Influence of fatty acids in maternal diet on atherogenesis in offspring of LDL receptor-deficient mice
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/28577 |
Resumo: | Fundação Oswaldo Cruz (FIOCRUZ), Centro de Tecnologias Estratégicas do Nordeste (CETENE), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) e Fundação de Apoio ao Desenvolvimento Científico de Pernambuco (FACEPE). |
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Torres, Dilênia de Oliveira CiprianoSantos, Ana Célia Oliveira DosSilva, Amanda Karolina Soares eMoura, Patrícia Muniz Mendes Freire deBeltrão, Eduardo Isidoro CarneiroPeixoto, Christina Alves2018-09-06T12:14:41Z2018-09-06T12:14:41Z2012TORRES, Dilênia de Oliveira Cipriano et al. Influence of fatty acids in maternal diet on atherogenesis in offspring of LDL receptor-deficient mice. International Journal of Clinical and Experimental Medicine, v. 5, n. 1, p. 56–63, 2012.1940-5901https://www.arca.fiocruz.br/handle/icict/28577Fundação Oswaldo Cruz (FIOCRUZ), Centro de Tecnologias Estratégicas do Nordeste (CETENE), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) e Fundação de Apoio ao Desenvolvimento Científico de Pernambuco (FACEPE).Universidade de Pernambuco. Hospital Universitário Oswaldo Cruz–HUOC. Pronto-Socorro Cardiológico Universitário de Pernambuco - PROCAPE. Laboratório de Análises Clínicas. Recife, PE, Brasil / Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Ultraestrutura. Recife, PE, Brasil.Universidade de Pernambuco. Instituto de Ciências Biológicas. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Ultraestrutura. Recife, PE, Brasil.Universidade de Pernambuco. Instituto de Ciências Biológicas. Recife, PE, Brasil.Universidade Federal de Pernambuco. Departamento de Bioquímica. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Ultraestrutura. Recife, PE, Brasil / Centro de Tecnologias Estratégicas do Nordeste - CETENE. Recife, PE, Brasil.AIMS: The present study investigated the effect of a maternal diet rich in omega-6 (E6D) or omega-9 (E9D) on atherogenesis in the offspring of mice. MAIN METHODS: LDL receptor-deficient mice were fed a diet rich in either omega-6 (E6D) or omega-9 (E9D) for 45 days prior to mating and until the birth of the offspring, evaluating the effect on the offspring aorta in comparison to a standard diet (STD), by immunohistochemical analysis, morphometric analysis and electron microscopy. KEY FINDINGS: Hypercholesterolemic female mice fed E6D generated offspring with high levels of total cholesterol, triglycerides (TG) and CC-chemokine ligand 2/monocyte chemoattractant protein 1 (CCL2/ MCP-1) as well as a reduction in high-density lipoprotein. The ascending aorta of these animals exhibited an increase in arterial wall thickness as well as increased expression of CCL2/MCP-1 and vascular cell adhesion molecule 1. The ultrastructural analysis revealed severe alterations in endothelial cells. The offspring from mothers fed E9D exhibited a reduction in TG and an increase in low-density lipoprotein. The ultrastructural analysis revealed a well-preserved aortic endothelium in these