Immunochemotherapy with interferon-gamma and multidrug therapy for multibacillary leprosy.

Detalhes bibliográficos
Autor(a) principal: Barral Netto, Manoel
Data de Publicação: 1999
Outros Autores: Santos, S, Santos, Isis Fernandes Magalhães, Von Sohsten, R. L, Bittencourt, Achilea Candida Lisboa, Carvalho Filho, Edgar Marcelino, Barral, Aldina Maria Prado, Waters, M
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7443
Resumo: Universidade Federal da Bahia. HUPES. Serviço de Imunologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Integrado de Microbiologia e Imunoregulação. Salvador, BA, Brasil
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spelling Barral Netto, ManoelSantos, SSantos, Isis Fernandes MagalhãesVon Sohsten, R. LBittencourt, Achilea Candida LisboaCarvalho Filho, Edgar MarcelinoBarral, Aldina Maria PradoWaters, M2014-03-25T13:50:54Z2014-03-25T13:50:54Z1999BARRAL-NETTO, M. et al. Immunochemotherapy with interferon-gamma and multidrug therapy for multibacillary leprosy. Acta Tropica, v. 72, n. 2, p. 185-201, 1999.0001-706Xhttps://www.arca.fiocruz.br/handle/icict/7443engElsevier B.VImmunochemotherapy with interferon-gamma and multidrug therapy for multibacillary leprosy.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. HUPES. Serviço de Imunologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Integrado de Microbiologia e Imunoregulação. Salvador, BA, BrasilUniversidade Federal da Bahia. HUPES. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. HUPES. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. HUPES. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. HUPES. Serviço de Anatomia Patológica. SAlvador, BA, BrasilUniversidade Federal da Bahia. HUPES. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. HUPES. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. HUPES. Serviço de Imunologia. Salvador, BA, BrasilHospital for Tropical Diseases, London, UKTreatment for multibacillary leprosy is presently performed with a multidrug therapy (MDT) scheme maintained for 2 years. Leprosy treatment however can benefit from the reduction of length. The lack of interferon-gamma (IFN-gamma) production by lepromatous leprosy (LL) patients' lymphocytes lead us to use this cytokine in the treatment of multibacillary leprosy associated with MDT in the treatment of multibacillary leprosy, and monitor several clinical and immunological parameters during the course of treatment. A total of 20 multibacillary leprosy patients were evaluated, 10 treated with MDT alone, and 10 treated with MDT + 10 daily doses of 2 x 10(6) international units (IU) of recombinant human IFN-gamma/m2 followed by 10 daily doses of 10(7) IU IFN-gamma/m2, intramuscularly, during the first 20 days of MDT. IFN-gamma was well tolerated and did not cause any increase in the rate of leprosy reactions development during treatment. Decrease of bacillary load, fall of anti-Mycobacterium leprae IgG serum antibodies, changes of histological pattern, as well as changes in lymphocyte proliferation assay in response to mitogens (PHA or PWM), M. leprae antigen or PPD was similar in both groups of patients. Among several soluble immunological markers measured before and 30 days after beginning of treatment, levels of soluble IL-2R receptor increased in patients treated with MDT plus IFN-gamma whereas decreased in patients treated with MDT alone. Soluble ICAM-1 levels decreased in the MDT group but did not change in the MDT + IFN-gamma treated patients. Soluble CD4 and soluble CD8 markers did not change significantly in either group of patients. Neopterin, a marker of macrophage activation, increased in all but one patient treated with MDT + IFN-gamma but in none treated with MDT alone, indicating that IFN-gamma was active in vivo. Our findings indicate that despite being able to promote macrophage activation in multibacillary leprosy patients a short course of systemically administered IFN-gamma is not able to change the clinical course of a long standing disease such as leprosy.Interferon gama/uso terapêuticoHansenostáticos/uso terapêuticoHanseníase/quimioterapiaAnticorpos Antibacterianos/sangueAdolescenteAdultoCriançaClofazimina/uso terapêuticoDapsona/uso terapêuticoQuimioterapia CombinadaFemininoHumanosInterferon gama/biossínteseHanseníase/imunologiaAtivação LinfocitáriaMeia-IdadeMasculinoNeopterina/análiseProteínas RecombinantesRifampina/uso terapêuticoPele/microbiologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALBarral-Netto Immunochemotherapy....pdfBarral-Netto Immunochemotherapy....pdfapplication/pdf156070https://www.arca.fiocruz.br/bitstream/icict/7443/1/Barral-Netto%20Immunochemotherapy....pdf823b4dad01937db1d16063b5ebe6f264MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7443/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTBarral-Netto Immunochemotherapy....pdf.txtBarral-Netto Immunochemotherapy....pdf.txtExtracted texttext/plain43050https://www.arca.fiocruz.br/bitstream/icict/7443/5/Barral-Netto%20Immunochemotherapy....pdf.txt6516b389142ed9b987ab1df59d8920edMD55THUMBNAILBarral-Netto Immunochemotherapy....pdf.jpgBarral-Netto Immunochemotherapy....pdf.jpgGenerated Thumbnailimage/jpeg1655https://www.arca.fiocruz.br/bitstream/icict/7443/4/Barral-Netto%20Immunochemotherapy....pdf.jpgcafe672ea457b0bcd373f5df20257281MD54icict/74432023-03-15 14:33:14.446oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:14Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Immunochemotherapy with interferon-gamma and multidrug therapy for multibacillary leprosy.
title Immunochemotherapy with interferon-gamma and multidrug therapy for multibacillary leprosy.
spellingShingle Immunochemotherapy with interferon-gamma and multidrug therapy for multibacillary leprosy.
