Angiogenesis and schistosomiasis

Detalhes bibliográficos
Autor(a) principal: Andrade, Zilton de Araújo
Data de Publicação: 2010
Outros Autores: Santana, Thayna Souto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/1789
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Andrade, Zilton de AraújoSantana, Thayna Souto2011-03-29T14:40:56Z2011-03-29T14:40:56Z2010ANDRADE, Z. A.; SANTANA, T. S. Angiogenesis and schistosomiasis. Memórias do Instituto Oswaldo Cruz, v. 105, n. 5, p. 436-439, 2010.0074-0216https://www.arca.fiocruz.br/handle/icict/178910.1590/S0074-02762010000400013engSchistosoma mansoniAngiogeneseFibrose hepaticaPericitosAngiogenesisPericytesHepatic fibrosisRemodellingCirrose Hepática/PSNeovascularização PatológicaEsquistossomose mansoniGranuloma/PSAngiogenesis and schistosomiasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilAngiogenesis has been recognised as a precursor of fibrosis in several pathologic conditions. Its participation has been demonstrated in schistosomiasis, both during periovular granuloma formation and in the genesis of schistosomal periportal fibrosis. Paradoxically, proliferation of new blood vessels, accompanied by production of vascular-endothelial growth factor, appeared prominent during fibrosis regression months after curative treatment of schistosomiasis. Thus, angiogenesis in schistosomiasis seems to have a two-way mode of action, participating both in fibrogenesis and in fibrosis degradation. Morphological observations presented here are in keeping with the possibility that, in the first case, angiogenesis allows pericytes to come in great numbers to the site of lesions and be detached from capillary walls and transformed into myofibroblasts, which are important extra-cellular matrix forming cells. During post-curative fibrosis regression, actin-containing pericytes appeared at various foci of tissue remodelling, especially at sites of repair of vascular lesions. The molecular and cell factors involved in both situations seem to be important subjects in need of further investigations and the schistosomiasis model certainly will be of great avail in this regard.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALAngiogenesis and schistosomiasis.pdfAngiogenesis and schistosomiasis.pdfapplication/pdf1050210https://www.arca.fiocruz.br/bitstream/icict/1789/1/Angiogenesis%20and%20schistosomiasis.pdfab26c783f1ae12c1b3c4a5268732fa07MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://www.arca.fiocruz.br/bitstream/icict/1789/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTAngiogenesis and schistosomiasis.pdf.txtAngiogenesis and schistosomiasis.pdf.txtExtracted texttext/plain22634https://www.arca.fiocruz.br/bitstream/icict/1789/5/Angiogenesis%20and%20schistosomiasis.pdf.txt14385feb4f619e665280190af217cc8dMD55THUMBNAILAngiogenesis and schistosomiasis.pdf.jpgAngiogenesis and schistosomiasis.pdf.jpgGenerated Thumbnailimage/jpeg2270https://www.arca.fiocruz.br/bitstream/icict/1789/4/Angiogenesis%20and%20schistosomiasis.pdf.jpg87082cefc49ea6874acda7f5435c7634MD54icict/17892023-03-15 14:33:56.756oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:56Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Angiogenesis and schistosomiasis
title Angiogenesis and schistosomiasis
spellingShingle Angiogenesis and schistosomiasis
Andrade, Zilton de Araújo
Schistosoma mansoni
Angiogenese
Fibrose hepatica
Pericitos
Angiogenesis
Pericytes
Hepatic fibrosis
Remodelling
Cirrose Hepática/PS
Neovascularização Patológica
Esquistossomose mansoni
Granuloma/PS
title_short Angiogenesis and schistosomiasis
title_full Angiogenesis and schistosomiasis
title_fullStr Angiogenesis and schistosomiasis
title_full_unstemmed Angiogenesis and schistosomiasis
title_sort Angiogenesis and schistosomiasis
author Andrade, Zilton de Araújo
author_facet Andrade, Zilton de Araújo
Santana, Thayna Souto
author_role author
author2 Santana, Thayna Souto
author2_role author
dc.contributor.author.fl_str_mv Andrade, Zilton de Araújo
Santana, Thayna Souto
dc.subject.other.pt_BR.fl_str_mv Schistosoma mansoni
Angiogenese
Fibrose hepatica
Pericitos
topic Schistosoma mansoni
Angiogenese
Fibrose hepatica
Pericitos
Angiogenesis
Pericytes
Hepatic fibrosis
Remodelling
Cirrose Hepática/PS
Neovascularização Patológica
Esquistossomose mansoni
Granuloma/PS
dc.subject.en.pt_BR.fl_str_mv Angiogenesis
Pericytes
Hepatic fibrosis
Remodelling
dc.subject.decs.pt_BR.fl_str_mv Cirrose Hepática/PS
Neovascularização Patológica
Esquistossomose mansoni
Granuloma/PS
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2011-03-29T14:40:56Z
dc.date.available.fl_str_mv 2011-03-29T14:40:56Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ANDRADE, Z. A.; SANTANA, T. S. Angiogenesis and schistosomiasis. Memórias do Instituto Oswaldo Cruz, v. 105, n. 5, p. 436-439, 2010.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/1789
dc.identifier.issn.none.fl_str_mv 0074-0216
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02762010000400013
identifier_str_mv ANDRADE, Z. A.; SANTANA, T. S. Angiogenesis and schistosomiasis. Memórias do Instituto Oswaldo Cruz, v. 105, n. 5, p. 436-439, 2010.
0074-0216
10.1590/S0074-02762010000400013
url https://www.arca.fiocruz.br/handle/icict/1789
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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