Social conditions and immune response in human immunodeficiency virus-seropositive pregnant women: a cross-sectional study in Brazil

Detalhes bibliográficos
Autor(a) principal: Sampaio, Aletheia Soares
Data de Publicação: 2018
Outros Autores: Vasconcelos, Ana Lúcia Ribeiro de, Morais, Clarice Neuenschwander Lins de, Diniz, George Tadeu Nunes, Figueiredo, Anna Lígia de Castro, Montenegro, Sílvia Maria Lucena
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33067
Resumo: Strategic Program to Support Research in Health (PAPES VI), National Council for Technological and Scientific Development, Oswaldo Cruz Foundation, 407.650/2012-1.
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spelling Sampaio, Aletheia SoaresVasconcelos, Ana Lúcia Ribeiro deMorais, Clarice Neuenschwander Lins deDiniz, George Tadeu NunesFigueiredo, Anna Lígia de CastroMontenegro, Sílvia Maria Lucena2019-05-14T16:07:10Z2019-05-14T16:07:10Z2018SAMPAIO, Aletheia Soares et al. Social Conditions and Immune Response in Human Immunodeficiency Virus-Seropositive Pregnant Women: A Cross-Sectional Study in Brazil. Revista da Sociedade Brasileira de Medicina Tropical, v. 51, n. 1, p. 21–29, fev. 2018.1678-9849https://www.arca.fiocruz.br/handle/icict/3306710.1590/0037-8682-0107-2017Strategic Program to Support Research in Health (PAPES VI), National Council for Technological and Scientific Development, Oswaldo Cruz Foundation, 407.650/2012-1.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Saúde Coletiva. Recife, PE, Brasil / Universidade de Pernambuco. Centro Integrado de Saúde Amaury de Medeiros. Serviço de Atendimento Especializado em HIV/AIDS. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Saúde Coletiva. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Saúde Coletiva. Recife, PE, Brasil.Universidade de Pernambuco. Centro Integrado de Saúde Amaury de Medeiros. Serviço de Atendimento Especializado em HIV/AIDS. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia e Imunopatologia Celular. Recife, PE, Brasil.The functioning of the immune system during pregnancy is altered in both human immunodeficiency virus (HIV)-infected and uninfected women. Unfavorable socioeconomic conditions have been indicative of higher morbidity and mortality and worsening of the immune system. The aim of this study was to correlate social status with levels of interleukin (IL)-10 (non-inflammatory) and interferon-gamma (IFN-γ; inflammatory) cytokines. METHODS: A cross-sectional study was conducted with three groups of women: 33 pregnant HIV-infected (G1); 40 non-pregnant, HIV-infected (G2); and 35 pregnant, HIV-uninfected. To measure the social status, a compound indicator called the social status index (SSI), was established using sociodemographic variables (i.e., education level, housing conditions, per capita income, and habitation and sanitary conditions). RESULTS: The HIV-infected women had a higher proportion of unfavorable SSI (73% and 75% of G1 and G2, respectively). There were significantly lower IL-10 levels in the G1 group with both unfavorable and favorable SSI than in the other groups. No significant difference in IFN-γ levels was observed among groups. However, the G1 group had higher IFN-γ values among both favorable and unfavorable SSI groups. CONCLUSIONS: Higher rates of unfavorable conditions, including lower education levels, IL-10 levels, and a trend for higher IFN-γ levels, were identified among HIV-infected women, pregnant and non-pregnant. These factors may interfere in health care and lead to poor outcomes during pregnancy. Therefore, we suggest that health policies could be created to specifically address these factors in this population.engSocial conditions and immune response in human immunodeficiency virus-seropositive pregnant women: a cross-sectional study in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAcquired immunodeficiency syndromePregnancyPovertyInterleukin-10AdultoBrasilEstudos TransversaisFêmeaInfecções por HIV / sangueInfecções por HIV / imunologiaHumanosInterferon gama / sangueInterferon gama / imunologiaInterleucina-10 / sangueInterleucina-10 / imunologiaGravidezComplicações na Gravidez Infecciosa / sangueComplicações na Gravidez Infecciosa / imunologiaComplicações na Gravidez Infecciosa / virologiaCondições sociaisFatores Socioeconômicosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Social conditions and immune response in human immunodeficiency virus-seropositive pregnant women: a cross-sectional study in Brazil
