Development of an urban molecular xenomonitoring system for lymphatic filariasis in the Recife Metropolitan Region, Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/32360 |
Resumo: | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Parasitologia. Recife, PE, Brasil / London School of Hygiene & Tropical Medicine (LSHTM). Department of Infectious Disease Epidemiology. London, United Kingdom. |
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Ramesh, AnitaCameron, MarySpence, KirstinHoek Spaans, RemyMelo-Santos, Maria A. V.Paiva, Marcelo H. S.Guedes, Duschinka R. D.Barbosa, Rosangela M. R.Oliveira, Claudia M. F.Sá, AndréJeffries, Claire L.Castanha, Priscila M. S.Oliveira, Paula A. S.Walker, ThomasAlexander, NealBraga, Cynthia2019-04-04T13:47:11Z2019-04-04T13:47:11Z2018RAMESH, A. et al. Development of an Urban Molecular Xenomonitoring System for Lymphatic Filariasis in the Recife Metropolitan Region, Brazil. PLoS Neglected Tropical Diseases, v. 12, n. 10, p. 1-24, 2018.1935-2735https://www.arca.fiocruz.br/handle/icict/3236010.1371/journal.pntd.0006816engDevelopment of an urban molecular xenomonitoring system for lymphatic filariasis in the Recife Metropolitan Region, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Parasitologia. Recife, PE, Brasil / London School of Hygiene & Tropical Medicine (LSHTM). Department of Infectious Disease Epidemiology. London, United Kingdom.LSHTM. Department of Disease Control. London, United Kingdom.LSHTM. Department of Disease Control. London, United Kingdom.LSHTM. Department of Disease Control. London, United Kingdom.LSHTM. Department of Disease Control. London, United Kingdom.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Entomologia. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Entomologia. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Entomologia. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Entomologia. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Entomologia. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Centro de Geoprocessamento e Estatística. Recife, PE, Brasil.LSHTM. Department of Disease Control. London, United Kingdom.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia. Recife, PE, Brasil / Universidade de Pernambuco. Faculdade de Ciências Médicas. Instituto Biológico de Medicina. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Parasitologia. Recife, PE, Brasil.LSHTM. Department of Disease Control. London, United Kingdom.London School of Hygiene & Tropical Medicine (LSHTM). Department of Infectious Disease Epidemiology. London, United Kingdom.Introduction: Molecular xenomonitoring (MX)—pathogen detection in the mosquito rather than human— is a promising tool for lymphatic filariasis (LF) surveillance. In the Recife Metropolitan Region (RMR), the last LF focus in Brazil, Culex quinquefasciatus mosquitoes have been implicated in transmitting Wuchereria bancrofti parasites. This paper presents findings on the ideal mosquito collection method, mosquito dispersion, W. bancrofti infection in mosquitoes and W. bancrofti antigen in humans to aid MX development. Methods: Experiments occurred within two densely populated urban areas of Olinda, RMR, in July and August 2015. U.S. Centers for Disease Control and Prevention (CDC) light traps were compared to battery-powered aspirators as collection methods, and mosquito dispersion was measured by mosquito mark release recapture (MMRR). Female Cx. quinquefasciatus were tested by PCR for W. bancrofti infection, and study area residents were screened by rapid tests for W. bancrofti antigen. Results: Aspirators caught 2.6 times more total Cx. quinquefasciatus, including 38 times more bloodfed and 5 times more gravid stages, than CDC light traps. They also collected 123 times more Aedes aegypti. Of the 9,644 marked mosquitoes released, only ten (0.01%) were recaptured, nine of which were < 50m (34.8m median, 85.4m maximum) from the release point. Of 9,169 unmarked mosquitoes captured in the MMR, 38.3% were unfed, 48.8% blood-fed, 5.5% semi-gravid, and 7.3% gravid. PCR on 182 pools (1,556 mosquitoes) found no evidence of W. bancrofti infection in Cx. quinquefasciatus. Rapid tests on 110 of 111 eligible residents were all negative for W. bancrofti antigen. Conclusions: Aspirators were more effective than CDC light traps at capturing