Cryptococcus neoformans vnii as the main cause of cryptococcosis in domestic cats from rio de janeiro, Brazil

Detalhes bibliográficos
Autor(a) principal: Reis, Rosani Santos
Data de Publicação: 2021
Outros Autores: Bonna, Isabel Cristina Fábregas, Antonio, Isabela Maria da Silva, Pereira, Sandro Antonio, Nascimento, Carlos Roberto Sobrinho do, Ferraris, Fausto Klabund, Brito-Santos, Fábio, Gremião, Isabella Dib Ferreira, Trilles, Luciana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/50434
Resumo: Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.
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spelling Reis, Rosani SantosBonna, Isabel Cristina FábregasAntonio, Isabela Maria da SilvaPereira, Sandro AntonioNascimento, Carlos Roberto Sobrinho doFerraris, Fausto KlabundBrito-Santos, FábioGremião, Isabella Dib FerreiraTrilles, Luciana2021-12-14T22:03:31Z2021-12-14T22:03:31Z2021REIS, Rosani Santos et al. Cryptococcus neoformans VNII as the Main Cause of Cryptococcosis in Domestic Cats from Rio de Janeiro, Brazil. Journal of fungi, v. 7, n. 11, p. 1-11, 20212309-608Xhttps://www.arca.fiocruz.br/handle/icict/5043410.3390/jof7110980engMDPICryptococcus neoformans vnii as the main cause of cryptococcosis in domestic cats from rio de janeiro, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica de Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica de Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Laboratório de Farmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Cryptococcosis is a systemic fungal disease acquired from contaminated environments with propagules of the basidiomycetous yeasts of the Cryptococcus neoformans and C. gattii species complexes. The C. neoformans species complex classically comprises four major molecular types (VNI, VNII, VNIII, and VNIV), and the C. gattii species complex comprises another four (VGI, VGII, VGIII, and VGIV) and the newly identified molecular type VGV. These major molecular types differ in their epidemiological and ecological features, clinical presentations, and therapeutic outcomes. Generally, the most common isolated types are VNI, VGI, and VGII. The epidemiological profile of cryptococcosis in domestic cats is poorly studied and cats can be the sentinels for human infections. Therefore, the present study aimed to determine the molecular characterization of Cryptococcus spp. isolated from domestic cats and their dwellings in the metropolitan area of Rio de Janeiro, Brazil. A total of 36 Cryptococcus spp. strains, both clinical and environmental, from 19 cats were subtyped using multilocus sequence typing (MLST). The ploidy was identified using flow cytometry and the mating type was determined through amplification with specific pheromone primers. All strains were mating type alpha and 6/36 were diploid (all VNII). Most isolates (63.88%) were identified as VNII, a rare molecular type, leading to the consideration that this genotype is more likely related to skin lesions, since there was a high percentage (68.75%) of cats with skin lesions, which is also considered rare. Further studies regarding the molecular epidemiology of cryptococcosis in felines are still needed to clarify the reason for the large proportion of the rare molecular type VNII causing infections in cats.MLSTCryptococcosisDomestic catsMolecular epidemiologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/50434/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALCryptococcus_Rosani_Reis_etal_INI_2021.pdfCryptococcus_Rosani_Reis_etal_INI_2021.pdfapplication/pdf1096837https://www.arca.fiocruz.br/bitstream/icict/50434/2/Cryptococcus_Rosani_Reis_etal_INI_2021.pdf73ccd74b7306e91a3d2bda25ef2a2e4cMD52icict/504342021-12-14 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dc.title.pt_BR.fl_str_mv Cryptococcus neoformans vnii as the main cause of cryptococcosis in domestic cats from rio de janeiro, Brazil
title Cryptococcus neoformans vnii as the main cause of cryptococcosis in domestic cats from rio de janeiro, Brazil
spellingShingle Cryptococcus neoformans vnii as the main cause of cryptococcosis in domestic cats from rio de janeiro, Brazil
Reis, Rosani Santos
MLST
Cryptococcosis
Domestic cats
Molecular epidemiology
title_short Cryptococcus neoformans vnii as the main cause of cryptococcosis in domestic cats from rio de janeiro, Brazil
title_full Cryptococcus neoformans vnii as the main cause of cryptococcosis in domestic cats from rio de janeiro, Brazil
title_fullStr Cryptococcus neoformans vnii as the main cause of cryptococcosis in domestic cats from rio de janeiro, Brazil
title_full_unstemmed Cryptococcus neoformans vnii as the main cause of cryptococcosis in domestic cats from rio de janeiro, Brazil
title_sort Cryptococcus neoformans vnii as the main cause of cryptococcosis in domestic cats from rio de janeiro, Brazil
author Reis, Rosani Santos
author_facet Reis, Rosani Santos
Bonna, Isabel Cristina Fábregas
Antonio, Isabela Maria da Silva
Pereira, Sandro Antonio
Nascimento, Carlos Roberto Sobrinho do
Ferraris, Fausto Klabund
Brito-Santos, Fábio
Gremião, Isabella Dib Ferreira
Trilles, Luciana
author_role author
author2 Bonna, Isabel Cristina Fábregas
Antonio, Isabela Maria da Silva
Pereira, Sandro Antonio
Nascimento, Carlos Roberto Sobrinho do
Ferraris, Fausto Klabund
Brito-Santos, Fábio
Gremião, Isabella Dib Ferreira
Trilles, Luciana
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Reis, Rosani Santos
Bonna, Isabel Cristina Fábregas
Antonio, Isabela Maria da Silva
Pereira, Sandro Antonio
Nascimento, Carlos Roberto Sobrinho do
Ferraris, Fausto Klabund
Brito-Santos, Fábio
Gremião, Isabella Dib Ferreira
Trilles, Luciana
dc.subject.en.pt_BR.fl_str_mv MLST
Cryptococcosis
Domestic cats
Molecular epidemiology
topic MLST
Cryptococcosis
Domestic cats
Molecular epidemiology
description Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-12-14T22:03:31Z
dc.date.available.fl_str_mv 2021-12-14T22:03:31Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv REIS, Rosani Santos et al. Cryptococcus neoformans VNII as the Main Cause of Cryptococcosis in Domestic Cats from Rio de Janeiro, Brazil. Journal of fungi, v. 7, n. 11, p. 1-11, 2021
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/50434
dc.identifier.issn.pt_BR.fl_str_mv 2309-608X
dc.identifier.doi.none.fl_str_mv 10.3390/jof7110980
identifier_str_mv REIS, Rosani Santos et al. Cryptococcus neoformans VNII as the Main Cause of Cryptococcosis in Domestic Cats from Rio de Janeiro, Brazil. Journal of fungi, v. 7, n. 11, p. 1-11, 2021
2309-608X
10.3390/jof7110980
url https://www.arca.fiocruz.br/handle/icict/50434
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/50434/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/50434/2/Cryptococcus_Rosani_Reis_etal_INI_2021.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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