase II nor the views or policy of the World Health Organization. We are grateful to the Harm Reduction Program team for the fieldwork with such hard-to-reach and population; to Aline Santos Moreira, from the Genomic Platform-DNA Sequencing (PDTISFiocruz) for DNA sequencing of samples included in this study and to Dr. José Paulo Leite, Dr.Milton Moraes, Mrs. Marcia Paschoal, and Dr. Elisabeth Lampe, for their helpful suggestions. |
id |
CRUZ_d809c920469f6ed1afc041cd5a0465c2 |
---|---|
oai_identifier_str |
oai:www.arca.fiocruz.br:icict/1261 |
network_acronym_str |
CRUZ |
network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
repository_id_str |
2135 |
spelling |
Oliveira, Maria de Lourdes AguiarBastos, Francisco Inácio Pinkusfeld MonteiroDias, Paulo Roberto Telles PiresVilas-Boas Hacker, Mariana de AndreaOliveira, Sabrina Alberti Nóbrega deMiguel, Juliana CustódioYoshida, Clara Fumiko Tachibana2010-11-04T18:25:04Z2010-11-04T18:25:04Z2009Journal of Clinical Virology 44 (2009) 200–2061386-6532https://www.arca.fiocruz.br/handle/icict/1261This paper is based on the data and experience obtained during the WHO Drug Injection Study Phase II—a project, coordinated and sponsored by the World Health Organization and implemented by the WHO Phase II Drug Injection Collaborative Study Group. The authors alone are responsible for the views expressed in this paper, which do not necessarily represent those of the other investigators participating in the WHO Drug Injection Study Phase II nor the views or policy of the World Health Organization. We are grateful to the Harm Reduction Program team for the fieldwork with such hard-to-reach and population; to Aline Santos Moreira, from the Genomic Platform-DNA Sequencing (PDTISFiocruz) for DNA sequencing of samples included in this study and to Dr. José Paulo Leite, Dr.Milton Moraes, Mrs. Marcia Paschoal, and Dr. Elisabeth Lampe, for their helpful suggestions.The Brazilian component of the study was sponsored by WHO, as well as by the Coordenac¸ ão Geral de Laboratórios, National Health Foundation, SVS, Ministry of Health and Conselho Nacional de Desenvolvimento Científico e Tecnológico, CNPq, Grant no. 475668/03.National Reference Laboratory for Viral Hepatitis & National Reference Laboratory for Influenza and Exanthematic Diseases, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilOswaldo Cruz Foundation. Department of Health Information. Rio de Janeiro, RJ, Brazil.Harm Reduction Initiative (NEPAD), State University of Rio de Janeiro, Rio de Janeiro, BrazilLaboratory of Leprosy, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilNational Reference Laboratory for Viral Hepatitis, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilNational Reference Laboratory for Viral Hepatitis, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilNational Reference Laboratory for Viral Hepatitis, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilBackground: Injecting drug users (IDU) have a key role in Hepatitis C Virus (HCV) epidemiology. Young/short-term IDUs constitute a target group for preventive/harm reduction interventions. Objectives: To investigate HCV transmission among young/short-term (ST) and long-term (LT) IDUs, from the perspective of epidemiology and molecular biology. Study design: Cross-sectional study assessing the prevalence of HCV infection/genotypes, as well as risk behaviours/practices among IDUs from Rio de Janeiro. Phylogenetic analyses were performed and the extent of segregation between sequences was quantified by the Association Index. Results: ST were more likely to engage into needle-sharing (p = .021) and LT to attend Needle Exchange Programs (p = .006). HCV prevalence was 10.1% vs. 23.4% among initiates and LT, respectively (p < .001). Older age vs. imprisonment and longer duration of IDU career were independent predictors for HCV infection among ST and LT, respectively. Among the latter, NEP attendance was inversely associated with viral infection. HCV3a infectionswere the most prevalent. A moderate extent of phylogenetic segregation between sequences was found, suggestive of transmission between IDU subgroups. Conclusions: The lower HCV prevalence among young/short-term IDUs cannot be viewed with complacency, due to their frequent engagement into direct/indirect sharing practices and the ongoing transmission between IDU subsets. To avert new infections, preventive/harm reduction policies must be tailored to empirical findings.engElsevier B.V.Epidemiological and genetic analyses of Hepatitis C virus transmission among young/short- and long-term injecting drug users from Rio de Janeiro, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInjecting drug useSubstance abuseHepatitis C virusHCV epidemiologyHCV subtypesPhylogenetic analysisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALBastos_. Epidemiological and genetic.pdfBastos_. Epidemiological and genetic.pdfapplication/pdf406922https://www.arca.fiocruz.br/bitstream/icict/1261/1/Bastos_.%20Epidemiological%20and%20genetic.pdf71fa15f3494602f12fcb51291809cd3eMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://www.arca.fiocruz.br/bitstream/icict/1261/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTBastos_. Epidemiological and genetic.pdf.txtBastos_. Epidemiological and genetic.pdf.txtExtracted texttext/plain34521https://www.arca.fiocruz.br/bitstream/icict/1261/5/Bastos_.%20Epidemiological%20and%20genetic.pdf.txt56611ca978cbe14f27313e600003c212MD55THUMBNAILBastos_. Epidemiological and genetic.pdf.jpgBastos_. Epidemiological and genetic.pdf.jpgGenerated Thumbnailimage/jpeg2171https://www.arca.fiocruz.br/bitstream/icict/1261/4/Bastos_.%20Epidemiological%20and%20genetic.pdf.jpg529f18a5462e7535fe80796872e2cc80MD54icict/12612023-08-23 15:29:32.179oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-08-23T18:29:32Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Epidemiological and genetic analyses of Hepatitis C virus transmission among young/short- and long-term injecting drug users from Rio de Janeiro, Brazil |