Ae. aegypti and all but unfed stages of Cx. quinquefasciatus. Female Cx. quinquefasciatus traveled short (< 86m) distances in this urban area. Lack of evidence for W. bancrofti infection in mosquitoes and antigen in humans in these fine-scale studies does not indicate that LF transmission has ceased in the RMR. A MX surveillance system should consider vector-specific collection methods, mosquito dispersion, and spatial scale but also local context, environmental factors such as sanitation, and host factors such as infection prevalence and treatment history.AdultAedes/growth & developmentAedes/parasitologyAgedAnimalsAntigens, Protozoan/bloodBrazil/epidemiologyCross-Over StudiesCulex/growth & developmentDisease Transmission, InfectiousElephantiasis, Filarial/epidemiologyCulex/parasitologyEntomology/methodsEpidemiological MonitoringFemaleHumansImmunoassayMaleMiddle AgedPolymerase Chain ReactionPrevalenceUrban PopulationWuchereria bancrofti/geneticsAdultoAedes / crescimento e desenvolvimentoAedes / parasitologiaEnvelhecidoIdoso, 80 anos ou maisAnimaisAntígenos, Protozoários / sangueBrasil / epidemiologiaEstudos Cross-OverCulex / crescimento e desenvolvimentoCulex / parasitologiaTransmissão de Doenças InfecciosasFilariose Linfática / epidemiologiaEntomologia / métodosMonitorização EpidemiológicaFêmeaHumanosImunoensaioMasculinoMeia idadeReação em Cadeia da PolimerasePrevalênciaPopulação urbanaWuchereria bancrofti / genéticaWuchereria bancrofti / isolamento e purificaçãoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83094https://www.arca.fiocruz.br/bitstream/icict/32360/1/license.txtee3692f7b0b97d5638099ab94397d05fMD51ORIGINALDevelopment of an urban molecular xenomonitoring system for lymphatic filariasis in the Recife Metropolitan Region, Brazil.pdfDevelopment of an urban molecular xenomonitoring system for lymphatic filariasis in the Recife Metropolitan Region, 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| dc.title.pt_BR.fl_str_mv |
Development of an urban molecular xenomonitoring system for lymphatic filariasis in the Recife Metropolitan Region, Brazil |
| title |
Development of an urban molecular xenomonitoring system for lymphatic filariasis in the Recife Metropolitan Region, Brazil |
| spellingShingle |
Development of an urban molecular xenomonitoring system for lymphatic filariasis in the Recife Metropolitan Region, Brazil Ramesh, Anita Adult Aedes/growth & development Aedes/parasitology Aged Animals Antigens, Protozoan/blood Brazil/epidemiology Cross-Over Studies Culex/growth & development Disease Transmission, Infectious Elephantiasis, Filarial/epidemiology Culex/parasitology Entomology/methods Epidemiological Monitoring Female Humans Immunoassay Male Middle Aged Polymerase Chain Reaction Prevalence Urban Population Wuchereria bancrofti/genetics Adulto Aedes / crescimento e desenvolvimento Aedes / parasitologia Envelhecido Idoso, 80 anos ou mais Animais Antígenos, Protozoários / sangue Brasil / epidemiologia Estudos Cross-Over Culex / crescimento e desenvolvimento Culex / parasitologia Transmissão de Doenças Infecciosas Filariose Linfática / epidemiologia Entomologia / métodos Monitorização Epidemiológica Fêmea Humanos Imunoensaio Masculino Meia idade Reação em Cadeia da Polimerase Prevalência População urbana Wuchereria bancrofti / genética Wuchereria bancrofti / isolamento e purificação |
| title_short |
Development of an urban molecular xenomonitoring system for lymphatic filariasis in the Recife Metropolitan Region, Brazil |
| title_full |
Development of an urban molecular xenomonitoring system for lymphatic filariasis in the Recife Metropolitan Region, Brazil |
| title_fullStr |
Development of an urban molecular xenomonitoring system for lymphatic filariasis in the Recife Metropolitan Region, Brazil |
| title_full_unstemmed |
Development of an urban molecular xenomonitoring system for lymphatic filariasis in the Recife Metropolitan Region, Brazil |
| title_sort |
Development of an urban molecular xenomonitoring system for lymphatic filariasis in the Recife Metropolitan Region, Brazil |
| author |
Ramesh, Anita |
| author_facet |
Ramesh, Anita Cameron, Mary Spence, Kirstin Hoek Spaans, Remy Melo-Santos, Maria A. V. Paiva, Marcelo H. S. Guedes, Duschinka R. D. Barbosa, Rosangela M. R. Oliveira, Claudia M. F. Sá, André Jeffries, Claire L. Castanha, Priscila M. S. Oliveira, Paula A. S. Walker, Thomas Alexander, Neal Braga, Cynthia |
