Vaccination against hepatitis B with 4-double doses increases response rates and antibodies titers in HIV-infected adults
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/16866 |
Resumo: | Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil. |
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Potsch, D. V.Camacho, L. A. B.Tuboi, S.Villar, L. M.Miguel, J. C.Ginuíno, C.Silva, E. F.Mendonça, R. M. M.Moreira, R. B.Barroso, P. F.2017-01-17T14:21:49Z2017-01-17T14:21:49Z2012POTSCH, D. V. et al. Vaccination against hepatitis B with 4-double doses increases response rates and antibodies titers in HIV-infected adults. Vaccine, v.30, p.5973-5977, 2012.0264-410Xhttps://www.arca.fiocruz.br/handle/icict/1686610.1016/j.vaccine.2012.07.0281873-2518engElsevierHepatite BVacinaInfecção por HIVResposta imuneHepatitis B vaccinationHIV infectionImmune responseVaccination against hepatitis B with 4-double doses increases response rates and antibodies titers in HIV-infected adultsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Faculdade de Medicina. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Referência Nacional Para Hepatites Virais. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Referência Nacional Para Hepatites Virais. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Referência Nacional Para Hepatites Virais. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Referência Nacional Para Hepatites Virais. Rio de Janeiro, RJ. Brasil.Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil.Background: Antibody responses to standard regimens of hepatitis B (HBV) vaccination are lower in HIVinfected subjects and the best hepatitis B vaccine schedule in this population is not known. Objective: To assess the immunogenicity and to evaluate predictors of serologic response of a modified regimen of a HBV recombinant vaccine in a cohort of HIV-infected subjects. Methods: HIV-infected subjects received 4 doses (40 g) of a recombinant HBV vaccine at 0, 1, 2 and 6 months. Demographic information as well as CD4 cell count and plasma viral load were assessed at baseline. Protective and strong responses were defined as an anti-HBs titer ≥10 mIU/mL and ≥100 mIU/mL, respectively and were evaluated one month after the third and the fourth doses. Results: 163 HIV-infected individuals were evaluated 67 (40%) were male and median age was 37 years. Median CD4 cell count was 385 cells/mm3 and 113 (70%) had undetectable HIV-1 viral load. Protective antibody response was observed in 83 and 91% and a strong antibody response was observed in 62 and 80% of the subjects after 3 and 4 doses, respectively. In a multivariate logistic model undetectable HIV-1 viral load and higher CD4 cell counts were independent predictors of a strong antibody response after 4 doses. Patients with undetectable HIV viral load were almost 3 times more likely to have anti-HBs titers above 100 mIU/mL than those with detectable viral load. Conclusions: A 4-double-dose regimen of a recombinant HBV vaccine increased response rates and determined higher antibody titers which may translate in prolonged protection agains HBV. Inclusion of a fourth dose of HBV vaccine for HIV-infected subjects should be considered in the public health setting.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16866/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALjc_miguel_etal_IOC_2012.pdfjc_miguel_etal_IOC_2012.pdfapplication/pdf346787https://www.arca.fiocruz.br/bitstream/icict/16866/2/jc_miguel_etal_IOC_2012.pdf7a75068f25ae94e6e7e0bb55614fc4f4MD52TEXTjc_miguel_etal_IOC_2012.pdf.txtjc_miguel_etal_IOC_2012.pdf.txtExtracted texttext/plain26818https://www.arca.fiocruz.br/bitstream/icict/16866/3/jc_miguel_etal_IOC_2012.pdf.txt55e729bb03107de3f737c8aa69b0b59eMD53icict/168662018-08-15 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| dc.title.pt_BR.fl_str_mv |
Vaccination against hepatitis B with 4-double doses increases response rates and antibodies titers in HIV-infected adults |
| title |
Vaccination against hepatitis B with 4-double doses increases response rates and antibodies titers in HIV-infected adults |
| spellingShingle |
Vaccination against hepatitis B with 4-double doses increases response rates and antibodies titers in HIV-infected adults Potsch, D. V. Hepatite B Vacina Infecção por HIV Resposta imune Hepatitis B vaccination HIV infection Immune response |
| title_short |
Vaccination against hepatitis B with 4-double doses increases response rates and antibodies titers in HIV-infected adults |
| title_full |
Vaccination against hepatitis B with 4-double doses increases response rates and antibodies titers in HIV-infected adults |
| title_fullStr |
Vaccination against hepatitis B with 4-double doses increases response rates and antibodies titers in HIV-infected adults |
| title_full_unstemmed |
Vaccination against hepatitis B with 4-double doses increases response rates and antibodies titers in HIV-infected adults |
| title_sort |
Vaccination against hepatitis B with 4-double doses increases response rates and antibodies titers in HIV-infected adults |
| author |
Potsch, D. V. |
| author_facet |
Potsch, D. V. Camacho, L. A. B. Tuboi, S. Villar, L. M. Miguel, J. C. Ginuíno, C. Silva, E. F. Mendonça, R. M. M. Moreira, R. B. Barroso, P. F. |
| author_role |
author |
| author2 |
Camacho, L. A. B. Tuboi, S. Villar, L. M. Miguel, J. C. Ginuíno, C. Silva, E. F. Mendonça, R. M. M. Moreira, R. B. Barroso, P. F. |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Potsch, D. V. Camacho, L. A. B. Tuboi, S. Villar, L. M. Miguel, J. C. Ginuíno, C. Silva, E. F. Mendonça, R. M. M. Moreira, R. B. Barroso, P. F. |
| dc.subject.other.pt_BR.fl_str_mv |
Hepatite B Vacina Infecção por HIV Resposta imune |
| topic |
Hepatite B Vacina Infecção por HIV Resposta imune Hepatitis B vaccination HIV infection Immune response |
| dc.subject.en.pt_BR.fl_str_mv |
Hepatitis B vaccination HIV infection Immune response |
| description |
Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil. |
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2012 |
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2012 |
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2017-01-17T14:21:49Z |
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2017-01-17T14:21:49Z |
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POTSCH, D. V. et al. Vaccination against hepatitis B with 4-double doses increases response rates and antibodies titers in HIV-infected adults. Vaccine, v.30, p.5973-5977, 2012. |
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https://www.arca.fiocruz.br/handle/icict/16866 |
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0264-410X |
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10.1016/j.vaccine.2012.07.028 |
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1873-2518 |
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POTSCH, D. V. et al. Vaccination against hepatitis B with 4-double doses increases response rates and antibodies titers in HIV-infected adults. Vaccine, v.30, p.5973-5977, 2012. 0264-410X 10.1016/j.vaccine.2012.07.028 1873-2518 |
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