Effect of chronic treatment with Rosiglitazone on Leydig cell steroidogenesis in rats: in vivo and ex vivo studies
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/28488 |
Resumo: | Universidade Federal de Pernambuco (UFPE), Fundação Oswaldo Cruz (FIOCRUZ), Centro de Tecnologias Estratégicas do Nordeste (CETENE) e Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). |
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Couto, Janaína A.Saraiva, Karina L. A.Barros, Cleiton D.Udrisar, Daniel P.Peixoto, Christina A.Vieira, Juliany S. B. CésarLima, Maria C.Galdino, Suely L.Pitta, Ivan R.Wanderley, Maria I.2018-08-31T12:07:18Z2018-08-31T12:07:18Z2010COUTO, J. A. et al. Effect of chronic treatment with Rosiglitazone on Leydig cell steroidogenesis in rats: in vivo and ex vivo studies. Reproductive biology and endocrinology: RB&E, v. 8, p. 13, 9 fev. 2010.1477-7827https://www.arca.fiocruz.br/handle/icict/2848810.1186/1477-7827-8-13Universidade Federal de Pernambuco (UFPE), Fundação Oswaldo Cruz (FIOCRUZ), Centro de Tecnologias Estratégicas do Nordeste (CETENE) e Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).Universidade Federal Rural de Pernambuco. Department of Morphology and Physiology. Recife, PE, Brazil.Instituto Aggeu Magalhães (FIOCRUZ). Centro de Tecnologias Estratégicas do Nordeste (CETENE). Ultrastructure Laboratory. Recife, PE, Brazil.Universidade Federal de Pernambuco. Department of Antibiotics. Recife, PE, Brazil.Universidade Federal de Pernambuco. Department of Physiology and Pharmacology. Recife, PE, Brazil.Instituto Aggeu Magalhães (FIOCRUZ). Centro de Tecnologias Estratégicas do Nordeste (CETENE). Ultrastructure Laboratory. Recife, PE, Brazil.Universidade Federal de Pernambuco. Department of Physiology and Pharmacology. Recife, PE, Brazil.Universidade Federal de Pernambuco. Department of Antibiotics. Recife, PE, Brazil.Universidade Federal de Pernambuco. Department of Antibiotics. Recife, PE, Brazil.Universidade Federal de Pernambuco. Department of Antibiotics. Recife, PE, Brazil.Universidade Federal de Pernambuco. Department of Physiology and Pharmacology. Recife, PE, Brazil.The present study was designed to examine the effect of chronic treatment with rosiglitazone - thiazolidinedione used in the treatment of type 2 diabetes mellitus for its insulin sensitizing effects - on the Leydig cell steroidogenic capacity and expression of the steroidogenic acute regulatory protein (StAR) and cholesterol side-chain cleavage enzyme (P450scc) in normal adult rats.engTestosteronaRosiglitazonaPioglitazonaCélula de LeydigPregnenolonaTestosteroneRosiglitazonePioglitazoneLeydig CellPregnenoloneCélulas de Leydig / efeitos de drogasEsteróides / biossínteseTiazolidinedionas / farmacologiaPeso Corporal / efeitos de drogasTamanho do órgão / efeitos de drogasFosfoproteínas / metabolismoAvaliação de Medicamentos Pré-ClínicosHipoglicemiantes / efeitos adversosEffect of chronic treatment with Rosiglitazone on Leydig cell steroidogenesis in rats: in vivo and ex vivo 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| dc.title.pt_BR.fl_str_mv |
Effect of chronic treatment with Rosiglitazone on Leydig cell steroidogenesis in rats: in vivo and ex vivo studies |
| title |
Effect of chronic treatment with Rosiglitazone on Leydig cell steroidogenesis in rats: in vivo and ex vivo studies |
| spellingShingle |
Effect of chronic treatment with Rosiglitazone on Leydig cell steroidogenesis in rats: in vivo and ex vivo studies Couto, Janaína A. Testosterona Rosiglitazona Pioglitazona Célula de Leydig Pregnenolona Testosterone Rosiglitazone Pioglitazone Leydig Cell Pregnenolone Células de Leydig / efeitos de drogas Esteróides / biossíntese Tiazolidinedionas / farmacologia Peso Corporal / efeitos de drogas Tamanho do órgão / efeitos de drogas Fosfoproteínas / metabolismo Avaliação de Medicamentos Pré-Clínicos Hipoglicemiantes / efeitos adversos |
