Efficacy of a diarylheptanoid derivative against Leishmania amazonensis

Detalhes bibliográficos
Autor(a) principal: Alves, Luciana Vignólio
Data de Publicação: 2003
Outros Autores: Temporal, Rosane Maria, Cysne-Finkelstein, Léa, Leon, Leonor Laura
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/44404
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.
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spelling Alves, Luciana VignólioTemporal, Rosane MariaCysne-Finkelstein, LéaLeon, Leonor Laura2020-11-13T19:27:26Z2020-11-13T19:27:26Z2003ALVES, Luciana Vignólio et al. Efficacy of a diarylheptanoid derivative against Leishmania amazonensis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 98, n. 4, p. 553-555, June 2003.0074-0276https://www.arca.fiocruz.br/handle/icict/4440410.1590/S0074-027620030004000241678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.Leishmania amazonensisLeishmanioseEnsaio de tratamentoDiarilheptanoideDiarylheptanoidTreatment trialLeishmania amazonensisLeishmaniasisEfficacy of a diarylheptanoid derivative against Leishmania amazonensisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.The activity of several diarylheptanoid derivatives (curcuminoids) was previously evaluated against Leishmania amazonensis promastigotes and among them the most active compound was the [1-(4-methoxy-phenyl)-7-(3,4- methoxy-4-hydroxy-phenyl)-1,6-heptadien-3, 5-dione]. This derivative was chosen to be assayed in vivo in a treatment trial. For these experiments, the curcuminoid compound was used in a concentration equivalent to the IC50/ 24 h, obtained from the previous study. Balb/c mice were inoculated subcutaneously in the footpad with L. amazonensis infective promastigotes and 4 weeks after the inoculation, the animals were treated with different schemes, varying from 1 to 3 doses. In all the experiments, Pentamidine Isethionate was used as reference drug under the same experimental conditions. The results showed that one dose was not enough to heal the lesion, however, with 2 and 3 doses the efficiency of the assayed compound was clear. On the other hand, treatment with Pentamidine Isethionate using the three different schemes was not satisfactory when compared to the curcuminoid derivative.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/44404/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALLucianAlves_LeoorLLeon_IOC_2003.pdfLucianAlves_LeoorLLeon_IOC_2003.pdfapplication/pdf560878https://www.arca.fiocruz.br/bitstream/icict/44404/2/LucianAlves_LeoorLLeon_IOC_2003.pdff7426cc23067291fe26e5893061b6a7dMD52TEXTLucianAlves_LeoorLLeon_IOC_2003.pdf.txtLucianAlves_LeoorLLeon_IOC_2003.pdf.txtExtracted texttext/plain11784https://www.arca.fiocruz.br/bitstream/icict/44404/3/LucianAlves_LeoorLLeon_IOC_2003.pdf.txt513523b08a9cc651d3c088698978826cMD53icict/444042020-11-14 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dc.title.pt_BR.fl_str_mv Efficacy of a diarylheptanoid derivative against Leishmania amazonensis
title Efficacy of a diarylheptanoid derivative against Leishmania amazonensis
spellingShingle Efficacy of a diarylheptanoid derivative against Leishmania amazonensis
Alves, Luciana Vignólio
Leishmania amazonensis
Leishmaniose
Ensaio de tratamento
Diarilheptanoide
Diarylheptanoid
Treatment trial
Leishmania amazonensis
Leishmaniasis
title_short Efficacy of a diarylheptanoid derivative against Leishmania amazonensis
title_full Efficacy of a diarylheptanoid derivative against Leishmania amazonensis
title_fullStr Efficacy of a diarylheptanoid derivative against Leishmania amazonensis
title_full_unstemmed Efficacy of a diarylheptanoid derivative against Leishmania amazonensis
title_sort Efficacy of a diarylheptanoid derivative against Leishmania amazonensis
author Alves, Luciana Vignólio
author_facet Alves, Luciana Vignólio
Temporal, Rosane Maria
Cysne-Finkelstein, Léa
Leon, Leonor Laura
author_role author
author2 Temporal, Rosane Maria
Cysne-Finkelstein, Léa
Leon, Leonor Laura
author2_role author
author
author
dc.contributor.author.fl_str_mv Alves, Luciana Vignólio
Temporal, Rosane Maria
Cysne-Finkelstein, Léa
Leon, Leonor Laura
dc.subject.other.pt_BR.fl_str_mv Leishmania amazonensis
Leishmaniose
Ensaio de tratamento
Diarilheptanoide
topic Leishmania amazonensis
Leishmaniose
Ensaio de tratamento
Diarilheptanoide
Diarylheptanoid
Treatment trial
Leishmania amazonensis
Leishmaniasis
dc.subject.en.pt_BR.fl_str_mv Diarylheptanoid
Treatment trial
Leishmania amazonensis
Leishmaniasis
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.
publishDate 2003
dc.date.issued.fl_str_mv 2003
dc.date.accessioned.fl_str_mv 2020-11-13T19:27:26Z
dc.date.available.fl_str_mv 2020-11-13T19:27:26Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ALVES, Luciana Vignólio et al. Efficacy of a diarylheptanoid derivative against Leishmania amazonensis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 98, n. 4, p. 553-555, June 2003.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/44404
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02762003000400024
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv ALVES, Luciana Vignólio et al. Efficacy of a diarylheptanoid derivative against Leishmania amazonensis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 98, n. 4, p. 553-555, June 2003.
0074-0276
10.1590/S0074-02762003000400024
1678-8060
url https://www.arca.fiocruz.br/handle/icict/44404
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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