Post-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae: report of two cases
Autor(a) principal: | |
---|---|
Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/42577 |
Resumo: | Universidade Anhanguera Uniderp. Campo Grande, MS, Brasil. |
id |
CRUZ_6f4567142ed37922f5a5b48464b72bc9 |
---|---|
oai_identifier_str |
oai:www.arca.fiocruz.br:icict/42577 |
network_acronym_str |
CRUZ |
network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
repository_id_str |
2135 |
spelling |
Patrial, Yasmin CoelhoTortorelli, Luma PetriRodrigues, Ana Claudia SouzaSantos, Ivson Cassiano de OliveiraChaves, Cláudia Elizabeth VolpeCapato, Gislaine SouzaBarbosa, Gustavo Augusto RibeiroCarvalho-Assef, Ana Paula D' A.Chang, Marilene Rodrigues2020-08-06T18:27:47Z2020-08-06T18:27:47Z2019PATRIAL, Yasmin Coelho et al. Post-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae: report of two cases. Rev. Inst. Med. Trop. São Paulo, v. 61, e 69, 5p, 2019.1678-9946https://www.arca.fiocruz.br/handle/icict/4257710.1590/S1678-9946201961069engInstituto de Medicina Tropical de São PauloMeningiteKlebsiella pneumoniaeResistente ao carbapenemBeta-lactamasesFluido cefalorraquidianoMeningitisKlebsiella pneumoniaeCarbapenem-resistantBeta-lactamasesCerebrospinal fluidPost-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae: report of two casesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Anhanguera Uniderp. Campo Grande, MS, Brasil.Universidade Anhanguera Uniderp. Campo Grande, MS, Brasil.Universidade Anhanguera Uniderp. Campo Grande, MS, Brasil / Universidade Federal de Mato Grosso do Sul. Faculdade de Medicina. Programa de Pós-Graduação em Saúde e Desenvolvimento na Região Centro Oeste. Campo Grande, MS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa de Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.Hospital Regional de Mato Grosso do Sul. Campo Grande, MS, Brasil / Universidade Federal de Mato Grosso do Sul. Faculdade de Medicina. Programa de Pós-Graduação em Doenças Infecciosas e Parasitárias. Campo Grande, MS, Brasil.Hospital Santa Casa. Campo Grande. MS, Brasil.Hospital Santa Casa. Campo Grande. MS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa de Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.Universidade Federal de Mato Grosso do Sul. Laboratório de Pesquisas Microbiológicas. Campo Grande, MS, Brasil.Nosocomial bacterial infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP) is associated with high mortality in neurosurgical patients. There are few reports in the literature on meningitis caused by CRKP. We report two cases of CRKP meningitis after neurosurgery. The K. pneumoniae identification and antimicrobial susceptibility testing were performed using the Vitek Compact System. Minimum inhibitory concentrations of polymyxin B were determined using the broth microdilution method. Molecular typing of K. pneumoniae isolates was investigated using multilocus sequence typing. Antimicrobial susceptibility testing showed that the K. pneumoniae isolates were multidrug resistant and co-produced extended-spectrum β-lactamases and KPC enzymes. The patients were treated with intrathecal polymyxin. Genetic polymorphism analyses revealed two different K. pneumoniae clones (ST1298 and ST2687), which were observed for the first time in CRKP infections. We recommend intravenous administration of intrathecal polymyxin for treating meningitis caused by multidrug-resistant K. pneumoniae .info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/42577/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAnaPAssef_IvsonSantos_etal_IOC_2020.pdfAnaPAssef_IvsonSantos_etal_IOC_2020.pdfapplication/pdf170977https://www.arca.fiocruz.br/bitstream/icict/42577/2/AnaPAssef_IvsonSantos_etal_IOC_2020.pdf4e7013a4220f34d9b72bcd5494949e04MD52TEXTAnaPAssef_IvsonSantos_etal_IOC_2020.pdf.txtAnaPAssef_IvsonSantos_etal_IOC_2020.pdf.txtExtracted texttext/plain21052https://www.arca.fiocruz.br/bitstream/icict/42577/3/AnaPAssef_IvsonSantos_etal_IOC_2020.pdf.txta6369b5482d6a96550983320c60e038bMD53icict/425772023-09-05 10:36:26.227oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-05T13:36:26Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Post-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae: report of two cases |
