The Association of the Fat Mass and Obesity-Associated Gene (FTO) rs9939609 Polymorphism and the Severe Obesity in a Brazilian Population
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/42048 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil. |
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Fonseca, Ana Carolina Proença daAbreu, Gabriella de MedeirosZembrzuski, Veronica MarquesCampos Junior, MarioCarneiro, João Regis IvarNogueira Neto, José FirminoCabello, Giselda Maria KalilCabello, Pedro Hernán2020-07-02T19:12:11Z2020-07-02T19:12:11Z2019FONSECA, Ana Carolina Proença da et al. The association of the fat mass and obesity-associated gene (FTO) rs9939609 polymorphism and the severe obesity in a Brazilian population. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, v. 12, p. 667-684, 2019.1178-7007https://www.arca.fiocruz.br/handle/icict/4204810.2147/DMSO.S199542. eCollection 2019engDove Medical PressCaminho leptina-melanocortinaObesidadePolimorfismosHipotálamoLeptin-melanocortin pathwayFTOObesityPolymorphismsHypothalamusThe Association of the Fat Mass and Obesity-Associated Gene (FTO) rs9939609 Polymorphism and the Severe Obesity in a Brazilian Populationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Departamento e Laboratório de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil / Universidade Grande Rio. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.Obesity occurs due to the interaction between the genetic background and environmental factors, including an increased food intake and a sedentary lifestyle. Nowadays, it is clear that there is a specific circuit, called leptin-melanocortin pathway, which stimulates and suppresses food intake and energy expenditure. Therefore, the aim of this study was to evaluate the influence of genetic variants related to appetite regulation and energy expenditure on severe obesity susceptibility and metabolic phenotypes in a Brazilian cohort.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/42048/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAnaCArolinaFonseca_PedroCabello_etal_IOC_2019.pdfAnaCArolinaFonseca_PedroCabello_etal_IOC_2019.pdfapplication/pdf364598https://www.arca.fiocruz.br/bitstream/icict/42048/2/AnaCArolinaFonseca_PedroCabello_etal_IOC_2019.pdfc32983100749e4ad47728eada8aa8248MD52TEXTAnaCArolinaFonseca_PedroCabello_etal_IOC_2019.pdf.txtAnaCArolinaFonseca_PedroCabello_etal_IOC_2019.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
The Association of the Fat Mass and Obesity-Associated Gene (FTO) rs9939609 Polymorphism and the Severe Obesity in a Brazilian Population |
| title |
The Association of the Fat Mass and Obesity-Associated Gene (FTO) rs9939609 Polymorphism and the Severe Obesity in a Brazilian Population |
| spellingShingle |
The Association of the Fat Mass and Obesity-Associated Gene (FTO) rs9939609 Polymorphism and the Severe Obesity in a Brazilian Population Fonseca, Ana Carolina Proença da Caminho leptina-melanocortina Obesidade Polimorfismos Hipotálamo Leptin-melanocortin pathway FTO Obesity Polymorphisms Hypothalamus |
| title_short |
The Association of the Fat Mass and Obesity-Associated Gene (FTO) rs9939609 Polymorphism and the Severe Obesity in a Brazilian Population |
| title_full |
The Association of the Fat Mass and Obesity-Associated Gene (FTO) rs9939609 Polymorphism and the Severe Obesity in a Brazilian Population |
| title_fullStr |
The Association of the Fat Mass and Obesity-Associated Gene (FTO) rs9939609 Polymorphism and the Severe Obesity in a Brazilian Population |
| title_full_unstemmed |
The Association of the Fat Mass and Obesity-Associated Gene (FTO) rs9939609 Polymorphism and the Severe Obesity in a Brazilian Population |
| title_sort |
The Association of the Fat Mass and Obesity-Associated Gene (FTO) rs9939609 Polymorphism and the Severe Obesity in a Brazilian Population |
| author |
Fonseca, Ana Carolina Proença da |
| author_facet |
Fonseca, Ana Carolina Proença da Abreu, Gabriella de Medeiros Zembrzuski, Veronica Marques Campos Junior, Mario Carneiro, João Regis Ivar Nogueira Neto, José Firmino Cabello, Giselda Maria Kalil Cabello, Pedro Hernán |
| author_role |
author |
| author2 |
Abreu, Gabriella de Medeiros Zembrzuski, Veronica Marques Campos Junior, Mario Carneiro, João Regis Ivar Nogueira Neto, José Firmino Cabello, Giselda Maria Kalil Cabello, Pedro Hernán |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Fonseca, Ana Carolina Proença da Abreu, Gabriella de Medeiros Zembrzuski, Veronica Marques Campos Junior, Mario Carneiro, João Regis Ivar Nogueira Neto, José Firmino Cabello, Giselda Maria Kalil Cabello, Pedro Hernán |
| dc.subject.other.pt_BR.fl_str_mv |
Caminho leptina-melanocortina Obesidade Polimorfismos Hipotálamo |
| topic |
Caminho leptina-melanocortina Obesidade Polimorfismos Hipotálamo Leptin-melanocortin pathway FTO Obesity Polymorphisms Hypothalamus |
| dc.subject.en.pt_BR.fl_str_mv |
Leptin-melanocortin pathway FTO Obesity Polymorphisms Hypothalamus |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil. |
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2019 |
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2019 |
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2020-07-02T19:12:11Z |
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2020-07-02T19:12:11Z |
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info:eu-repo/semantics/article |
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FONSECA, Ana Carolina Proença da et al. The association of the fat mass and obesity-associated gene (FTO) rs9939609 polymorphism and the severe obesity in a Brazilian population. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, v. 12, p. 667-684, 2019. |
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https://www.arca.fiocruz.br/handle/icict/42048 |
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1178-7007 |
| dc.identifier.eissn.none.fl_str_mv |
10.2147/DMSO.S199542. eCollection 2019 |
| identifier_str_mv |
FONSECA, Ana Carolina Proença da et al. The association of the fat mass and obesity-associated gene (FTO) rs9939609 polymorphism and the severe obesity in a Brazilian population. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, v. 12, p. 667-684, 2019. 1178-7007 10.2147/DMSO.S199542. eCollection 2019 |
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Dove Medical Press |
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Dove Medical Press |
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