Effects of Cissampelos sympodialis Eichl. and its alkaloid, warifteine, in an experimental model of respiratory Allergy to Blomia tropicalis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/12149 |
Resumo: | Texto completo: acesso restrito. p.1458-1467 |
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Lima, Ana Tereza CerqueiraNeves, Neuza Maria AlcântaraCarvalho, Lain Carlos Pontes deCosta, Ryan dos SantosBarbosa Filho, José MariaPiuvezam, MárciaRusso, MomtchiloBarboza, RenatoOliveira, Eduardo de JesusMarinho, AlexsandroFigueiredo, Camila AlexandrinaLima, Ana Tereza CerqueiraNeves, Neuza Maria AlcântaraCarvalho, Lain Carlos Pontes deCosta, Ryan dos SantosBarbosa Filho, José MariaPiuvezam, MárciaRusso, MomtchiloBarboza, RenatoOliveira, Eduardo de JesusMarinho, AlexsandroFigueiredo, Camila Alexandrina2013-07-09T13:16:23Z20101389-4501http://www.repositorio.ufba.br/ri/handle/ri/12149v. 11, n. 11Texto completo: acesso restrito. p.1458-1467Asthma is one of the most prevalent chronic diseases worldwide. Medicinal plants are historically used in its treatment. The plant Cissampelos sympodialis, known in Northeastern Brazil as “Jarrinha”or “Milona”, is used to treat some inflammatory conditions, including asthma. The objective of this study was to evaluate the potential of Cissampelos sympodialis EICHL. extract (CsE) and its isolated alkaloids, especially warifteine (Wa) on a Blomia tropicalis extract (BtE)-induced experimental model of allergy. The respiratory allergy was induced in AJ mice by the administration of BtE. Mice were orally treated with the 400 mg/kg of CsE or 8 mg/kg of total alkaloids fraction (TAF) or 4 mg/kg of Wa and the following parameters were analyzed: (a) total cell numbers in bronchoalveolar fluid (BAF); (b) differential cell numbers in BAF; (c) eosinophil peroxidase (EPO) activity in BAF; (d) IgE serum levels by passive cutaneous anaphylaxis; (e) IL-5, IL-13, IL-10, and IFN-γ levels in BAF; (f) histopathological alterations in the lung. The treatment of the animals with CsE, Wa or TAF led to a reduction in the numbers of total cells and eosinophils in BAF. The same reduction was observed in EPO levels in the BAF. The levels of IL-5 and IL-13 were also reduced in animals treated with Cissampelos sympodialis, while IL-10 levels were significantly increased in the BAF of CsE-treated animals. The treatment also decreased the density of inflammatory cells in the lung by histopathological examinations demonstrating the potential of this medicinal plant as new agent for asthma treatment.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-06-19T13:40:02Z No. of bitstreams: 1 Ana Lima.pdf: 889380 bytes, checksum: b230ab8f4212f638ea6cb6face2e46db (MD5)Approved for entry into archive by Flávia Ferreira(flaviaccf@yahoo.com.br) on 2013-07-09T13:16:23Z (GMT) No. of bitstreams: 1 Ana Lima.pdf: 889380 bytes, checksum: b230ab8f4212f638ea6cb6face2e46db (MD5)Made available in DSpace on 2013-07-09T13:16:23Z (GMT). No. of bitstreams: 1 Ana Lima.pdf: 889380 bytes, checksum: b230ab8f4212f638ea6cb6face2e46db (MD5) Previous issue date: 2010http://dx.doi.org/10.2174/1389450111009011458reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAAsthmaBlomia tropicalisCissampelos sympodialisNatural productsWarifteineCytokinesEffects of Cissampelos sympodialis Eichl. and its alkaloid, warifteine, in an experimental model of respiratory Allergy to Blomia tropicalisCurrent Drug Targetsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINALAna Lima.pdfAna Lima.pdfapplication/pdf889380https://repositorio.ufba.br/bitstream/ri/12149/1/Ana%20Lima.pdfb230ab8f4212f638ea6cb6face2e46dbMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/12149/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTAna Lima.pdf.txtAna Lima.pdf.txtExtracted texttext/plain41244https://repositorio.ufba.br/bitstream/ri/12149/3/Ana%20Lima.pdf.txtcc02eea28d097e91659881a4f21b0e9eMD53ri/121492022-08-08 13:18:28.893oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:18:28Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Effects of Cissampelos sympodialis Eichl. and its alkaloid, warifteine, in an experimental model of respiratory Allergy to Blomia tropicalis |
