Geographic and socioeconomic factors associated with leprosy treatment default: an analysis from the 100 Million Brazilian Cohort

Detalhes bibliográficos
Autor(a) principal: Andrade, Kaio Vinicius Freitas de
Data de Publicação: 2019
Outros Autores: Nery, Joilda Silva, Pescarini, Júlia Moreira, Ramond, Anna, Santos, Carlos Antônio de Souza Teles, Ichihara, Maria Yury Travassos, Penna, Maria Lucia Fernandes, Brickley, Elizabeth B., Rodrigues, Laura Cunha, Smeeth, Liam, Barreto, Mauricio Lima, Pereira, Susan Martins, Penna, Gerson Oliveira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/36841
Resumo: Medical Research Council (MRC) (MR/N017250/1), CONFAP/ESRC/MRC/BBSRC/CNPq/FAPDF 2015 – Neglected Tropical Diseases (Process number FAP-DF 193.000.008/2016) to Gerson Oliveira Penna, and Wellcome Trust (Grant 202912/Z/16/Z).
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spelling Andrade, Kaio Vinicius Freitas deNery, Joilda SilvaPescarini, Júlia MoreiraRamond, AnnaSantos, Carlos Antônio de Souza TelesIchihara, Maria Yury TravassosPenna, Maria Lucia FernandesBrickley, Elizabeth B.Rodrigues, Laura CunhaSmeeth, LiamBarreto, Mauricio LimaPereira, Susan MartinsPenna, Gerson Oliveira2019-11-04T14:28:51Z2019-11-04T14:28:51Z2019ANDRADE, Kaio Vinicius Freitas de et al. Geographic and socioeconomic factors associated with leprosy treatment default: an analysis from the 100 Million Brazilian Cohort. Plos Neglected Tropical Diseases, p. 1-18, Sept. 2019.1935-2727https://www.arca.fiocruz.br/handle/icict/3684110.1371/journal.pntd.0007714Medical Research Council (MRC) (MR/N017250/1), CONFAP/ESRC/MRC/BBSRC/CNPq/FAPDF 2015 – Neglected Tropical Diseases (Process number FAP-DF 193.000.008/2016) to Gerson Oliveira Penna, and Wellcome Trust (Grant 202912/Z/16/Z).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil / Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brazil / State University of Feira de Santana. Department of Health. Feira de Santana, BA, Brazil.Federal University of Bahia. Institute of Collective Health. Salvador, BA, BrazilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil / Universidade Federal da Bahia, Instituto de Matemática. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilLondon School of Hygiene & Tropical Medicine. Department of Infectious Disease Epidemiology. London, United Kingdom.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil / Federal University of Bahia. Institute of Collective Health. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.Federal University Fluminense. Department of Epidemiology and Biostatistics. Rio de Janeiro, RJ, Brazil.London School of Hygiene & Tropical Medicine. Department of Infectious Disease Epidemiology. London, United Kingdom.London School of Hygiene & Tropical Medicine. Department of Infectious Disease Epidemiology. London, United Kingdom.London School of Hygiene & Tropical Medicine. Department of Non-communicable Disease Epidemiology. London, United Kingdom.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil / Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brazil.Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Fiocruz Brasília. Escola de Governo. Brasília, DF, Brasil / Universidade de Brasília. Centro de Medicina Tropical. Brasília, DF, Brasil.Although leprosy is largely curable with multidrug therapy, incomplete treatment limits therapeutic effectiveness and is an important obstacle to disease control. To inform efforts to improve treatment completion rates, we aimed to identify the geographic and socioeconomic factors associated with leprosy treatment default in Brazil. Methodology/Principal findings Using individual participant data collected in the Brazilian national registries for social programs and notifiable diseases and linked as part of the 100 Million Brazilian Cohort, we evaluated the odds of treatment default among 20,063 leprosy cases diagnosed and followed up between 2007 and 2014. We investigated geographic and socioeconomic risk factors using a multivariate hierarchical analysis and carried out additional stratified analyses by leprosy subtype and geographic region. Over the duration of follow-up, 1,011 (5.0%) leprosy cases were observed to default from treatment. Treatment default was markedly increased among leprosy cases residing in the North (OR = 1.57; 95%CI 1.25–1.97) and Northeast (OR = 1.44; 95%CI 1.17–1.78) regions of Brazil.engPublic Library of ScienceFatores socioeconomicosHanseniaseTratamentoAnálise de CoortesSocioeconomic FactorsLeprosyTreatmentCohort StudiesGeographic and socioeconomic factors associated with leprosy treatment default: an analysis from the 100 Million Brazilian Cohortinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/36841/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALKaio. V.F A. Geographic.pdfKaio. V.F A. 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dc.title.en.fl_str_mv Geographic and socioeconomic factors associated with leprosy treatment default: an analysis from the 100 Million Brazilian Cohort
