Infectious disease‑associated encephalopathies
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/48717 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. |
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Silva, Maria C. BarbosaLima, Maiara N.Battaglini, DeniseRobba, ChiaraPelosi, PaoloRocco, Patricia R. M.Maron‑Gutierrez, Tatiana2021-08-24T13:59:25Z2021-08-24T13:59:25Z2021SILVA, Maria C. Barbosa et al. Infectious disease‑associated encephalopathies. Critical Care, v. 25, n 236, 14 p, 2021.1466-609Xhttps://www.arca.fiocruz.br/handle/icict/4871710.1186/s113054-021-03659-6engBMCSepseMaláriaInfluenzaCOVID-19SARS-CoV-2InfecçãoNeuroinflamaçãoPriming MicroglialConhecimentoEncefalopatiaSepsisMalariaInfluenzaCOVID-19SARS-CoV-2InfectionNeuroinfammation,Microglial primingCognitionEncephalopathyInfectious disease‑associated encephalopathiesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Anesthesia and Intensive Care, San Martino Policlinico Hospital, IRCCS for Oncology and Neuroscience. Genoa, Italy.Anesthesia and Intensive Care, San Martino Policlinico Hospital, IRCCS for Oncology and Neuroscience. Genoa, Italy / Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa. Genoa, Italy.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratorio de Investigação Pulmonar. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia para Medicina Regenerativa. Rio de Janeiro, RJ, Brasil. / Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro. Rede de Neuroinformação Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratorio de Investigação Pulmonar. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia para Medicina Regenerativa. Rio de Janeiro, RJ, Brasil. / Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro. Rede de Neuroinformação Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro. Rede de Neuroinformação Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil.Infectious diseases may afect brain function and cause encephalopathy even when the pathogen does not directly infect the central nervous system, known as infectious disease-associated encephalopathy. The systemic infamma‑ tory process may result in neuroinfammation, with glial cell activation and increased levels of cytokines, reduced neurotrophic factors, blood–brain barrier dysfunction, neurotransmitter metabolism imbalances, and neurotoxicity, and behavioral and cognitive impairments often occur in the late course. Even though infectious disease-associated encephalopathies may cause devastating neurologic and cognitive defcits, the concept of infectious disease-associ‑ ated encephalopathies is still under-investigated; knowledge of the underlying mechanisms, which may be distinct from those of encephalopathies of non-infectious cause, is still limited. In this review, we focus on the pathophysiol‑ ogy of encephalopathies associated with peripheral (sepsis, malaria, infuenza, and COVID-19), emerging therapeutic strategies, and the role of neuroinfammation.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/48717/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMariaCB_Silva_etal_IOC_2021.pdfMariaCB_Silva_etal_IOC_2021.pdfapplication/pdf3013868https://www.arca.fiocruz.br/bitstream/icict/48717/2/MariaCB_Silva_etal_IOC_2021.pdf51716fdf1a6133ec2d9530c689b42314MD52TEXTMariaCB_Silva_etal_IOC_2021.pdf.txtMariaCB_Silva_etal_IOC_2021.pdf.txtExtracted texttext/plain78402https://www.arca.fiocruz.br/bitstream/icict/48717/3/MariaCB_Silva_etal_IOC_2021.pdf.txt377c7d9e77f387e2543178a4d1cf9580MD53icict/487172021-08-25 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dc.title.pt_BR.fl_str_mv |
Infectious disease‑associated encephalopathies |
title |
Infectious disease‑associated encephalopathies |
spellingShingle |
Infectious disease‑associated encephalopathies Silva, Maria C. Barbosa Sepse Malária Influenza COVID-19 SARS-CoV-2 Infecção Neuroinflamação Priming Microglial Conhecimento Encefalopatia Sepsis Malaria Influenza COVID-19 SARS-CoV-2 Infection Neuroinfammation, Microglial priming Cognition Encephalopathy |
title_short |
Infectious disease‑associated encephalopathies |
title_full |
Infectious disease‑associated encephalopathies |
title_fullStr |
Infectious disease‑associated encephalopathies |
title_full_unstemmed |
Infectious disease‑associated encephalopathies |
title_sort |
Infectious disease‑associated encephalopathies |
author |
Silva, Maria C. Barbosa |
author_facet |
Silva, Maria C. Barbosa Lima, Maiara N. Battaglini, Denise Robba, Chiara Pelosi, Paolo Rocco, Patricia R. M. Maron‑Gutierrez, Tatiana |
author_role |
author |
author2 |
Lima, Maiara N. Battaglini, Denise Robba, Chiara Pelosi, Paolo Rocco, Patricia R. M. Maron‑Gutierrez, Tatiana |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Silva, Maria C. Barbosa Lima, Maiara N. Battaglini, Denise Robba, Chiara Pelosi, Paolo Rocco, Patricia R. M. Maron‑Gutierrez, Tatiana |
dc.subject.other.pt_BR.fl_str_mv |
Sepse Malária Influenza COVID-19 SARS-CoV-2 Infecção Neuroinflamação Priming Microglial Conhecimento Encefalopatia |
topic |
Sepse Malária Influenza COVID-19 SARS-CoV-2 Infecção Neuroinflamação Priming Microglial Conhecimento Encefalopatia Sepsis Malaria Influenza COVID-19 SARS-CoV-2 Infection Neuroinfammation, Microglial priming Cognition Encephalopathy |
dc.subject.en.pt_BR.fl_str_mv |
Sepsis Malaria Influenza COVID-19 SARS-CoV-2 Infection Neuroinfammation, Microglial priming Cognition Encephalopathy |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. |
publishDate |
2021 |
dc.date.accessioned.fl_str_mv |
2021-08-24T13:59:25Z |
dc.date.available.fl_str_mv |
2021-08-24T13:59:25Z |
dc.date.issued.fl_str_mv |
2021 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
SILVA, Maria C. Barbosa et al. Infectious disease‑associated encephalopathies. Critical Care, v. 25, n 236, 14 p, 2021. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/48717 |
dc.identifier.issn.pt_BR.fl_str_mv |
1466-609X |
dc.identifier.doi.none.fl_str_mv |
10.1186/s113054-021-03659-6 |
identifier_str_mv |
SILVA, Maria C. Barbosa et al. Infectious disease‑associated encephalopathies. Critical Care, v. 25, n 236, 14 p, 2021. 1466-609X 10.1186/s113054-021-03659-6 |
url |
https://www.arca.fiocruz.br/handle/icict/48717 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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BMC |
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