Effects of Cissampelos sympodialis Eichl. and its alkaloid, warifteine, in an experimental model of respiratory allergy to Blomia tropicalis.

Detalhes bibliográficos
Autor(a) principal: Lima, Ana Tereza Cerqueira
Data de Publicação: 2010
Outros Autores: Neves, Neuza Maria Alcântara, Pontes-de-Carvalho, Lain Carlos, Costa, Ryan dos Santos, Barbosa Filho, José Maria, Piuvezam, Márcia, Russo, Momtchilo, Barboza, Renato, Oliveira, Eduardo de Jesus, Marinho, Alexsandro, Figueiredo, Camila Alexandrina Viana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/8296
Resumo: Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil
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spelling Lima, Ana Tereza CerqueiraNeves, Neuza Maria AlcântaraPontes-de-Carvalho, Lain CarlosCosta, Ryan dos SantosBarbosa Filho, José MariaPiuvezam, MárciaRusso, MomtchiloBarboza, RenatoOliveira, Eduardo de JesusMarinho, AlexsandroFigueiredo, Camila Alexandrina Viana2014-08-29T18:43:05Z2014-08-29T18:43:05Z2010CERQUEIRA-LIMA, A. T. et al. Effects of Cissampelos sympodialis Eichl. and its alkaloid, warifteine, in an experimental model of respiratory allergy to Blomia tropicalis. Current Drug Targets, v. 11, n. 11, p. 1458-1467, 2010.1873-5592https://www.arca.fiocruz.br/handle/icict/8296engBentham Science Publishers Ltd.Effects of Cissampelos sympodialis Eichl. and its alkaloid, warifteine, in an experimental model of respiratory allergy to Blomia tropicalis.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal da Paraíba. Laboratório de Tecnologia Farmacêutica. João Pessoa, PB, BrasilUniversidade Federal da Paraíba. Laboratório de Tecnologia Farmacêutica. João Pessoa, PB, BrasilUniversidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Imunologia. São Paulo, SP, BrasilUniversidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Imunologia. São Paulo, SP, BrasilUniversidade Federal da Paraíba. Laboratório de Tecnologia Farmacêutica. João Pessoa, PB, BrasilUniversidade Federal da Paraíba. Laboratório de Tecnologia Farmacêutica. João Pessoa, PB, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilAsthma is one of the most prevalent chronic diseases worldwide. Medicinal plants are historically used in its treatment. The plant Cissampelos sympodialis, known in Northeastern Brazil as "Jarrinha" or "Milona", is used to treat some inflammatory conditions, including asthma. The objective of this study was to evaluate the potential of Cissampelos sympodialis EICHL. extract (CsE) and its isolated alkaloids, especially warifteine (Wa) on a Blomia tropicalis extract (BtE)-induced experimental model of allergy. The respiratory allergy was induced in AJ mice by the administration of BtE. Mice were orally treated with the 400 mg/kg of CsE or 8 mg/kg of total alkaloids fraction (TAF) or 4 mg/kg of Wa and the following parameters were analyzed: (a) total cell numbers in bronchoalveolar fluid (BAF); (b) differential cell numbers in BAF; (c) eosinophil peroxidase (EPO) activity in BAF; (d) IgE serum levels by passive cutaneous anaphylaxis; (e) IL-5, IL-13, IL-10, and IFN-γ levels in BAF; (f) histopathological alterations in the lung. The treatment of the animals with CsE, Wa or TAF led to a reduction in the numbers of total cells and eosinophils in BAF. The same reduction was observed in EPO levels in the BAF. The levels of IL-5 and IL-13 were also reduced in animals treated with Cissampelos sympodialis, while IL-10 levels were significantly increased in the BAF of CsE-treated animals. The treatment also decreased the density of inflammatory cells in the lung by histopathological examination demonstrating the potential of this medicinal plant as new agent for asthma treatmentAsthmaBlomia tropicalisCissampelos sympodialisNatural productsWarifteineCytokinesAlcaloides/farmacologiaAsma/quimioterapiaAsma/imunologiaCissampelos/químicaÁcaros/imunologiaAlcaloides/isolamento & purificaçãoAnimaisAsma/metabolismoLíquido da Lavagem Broncoalveolar/citologiaCitocinas/imunologiaCitocinas/metabolismoPeroxidase de Eosinófilo/metabolismoFemininoImunoglobulina E/imunologiaCamundongosCamundongos Endogâmicos AModelos TeóricosExtratos Vegetais/farmacologiaFolhas de Planta/químicaRatosRatos wistarinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALCerqueira-Lima A Effects of sympodialis....pdfCerqueira-Lima A Effects of sympodialis....pdfapplication/pdf883712https://www.arca.fiocruz.br/bitstream/icict/8296/2/Cerqueira-Lima%20A%20Effects%20of%20sympodialis....pdf094b2177a323277d0587122aaaf364b6MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8296/3/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD53TEXTCerqueira-Lima A Effects of sympodialis....pdf.txtCerqueira-Lima A Effects of sympodialis....pdf.txtExtracted texttext/plain40713https://www.arca.fiocruz.br/bitstream/icict/8296/4/Cerqueira-Lima%20A%20Effects%20of%20sympodialis....pdf.txtfd2a0a9149ce5cc82bfbd883a3a98470MD54icict/82962023-03-15 14:33:21.878oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:21Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Effects of Cissampelos sympodialis Eichl. and its alkaloid, warifteine, in an experimental model of respiratory allergy to Blomia tropicalis.
title Effects of Cissampelos sympodialis Eichl. and its alkaloid, warifteine, in an experimental model of respiratory allergy to Blomia tropicalis.
spellingShingle Effects of Cissampelos sympodialis Eichl. and its alkaloid, warifteine, in an experimental model of respiratory allergy to Blomia tropicalis.