animals. SIGNIFICANCE: The results suggest that hypercholesterolemic mothers feed a diet rich in omega-6 predispose their offspring to endothelial dysfunction.engNutrição maternaHipercolesterolemia maternaÔmega-6Ômega-9ProleMCP-1VCAM-1AterogêneseLipídios sangüíneosMaternal nutritionMaternal hypercholesterolemiaOmega-6Omega-9OffspringMCP-1VCAM-1AtherogenesisBlood lipidsInfluence of fatty acids in maternal diet on atherogenesis in offspring of LDL receptor-deficient miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83092https://www.arca.fiocruz.br/bitstream/icict/28577/1/license.txt447f2497af1ef5cf99b5c07f6fa18dceMD51ORIGINALInfluence of fatty acids in maternal diet on atherogenesis.pdfInfluence of fatty acids in maternal diet on atherogenesis.pdfapplication/pdf2716546https://www.arca.fiocruz.br/bitstream/icict/28577/2/Influence%20of%20fatty%20acids%20in%20maternal%20diet%20on%20atherogenesis.pdf0d29646fdef7aa776287415e3292f730MD52TEXTInfluence of fatty acids in maternal diet on atherogenesis.pdf.txtInfluence of fatty acids in maternal diet on atherogenesis.pdf.txtExtracted texttext/plain30313https://www.arca.fiocruz.br/bitstream/icict/28577/3/Influence%20of%20fatty%20acids%20in%20maternal%20diet%20on%20atherogenesis.pdf.txtc110b8ee10742991742ba141a1c5d073MD53icict/285772018-09-07 02:01:01.534oai:www.arca.fiocruz.br:icict/28577Q0VTU8ODTyBOw4NPIEVYQ0xVU0lWQSBERSBESVJFSVRPUyBBVVRPUkFJUw0KDQpLYW15bGxhIE5hc2NpbWVudG8sIENQRjogMDc1LjExNC41MTQtOTcsIHZpbmN1bGFkbyBhIENQcUFNIC0gQ2VudHJvIGRlIFBlc3F1aXNhcyBBZ2dldSBNYWdhbGjDo2VzCgpBbyBhY2VpdGFyIG9zIFRFUk1PUyBlIENPTkRJw4fDlUVTIGRlc3RhIENFU1PDg08sIG8gQVVUT1IgZS9vdSBUSVRVTEFSIGRlIGRpcmVpdG9zCmF1dG9yYWlzIHNvYnJlIGEgT0JSQSBkZSBxdWUgdHJhdGEgZXN0ZSBkb2N1bWVudG86CgooMSkgQ0VERSBlIFRSQU5TRkVSRSwgdG90YWwgZSBncmF0dWl0YW1lbnRlLCDDoCBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVosIGVtCmNhcsOhdGVyIHBlcm1hbmVudGUsIGlycmV2b2fDoXZlbCBlIE7Dg08gRVhDTFVTSVZPLCB0b2RvcyBvcyBkaXJlaXRvcyBwYXRyaW1vbmlhaXMgTsODTwpDT01FUkNJQUlTIGRlIHV0aWxpemHDp8OjbyBkYSBPQlJBIGFydMOtc3RpY2EgZS9vdSBjaWVudMOtZmljYSBpbmRpY2FkYSBhY2ltYSwgaW5jbHVzaXZlIG9zIGRpcmVpdG9zCmRlIHZveiBlIGltYWdlbSB2aW5jdWxhZG9zIMOgIE9CUkEsIGR1cmFudGUgdG9kbyBvIHByYXpvIGRlIGR1cmHDp8OjbyBkb3MgZGlyZWl0b3MgYXV0b3JhaXMsIGVtCnF1YWxxdWVyIGlkaW9tYSBlIGVtIHRvZG9zIG9zIHBhw61zZXM7CgooMikgQUNFSVRBIHF1ZSBhIGNlc3PDo28gdG90YWwgbsOjbyBleGNsdXNpdmEsIHBlcm1hbmVudGUgZSBpcnJldm9nw6F2ZWwgZG9zIGRpcmVpdG9zIGF1dG9yYWlzCnBhdHJpbW9uaWFpcyBuw6NvIGNvbWVyY2lhaXMgZGUgdXRpbGl6YcOnw6NvIGRlIHF1ZSB0cmF0YSBlc3RlIGRvY3VtZW50byBpbmNsdWksIGV4ZW1wbGlmaWNhdGl2YW1lbnRlLApvcyBkaXJlaXRvcyBkZSBkaXNwb25pYmlsaXphw6fDo28gZSBjb211bmljYcOnw6NvIHDDumJsaWNhIGRhIE9CUkEsIGVtIHF1YWxxdWVyIG1laW8gb3UgdmXDrWN1bG8sCmluY2x1c2l2ZSBlbSBSZXBvc2l0w7NyaW9zIERpZ2l0YWlzLCBiZW0gY29tbyBvcyBkaXJlaXRvcyBkZSByZXByb2R1w6fDo28sIGV4aWJpw6fDo28sIGV4ZWN1w6fDo28sCmRlY2xhbWHDp8OjbywgcmVjaXRhw6fDo28sIGV4cG9zacOnw6NvLCBhcnF1aXZhbWVudG8sIGluY2x1c8OjbyBlbSBiYW5jbyBkZSBkYWRvcywgcHJlc2VydmHDp8OjbywgZGlmdXPDo28sCmRpc3RyaWJ1acOnw6NvLCBkaXZ1bGdhw6fDo28sIGVtcHLDqXN0aW1vLCB0cmFkdcOnw6NvLCBkdWJsYWdlbSwgbGVnZW5kYWdlbSwgaW5jbHVzw6NvIGVtIG5vdmFzIG9icmFzIG91CmNvbGV0w6JuZWFzLCByZXV0aWxpemHDp8OjbywgZWRpw6fDo28sIHByb2R1w6fDo28gZGUgbWF0ZXJpYWwgZGlkw6F0aWNvIGUgY3Vyc29zIG91IHF1YWxxdWVyIGZvcm1hIGRlCnV0aWxpemHDp8OjbyBuw6NvIGNvbWVyY2lhbDsKCigzKSBSRUNPTkhFQ0UgcXVlIGEgY2Vzc8OjbyBhcXVpIGVzcGVjaWZpY2FkYSBjb25jZWRlIMOgIEZJT0NSVVogLSBGVU5EQcOHw4NPIE9TV0FMRE8KQ1JVWiBvIGRpcmVpdG8gZGUgYXV0b3JpemFyIHF1YWxxdWVyIHBlc3NvYSDigJMgZsOtc2ljYSBvdSBqdXLDrWRpY2EsIHDDumJsaWNhIG91IHByaXZhZGEsIG5hY2lvbmFsIG91CmVzdHJhbmdlaXJhIOKAkyBhIGFjZXNzYXIgZSB1dGlsaXphciBhbXBsYW1lbnRlIGEgT0JSQSwgc2VtIGV4Y2x1c2l2aWRhZGUsIHBhcmEgcXVhaXNxdWVyCmZpbmFsaWRhZGVzIG7Do28gY29tZXJjaWFpczsKCig0KSBERUNMQVJBIHF1ZSBhIG9icmEgw6kgY3JpYcOnw6NvIG9yaWdpbmFsIGUgcXVlIMOpIG8gdGl0dWxhciBkb3MgZGlyZWl0b3MgYXF1aSBjZWRpZG9zIGUgYXV0b3JpemFkb3MsCnJlc3BvbnNhYmlsaXphbmRvLXNlIGludGVncmFsbWVudGUgcGVsbyBjb250ZcO6ZG8gZSBvdXRyb3MgZWxlbWVudG9zIHF1ZSBmYXplbSBwYXJ0ZSBkYSBPQlJBLAppbmNsdXNpdmUgb3MgZGlyZWl0b3MgZGUgdm96IGUgaW1hZ2VtIHZpbmN1bGFkb3Mgw6AgT0JSQSwgb2JyaWdhbmRvLXNlIGEgaW5kZW5pemFyIHRlcmNlaXJvcyBwb3IKZGFub3MsIGJlbSBjb21vIGluZGVuaXphciBlIHJlc3NhcmNpciBhIEZJT0NSVVogLSBGVU5EQcOHw4NPIE9TV0FMRE8gQ1JVWiBkZQpldmVudHVhaXMgZGVzcGVzYXMgcXVlIHZpZXJlbSBhIHN1cG9ydGFyLCBlbSByYXrDo28gZGUgcXVhbHF1ZXIgb2ZlbnNhIGEgZGlyZWl0b3MgYXV0b3JhaXMgb3UKZGlyZWl0b3MgZGUgdm96IG91IGltYWdlbSwgcHJpbmNpcGFsbWVudGUgbm8gcXVlIGRpeiByZXNwZWl0byBhIHBsw6FnaW8gZSB2aW9sYcOnw7VlcyBkZSBkaXJlaXRvczsKCig1KSBBRklSTUEgcXVlIGNvbmhlY2UgYSBQb2zDrXRpY2EgSW5zdGl0dWNpb25hbCBkZSBBY2Vzc28gQWJlcnRvIGRhIEZJT0NSVVogLSBGVU5EQcOHw4NPCk9TV0FMRE8gQ1JVWiBlIGFzIGRpcmV0cml6ZXMgcGFyYSBvIGZ1bmNpb25hbWVudG8gZG8gcmVwb3NpdMOzcmlvIGluc3RpdHVjaW9uYWwgQVJDQS4KCkEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVogcmVzZXJ2YQpleGNsdXNpdmFtZW50ZSBhbyBBVVRPUiBvcyBkaXJlaXRvcyBtb3JhaXMgZSBvcyB1c29zIGNvbWVyY2lhaXMgc29icmUgYXMgb2JyYXMgZGUgc3VhIGF1dG9yaWEKZS9vdSB0aXR1bGFyaWRhZGUsIHNlbmRvIG9zIHRlcmNlaXJvcyB1c3XDoXJpb3MgcmVzcG9uc8OhdmVpcyBwZWxhIGF0cmlidWnDp8OjbyBkZSBhdXRvcmlhIGUgbWFudXRlbsOnw6NvCmRhIGludGVncmlkYWRlIGRhIE9CUkEgZW0gcXVhbHF1ZXIgdXRpbGl6YcOnw6NvLgoKQSBQb2zDrXRpY2EgSW5zdGl0dWNpb25hbCBkZSBBY2Vzc28gQWJlcnRvIGRhIEZJT0NSVVogLSBGVU5EQcOHw4NPIE9TV0FMRE8gQ1JVWgpyZXNwZWl0YSBvcyBjb250cmF0b3MgZSBhY29yZG9zIHByZWV4aXN0ZW50ZXMgZG9zIEF1dG9yZXMgY29tIHRlcmNlaXJvcywgY2FiZW5kbyBhb3MgQXV0b3JlcwppbmZvcm1hciDDoCBJbnN0aXR1acOnw6NvIGFzIGNvbmRpw6fDtWVzIGUgb3V0cmFzIHJlc3RyacOnw7VlcyBpbXBvc3RhcyBwb3IgZXN0ZXMgaW5zdHJ1bWVudG9zLgo=Repositório 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| dc.title.pt_BR.fl_str_mv |
Influence of fatty acids in maternal diet on atherogenesis in offspring of LDL receptor-deficient mice |
| title |
Influence of fatty acids in maternal diet on atherogenesis in offspring of LDL receptor-deficient mice |
| spellingShingle |
Influence of fatty acids in maternal diet on atherogenesis in offspring of LDL receptor-deficient mice Torres, Dilênia de Oliveira Cipriano Nutrição materna Hipercolesterolemia materna Ômega-6 Ômega-9 Prole MCP-1 VCAM-1 Aterogênese Lipídios sangüíneos Maternal nutrition Maternal hypercholesterolemia Omega-6 Omega-9 Offspring MCP-1 VCAM-1 Atherogenesis Blood lipids |
| title_short |
Influence of fatty acids in maternal diet on atherogenesis in offspring of LDL receptor-deficient mice |
