High IFN-γ/IL-10 expression ratio and increased frequency of persistent human T-cell lymphotropic virus type 1-infected clones are associated with human T-cell lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis development

Detalhes bibliográficos
Autor(a) principal: Espíndola, Otávio M.
Data de Publicação: 2015
Outros Autores: Oliveira, Luã C., Ferreira, Priscilla M. S., Leite, Ana Claudia C. B., Lima, Marco Antonio S. D., Andrada-Serpa, Maria José
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/32245
Resumo: 2020-03-28
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spelling Espíndola, Otávio M.Oliveira, Luã C.Ferreira, Priscilla M. S.Leite, Ana Claudia C. B.Lima, Marco Antonio S. D.Andrada-Serpa, Maria José2019-03-27T13:47:40Z2019-03-27T13:47:40Z2015ESPÍNDOLA, Otávio M. et al. High IFN-γ/IL-10 expression ratio and increased frequency of persistent human T-cell lymphotropic virus Type 1-infected clones are associated with human T-cell lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis development. Intervirology, v. 58, p. 106-114, 2015.0300-5526https://www.arca.fiocruz.br/handle/icict/3224510.1159/0003717661423-0100engKarger PublishersHigh IFN-γ/IL-10 expression ratio and increased frequency of persistent human T-cell lymphotropic virus type 1-infected clones are associated with human T-cell lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis developmentinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-03-28Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa em Patogenia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa em Patogenia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa em Patogenia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ, Brasil / The Federal University of Rio de Janeiro. Neurology Department. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa em Patogenia Viral. Rio de Janeiro, RJ, Brasil.Human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus that causes a persistent infection, and only 0.5-5% of infected individuals will develop HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Therefore, we investigated parameters to discriminate HTLV-1 asymptomatic carriers (ACs) with an increased chance to develop HAM/TSP. Methods: We evaluated integration patterns of HTLV-1 provirus, the relative expression of HTLV-1 tax and HBZ mRNAs and of IFN-γ and IL-10 mRNAs, in addition to proviral load (PVL) levels. Results: HAM/TSP patients presented a higher number of large persistent HTLV-1-carrying clones compared to ACs, and the expression of the HTLV-1 tax and HBZ genes by infected cells was detected at low levels and correlated positively with PVL. In addition, HAM/TSP patients and ACs with high PVL expressed higher levels of IFN-γ mRNA in comparison to IL-10, while ACs with low PVL presented an equilibrate IFN-γ/IL-10 ratio. Conclusions: The presence of large persistent HTLV1-infected clones in association with viral gene expression, even at small levels, could stimulate the intense inflammatory response in HTLV-1-infected individuals. This was supported by a high ratio of IFN-γ/IL-10 relative expression in HAM/TSP patients and ACs with high PVL, indicating that these parameters could aid the identification of ACs with a high risk to develop HAM/TSP.Human T-cell lymphotropic virus type 1Human T-cell lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesisIFN-γIL-10ClonalityBiological markersinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv High IFN-γ/IL-10 expression ratio and increased frequency of persistent human T-cell lymphotropic virus type 1-infected clones are associated with human T-cell lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis development
title High IFN-γ/IL-10 expression ratio and increased frequency of persistent human T-cell lymphotropic virus type 1-infected clones are associated with human T-cell lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis development
spellingShingle High IFN-γ/IL-10 expression ratio and increased frequency of persistent human T-cell lymphotropic virus type 1-infected clones are associated with human T-cell lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis development
Espíndola, Otávio M.
Human T-cell lymphotropic virus type 1
Human T-cell lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis
IFN-γ
IL-10
Clonality
Biological markers
title_short High IFN-γ/IL-10 expression ratio and increased frequency of persistent human T-cell lymphotropic virus type 1-infected clones are associated with human T-cell lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis development
title_full High IFN-γ/IL-10 expression ratio and increased frequency of persistent human T-cell lymphotropic virus type 1-infected clones are associated with human T-cell lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis development
title_fullStr High IFN-γ/IL-10 expression ratio and increased frequency of persistent human T-cell lymphotropic virus type 1-infected clones are associated with human T-cell lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis development
title_full_unstemmed High IFN-γ/IL-10 expression ratio and increased frequency of persistent human T-cell lymphotropic virus type 1-infected clones are associated with human T-cell lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis development
title_sort High IFN-γ/IL-10 expression ratio and increased frequency of persistent human T-cell lymphotropic virus type 1-infected clones are associated with human T-cell lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis development
author Espíndola, Otávio M.
author_facet Espíndola, Otávio M.
Oliveira, Luã C.
Ferreira, Priscilla M. S.
Leite, Ana Claudia C. B.
Lima, Marco Antonio S. D.
Andrada-Serpa, Maria José
author_role author
author2 Oliveira, Luã C.
Ferreira, Priscilla M. S.
Leite, Ana Claudia C. B.
Lima, Marco Antonio S. D.
Andrada-Serpa, Maria José
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Espíndola, Otávio M.
Oliveira, Luã C.
Ferreira, Priscilla M. S.
Leite, Ana Claudia C. B.
Lima, Marco Antonio S. D.
Andrada-Serpa, Maria José
dc.subject.en.pt_BR.fl_str_mv Human T-cell lymphotropic virus type 1
Human T-cell lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis
IFN-γ
IL-10
Clonality
Biological markers
topic Human T-cell lymphotropic virus type 1
Human T-cell lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis
IFN-γ
IL-10
Clonality
Biological markers
description 2020-03-28
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2019-03-27T13:47:40Z
dc.date.available.fl_str_mv 2019-03-27T13:47:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ESPÍNDOLA, Otávio M. et al. High IFN-γ/IL-10 expression ratio and increased frequency of persistent human T-cell lymphotropic virus Type 1-infected clones are associated with human T-cell lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis development. Intervirology, v. 58, p. 106-114, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/32245
dc.identifier.issn.pt_BR.fl_str_mv 0300-5526
dc.identifier.doi.none.fl_str_mv 10.1159/000371766
dc.identifier.eissn.none.fl_str_mv 1423-0100
identifier_str_mv ESPÍNDOLA, Otávio M. et al. High IFN-γ/IL-10 expression ratio and increased frequency of persistent human T-cell lymphotropic virus Type 1-infected clones are associated with human T-cell lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis development. Intervirology, v. 58, p. 106-114, 2015.
0300-5526
10.1159/000371766
1423-0100
url https://www.arca.fiocruz.br/handle/icict/32245
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Karger Publishers
publisher.none.fl_str_mv Karger Publishers
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/32245/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/32245/2/ve_Esp%c3%adndola_Ot%c3%a1vio_etal_INI_2015.pdf
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