Barral Netto, Manoel
Interferon gama/uso terapêutico
Hansenostáticos/uso terapêutico
Hanseníase/quimioterapia
Anticorpos Antibacterianos/sangue
Adolescente
Adulto
Criança
Clofazimina/uso terapêutico
Dapsona/uso terapêutico
Quimioterapia Combinada
Feminino
Humanos
Interferon gama/biossíntese
Hanseníase/imunologia
Ativação Linfocitária
Meia-Idade
Masculino
Neopterina/análise
Proteínas Recombinantes
Rifampina/uso terapêutico
Pele/microbiologia
title_short Immunochemotherapy with interferon-gamma and multidrug therapy for multibacillary leprosy.
title_full Immunochemotherapy with interferon-gamma and multidrug therapy for multibacillary leprosy.
title_fullStr Immunochemotherapy with interferon-gamma and multidrug therapy for multibacillary leprosy.
title_full_unstemmed Immunochemotherapy with interferon-gamma and multidrug therapy for multibacillary leprosy.
title_sort Immunochemotherapy with interferon-gamma and multidrug therapy for multibacillary leprosy.
author Barral Netto, Manoel
author_facet Barral Netto, Manoel
Santos, S
Santos, Isis Fernandes Magalhães
Von Sohsten, R. L
Bittencourt, Achilea Candida Lisboa
Carvalho Filho, Edgar Marcelino
Barral, Aldina Maria Prado
Waters, M
author_role author
author2 Santos, S
Santos, Isis Fernandes Magalhães
Von Sohsten, R. L
Bittencourt, Achilea Candida Lisboa
Carvalho Filho, Edgar Marcelino
Barral, Aldina Maria Prado
Waters, M
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Barral Netto, Manoel
Santos, S
Santos, Isis Fernandes Magalhães
Von Sohsten, R. L
Bittencourt, Achilea Candida Lisboa
Carvalho Filho, Edgar Marcelino
Barral, Aldina Maria Prado
Waters, M
dc.subject.decs.pt_BR.fl_str_mv Interferon gama/uso terapêutico
Hansenostáticos/uso terapêutico
Hanseníase/quimioterapia
Anticorpos Antibacterianos/sangue
Adolescente
Adulto
Criança
Clofazimina/uso terapêutico
Dapsona/uso terapêutico
Quimioterapia Combinada
Feminino
Humanos
Interferon gama/biossíntese
Hanseníase/imunologia
Ativação Linfocitária
Meia-Idade
Masculino
Neopterina/análise
Proteínas Recombinantes
Rifampina/uso terapêutico
Pele/microbiologia
topic Interferon gama/uso terapêutico
Hansenostáticos/uso terapêutico
Hanseníase/quimioterapia
Anticorpos Antibacterianos/sangue
Adolescente
Adulto
Criança
Clofazimina/uso terapêutico
Dapsona/uso terapêutico
Quimioterapia Combinada
Feminino
Humanos
Interferon gama/biossíntese
Hanseníase/imunologia
Ativação Linfocitária
Meia-Idade
Masculino
Neopterina/análise
Proteínas Recombinantes
Rifampina/uso terapêutico
Pele/microbiologia
description Universidade Federal da Bahia. HUPES. Serviço de Imunologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Integrado de Microbiologia e Imunoregulação. Salvador, BA, Brasil
publishDate 1999
dc.date.issued.fl_str_mv 1999
dc.date.accessioned.fl_str_mv 2014-03-25T13:50:54Z
dc.date.available.fl_str_mv 2014-03-25T13:50:54Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BARRAL-NETTO, M. et al. Immunochemotherapy with interferon-gamma and multidrug therapy for multibacillary leprosy. Acta Tropica, v. 72, n. 2, p. 185-201, 1999.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7443
dc.identifier.issn.none.fl_str_mv 0001-706X
identifier_str_mv BARRAL-NETTO, M. et al. Immunochemotherapy with interferon-gamma and multidrug therapy for multibacillary leprosy. Acta Tropica, v. 72, n. 2, p. 185-201, 1999.
0001-706X
url https://www.arca.fiocruz.br/handle/icict/7443
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier B.V
publisher.none.fl_str_mv Elsevier B.V
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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