Post-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae: report of two cases

Detalhes bibliográficos
Autor(a) principal: Patrial, Yasmin Coelho
Data de Publicação: 2019
Outros Autores: Tortorelli, Luma Petri, Rodrigues, Ana Claudia Souza, Santos, Ivson Cassiano de Oliveira, Chaves, Cláudia Elizabeth Volpe, Capato, Gislaine Souza, Barbosa, Gustavo Augusto Ribeiro, Carvalho-Assef, Ana Paula D' A., Chang, Marilene Rodrigues
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/42577
Resumo: Universidade Anhanguera Uniderp. Campo Grande, MS, Brasil.
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spelling Patrial, Yasmin CoelhoTortorelli, Luma PetriRodrigues, Ana Claudia SouzaSantos, Ivson Cassiano de OliveiraChaves, Cláudia Elizabeth VolpeCapato, Gislaine SouzaBarbosa, Gustavo Augusto RibeiroCarvalho-Assef, Ana Paula D' A.Chang, Marilene Rodrigues2020-08-06T18:27:47Z2020-08-06T18:27:47Z2019PATRIAL, Yasmin Coelho et al. Post-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae: report of two cases. Rev. Inst. Med. Trop. São Paulo, v. 61, e 69, 5p, 2019.1678-9946https://www.arca.fiocruz.br/handle/icict/4257710.1590/S1678-9946201961069engInstituto de Medicina Tropical de São PauloMeningiteKlebsiella pneumoniaeResistente ao carbapenemBeta-lactamasesFluido cefalorraquidianoMeningitisKlebsiella pneumoniaeCarbapenem-resistantBeta-lactamasesCerebrospinal fluidPost-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae: report of two casesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Anhanguera Uniderp. Campo Grande, MS, Brasil.Universidade Anhanguera Uniderp. Campo Grande, MS, Brasil.Universidade Anhanguera Uniderp. Campo Grande, MS, Brasil / Universidade Federal de Mato Grosso do Sul. Faculdade de Medicina. Programa de Pós-Graduação em Saúde e Desenvolvimento na Região Centro Oeste. Campo Grande, MS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa de Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.Hospital Regional de Mato Grosso do Sul. Campo Grande, MS, Brasil / Universidade Federal de Mato Grosso do Sul. Faculdade de Medicina. Programa de Pós-Graduação em Doenças Infecciosas e Parasitárias. Campo Grande, MS, Brasil.Hospital Santa Casa. Campo Grande. MS, Brasil.Hospital Santa Casa. Campo Grande. MS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa de Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.Universidade Federal de Mato Grosso do Sul. Laboratório de Pesquisas Microbiológicas. Campo Grande, MS, Brasil.Nosocomial bacterial infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP) is associated with high mortality in neurosurgical patients. There are few reports in the literature on meningitis caused by CRKP. We report two cases of CRKP meningitis after neurosurgery. The K. pneumoniae identification and antimicrobial susceptibility testing were performed using the Vitek Compact System. Minimum inhibitory concentrations of polymyxin B were determined using the broth microdilution method. Molecular typing of K. pneumoniae isolates was investigated using multilocus sequence typing. Antimicrobial susceptibility testing showed that the K. pneumoniae isolates were multidrug resistant and co-produced extended-spectrum β-lactamases and KPC enzymes. The patients were treated with intrathecal polymyxin. Genetic polymorphism analyses revealed two different K. pneumoniae clones (ST1298 and ST2687), which were observed for the first time in CRKP infections. We recommend intravenous administration of intrathecal polymyxin for treating meningitis caused by multidrug-resistant K. pneumoniae .info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/42577/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAnaPAssef_IvsonSantos_etal_IOC_2020.pdfAnaPAssef_IvsonSantos_etal_IOC_2020.pdfapplication/pdf170977https://www.arca.fiocruz.br/bitstream/icict/42577/2/AnaPAssef_IvsonSantos_etal_IOC_2020.pdf4e7013a4220f34d9b72bcd5494949e04MD52TEXTAnaPAssef_IvsonSantos_etal_IOC_2020.pdf.txtAnaPAssef_IvsonSantos_etal_IOC_2020.pdf.txtExtracted texttext/plain21052https://www.arca.fiocruz.br/bitstream/icict/42577/3/AnaPAssef_IvsonSantos_etal_IOC_2020.pdf.txta6369b5482d6a96550983320c60e038bMD53icict/425772023-09-05 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dc.title.pt_BR.fl_str_mv Post-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae: report of two cases
title Post-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae: report of two cases
spellingShingle Post-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae: report of two cases
Patrial, Yasmin Coelho
Meningite
Klebsiella pneumoniae
Resistente ao carbapenem
Beta-lactamases
Fluido cefalorraquidiano
Meningitis
Klebsiella pneumoniae
Carbapenem-resistant
Beta-lactamases
Cerebrospinal fluid
title_short Post-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae: report of two cases
title_full Post-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae: report of two cases
title_fullStr Post-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae: report of two cases
title_full_unstemmed Post-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae: report of two cases
title_sort Post-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae: report of two cases
author Patrial, Yasmin Coelho
author_facet Patrial, Yasmin Coelho
Tortorelli, Luma Petri
Rodrigues, Ana Claudia Souza
Santos, Ivson Cassiano de Oliveira
Chaves, Cláudia Elizabeth Volpe
Capato, Gislaine Souza
Barbosa, Gustavo Augusto Ribeiro
Carvalho-Assef, Ana Paula D' A.
Chang, Marilene Rodrigues
author_role author
author2 Tortorelli, Luma Petri
Rodrigues, Ana Claudia Souza
Santos, Ivson Cassiano de Oliveira
Chaves, Cláudia Elizabeth Volpe
Capato, Gislaine Souza
Barbosa, Gustavo Augusto Ribeiro
Carvalho-Assef, Ana Paula D' A.
Chang, Marilene Rodrigues
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Patrial, Yasmin Coelho
Tortorelli, Luma Petri
Rodrigues, Ana Claudia Souza
Santos, Ivson Cassiano de Oliveira
Chaves, Cláudia Elizabeth Volpe
Capato, Gislaine Souza
Barbosa, Gustavo Augusto Ribeiro
Carvalho-Assef, Ana Paula D' A.
Chang, Marilene Rodrigues
dc.subject.other.pt_BR.fl_str_mv Meningite
Klebsiella pneumoniae
Resistente ao carbapenem
Beta-lactamases
Fluido cefalorraquidiano
topic Meningite
Klebsiella pneumoniae
Resistente ao carbapenem
Beta-lactamases
Fluido cefalorraquidiano
Meningitis
Klebsiella pneumoniae
Carbapenem-resistant
Beta-lactamases
Cerebrospinal fluid
dc.subject.en.pt_BR.fl_str_mv Meningitis
Klebsiella pneumoniae
Carbapenem-resistant
Beta-lactamases
Cerebrospinal fluid
description Universidade Anhanguera Uniderp. Campo Grande, MS, Brasil.
publishDate 2019
dc.date.issued.fl_str_mv 2019
dc.date.accessioned.fl_str_mv 2020-08-06T18:27:47Z
dc.date.available.fl_str_mv 2020-08-06T18:27:47Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PATRIAL, Yasmin Coelho et al. Post-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae: report of two cases. Rev. Inst. Med. Trop. São Paulo, v. 61, e 69, 5p, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/42577
dc.identifier.issn.pt_BR.fl_str_mv 1678-9946
dc.identifier.doi.none.fl_str_mv 10.1590/S1678-9946201961069
identifier_str_mv PATRIAL, Yasmin Coelho et al. Post-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae: report of two cases. Rev. Inst. Med. Trop. São Paulo, v. 61, e 69, 5p, 2019.
1678-9946
10.1590/S1678-9946201961069
url https://www.arca.fiocruz.br/handle/icict/42577
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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