Lima, Ana Tereza Cerqueira
Asthma
Blomia tropicalis
Cissampelos sympodialis
Natural products
Warifteine
Cytokines
Alcaloides/farmacologia
Asma/quimioterapia
Asma/imunologia
Cissampelos/química
Ácaros/imunologia
Alcaloides/isolamento & purificação
Animais
Asma/metabolismo
Líquido da Lavagem Broncoalveolar/citologia
Citocinas/imunologia
Citocinas/metabolismo
Peroxidase de Eosinófilo/metabolismo
Feminino
Imunoglobulina E/imunologia
Camundongos
Camundongos Endogâmicos A
Modelos Teóricos
Extratos Vegetais/farmacologia
Folhas de Planta/química
Ratos
Ratos wistar
title_short Effects of Cissampelos sympodialis Eichl. and its alkaloid, warifteine, in an experimental model of respiratory allergy to Blomia tropicalis.
title_full Effects of Cissampelos sympodialis Eichl. and its alkaloid, warifteine, in an experimental model of respiratory allergy to Blomia tropicalis.
title_fullStr Effects of Cissampelos sympodialis Eichl. and its alkaloid, warifteine, in an experimental model of respiratory allergy to Blomia tropicalis.
title_full_unstemmed Effects of Cissampelos sympodialis Eichl. and its alkaloid, warifteine, in an experimental model of respiratory allergy to Blomia tropicalis.
title_sort Effects of Cissampelos sympodialis Eichl. and its alkaloid, warifteine, in an experimental model of respiratory allergy to Blomia tropicalis.
author Lima, Ana Tereza Cerqueira
author_facet Lima, Ana Tereza Cerqueira
Neves, Neuza Maria Alcântara
Pontes-de-Carvalho, Lain Carlos
Costa, Ryan dos Santos
Barbosa Filho, José Maria
Piuvezam, Márcia
Russo, Momtchilo
Barboza, Renato
Oliveira, Eduardo de Jesus
Marinho, Alexsandro
Figueiredo, Camila Alexandrina Viana
author_role author
author2 Neves, Neuza Maria Alcântara
Pontes-de-Carvalho, Lain Carlos
Costa, Ryan dos Santos
Barbosa Filho, José Maria
Piuvezam, Márcia
Russo, Momtchilo
Barboza, Renato
Oliveira, Eduardo de Jesus
Marinho, Alexsandro
Figueiredo, Camila Alexandrina Viana
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lima, Ana Tereza Cerqueira
Neves, Neuza Maria Alcântara
Pontes-de-Carvalho, Lain Carlos
Costa, Ryan dos Santos
Barbosa Filho, José Maria
Piuvezam, Márcia
Russo, Momtchilo
Barboza, Renato
Oliveira, Eduardo de Jesus
Marinho, Alexsandro
Figueiredo, Camila Alexandrina Viana
dc.subject.en.pt_BR.fl_str_mv Asthma
Blomia tropicalis
Cissampelos sympodialis
Natural products
Warifteine
Cytokines
topic Asthma
Blomia tropicalis
Cissampelos sympodialis
Natural products
Warifteine
Cytokines
Alcaloides/farmacologia
Asma/quimioterapia
Asma/imunologia
Cissampelos/química
Ácaros/imunologia
Alcaloides/isolamento & purificação
Animais
Asma/metabolismo
Líquido da Lavagem Broncoalveolar/citologia
Citocinas/imunologia
Citocinas/metabolismo
Peroxidase de Eosinófilo/metabolismo
Feminino
Imunoglobulina E/imunologia
Camundongos
Camundongos Endogâmicos A
Modelos Teóricos
Extratos Vegetais/farmacologia
Folhas de Planta/química
Ratos
Ratos wistar
dc.subject.decs.pt_BR.fl_str_mv Alcaloides/farmacologia
Asma/quimioterapia
Asma/imunologia
Cissampelos/química
Ácaros/imunologia
Alcaloides/isolamento & purificação
Animais
Asma/metabolismo
Líquido da Lavagem Broncoalveolar/citologia
Citocinas/imunologia
Citocinas/metabolismo
Peroxidase de Eosinófilo/metabolismo
Feminino
Imunoglobulina E/imunologia
Camundongos
Camundongos Endogâmicos A
Modelos Teóricos
Extratos Vegetais/farmacologia
Folhas de Planta/química
Ratos
Ratos wistar
description Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2014-08-29T18:43:05Z
dc.date.available.fl_str_mv 2014-08-29T18:43:05Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CERQUEIRA-LIMA, A. T. et al. Effects of Cissampelos sympodialis Eichl. and its alkaloid, warifteine, in an experimental model of respiratory allergy to Blomia tropicalis. Current Drug Targets, v. 11, n. 11, p. 1458-1467, 2010.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/8296
dc.identifier.issn.none.fl_str_mv 1873-5592
identifier_str_mv CERQUEIRA-LIMA, A. T. et al. Effects of Cissampelos sympodialis Eichl. and its alkaloid, warifteine, in an experimental model of respiratory allergy to Blomia tropicalis. Current Drug Targets, v. 11, n. 11, p. 1458-1467, 2010.
1873-5592
url https://www.arca.fiocruz.br/handle/icict/8296
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Bentham Science Publishers Ltd.
publisher.none.fl_str_mv Bentham Science Publishers Ltd.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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