Morphological features of collagen degradation in advanced hepatic schistosomiasis of man.

Detalhes bibliográficos
Autor(a) principal: Andrade, Zilton de Araújo
Data de Publicação: 1992
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/5709
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Andrade, Zilton de Araújo2012-10-22T19:17:20Z2012-10-22T19:17:20Z1992ANDRADE, Z.A. Morphological features of collagen degradation in advanced hepatic schistosomiasis of man. Memórias do Instituto Oswaldo Cruz, v. 87, Suppl 4, p. 129-38, 1992.0074-0276https://www.arca.fiocruz.br/handle/icict/5709engMorphological features of collagen degradation in advanced hepatic schistosomiasis of man.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilOptical and electron microscopical evidences of focal matrix degradation were frequently seen in liver sections taken from patients with periportal ("pipe-stem") fibrosis caused by schistosomiasis mansoni. Besides the presence of focal areas of rarefaction, fragmentation and dispersion of collagen fibers, the enlarged portal spaces also showed hyperplasia of elastic tissue and disarray of smooth muscle fibers following the destruction of portal vein branches. Ultrastructural changes represented by focal lytic and/or electron dense alterations of collagen fibrils were similar to those first seen in experimental material and designated as "chronic collagen degradation". Elastin and related microfibrils were also affected by focal condensation, fragmentation, distortion and dissolution. Schistosome eggs were scanty in the tissue sections examined. Matrix degradation represented involuting changes related to the progressive diminution of parasite aggression, which occurs spontaneously with age or after cure by chemotherapy. Changes of focal matrix degradation now being described represent the basic morphological counterpart of periportal fibrosis involution documented clinically, especially by ultrasonography, in patients with hepatosplenic schistosomiasis submitted to curative chemotherapy.Hepatic schistosomiasisCollagen degradationColágeno/metabolismoCirrose Hepática/metabolismoEsquistossomose mansoni/metabolismoAdolescenteAdultoCriançaPré-EscolarTecido Elástico/patologiaMatriz Extracelular/metabolismoMatriz Extracelular/ultraestruturaFemininoHumanosLactenteCirrose Hepática/parasitologiaCirrose Hepática/patologiaMasculinoMicroscopia EletrônicaMeia-IdadeMúsculo Liso Vascular/patologiaEsquistossomose mansoni/quimioterapiaEsquistossomose mansoni/patologiaEsquistossomicidas/uso terapêuticoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALAndrade ZA Morphological features of collagen....pdfAndrade ZA Morphological features of collagen....pdfapplication/pdf705530https://www.arca.fiocruz.br/bitstream/icict/5709/1/Andrade%20ZA%20Morphological%20features%20of%20collagen....pdfae12136deb33b24ba86e605fa3b34ae9MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5709/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXTAndrade ZA Morphological features of collagen....pdf.txtAndrade ZA Morphological features of collagen....pdf.txtExtracted texttext/plain10https://www.arca.fiocruz.br/bitstream/icict/5709/5/Andrade%20ZA%20Morphological%20features%20of%20collagen....pdf.txt2c6eb67c8897d916ae47524b1a844d3fMD55THUMBNAILAndrade ZA Morphological features of collagen....pdf.jpgAndrade ZA Morphological features of collagen....pdf.jpgGenerated Thumbnailimage/jpeg2328https://www.arca.fiocruz.br/bitstream/icict/5709/4/Andrade%20ZA%20Morphological%20features%20of%20collagen....pdf.jpgd0d3f50ed1ee54ef5c10ee82b9383940MD54icict/57092023-03-15 14:32:57.851oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:57Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Morphological features of collagen degradation in advanced hepatic schistosomiasis of man.
title Morphological features of collagen degradation in advanced hepatic schistosomiasis of man.
spellingShingle Morphological features of collagen degradation in advanced hepatic schistosomiasis of man.
Andrade, Zilton de Araújo
Hepatic schistosomiasis
Collagen degradation
Colágeno/metabolismo
Cirrose Hepática/metabolismo
Esquistossomose mansoni/metabolismo
Adolescente
Adulto
Criança
Pré-Escolar
Tecido Elástico/patologia
Matriz Extracelular/metabolismo
Matriz Extracelular/ultraestrutura
Feminino
Humanos
Lactente
Cirrose Hepática/parasitologia
Cirrose Hepática/patologia
Masculino
Microscopia Eletrônica
Meia-Idade
Músculo Liso Vascular/patologia
Esquistossomose mansoni/quimioterapia
Esquistossomose mansoni/patologia
Esquistossomicidas/uso terapêutico
title_short Morphological features of collagen degradation in advanced hepatic schistosomiasis of man.
title_full Morphological features of collagen degradation in advanced hepatic schistosomiasis of man.
title_fullStr Morphological features of collagen degradation in advanced hepatic schistosomiasis of man.
title_full_unstemmed Morphological features of collagen degradation in advanced hepatic schistosomiasis of man.
title_sort Morphological features of collagen degradation in advanced hepatic schistosomiasis of man.
author Andrade, Zilton de Araújo
author_facet Andrade, Zilton de Araújo
author_role author
dc.contributor.author.fl_str_mv Andrade, Zilton de Araújo
dc.subject.en.pt_BR.fl_str_mv Hepatic schistosomiasis
Collagen degradation
topic Hepatic schistosomiasis
Collagen degradation
Colágeno/metabolismo
Cirrose Hepática/metabolismo
Esquistossomose mansoni/metabolismo
Adolescente
Adulto
Criança
Pré-Escolar
Tecido Elástico/patologia
Matriz Extracelular/metabolismo
Matriz Extracelular/ultraestrutura
Feminino
Humanos
Lactente
Cirrose Hepática/parasitologia
Cirrose Hepática/patologia
Masculino
Microscopia Eletrônica
Meia-Idade
Músculo Liso Vascular/patologia
Esquistossomose mansoni/quimioterapia
Esquistossomose mansoni/patologia
Esquistossomicidas/uso terapêutico
dc.subject.decs.pt_BR.fl_str_mv Colágeno/metabolismo
Cirrose Hepática/metabolismo
Esquistossomose mansoni/metabolismo
Adolescente
Adulto
Criança
Pré-Escolar
Tecido Elástico/patologia
Matriz Extracelular/metabolismo
Matriz Extracelular/ultraestrutura
Feminino
Humanos
Lactente
Cirrose Hepática/parasitologia
Cirrose Hepática/patologia
Masculino
Microscopia Eletrônica
Meia-Idade
Músculo Liso Vascular/patologia
Esquistossomose mansoni/quimioterapia
Esquistossomose mansoni/patologia
Esquistossomicidas/uso terapêutico
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 1992
dc.date.issued.fl_str_mv 1992
dc.date.accessioned.fl_str_mv 2012-10-22T19:17:20Z
dc.date.available.fl_str_mv 2012-10-22T19:17:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv ANDRADE, Z.A. Morphological features of collagen degradation in advanced hepatic schistosomiasis of man. Memórias do Instituto Oswaldo Cruz, v. 87, Suppl 4, p. 129-38, 1992.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/5709
dc.identifier.issn.none.fl_str_mv 0074-0276
identifier_str_mv ANDRADE, Z.A. Morphological features of collagen degradation in advanced hepatic schistosomiasis of man. Memórias do Instituto Oswaldo Cruz, v. 87, Suppl 4, p. 129-38, 1992.
0074-0276
url https://www.arca.fiocruz.br/handle/icict/5709
dc.language.iso.fl_str_mv eng
language eng
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