Interruption of persistent exposure to leprosy combined or not with recent BCG vaccination enhances the response to Mycobacterium leprae specific antigens

Detalhes bibliográficos
Autor(a) principal: Carvalho, Fernanda Marques de
Data de Publicação: 2017
Outros Autores: Rodrigues, Luciana Silva, Duppre, Nádia Cristina, Alvim, Iris Maria Peixoto, Alves, Marcelo Ribeiro, Pinheiro, Roberta Olmo, Sarno, Euzenir Nunes, Pessolani, Maria Cristina Vidal, Pereira, Geraldo Moura Batista
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/24878
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ. Brasil.
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spelling Carvalho, Fernanda Marques deRodrigues, Luciana SilvaDuppre, Nádia CristinaAlvim, Iris Maria PeixotoAlves, Marcelo RibeiroPinheiro, Roberta OlmoSarno, Euzenir NunesPessolani, Maria Cristina VidalPereira, Geraldo Moura Batista2018-02-20T13:09:20Z2018-02-20T13:09:20Z2017CARVALHO, Fernanda Marques de et al. Interruption of persistent exposure to leprosy combined or not with recent BCG vaccination enhances the response to Mycobacterium leprae specific antigens. PLoS Neglected Tropical Diseases, v. 11, n. 5, p. 1-16, May 2017.1935-2727https://www.arca.fiocruz.br/handle/icict/2487810.1371/journal.pntd.00055601935-2735engPublic Library of ScienceHanseníaseMycobacterium lepraeVacina BCGAntígenosLeprosyBCG vaccinationMycobacterium lepraeSpecific antigensInterruption of persistent exposure to leprosy combined or not with recent BCG vaccination enhances the response to Mycobacterium leprae specific antigensinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Pesquisa Clínica em DST-AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ. Brasil.Household contacts of multibacillary leprosy patients (HCMB) constitute the group of individuals at the highest risk of developing leprosy. Early diagnosis and treatment of their index cases combined with Bacille Calmette-Guerin (BCG) immunization remain important strategies adopted in Brazil to prevent HCMB from evolving into active disease. In the present study, we assessed the impact of these measures on the immune response to Mycobacterium leprae in HCMB. Peripheral blood mononuclear cells (PBMC) from HCMB (n = 16) were obtained at the beginning of leprosy index case treatment (T0). At this time point, contacts were vaccinated (n = 13) or not (n = 3) in accordance with their infancy history of BCG vaccination and PBMCs were recollected at least 6 months later (T1). As expected, a significant increase in memory CD4 and CD8 T cell frequencies responsive to M. leprae whole-cell sonicate was observed in most contacts. Of note, higher frequencies of CD4+ T cells that recognize M. leprae specific epitopes were also detected. Moreover, increased production of the inflammatory mediators IL1-β, IL-6, IL-17, TNF, IFN-γ, MIP1-β, and MCP-1 was found at T1. Interestingly, the increment in these parameters was observed even in those contacts that were not BCG vaccinated at T0. This result reinforces the hypothesis that the continuous exposure of HCMB to live M. leprae down regulates the specific cellular immune response against the pathogen. Moreover, our data suggest that BCG vaccination of HCMB induces activation of T cell clones, likely through "trained immunity", that recognize M. leprae specific antigens not shared with BCG as an additional protective mechanism besides the expected boost in cell-mediated immunity by BCG homologues of M. leprae antigens.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/24878/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALirismaria_alvim_etal_IOC_2017.pdfirismaria_alvim_etal_IOC_2017.pdfapplication/pdf1913205https://www.arca.fiocruz.br/bitstream/icict/24878/2/irismaria_alvim_etal_IOC_2017.pdfbcdfbf8267c751f330e1ebc696de7c5cMD52TEXTirismaria_alvim_etal_IOC_2017.pdf.txtirismaria_alvim_etal_IOC_2017.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Interruption of persistent exposure to leprosy combined or not with recent BCG vaccination enhances the response to Mycobacterium leprae specific antigens