| dc.title.alternative.pt_BR.fl_str_mv |
Current Drug Targets |
| title |
Effects of Cissampelos sympodialis Eichl. and its alkaloid, warifteine, in an experimental model of respiratory Allergy to Blomia tropicalis |
| spellingShingle |
Effects of Cissampelos sympodialis Eichl. and its alkaloid, warifteine, in an experimental model of respiratory Allergy to Blomia tropicalis Lima, Ana Tereza Cerqueira Asthma Blomia tropicalis Cissampelos sympodialis Natural products Warifteine Cytokines |
| title_short |
Effects of Cissampelos sympodialis Eichl. and its alkaloid, warifteine, in an experimental model of respiratory Allergy to Blomia tropicalis |
| title_full |
Effects of Cissampelos sympodialis Eichl. and its alkaloid, warifteine, in an experimental model of respiratory Allergy to Blomia tropicalis |
| title_fullStr |
Effects of Cissampelos sympodialis Eichl. and its alkaloid, warifteine, in an experimental model of respiratory Allergy to Blomia tropicalis |
| title_full_unstemmed |
Effects of Cissampelos sympodialis Eichl. and its alkaloid, warifteine, in an experimental model of respiratory Allergy to Blomia tropicalis |
| title_sort |
Effects of Cissampelos sympodialis Eichl. and its alkaloid, warifteine, in an experimental model of respiratory Allergy to Blomia tropicalis |
| author |
Lima, Ana Tereza Cerqueira |
| author_facet |
Lima, Ana Tereza Cerqueira Neves, Neuza Maria Alcântara Carvalho, Lain Carlos Pontes de Costa, Ryan dos Santos Barbosa Filho, José Maria Piuvezam, Márcia Russo, Momtchilo Barboza, Renato Oliveira, Eduardo de Jesus Marinho, Alexsandro Figueiredo, Camila Alexandrina |
| author_role |
author |
| author2 |
Neves, Neuza Maria Alcântara Carvalho, Lain Carlos Pontes de Costa, Ryan dos Santos Barbosa Filho, José Maria Piuvezam, Márcia Russo, Momtchilo Barboza, Renato Oliveira, Eduardo de Jesus Marinho, Alexsandro Figueiredo, Camila Alexandrina |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Lima, Ana Tereza Cerqueira Neves, Neuza Maria Alcântara Carvalho, Lain Carlos Pontes de Costa, Ryan dos Santos Barbosa Filho, José Maria Piuvezam, Márcia Russo, Momtchilo Barboza, Renato Oliveira, Eduardo de Jesus Marinho, Alexsandro Figueiredo, Camila Alexandrina Lima, Ana Tereza Cerqueira Neves, Neuza Maria Alcântara Carvalho, Lain Carlos Pontes de Costa, Ryan dos Santos Barbosa Filho, José Maria Piuvezam, Márcia Russo, Momtchilo Barboza, Renato Oliveira, Eduardo de Jesus Marinho, Alexsandro Figueiredo, Camila Alexandrina |
| dc.subject.por.fl_str_mv |
Asthma Blomia tropicalis Cissampelos sympodialis Natural products Warifteine Cytokines |
| topic |
Asthma Blomia tropicalis Cissampelos sympodialis Natural products Warifteine Cytokines |
| description |
Texto completo: acesso restrito. p.1458-1467 |
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2010 |
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2010 |
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2013-07-09T13:16:23Z |
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1389-4501 |
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v. 11, n. 11 |
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1389-4501 v. 11, n. 11 |
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