Traffic-related air pollution effect on fast glycemia of aged obese type 2 diabetic mice

Detalhes bibliográficos
Autor(a) principal: Matsuda, Monique
Data de Publicação: 2013
Outros Autores: Krempel, Paloma Gava, André, P. A, Freitas, J. R, Freitas, Luiz Antonio Rodrigues de, Veras, Patrícia Sampaio Tavares, Saldiva, P. H. N, Marquezini, Monica Valeria
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/19035
Resumo: Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Grant 2008/57717-6 and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) grant 2008/57717-6.
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spelling Matsuda, MoniqueKrempel, Paloma GavaAndré, P. AFreitas, J. RFreitas, Luiz Antonio Rodrigues deVeras, Patrícia Sampaio TavaresSaldiva, P. H. NMarquezini, Monica Valeria2017-05-29T16:20:38Z2017-05-29T16:20:38Z2013MATSUDA, Monique et al. Traffic-related air pollution effect on fast glycemia of aged obese type 2 diabetic mice. Journal of Clinical & Experimental Cardiology, v. 4, n. 7, p. 1-5, 2013.2155-9880https://www.arca.fiocruz.br/handle/icict/1903510.4172/2155-9880.1000255Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Grant 2008/57717-6 and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) grant 2008/57717-6.University of São Paulo Medical School. Laboratory of Investigation in Ophthalmology. São Paulo, SP, BrasiUniversity of São Paulo Medical School. Experimental Air Pollution Laboratory of Pathology Department. São Paulo, SP, BrasilFederal University of Bahia. Medical School. Department of Pathology and Forensic Medicine. Salvador, BA, BrazilFederal University of Bahia. Medical School. Department of Pathology and Forensic Medicine. Salvador, BA, BrazilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilUniversity of São Paulo Medical School. Experimental Air Pollution Laboratory of Pathology Department. São Paulo, SP, BrasilUniversity of São Paulo Medical School. Experimental Air Pollution Laboratory of Pathology Department. São Paulo, SP, Brasil / Pro-Sangue Foundation. São Paulo, SP, BrasilRecent experimental data have provided associations between ambient PM2.5 (fine particulate matter; diameter ≤ 2.5 μm) and propensity to inflammation and chronic diseases especially among susceptible groups, such as elderly people. There is cumulative evidence that type-2 diabetes mellitus is a chronic inflammatory state aggravated by factors that promote endothelium inflammation. Accordingly our hypothesis that the exposure of aged obese population to PM2.5 might aggravate type-2 diabetes, we used a model of aged, diet-induced obese mice. C57BL6 male mice were fed with regular chow (n=30; RC) or high-fat chow (n=36; HF) during one-year and randomly assigned to filtered (FA-RC, n=16; FA-HF, n=19) or PM2.5 concentrated air (600 μg.m-3) (EXP-RC, n=14; EXPHF, n=17) chambers to have a daily 1 hour exposition during consecutive 30- days. Fast glycemia was measured before the animals were euthanized. The Institution’s Ethics Committee approved all experimental procedures. Heart mRNA content of selected migration, signalization and adhesion proteins were measured by SYBR Green fluorescence Real Time RT-PCR protocol using appropriate primers. There were no difference between RC-EXP and RC-FA nor between HF-EXP and HF-FA body weight. Regarding fast glycemia, both, RC and HF groups, were diabetic, but only the HF group was affected by acute exposure to PM2.5 (mean ± SD, EXP-HF vs FA- HF, 172.8 ± 23.4 vs 156.7 ± 17.6, p <0.05; EXP-RC vs FA-RC, 149.8 ± 19.2, 139.7 ± 15.3, ns; ANOVA). The gene expression profile of E-selectin, IL-6, VCAM-1, ICAM-1 and MMP-9, was differently affected by PM2.5 in heart and lung. Proteins activated by inflammatory stimuli involved in the inhibition of insulin signaling are being investigated.engOMICS InternationalIdosoObesidadeRatos diabéticos Tipo 2Poluição do arAgedObesityType 2 diabetic miceAir pollutionIdosoObesidadePoluição do arGlicemiaTraffic-related air pollution effect on fast glycemia of aged obese type 2 diabetic miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/19035/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMatsuda M traffic-related-air-pollution-effect-on-fast-glycemia-of-aged-obese-type-2-diabetic-mice-2155-9880.1000255.pdfMatsuda M traffic-related-air-pollution-effect-on-fast-glycemia-of-aged-obese-type-2-diabetic-mice-2155-9880.1000255.pdfapplication/pdf651133https://www.arca.fiocruz.br/bitstream/icict/19035/2/Matsuda%20M%20traffic-related-air-pollution-effect-on-fast-glycemia-of-aged-obese-type-2-diabetic-mice-2155-9880.1000255.pdf949d59d733374dfc48fd0fb9d2ef07e8MD52TEXTMatsuda M traffic-related-air-pollution-effect-on-fast-glycemia-of-aged-obese-type-2-diabetic-mice-2155-9880.1000255.pdf.txtMatsuda M traffic-related-air-pollution-effect-on-fast-glycemia-of-aged-obese-type-2-diabetic-mice-2155-9880.1000255.pdf.txtExtracted texttext/plain32146https://www.arca.fiocruz.br/bitstream/icict/19035/3/Matsuda%20M%20traffic-related-air-pollution-effect-on-fast-glycemia-of-aged-obese-type-2-diabetic-mice-2155-9880.1000255.pdf.txt4a97c4c149c62f0d6df7cc49e0f37f6aMD53icict/190352023-03-15 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dc.title.en.fl_str_mv Traffic-related air pollution effect on fast glycemia of aged obese type 2 diabetic mice
title Traffic-related air pollution effect on fast glycemia of aged obese type 2 diabetic mice
spellingShingle Traffic-related air pollution effect on fast glycemia of aged obese type 2 diabetic mice
Matsuda, Monique
Idoso
Obesidade
Ratos diabéticos Tipo 2
Poluição do ar
Aged
Obesity
Type 2 diabetic mice
Air pollution
Idoso
Obesidade
Poluição do ar
Glicemia
title_short Traffic-related air pollution effect on fast glycemia of aged obese type 2 diabetic mice
title_full Traffic-related air pollution effect on fast glycemia of aged obese type 2 diabetic mice
title_fullStr Traffic-related air pollution effect on fast glycemia of aged obese type 2 diabetic mice
title_full_unstemmed Traffic-related air pollution effect on fast glycemia of aged obese type 2 diabetic mice
title_sort Traffic-related air pollution effect on fast glycemia of aged obese type 2 diabetic mice
author Matsuda, Monique
author_facet Matsuda, Monique
Krempel, Paloma Gava
André, P. A
Freitas, J. R
Freitas, Luiz Antonio Rodrigues de
Veras, Patrícia Sampaio Tavares
Saldiva, P. H. N
Marquezini, Monica Valeria
author_role author
author2 Krempel, Paloma Gava
André, P. A
Freitas, J. R
Freitas, Luiz Antonio Rodrigues de
Veras, Patrícia Sampaio Tavares
Saldiva, P. H. N
Marquezini, Monica Valeria
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Matsuda, Monique
Krempel, Paloma Gava
André, P. A
Freitas, J. R
Freitas, Luiz Antonio Rodrigues de
Veras, Patrícia Sampaio Tavares
Saldiva, P. H. N
Marquezini, Monica Valeria
dc.subject.other.pt_BR.fl_str_mv Idoso
Obesidade
Ratos diabéticos Tipo 2
Poluição do ar
topic Idoso
Obesidade
Ratos diabéticos Tipo 2
Poluição do ar
Aged
Obesity
Type 2 diabetic mice
Air pollution
Idoso
Obesidade
Poluição do ar
Glicemia
dc.subject.en.pt_BR.fl_str_mv Aged
Obesity
Type 2 diabetic mice
Air pollution
dc.subject.decs.pt_BR.fl_str_mv Idoso
Obesidade
Poluição do ar
Glicemia
description Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Grant 2008/57717-6 and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) grant 2008/57717-6.
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2017-05-29T16:20:38Z
dc.date.available.fl_str_mv 2017-05-29T16:20:38Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MATSUDA, Monique et al. Traffic-related air pollution effect on fast glycemia of aged obese type 2 diabetic mice. Journal of Clinical & Experimental Cardiology, v. 4, n. 7, p. 1-5, 2013.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/19035
dc.identifier.issn.pt_BR.fl_str_mv 2155-9880
dc.identifier.doi.pt_BR.fl_str_mv 10.4172/2155-9880.1000255
identifier_str_mv MATSUDA, Monique et al. Traffic-related air pollution effect on fast glycemia of aged obese type 2 diabetic mice. Journal of Clinical & Experimental Cardiology, v. 4, n. 7, p. 1-5, 2013.
2155-9880
10.4172/2155-9880.1000255
url https://www.arca.fiocruz.br/handle/icict/19035
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv OMICS International
publisher.none.fl_str_mv OMICS International
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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