title Interruption of persistent exposure to leprosy combined or not with recent BCG vaccination enhances the response to Mycobacterium leprae specific antigens
spellingShingle Interruption of persistent exposure to leprosy combined or not with recent BCG vaccination enhances the response to Mycobacterium leprae specific antigens
Carvalho, Fernanda Marques de
Hanseníase
Mycobacterium leprae
Vacina BCG
Antígenos
Leprosy
BCG vaccination
Mycobacterium leprae
Specific antigens
title_short Interruption of persistent exposure to leprosy combined or not with recent BCG vaccination enhances the response to Mycobacterium leprae specific antigens
title_full Interruption of persistent exposure to leprosy combined or not with recent BCG vaccination enhances the response to Mycobacterium leprae specific antigens
title_fullStr Interruption of persistent exposure to leprosy combined or not with recent BCG vaccination enhances the response to Mycobacterium leprae specific antigens
title_full_unstemmed Interruption of persistent exposure to leprosy combined or not with recent BCG vaccination enhances the response to Mycobacterium leprae specific antigens
title_sort Interruption of persistent exposure to leprosy combined or not with recent BCG vaccination enhances the response to Mycobacterium leprae specific antigens
author Carvalho, Fernanda Marques de
author_facet Carvalho, Fernanda Marques de
Rodrigues, Luciana Silva
Duppre, Nádia Cristina
Alvim, Iris Maria Peixoto
Alves, Marcelo Ribeiro
Pinheiro, Roberta Olmo
Sarno, Euzenir Nunes
Pessolani, Maria Cristina Vidal
Pereira, Geraldo Moura Batista
author_role author
author2 Rodrigues, Luciana Silva
Duppre, Nádia Cristina
Alvim, Iris Maria Peixoto
Alves, Marcelo Ribeiro
Pinheiro, Roberta Olmo
Sarno, Euzenir Nunes
Pessolani, Maria Cristina Vidal
Pereira, Geraldo Moura Batista
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Carvalho, Fernanda Marques de
Rodrigues, Luciana Silva
Duppre, Nádia Cristina
Alvim, Iris Maria Peixoto
Alves, Marcelo Ribeiro
Pinheiro, Roberta Olmo
Sarno, Euzenir Nunes
Pessolani, Maria Cristina Vidal
Pereira, Geraldo Moura Batista
dc.subject.other.pt_BR.fl_str_mv Hanseníase
Mycobacterium leprae
Vacina BCG
Antígenos
topic Hanseníase
Mycobacterium leprae
Vacina BCG
Antígenos
Leprosy
BCG vaccination
Mycobacterium leprae
Specific antigens
dc.subject.en.pt_BR.fl_str_mv Leprosy
BCG vaccination
Mycobacterium leprae
Specific antigens
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ. Brasil.
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2018-02-20T13:09:20Z
dc.date.available.fl_str_mv 2018-02-20T13:09:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CARVALHO, Fernanda Marques de et al. Interruption of persistent exposure to leprosy combined or not with recent BCG vaccination enhances the response to Mycobacterium leprae specific antigens. PLoS Neglected Tropical Diseases, v. 11, n. 5, p. 1-16, May 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/24878
dc.identifier.issn.pt_BR.fl_str_mv 1935-2727
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0005560
dc.identifier.eissn.none.fl_str_mv 1935-2735
identifier_str_mv CARVALHO, Fernanda Marques de et al. Interruption of persistent exposure to leprosy combined or not with recent BCG vaccination enhances the response to Mycobacterium leprae specific antigens. PLoS Neglected Tropical Diseases, v. 11, n. 5, p. 1-16, May 2017.
1935-2727
10.1371/journal.pntd.0005560
1935-2735
url https://www.arca.fiocruz.br/handle/icict/24878
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/24878/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/24878/2/irismaria_alvim_etal_IOC_2017.pdf
https://www.arca.fiocruz.br/bitstream/icict/24878/3/irismaria_alvim_etal_IOC_2017.pdf.txt
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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