Pathogenesis of septal fibrosis of the liver. (An experimental study with a new model.)

Detalhes bibliográficos
Autor(a) principal: Souza, Márcia Maria de
Data de Publicação: 2006
Outros Autores: Souza Junior, Miguel Tolentino de, Assis, Bárbara Cristina Alves de, Gonzalez, Ana Cristina de Oliveira, Silva, Tânia Maria Correia, Andrade, Zilton de Araújo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/15199
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil.
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spelling Souza, Márcia Maria deSouza Junior, Miguel Tolentino deAssis, Bárbara Cristina Alves deGonzalez, Ana Cristina de OliveiraSilva, Tânia Maria CorreiaAndrade, Zilton de Araújo2016-08-05T17:28:46Z2016-08-05T17:28:46Z2006SOUZA, Márcia Maria de et al. Pathogenesis of septal fibrosis of the liver. (An experimental study with a new model.). Pathology – Research and Practice, v. 202, p. 883–889, 2006.0344-0338https://www.arca.fiocruz.br/handle/icict/1519910.1016/j.prp.2006.07.004engElsevierPathogenesis of septal fibrosis of the liver. (An experimental study with a new model.)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil.Septal fibrosis is an important, frequent, and non-specific type of fibrosis associated with chronic liver diseases, but its pathogenesis is still poorly understood. An interesting model of septal fibrosis occurs in rats infected with the nematode Capillaria hepatica. This model was used to investigate the pathogenesis, site of origin, structure, and cell-types of septal fibrosis. Forty young adult Wistar rats were inoculated with 800 embryonated eggs of C. hepatica. Daily liver samples were obtained from the 20th to the 39th day after inoculation to cover the critical period when septal fibrosis usually starts. Routine histology, electron microscopy, immunohistochemistry, and indirect immunofluorescence were applied to the study of liver sections. Septal blood vessels were demonstrated by India ink perfusion of the portal vein system. Prominent angiogenesis was observed to precede collagen deposition. Besides angiogenesis and mesenchymal-cell mobilization, septal fibrosis was seen to originate from portal spaces and to course through acinar zone I in between sinusoids, inducing no alterations in them, with no evident participation of stellate hepatic cells. Septal fibrosis appeared as an adaptative type of response of the liver to chronic injury, which resulted in a new structure that is normal to other species and creates accessory vessels that drain portal blood into hepatic sinusoids.Hepatic fibrosisSeptal fibrosisCapillaria hepaticaAngiogenesisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15199/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSouza MM Pathogenesis of septal fibrosis of the liver.pdfSouza MM Pathogenesis of septal fibrosis of the liver.pdfapplication/pdf1457514https://www.arca.fiocruz.br/bitstream/icict/15199/2/Souza%20MM%20Pathogenesis%20of%20septal%20fibrosis%20of%20the%20liver.pdf0263474bd8cb07da9d5c9df4cd26831aMD52TEXTSouza MM Pathogenesis of septal fibrosis of the liver.pdf.txtSouza MM Pathogenesis of septal 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dc.title.pt_BR.fl_str_mv Pathogenesis of septal fibrosis of the liver. (An experimental study with a new model.)
title Pathogenesis of septal fibrosis of the liver. (An experimental study with a new model.)
spellingShingle Pathogenesis of septal fibrosis of the liver. (An experimental study with a new model.)
Souza, Márcia Maria de
Hepatic fibrosis
Septal fibrosis
Capillaria hepatica
Angiogenesis
title_short Pathogenesis of septal fibrosis of the liver. (An experimental study with a new model.)
title_full Pathogenesis of septal fibrosis of the liver. (An experimental study with a new model.)
title_fullStr Pathogenesis of septal fibrosis of the liver. (An experimental study with a new model.)
title_full_unstemmed Pathogenesis of septal fibrosis of the liver. (An experimental study with a new model.)
title_sort Pathogenesis of septal fibrosis of the liver. (An experimental study with a new model.)
author Souza, Márcia Maria de
author_facet Souza, Márcia Maria de
Souza Junior, Miguel Tolentino de
Assis, Bárbara Cristina Alves de
Gonzalez, Ana Cristina de Oliveira
Silva, Tânia Maria Correia
Andrade, Zilton de Araújo
author_role author
author2 Souza Junior, Miguel Tolentino de
Assis, Bárbara Cristina Alves de
Gonzalez, Ana Cristina de Oliveira
Silva, Tânia Maria Correia
Andrade, Zilton de Araújo
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Souza, Márcia Maria de
Souza Junior, Miguel Tolentino de
Assis, Bárbara Cristina Alves de
Gonzalez, Ana Cristina de Oliveira
Silva, Tânia Maria Correia
Andrade, Zilton de Araújo
dc.subject.en.pt_BR.fl_str_mv Hepatic fibrosis
Septal fibrosis
Capillaria hepatica
Angiogenesis
topic Hepatic fibrosis
Septal fibrosis
Capillaria hepatica
Angiogenesis
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil.
publishDate 2006
dc.date.issued.fl_str_mv 2006
dc.date.accessioned.fl_str_mv 2016-08-05T17:28:46Z
dc.date.available.fl_str_mv 2016-08-05T17:28:46Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv SOUZA, Márcia Maria de et al. Pathogenesis of septal fibrosis of the liver. (An experimental study with a new model.). Pathology – Research and Practice, v. 202, p. 883–889, 2006.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/15199
dc.identifier.issn.pt_BR.fl_str_mv 0344-0338
dc.identifier.doi.none.fl_str_mv 10.1016/j.prp.2006.07.004
identifier_str_mv SOUZA, Márcia Maria de et al. Pathogenesis of septal fibrosis of the liver. (An experimental study with a new model.). Pathology – Research and Practice, v. 202, p. 883–889, 2006.
0344-0338
10.1016/j.prp.2006.07.004
url https://www.arca.fiocruz.br/handle/icict/15199
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/15199/1/license.txt
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