Infectious disease‑associated encephalopathies

Detalhes bibliográficos
Autor(a) principal: Silva, Maria C. Barbosa
Data de Publicação: 2021
Outros Autores: Lima, Maiara N., Battaglini, Denise, Robba, Chiara, Pelosi, Paolo, Rocco, Patricia R. M., Maron‑Gutierrez, Tatiana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/48717
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.
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spelling Silva, Maria C. BarbosaLima, Maiara N.Battaglini, DeniseRobba, ChiaraPelosi, PaoloRocco, Patricia R. M.Maron‑Gutierrez, Tatiana2021-08-24T13:59:25Z2021-08-24T13:59:25Z2021SILVA, Maria C. Barbosa et al. Infectious disease‑associated encephalopathies. Critical Care, v. 25, n 236, 14 p, 2021.1466-609Xhttps://www.arca.fiocruz.br/handle/icict/4871710.1186/s113054-021-03659-6engBMCSepseMaláriaInfluenzaCOVID-19SARS-CoV-2InfecçãoNeuroinflamaçãoPriming MicroglialConhecimentoEncefalopatiaSepsisMalariaInfluenzaCOVID-19SARS-CoV-2InfectionNeuroinfammation,Microglial primingCognitionEncephalopathyInfectious disease‑associated encephalopathiesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Anesthesia and Intensive Care, San Martino Policlinico Hospital, IRCCS for Oncology and Neuroscience. Genoa, Italy.Anesthesia and Intensive Care, San Martino Policlinico Hospital, IRCCS for Oncology and Neuroscience. Genoa, Italy / Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa. Genoa, Italy.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratorio de Investigação Pulmonar. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia para Medicina Regenerativa. Rio de Janeiro, RJ, Brasil. / Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro. Rede de Neuroinformação Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratorio de Investigação Pulmonar. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia para Medicina Regenerativa. Rio de Janeiro, RJ, Brasil. / Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro. Rede de Neuroinformação Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro. Rede de Neuroinformação Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil.Infectious diseases may afect brain function and cause encephalopathy even when the pathogen does not directly infect the central nervous system, known as infectious disease-associated encephalopathy. The systemic infamma‑ tory process may result in neuroinfammation, with glial cell activation and increased levels of cytokines, reduced neurotrophic factors, blood–brain barrier dysfunction, neurotransmitter metabolism imbalances, and neurotoxicity, and behavioral and cognitive impairments often occur in the late course. Even though infectious disease-associated encephalopathies may cause devastating neurologic and cognitive defcits, the concept of infectious disease-associ‑ ated encephalopathies is still under-investigated; knowledge of the underlying mechanisms, which may be distinct from those of encephalopathies of non-infectious cause, is still limited. In this review, we focus on the pathophysiol‑ ogy of encephalopathies associated with peripheral (sepsis, malaria, infuenza, and COVID-19), emerging therapeutic strategies, and the role of neuroinfammation.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/48717/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMariaCB_Silva_etal_IOC_2021.pdfMariaCB_Silva_etal_IOC_2021.pdfapplication/pdf3013868https://www.arca.fiocruz.br/bitstream/icict/48717/2/MariaCB_Silva_etal_IOC_2021.pdf51716fdf1a6133ec2d9530c689b42314MD52TEXTMariaCB_Silva_etal_IOC_2021.pdf.txtMariaCB_Silva_etal_IOC_2021.pdf.txtExtracted texttext/plain78402https://www.arca.fiocruz.br/bitstream/icict/48717/3/MariaCB_Silva_etal_IOC_2021.pdf.txt377c7d9e77f387e2543178a4d1cf9580MD53icict/487172021-08-25 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dc.title.pt_BR.fl_str_mv Infectious disease‑associated encephalopathies
title Infectious disease‑associated encephalopathies
spellingShingle Infectious disease‑associated encephalopathies
Silva, Maria C. Barbosa
Sepse
Malária
Influenza
COVID-19
SARS-CoV-2
Infecção
Neuroinflamação
Priming Microglial
Conhecimento
Encefalopatia
Sepsis
Malaria
Influenza
COVID-19
SARS-CoV-2
Infection
Neuroinfammation,
Microglial priming
Cognition
Encephalopathy
title_short Infectious disease‑associated encephalopathies
title_full Infectious disease‑associated encephalopathies
title_fullStr Infectious disease‑associated encephalopathies
title_full_unstemmed Infectious disease‑associated encephalopathies
title_sort Infectious disease‑associated encephalopathies
author Silva, Maria C. Barbosa
author_facet Silva, Maria C. Barbosa
Lima, Maiara N.
Battaglini, Denise
Robba, Chiara
Pelosi, Paolo
Rocco, Patricia R. M.
Maron‑Gutierrez, Tatiana
author_role author
author2 Lima, Maiara N.
Battaglini, Denise
Robba, Chiara
Pelosi, Paolo
Rocco, Patricia R. M.
Maron‑Gutierrez, Tatiana
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Maria C. Barbosa
Lima, Maiara N.
Battaglini, Denise
Robba, Chiara
Pelosi, Paolo
Rocco, Patricia R. M.
Maron‑Gutierrez, Tatiana
dc.subject.other.pt_BR.fl_str_mv Sepse
Malária
Influenza
COVID-19
SARS-CoV-2
Infecção
Neuroinflamação
Priming Microglial
Conhecimento
Encefalopatia
topic Sepse
Malária
Influenza
COVID-19
SARS-CoV-2
Infecção
Neuroinflamação
Priming Microglial
Conhecimento
Encefalopatia
Sepsis
Malaria
Influenza
COVID-19
SARS-CoV-2
Infection
Neuroinfammation,
Microglial priming
Cognition
Encephalopathy
dc.subject.en.pt_BR.fl_str_mv Sepsis
Malaria
Influenza
COVID-19
SARS-CoV-2
Infection
Neuroinfammation,
Microglial priming
Cognition
Encephalopathy
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-08-24T13:59:25Z
dc.date.available.fl_str_mv 2021-08-24T13:59:25Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Maria C. Barbosa et al. Infectious disease‑associated encephalopathies. Critical Care, v. 25, n 236, 14 p, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/48717
dc.identifier.issn.pt_BR.fl_str_mv 1466-609X
dc.identifier.doi.none.fl_str_mv 10.1186/s113054-021-03659-6
identifier_str_mv SILVA, Maria C. Barbosa et al. Infectious disease‑associated encephalopathies. Critical Care, v. 25, n 236, 14 p, 2021.
1466-609X
10.1186/s113054-021-03659-6
url https://www.arca.fiocruz.br/handle/icict/48717
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/48717/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/48717/2/MariaCB_Silva_etal_IOC_2021.pdf
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