| author_role |
author |
| author2 |
Cameron, Mary Spence, Kirstin Hoek Spaans, Remy Melo-Santos, Maria A. V. Paiva, Marcelo H. S. Guedes, Duschinka R. D. Barbosa, Rosangela M. R. Oliveira, Claudia M. F. Sá, André Jeffries, Claire L. Castanha, Priscila M. S. Oliveira, Paula A. S. Walker, Thomas Alexander, Neal Braga, Cynthia |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Ramesh, Anita Cameron, Mary Spence, Kirstin Hoek Spaans, Remy Melo-Santos, Maria A. V. Paiva, Marcelo H. S. Guedes, Duschinka R. D. Barbosa, Rosangela M. R. Oliveira, Claudia M. F. Sá, André Jeffries, Claire L. Castanha, Priscila M. S. Oliveira, Paula A. S. Walker, Thomas Alexander, Neal Braga, Cynthia |
| dc.subject.en.en.fl_str_mv |
Adult Aedes/growth & development Aedes/parasitology Aged Animals Antigens, Protozoan/blood Brazil/epidemiology Cross-Over Studies Culex/growth & development Disease Transmission, Infectious Elephantiasis, Filarial/epidemiology Culex/parasitology Entomology/methods Epidemiological Monitoring Female Humans Immunoassay Male Middle Aged Polymerase Chain Reaction Prevalence Urban Population Wuchereria bancrofti/genetics |
| topic |
Adult Aedes/growth & development Aedes/parasitology Aged Animals Antigens, Protozoan/blood Brazil/epidemiology Cross-Over Studies Culex/growth & development Disease Transmission, Infectious Elephantiasis, Filarial/epidemiology Culex/parasitology Entomology/methods Epidemiological Monitoring Female Humans Immunoassay Male Middle Aged Polymerase Chain Reaction Prevalence Urban Population Wuchereria bancrofti/genetics Adulto Aedes / crescimento e desenvolvimento Aedes / parasitologia Envelhecido Idoso, 80 anos ou mais Animais Antígenos, Protozoários / sangue Brasil / epidemiologia Estudos Cross-Over Culex / crescimento e desenvolvimento Culex / parasitologia Transmissão de Doenças Infecciosas Filariose Linfática / epidemiologia Entomologia / métodos Monitorização Epidemiológica Fêmea Humanos Imunoensaio Masculino Meia idade Reação em Cadeia da Polimerase Prevalência População urbana Wuchereria bancrofti / genética Wuchereria bancrofti / isolamento e purificação |
| dc.subject.decs.pt_BR.fl_str_mv |
Adulto Aedes / crescimento e desenvolvimento Aedes / parasitologia Envelhecido Idoso, 80 anos ou mais Animais Antígenos, Protozoários / sangue Brasil / epidemiologia Estudos Cross-Over Culex / crescimento e desenvolvimento Culex / parasitologia Transmissão de Doenças Infecciosas Filariose Linfática / epidemiologia Entomologia / métodos Monitorização Epidemiológica Fêmea Humanos Imunoensaio Masculino Meia idade Reação em Cadeia da Polimerase Prevalência População urbana Wuchereria bancrofti / genética Wuchereria bancrofti / isolamento e purificação |
| description |
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Parasitologia. Recife, PE, Brasil / London School of Hygiene & Tropical Medicine (LSHTM). Department of Infectious Disease Epidemiology. London, United Kingdom. |
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2018 |
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2018 |
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2019-04-04T13:47:11Z |
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2019-04-04T13:47:11Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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RAMESH, A. et al. Development of an Urban Molecular Xenomonitoring System for Lymphatic Filariasis in the Recife Metropolitan Region, Brazil. PLoS Neglected Tropical Diseases, v. 12, n. 10, p. 1-24, 2018. |
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https://www.arca.fiocruz.br/handle/icict/32360 |
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1935-2735 |
| dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pntd.0006816 |
| identifier_str_mv |
RAMESH, A. et al. Development of an Urban Molecular Xenomonitoring System for Lymphatic Filariasis in the Recife Metropolitan Region, Brazil. PLoS Neglected Tropical Diseases, v. 12, n. 10, p. 1-24, 2018. 1935-2735 10.1371/journal.pntd.0006816 |
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https://www.arca.fiocruz.br/handle/icict/32360 |
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MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1813008829523165184 |