title |
Post-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae: report of two cases |
spellingShingle |
Post-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae: report of two cases Patrial, Yasmin Coelho Meningite Klebsiella pneumoniae Resistente ao carbapenem Beta-lactamases Fluido cefalorraquidiano Meningitis Klebsiella pneumoniae Carbapenem-resistant Beta-lactamases Cerebrospinal fluid |
title_short |
Post-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae: report of two cases |
title_full |
Post-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae: report of two cases |
title_fullStr |
Post-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae: report of two cases |
title_full_unstemmed |
Post-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae: report of two cases |
title_sort |
Post-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae: report of two cases |
author |
Patrial, Yasmin Coelho |
author_facet |
Patrial, Yasmin Coelho Tortorelli, Luma Petri Rodrigues, Ana Claudia Souza Santos, Ivson Cassiano de Oliveira Chaves, Cláudia Elizabeth Volpe Capato, Gislaine Souza Barbosa, Gustavo Augusto Ribeiro Carvalho-Assef, Ana Paula D' A. Chang, Marilene Rodrigues |
author_role |
author |
author2 |
Tortorelli, Luma Petri Rodrigues, Ana Claudia Souza Santos, Ivson Cassiano de Oliveira Chaves, Cláudia Elizabeth Volpe Capato, Gislaine Souza Barbosa, Gustavo Augusto Ribeiro Carvalho-Assef, Ana Paula D' A. Chang, Marilene Rodrigues |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Patrial, Yasmin Coelho Tortorelli, Luma Petri Rodrigues, Ana Claudia Souza Santos, Ivson Cassiano de Oliveira Chaves, Cláudia Elizabeth Volpe Capato, Gislaine Souza Barbosa, Gustavo Augusto Ribeiro Carvalho-Assef, Ana Paula D' A. Chang, Marilene Rodrigues |
dc.subject.other.pt_BR.fl_str_mv |
Meningite Klebsiella pneumoniae Resistente ao carbapenem Beta-lactamases Fluido cefalorraquidiano |
topic |
Meningite Klebsiella pneumoniae Resistente ao carbapenem Beta-lactamases Fluido cefalorraquidiano Meningitis Klebsiella pneumoniae Carbapenem-resistant Beta-lactamases Cerebrospinal fluid |
dc.subject.en.pt_BR.fl_str_mv |
Meningitis Klebsiella pneumoniae Carbapenem-resistant Beta-lactamases Cerebrospinal fluid |
description |
Universidade Anhanguera Uniderp. Campo Grande, MS, Brasil. |
publishDate |
2019 |
dc.date.issued.fl_str_mv |
2019 |
dc.date.accessioned.fl_str_mv |
2020-08-06T18:27:47Z |
dc.date.available.fl_str_mv |
2020-08-06T18:27:47Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
PATRIAL, Yasmin Coelho et al. Post-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae: report of two cases. Rev. Inst. Med. Trop. São Paulo, v. 61, e 69, 5p, 2019. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/42577 |
dc.identifier.issn.pt_BR.fl_str_mv |
1678-9946 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S1678-9946201961069 |
identifier_str_mv |
PATRIAL, Yasmin Coelho et al. Post-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae: report of two cases. Rev. Inst. Med. Trop. São Paulo, v. 61, e 69, 5p, 2019. 1678-9946 10.1590/S1678-9946201961069 |
url |
https://www.arca.fiocruz.br/handle/icict/42577 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
collection |
Repositório Institucional da FIOCRUZ (ARCA) |
bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/42577/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/42577/2/AnaPAssef_IvsonSantos_etal_IOC_2020.pdf https://www.arca.fiocruz.br/bitstream/icict/42577/3/AnaPAssef_IvsonSantos_etal_IOC_2020.pdf.txt |
bitstream.checksum.fl_str_mv |
5a560609d32a3863062d77ff32785d58 4e7013a4220f34d9b72bcd5494949e04 a6369b5482d6a96550983320c60e038b |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
_version_ |
1813008925235085312 |