Studies on the Effectiveness of Diarylheptanoids Derivatives against Leishmania amazonensis

Detalhes bibliográficos
Autor(a) principal: Araujo, Catarina A.. C.
Data de Publicação: 1999
Outros Autores: Alegrio, Leila V., Gomes, Denise C. F., LIma, Marco Edilson F., Cardoso, Leonardo Gomes, Leon, Leonor L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/44033
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.
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spelling Araujo, Catarina A.. C.Alegrio, Leila V.Gomes, Denise C. F.LIma, Marco Edilson F.Cardoso, Leonardo GomesLeon, Leonor L.2020-10-17T19:10:39Z2020-10-17T19:10:39Z1999ARAUJO, Catarina A. C. et al. Studies on the Effectiveness of Diarylheptanoids Derivatives against Leishmania amazonensis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 94, n. 6, p. 791-794, Nov./Dec, 1999.0074-0276https://www.arca.fiocruz.br/handle/icict/4403310.1590/S0074-027619990006000151678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.Leishmania amazonensiCentrolobium sclerophyllumDiarilheptanoidesLeishmania amazonensiCentrolobium sclerophyllumDiarylheptanoidsStudies on the Effectiveness of Diarylheptanoids Derivatives against Leishmania amazonensisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Universidade Federal Rural do Rio de Janeiro. Departamento de Química. Seropédica, RJ, Brasil.Universidade Federal Rural do Rio de Janeiro. Departamento de Química. Seropédica, RJ, Brasil.Universidade Federal Rural do Rio de Janeiro. Departamento de Química. Seropédica, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.In a previous work we demonstrated that diarylheptanoids extracted from Centrolobium sclerophyllum are very active against Leishmania amazonensis promastigotes. In order to continue our studies with these class of compounds, we decided to evaluate the activity of several diarylheptanoids derived from curcumin (diferuloyl methane) against the extracellular form (promastigotes) of L. amazonensis. Furthermore, an experiment against the intracellular form of the parasite (amastigotes) was carried out, comparing the most active compound among the curcumin derivatives (the methylcurcumin) with des-O-methylcentrolobine, the most active diarylheptanoid derived from C. sclerophyllum.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/44033/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCatarinaC_Araujo_etal_IOC_1999.pdfCatarinaC_Araujo_etal_IOC_1999.pdfapplication/pdf58826https://www.arca.fiocruz.br/bitstream/icict/44033/2/CatarinaC_Araujo_etal_IOC_1999.pdf9f9cca5efbbb5bce3304a57a182e0a24MD52TEXTCatarinaC_Araujo_etal_IOC_1999.pdf.txtCatarinaC_Araujo_etal_IOC_1999.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Studies on the Effectiveness of Diarylheptanoids Derivatives against Leishmania amazonensis
title Studies on the Effectiveness of Diarylheptanoids Derivatives against Leishmania amazonensis
spellingShingle Studies on the Effectiveness of Diarylheptanoids Derivatives against Leishmania amazonensis
Araujo, Catarina A.. C.
Leishmania amazonensi
Centrolobium sclerophyllum
Diarilheptanoides
Leishmania amazonensi
Centrolobium sclerophyllum
Diarylheptanoids
title_short Studies on the Effectiveness of Diarylheptanoids Derivatives against Leishmania amazonensis
title_full Studies on the Effectiveness of Diarylheptanoids Derivatives against Leishmania amazonensis
title_fullStr Studies on the Effectiveness of Diarylheptanoids Derivatives against Leishmania amazonensis
title_full_unstemmed Studies on the Effectiveness of Diarylheptanoids Derivatives against Leishmania amazonensis
title_sort Studies on the Effectiveness of Diarylheptanoids Derivatives against Leishmania amazonensis
author Araujo, Catarina A.. C.
author_facet Araujo, Catarina A.. C.
Alegrio, Leila V.
Gomes, Denise C. F.
LIma, Marco Edilson F.
Cardoso, Leonardo Gomes
Leon, Leonor L.
author_role author
author2 Alegrio, Leila V.
Gomes, Denise C. F.
LIma, Marco Edilson F.
Cardoso, Leonardo Gomes
Leon, Leonor L.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Araujo, Catarina A.. C.
Alegrio, Leila V.
Gomes, Denise C. F.
LIma, Marco Edilson F.
Cardoso, Leonardo Gomes
Leon, Leonor L.
dc.subject.other.pt_BR.fl_str_mv Leishmania amazonensi
Centrolobium sclerophyllum
Diarilheptanoides
topic Leishmania amazonensi
Centrolobium sclerophyllum
Diarilheptanoides
Leishmania amazonensi
Centrolobium sclerophyllum
Diarylheptanoids
dc.subject.en.pt_BR.fl_str_mv Leishmania amazonensi
Centrolobium sclerophyllum
Diarylheptanoids
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.
publishDate 1999
dc.date.issued.fl_str_mv 1999
dc.date.accessioned.fl_str_mv 2020-10-17T19:10:39Z
dc.date.available.fl_str_mv 2020-10-17T19:10:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
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dc.identifier.citation.fl_str_mv ARAUJO, Catarina A. C. et al. Studies on the Effectiveness of Diarylheptanoids Derivatives against Leishmania amazonensis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 94, n. 6, p. 791-794, Nov./Dec, 1999.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/44033
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02761999000600015
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv ARAUJO, Catarina A. C. et al. Studies on the Effectiveness of Diarylheptanoids Derivatives against Leishmania amazonensis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 94, n. 6, p. 791-794, Nov./Dec, 1999.
0074-0276
10.1590/S0074-02761999000600015
1678-8060
url https://www.arca.fiocruz.br/handle/icict/44033
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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