title Geographic and socioeconomic factors associated with leprosy treatment default: an analysis from the 100 Million Brazilian Cohort
spellingShingle Geographic and socioeconomic factors associated with leprosy treatment default: an analysis from the 100 Million Brazilian Cohort
Andrade, Kaio Vinicius Freitas de
Fatores socioeconomicos
Hanseniase
Tratamento
Análise de Coortes
Socioeconomic Factors
Leprosy
Treatment
Cohort Studies
title_short Geographic and socioeconomic factors associated with leprosy treatment default: an analysis from the 100 Million Brazilian Cohort
title_full Geographic and socioeconomic factors associated with leprosy treatment default: an analysis from the 100 Million Brazilian Cohort
title_fullStr Geographic and socioeconomic factors associated with leprosy treatment default: an analysis from the 100 Million Brazilian Cohort
title_full_unstemmed Geographic and socioeconomic factors associated with leprosy treatment default: an analysis from the 100 Million Brazilian Cohort
title_sort Geographic and socioeconomic factors associated with leprosy treatment default: an analysis from the 100 Million Brazilian Cohort
author Andrade, Kaio Vinicius Freitas de
author_facet Andrade, Kaio Vinicius Freitas de
Nery, Joilda Silva
Pescarini, Júlia Moreira
Ramond, Anna
Santos, Carlos Antônio de Souza Teles
Ichihara, Maria Yury Travassos
Penna, Maria Lucia Fernandes
Brickley, Elizabeth B.
Rodrigues, Laura Cunha
Smeeth, Liam
Barreto, Mauricio Lima
Pereira, Susan Martins
Penna, Gerson Oliveira
author_role author
author2 Nery, Joilda Silva
Pescarini, Júlia Moreira
Ramond, Anna
Santos, Carlos Antônio de Souza Teles
Ichihara, Maria Yury Travassos
Penna, Maria Lucia Fernandes
Brickley, Elizabeth B.
Rodrigues, Laura Cunha
Smeeth, Liam
Barreto, Mauricio Lima
Pereira, Susan Martins
Penna, Gerson Oliveira
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Andrade, Kaio Vinicius Freitas de
Nery, Joilda Silva
Pescarini, Júlia Moreira
Ramond, Anna
Santos, Carlos Antônio de Souza Teles
Ichihara, Maria Yury Travassos
Penna, Maria Lucia Fernandes
Brickley, Elizabeth B.
Rodrigues, Laura Cunha
Smeeth, Liam
Barreto, Mauricio Lima
Pereira, Susan Martins
Penna, Gerson Oliveira
dc.subject.other.pt_BR.fl_str_mv Fatores socioeconomicos
Hanseniase
Tratamento
Análise de Coortes
topic Fatores socioeconomicos
Hanseniase
Tratamento
Análise de Coortes
Socioeconomic Factors
Leprosy
Treatment
Cohort Studies
dc.subject.en.en.fl_str_mv Socioeconomic Factors
Leprosy
Treatment
Cohort Studies
description Medical Research Council (MRC) (MR/N017250/1), CONFAP/ESRC/MRC/BBSRC/CNPq/FAPDF 2015 – Neglected Tropical Diseases (Process number FAP-DF 193.000.008/2016) to Gerson Oliveira Penna, and Wellcome Trust (Grant 202912/Z/16/Z).
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-11-04T14:28:51Z
dc.date.available.fl_str_mv 2019-11-04T14:28:51Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ANDRADE, Kaio Vinicius Freitas de et al. Geographic and socioeconomic factors associated with leprosy treatment default: an analysis from the 100 Million Brazilian Cohort. Plos Neglected Tropical Diseases, p. 1-18, Sept. 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/36841
dc.identifier.issn.pt_BR.fl_str_mv 1935-2727
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0007714
identifier_str_mv ANDRADE, Kaio Vinicius Freitas de et al. Geographic and socioeconomic factors associated with leprosy treatment default: an analysis from the 100 Million Brazilian Cohort. Plos Neglected Tropical Diseases, p. 1-18, Sept. 2019.
1935-2727
10.1371/journal.pntd.0007714
url https://www.arca.fiocruz.br/handle/icict/36841
dc.language.iso.fl_str_mv eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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