| title_full |
Influence of fatty acids in maternal diet on atherogenesis in offspring of LDL receptor-deficient mice |
| title_fullStr |
Influence of fatty acids in maternal diet on atherogenesis in offspring of LDL receptor-deficient mice |
| title_full_unstemmed |
Influence of fatty acids in maternal diet on atherogenesis in offspring of LDL receptor-deficient mice |
| title_sort |
Influence of fatty acids in maternal diet on atherogenesis in offspring of LDL receptor-deficient mice |
| author |
Torres, Dilênia de Oliveira Cipriano |
| author_facet |
Torres, Dilênia de Oliveira Cipriano Santos, Ana Célia Oliveira Dos Silva, Amanda Karolina Soares e Moura, Patrícia Muniz Mendes Freire de Beltrão, Eduardo Isidoro Carneiro Peixoto, Christina Alves |
| author_role |
author |
| author2 |
Santos, Ana Célia Oliveira Dos Silva, Amanda Karolina Soares e Moura, Patrícia Muniz Mendes Freire de Beltrão, Eduardo Isidoro Carneiro Peixoto, Christina Alves |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Torres, Dilênia de Oliveira Cipriano Santos, Ana Célia Oliveira Dos Silva, Amanda Karolina Soares e Moura, Patrícia Muniz Mendes Freire de Beltrão, Eduardo Isidoro Carneiro Peixoto, Christina Alves |
| dc.subject.other.pt_BR.fl_str_mv |
Nutrição materna Hipercolesterolemia materna Ômega-6 Ômega-9 Prole MCP-1 VCAM-1 Aterogênese Lipídios sangüíneos |
| topic |
Nutrição materna Hipercolesterolemia materna Ômega-6 Ômega-9 Prole MCP-1 VCAM-1 Aterogênese Lipídios sangüíneos Maternal nutrition Maternal hypercholesterolemia Omega-6 Omega-9 Offspring MCP-1 VCAM-1 Atherogenesis Blood lipids |
| dc.subject.en.pt_BR.fl_str_mv |
Maternal nutrition Maternal hypercholesterolemia Omega-6 Omega-9 Offspring MCP-1 VCAM-1 Atherogenesis Blood lipids |
| description |
Fundação Oswaldo Cruz (FIOCRUZ), Centro de Tecnologias Estratégicas do Nordeste (CETENE), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) e Fundação de Apoio ao Desenvolvimento Científico de Pernambuco (FACEPE). |
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2012 |
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2012 |
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2018-09-06T12:14:41Z |
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2018-09-06T12:14:41Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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TORRES, Dilênia de Oliveira Cipriano et al. Influence of fatty acids in maternal diet on atherogenesis in offspring of LDL receptor-deficient mice. International Journal of Clinical and Experimental Medicine, v. 5, n. 1, p. 56–63, 2012. |
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https://www.arca.fiocruz.br/handle/icict/28577 |
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1940-5901 |
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TORRES, Dilênia de Oliveira Cipriano et al. Influence of fatty acids in maternal diet on atherogenesis in offspring of LDL receptor-deficient mice. International Journal of Clinical and Experimental Medicine, v. 5, n. 1, p. 56–63, 2012. 1940-5901 |
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