title |
Epidemiological and genetic analyses of Hepatitis C virus transmission among young/short- and long-term injecting drug users from Rio de Janeiro, Brazil |
spellingShingle |
Epidemiological and genetic analyses of Hepatitis C virus transmission among young/short- and long-term injecting drug users from Rio de Janeiro, Brazil Oliveira, Maria de Lourdes Aguiar Injecting drug use Substance abuse Hepatitis C virus HCV epidemiology HCV subtypes Phylogenetic analysis |
title_short |
Epidemiological and genetic analyses of Hepatitis C virus transmission among young/short- and long-term injecting drug users from Rio de Janeiro, Brazil |
title_full |
Epidemiological and genetic analyses of Hepatitis C virus transmission among young/short- and long-term injecting drug users from Rio de Janeiro, Brazil |
title_fullStr |
Epidemiological and genetic analyses of Hepatitis C virus transmission among young/short- and long-term injecting drug users from Rio de Janeiro, Brazil |
title_full_unstemmed |
Epidemiological and genetic analyses of Hepatitis C virus transmission among young/short- and long-term injecting drug users from Rio de Janeiro, Brazil |
title_sort |
Epidemiological and genetic analyses of Hepatitis C virus transmission among young/short- and long-term injecting drug users from Rio de Janeiro, Brazil |
author |
Oliveira, Maria de Lourdes Aguiar |
author_facet |
Oliveira, Maria de Lourdes Aguiar Bastos, Francisco Inácio Pinkusfeld Monteiro Dias, Paulo Roberto Telles Pires Vilas-Boas Hacker, Mariana de Andrea Oliveira, Sabrina Alberti Nóbrega de Miguel, Juliana Custódio Yoshida, Clara Fumiko Tachibana |
author_role |
author |
author2 |
Bastos, Francisco Inácio Pinkusfeld Monteiro Dias, Paulo Roberto Telles Pires Vilas-Boas Hacker, Mariana de Andrea Oliveira, Sabrina Alberti Nóbrega de Miguel, Juliana Custódio Yoshida, Clara Fumiko Tachibana |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Oliveira, Maria de Lourdes Aguiar Bastos, Francisco Inácio Pinkusfeld Monteiro Dias, Paulo Roberto Telles Pires Vilas-Boas Hacker, Mariana de Andrea Oliveira, Sabrina Alberti Nóbrega de Miguel, Juliana Custódio Yoshida, Clara Fumiko Tachibana |
dc.subject.en.pt_BR.fl_str_mv |
Injecting drug use Substance abuse Hepatitis C virus HCV epidemiology HCV subtypes Phylogenetic analysis |
topic |
Injecting drug use Substance abuse Hepatitis C virus HCV epidemiology HCV subtypes Phylogenetic analysis |
description |
This paper is based on the data and experience obtained during the WHO Drug Injection Study Phase II—a project, coordinated and sponsored by the World Health Organization and implemented by the WHO Phase II Drug Injection Collaborative Study Group. The authors alone are responsible for the views expressed in this paper, which do not necessarily represent those of the other investigators participating in the WHO Drug Injection Study Phase II nor the views or policy of the World Health Organization. We are grateful to the Harm Reduction Program team for the fieldwork with such hard-to-reach and population; to Aline Santos Moreira, from the Genomic Platform-DNA Sequencing (PDTISFiocruz) for DNA sequencing of samples included in this study and to Dr. José Paulo Leite, Dr.Milton Moraes, Mrs. Marcia Paschoal, and Dr. Elisabeth Lampe, for their helpful suggestions. |
publishDate |
2009 |
dc.date.issued.fl_str_mv |
2009 |
dc.date.accessioned.fl_str_mv |
2010-11-04T18:25:04Z |
dc.date.available.fl_str_mv |
2010-11-04T18:25:04Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Journal of Clinical Virology 44 (2009) 200–206 |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/1261 |
dc.identifier.issn.none.fl_str_mv |
1386-6532 |
identifier_str_mv |
Journal of Clinical Virology 44 (2009) 200–206 1386-6532 |
url |
https://www.arca.fiocruz.br/handle/icict/1261 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
collection |
Repositório Institucional da FIOCRUZ (ARCA) |
bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/1261/1/Bastos_.%20Epidemiological%20and%20genetic.pdf https://www.arca.fiocruz.br/bitstream/icict/1261/2/license.txt https://www.arca.fiocruz.br/bitstream/icict/1261/5/Bastos_.%20Epidemiological%20and%20genetic.pdf.txt https://www.arca.fiocruz.br/bitstream/icict/1261/4/Bastos_.%20Epidemiological%20and%20genetic.pdf.jpg |
bitstream.checksum.fl_str_mv |
71fa15f3494602f12fcb51291809cd3e 8a4605be74aa9ea9d79846c1fba20a33 56611ca978cbe14f27313e600003c212 529f18a5462e7535fe80796872e2cc80 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
_version_ |
1822792103462174720 |