| title_short |
Effect of chronic treatment with Rosiglitazone on Leydig cell steroidogenesis in rats: in vivo and ex vivo studies |
| title_full |
Effect of chronic treatment with Rosiglitazone on Leydig cell steroidogenesis in rats: in vivo and ex vivo studies |
| title_fullStr |
Effect of chronic treatment with Rosiglitazone on Leydig cell steroidogenesis in rats: in vivo and ex vivo studies |
| title_full_unstemmed |
Effect of chronic treatment with Rosiglitazone on Leydig cell steroidogenesis in rats: in vivo and ex vivo studies |
| title_sort |
Effect of chronic treatment with Rosiglitazone on Leydig cell steroidogenesis in rats: in vivo and ex vivo studies |
| author |
Couto, Janaína A. |
| author_facet |
Couto, Janaína A. Saraiva, Karina L. A. Barros, Cleiton D. Udrisar, Daniel P. Peixoto, Christina A. Vieira, Juliany S. B. César Lima, Maria C. Galdino, Suely L. Pitta, Ivan R. Wanderley, Maria I. |
| author_role |
author |
| author2 |
Saraiva, Karina L. A. Barros, Cleiton D. Udrisar, Daniel P. Peixoto, Christina A. Vieira, Juliany S. B. César Lima, Maria C. Galdino, Suely L. Pitta, Ivan R. Wanderley, Maria I. |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Couto, Janaína A. Saraiva, Karina L. A. Barros, Cleiton D. Udrisar, Daniel P. Peixoto, Christina A. Vieira, Juliany S. B. César Lima, Maria C. Galdino, Suely L. Pitta, Ivan R. Wanderley, Maria I. |
| dc.subject.other.pt_BR.fl_str_mv |
Testosterona Rosiglitazona Pioglitazona Célula de Leydig Pregnenolona |
| topic |
Testosterona Rosiglitazona Pioglitazona Célula de Leydig Pregnenolona Testosterone Rosiglitazone Pioglitazone Leydig Cell Pregnenolone Células de Leydig / efeitos de drogas Esteróides / biossíntese Tiazolidinedionas / farmacologia Peso Corporal / efeitos de drogas Tamanho do órgão / efeitos de drogas Fosfoproteínas / metabolismo Avaliação de Medicamentos Pré-Clínicos Hipoglicemiantes / efeitos adversos |
| dc.subject.en.pt_BR.fl_str_mv |
Testosterone Rosiglitazone Pioglitazone Leydig Cell Pregnenolone |
| dc.subject.decs.pt_BR.fl_str_mv |
Células de Leydig / efeitos de drogas Esteróides / biossíntese Tiazolidinedionas / farmacologia Peso Corporal / efeitos de drogas Tamanho do órgão / efeitos de drogas Fosfoproteínas / metabolismo Avaliação de Medicamentos Pré-Clínicos Hipoglicemiantes / efeitos adversos |
| description |
Universidade Federal de Pernambuco (UFPE), Fundação Oswaldo Cruz (FIOCRUZ), Centro de Tecnologias Estratégicas do Nordeste (CETENE) e Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). |
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2010 |
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2010 |
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2018-08-31T12:07:18Z |
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2018-08-31T12:07:18Z |
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COUTO, J. A. et al. Effect of chronic treatment with Rosiglitazone on Leydig cell steroidogenesis in rats: in vivo and ex vivo studies. Reproductive biology and endocrinology: RB&E, v. 8, p. 13, 9 fev. 2010. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/28488 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1477-7827 |
| dc.identifier.doi.none.fl_str_mv |
10.1186/1477-7827-8-13 |
| identifier_str_mv |
COUTO, J. A. et al. Effect of chronic treatment with Rosiglitazone on Leydig cell steroidogenesis in rats: in vivo and ex vivo studies. Reproductive biology and endocrinology: RB&E, v. 8, p. 13, 9 fev. 2010. 1477-7827 10.1186/1477-7827-8-13 |
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https://www.arca.fiocruz.br/handle/icict/28488 |
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eng |
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