title Social conditions and immune response in human immunodeficiency virus-seropositive pregnant women: a cross-sectional study in Brazil
spellingShingle Social conditions and immune response in human immunodeficiency virus-seropositive pregnant women: a cross-sectional study in Brazil
Sampaio, Aletheia Soares
Acquired immunodeficiency syndrome
Pregnancy
Poverty
Interleukin-10
Adulto
Brasil
Estudos Transversais
Fêmea
Infecções por HIV / sangue
Infecções por HIV / imunologia
Humanos
Interferon gama / sangue
Interferon gama / imunologia
Interleucina-10 / sangue
Interleucina-10 / imunologia
Gravidez
Complicações na Gravidez Infecciosa / sangue
Complicações na Gravidez Infecciosa / imunologia
Complicações na Gravidez Infecciosa / virologia
Condições sociais
Fatores Socioeconômicos
title_short Social conditions and immune response in human immunodeficiency virus-seropositive pregnant women: a cross-sectional study in Brazil
title_full Social conditions and immune response in human immunodeficiency virus-seropositive pregnant women: a cross-sectional study in Brazil
title_fullStr Social conditions and immune response in human immunodeficiency virus-seropositive pregnant women: a cross-sectional study in Brazil
title_full_unstemmed Social conditions and immune response in human immunodeficiency virus-seropositive pregnant women: a cross-sectional study in Brazil
title_sort Social conditions and immune response in human immunodeficiency virus-seropositive pregnant women: a cross-sectional study in Brazil
author Sampaio, Aletheia Soares
author_facet Sampaio, Aletheia Soares
Vasconcelos, Ana Lúcia Ribeiro de
Morais, Clarice Neuenschwander Lins de
Diniz, George Tadeu Nunes
Figueiredo, Anna Lígia de Castro
Montenegro, Sílvia Maria Lucena
author_role author
author2 Vasconcelos, Ana Lúcia Ribeiro de
Morais, Clarice Neuenschwander Lins de
Diniz, George Tadeu Nunes
Figueiredo, Anna Lígia de Castro
Montenegro, Sílvia Maria Lucena
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Sampaio, Aletheia Soares
Vasconcelos, Ana Lúcia Ribeiro de
Morais, Clarice Neuenschwander Lins de
Diniz, George Tadeu Nunes
Figueiredo, Anna Lígia de Castro
Montenegro, Sílvia Maria Lucena
dc.subject.en.pt_BR.fl_str_mv Acquired immunodeficiency syndrome
Pregnancy
Poverty
Interleukin-10
topic Acquired immunodeficiency syndrome
Pregnancy
Poverty
Interleukin-10
Adulto
Brasil
Estudos Transversais
Fêmea
Infecções por HIV / sangue
Infecções por HIV / imunologia
Humanos
Interferon gama / sangue
Interferon gama / imunologia
Interleucina-10 / sangue
Interleucina-10 / imunologia
Gravidez
Complicações na Gravidez Infecciosa / sangue
Complicações na Gravidez Infecciosa / imunologia
Complicações na Gravidez Infecciosa / virologia
Condições sociais
Fatores Socioeconômicos
dc.subject.decs.pt_BR.fl_str_mv Adulto
Brasil
Estudos Transversais
Fêmea
Infecções por HIV / sangue
Infecções por HIV / imunologia
Humanos
Interferon gama / sangue
Interferon gama / imunologia
Interleucina-10 / sangue
Interleucina-10 / imunologia
Gravidez
Complicações na Gravidez Infecciosa / sangue
Complicações na Gravidez Infecciosa / imunologia
Complicações na Gravidez Infecciosa / virologia
Condições sociais
Fatores Socioeconômicos
description Strategic Program to Support Research in Health (PAPES VI), National Council for Technological and Scientific Development, Oswaldo Cruz Foundation, 407.650/2012-1.
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-05-14T16:07:10Z
dc.date.available.fl_str_mv 2019-05-14T16:07:10Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv SAMPAIO, Aletheia Soares et al. Social Conditions and Immune Response in Human Immunodeficiency Virus-Seropositive Pregnant Women: A Cross-Sectional Study in Brazil. Revista da Sociedade Brasileira de Medicina Tropical, v. 51, n. 1, p. 21–29, fev. 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33067
dc.identifier.issn.pt_BR.fl_str_mv 1678-9849
dc.identifier.doi.none.fl_str_mv 10.1590/0037-8682-0107-2017
identifier_str_mv SAMPAIO, Aletheia Soares et al. Social Conditions and Immune Response in Human Immunodeficiency Virus-Seropositive Pregnant Women: A Cross-Sectional Study in Brazil. Revista da Sociedade Brasileira de Medicina Tropical, v. 51, n. 1, p. 21–29, fev. 2018.
1678-9849
10.1590/0037-8682-0107-2017
url https://www.arca.fiocruz.br/handle/icict/33067
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