Infectious complications following probiotic ingestion: a potentially underestimated problem? A systematic review of reports and case series

Detalhes bibliográficos
Autor(a) principal: Costa, Rafael Lessa
Data de Publicação: 2018
Outros Autores: Moreira, José, Lorenzo, Andrea, Lamas, Cristiane C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/30951
Resumo: Intensive Care Unit of Unimed-Rio Hospital. Rio de Janeiro, RJ, Brazil / Cardiointensive Unit of Americas Medical City. Rio de Janeiro, RJ, Brazil / National Institute of Cardiology. Rio de Janeiro, RJ, Brazil
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spelling Costa, Rafael LessaMoreira, JoséLorenzo, AndreaLamas, Cristiane C.2019-01-10T12:04:41Z2019-01-10T12:04:41Z2018COSTA, Rafael et al. Infectious complications following probiotic ingestion: a potentially underestimated problem? A systematic review of reports and case series. BMC Complementary and Alternative Medicine, p. 1-8, 2018.1472-6882https://www.arca.fiocruz.br/handle/icict/3095110.1186/s12906-018-2394-3engBMCInfectious complications following probiotic ingestion: a potentially underestimated problem? A systematic review of reports and case seriesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleIntensive Care Unit of Unimed-Rio Hospital. Rio de Janeiro, RJ, Brazil / Cardiointensive Unit of Americas Medical City. Rio de Janeiro, RJ, Brazil / National Institute of Cardiology. Rio de Janeiro, RJ, BrazilNational Institute of Cardiology. Rio de Janeiro, RJ, Brazil / Oswaldo Cruz Foundation. National Institute of Infectology Evandro Chagas. Rio de Janeiro, RJ, Brazil.National Institute of Cardiology. Rio de Janeiro, RJ, Brazil / Unigranrio University. Rio de Janeiro, RJ, Brazil / Oswaldo Cruz Foundation. National Institute of Infectology Evandro Chagas. Rio de Janeiro, RJ, Brazil.Background: Little is studied about complications related to probiotic ingestion. This study proposes to present a synthesis and critical evaluation of the reports and series of cases on the infectious complications related to the ingestion of probiotics, which can raise awareness for the prescribing and use of probiotics for certain groups of patients. Methods: Systematic review of reports and series of cases researched in the PubMed, SciELO and Scopus databases published until August 2018. The references of the articles were investigated manually for the search of cross references. SPSS version 23.0 was used for descriptive statistics and univariate analysis. Results: We found 60 case reports and 7 case series, making up a total of 93 patients. Fungemia was the most common infectious complications with 35 (37.6%) cases. The genus Saccharomyces was the most frequent with 47 (50.6%) cases, followed by Lactobacillus, Bifidobacterium, Bacillus, Pedioccocus and Escherichia with 26 (27.9%), 12 (12.8%), 5 (5.4%), 2 (2.2%) and 1 (1.1%) case, respectively. Adults over 60 years of age, Clostridium difficile colitis, antibiotic use and Saccharomyces infections were associated with overall mortality. HIV infections, immunosuppressive drugs, solid organ transplantation, deep intravenous lines, enteral or parenteral nutrition were not associated with death. Conclusion: The use of probiotics cannot be considered risk-free and should be carefully evaluated for some patient groups.ProbioticsInfectionFungemiaSepsisSaccharomycesLactobacillusinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83134https://www.arca.fiocruz.br/bitstream/icict/30951/1/license.txt0ab46789d568c4ba27c7b5d29a9fe9c4MD51ORIGINALve_Costa_Lessa_etal_INI_2018.pdfve_Costa_Lessa_etal_INI_2018.pdfapplication/pdf755575https://www.arca.fiocruz.br/bitstream/icict/30951/2/ve_Costa_Lessa_etal_INI_2018.pdf37c266c28e6078e6699ff0fcaf7781b1MD52TEXTve_Costa_Lessa_etal_INI_2018.pdf.txtve_Costa_Lessa_etal_INI_2018.pdf.txtExtracted texttext/plain36776https://www.arca.fiocruz.br/bitstream/icict/30951/3/ve_Costa_Lessa_etal_INI_2018.pdf.txt8b5050f64db451fb0d55b9f9cf7f8653MD53icict/309512019-01-11 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dc.title.pt_BR.fl_str_mv Infectious complications following probiotic ingestion: a potentially underestimated problem? A systematic review of reports and case series
title Infectious complications following probiotic ingestion: a potentially underestimated problem? A systematic review of reports and case series
spellingShingle Infectious complications following probiotic ingestion: a potentially underestimated problem? A systematic review of reports and case series
Costa, Rafael Lessa
Probiotics
Infection
Fungemia
Sepsis
Saccharomyces
Lactobacillus
title_short Infectious complications following probiotic ingestion: a potentially underestimated problem? A systematic review of reports and case series
title_full Infectious complications following probiotic ingestion: a potentially underestimated problem? A systematic review of reports and case series
title_fullStr Infectious complications following probiotic ingestion: a potentially underestimated problem? A systematic review of reports and case series
title_full_unstemmed Infectious complications following probiotic ingestion: a potentially underestimated problem? A systematic review of reports and case series
title_sort Infectious complications following probiotic ingestion: a potentially underestimated problem? A systematic review of reports and case series
author Costa, Rafael Lessa
author_facet Costa, Rafael Lessa
Moreira, José
Lorenzo, Andrea
Lamas, Cristiane C.
author_role author
author2 Moreira, José
Lorenzo, Andrea
Lamas, Cristiane C.
author2_role author
author
author
dc.contributor.author.fl_str_mv Costa, Rafael Lessa
Moreira, José
Lorenzo, Andrea
Lamas, Cristiane C.
dc.subject.en.pt_BR.fl_str_mv Probiotics
Infection
Fungemia
Sepsis
Saccharomyces
Lactobacillus
topic Probiotics
Infection
Fungemia
Sepsis
Saccharomyces
Lactobacillus
description Intensive Care Unit of Unimed-Rio Hospital. Rio de Janeiro, RJ, Brazil / Cardiointensive Unit of Americas Medical City. Rio de Janeiro, RJ, Brazil / National Institute of Cardiology. Rio de Janeiro, RJ, Brazil
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-01-10T12:04:41Z
dc.date.available.fl_str_mv 2019-01-10T12:04:41Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv COSTA, Rafael et al. Infectious complications following probiotic ingestion: a potentially underestimated problem? A systematic review of reports and case series. BMC Complementary and Alternative Medicine, p. 1-8, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/30951
dc.identifier.issn.pt_BR.fl_str_mv 1472-6882
dc.identifier.doi.none.fl_str_mv 10.1186/s12906-018-2394-3
identifier_str_mv COSTA, Rafael et al. Infectious complications following probiotic ingestion: a potentially underestimated problem? A systematic review of reports and case series. BMC Complementary and Alternative Medicine, p. 1-8, 2018.
1472-6882
10.1186/s12906-018-2394-3
url https://www.arca.fiocruz.br/handle/icict/30951
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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