Impaired TNF, IL-1β, and IL-17 production and increased susceptibility to Mycobacterium tuberculosis infection in HTLV-1 infected individuals
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/25909 |
Resumo: | CNPq (473459/2012-4), Ministry of Science and Technology (573839/2008-5), CAPES (573839/2008-5), and Maria Emília Pedreira Freire de Carvalho Foundation (160067). |
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Carvalho, Natália BarbosaBastos, Maria de LourdesSouza, Anselmo de SantanaMartins Netto, EduardoArruda, Sérgio MarcosSantos, Silvane BCarvalho, Edgar Marcelino de2018-04-17T16:21:37Z2018-04-17T16:21:37Z2018CARVALHO, N. B. et al. Impaired TNF, IL-1β, and IL-17 production and increased susceptibility to Mycobacterium tuberculosis infection in HTLV-1 infected individuals. Tuberculosis, v. 108, p. 35–40, 2018.1472-9792https://www.arca.fiocruz.br/handle/icict/2590910.1016/j.tube.2017.10.004CNPq (473459/2012-4), Ministry of Science and Technology (573839/2008-5), CAPES (573839/2008-5), and Maria Emília Pedreira Freire de Carvalho Foundation (160067).Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Laboratório de Pesquisa em Infectologia. Salvador, BA, Brasil / Fundação José Silveira. Instituto Brasileiro para a Investigação da Tuberculose. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Universidade Estadual de Feira de Santana. Departamento de Ciências Biológicas. Feira de Santana, BA, Brasil / Ministério de Ciência Tecnologia e Inovação. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Conselho Nacional de Desenvolvimento Científico e Tecnológico. Salvador, BA, BrasilUniversidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Ministério de Ciência Tecnologia e Inovação. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Conselho Nacional de Desenvolvimento Científico e Tecnológico. Salvador, BA, BrasilIFN-γ and TNF play critical roles in the control of Mycobacterium tuberculosis infection. Despite leading to an exaggerated production of inflammatory cytokines, HTLV-1 infection increases the risk of developing tuberculosis (TB). However, the immune mechanisms accounting for this phenomenon are still unclear. The aim of this study was to evaluate immunological aspects of the HTLV-1/M. tuberculosis co-infection. In this cross-sectional study, the levels of TNF, IL-1β, and IL-17 were determined by ELISA in the supernatants of either unstimulated or tuberculin purified protein derivative (PPD) stimulated peripheral blood mononuclear cells. Cells from HTLV-1 infected individuals produced lower levels of TNF following PPD stimulation compared to unstimulated cells. IL-1β and IL-17 production by cells from HTLV-1/M. tuberculosis co-infected individuals was lower than in cells from patients with TB. Impairment in TNF, IL-1β, and IL-17 production upon stimulation with mycobacterial antigens may contribute to the increased susceptibility to M. tuberculosis infection observed in HTLV-1 infected individuals.engElsevierHTLV-1TuberculoseCo-infecçãoResposta imuneHTLV-1TuberculosisCo-infectionImmune responseImpaired TNF, IL-1β, and IL-17 production and increased susceptibility to Mycobacterium tuberculosis infection in HTLV-1 infected individualsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/25909/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCarvalho N Impaired TNF, IL-1β, and IL-17 production....pdfCarvalho N Impaired TNF, IL-1β, and IL-17 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| dc.title.pt_BR.fl_str_mv |
Impaired TNF, IL-1β, and IL-17 production and increased susceptibility to Mycobacterium tuberculosis infection in HTLV-1 infected individuals |
| title |
Impaired TNF, IL-1β, and IL-17 production and increased susceptibility to Mycobacterium tuberculosis infection in HTLV-1 infected individuals |
| spellingShingle |
Impaired TNF, IL-1β, and IL-17 production and increased susceptibility to Mycobacterium tuberculosis infection in HTLV-1 infected individuals Carvalho, Natália Barbosa HTLV-1 Tuberculose Co-infecção Resposta imune HTLV-1 Tuberculosis Co-infection Immune response |
| title_short |
Impaired TNF, IL-1β, and IL-17 production and increased susceptibility to Mycobacterium tuberculosis infection in HTLV-1 infected individuals |
| title_full |
Impaired TNF, IL-1β, and IL-17 production and increased susceptibility to Mycobacterium tuberculosis infection in HTLV-1 infected individuals |
| title_fullStr |
Impaired TNF, IL-1β, and IL-17 production and increased susceptibility to Mycobacterium tuberculosis infection in HTLV-1 infected individuals |
| title_full_unstemmed |
Impaired TNF, IL-1β, and IL-17 production and increased susceptibility to Mycobacterium tuberculosis infection in HTLV-1 infected individuals |
| title_sort |
Impaired TNF, IL-1β, and IL-17 production and increased susceptibility to Mycobacterium tuberculosis infection in HTLV-1 infected individuals |
| author |
Carvalho, Natália Barbosa |
| author_facet |
Carvalho, Natália Barbosa Bastos, Maria de Lourdes Souza, Anselmo de Santana Martins Netto, Eduardo Arruda, Sérgio Marcos Santos, Silvane B Carvalho, Edgar Marcelino de |
| author_role |
author |
| author2 |
Bastos, Maria de Lourdes Souza, Anselmo de Santana Martins Netto, Eduardo Arruda, Sérgio Marcos Santos, Silvane B Carvalho, Edgar Marcelino de |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Carvalho, Natália Barbosa Bastos, Maria de Lourdes Souza, Anselmo de Santana Martins Netto, Eduardo Arruda, Sérgio Marcos Santos, Silvane B Carvalho, Edgar Marcelino de |
| dc.subject.other.pt_BR.fl_str_mv |
HTLV-1 Tuberculose Co-infecção Resposta imune |
| topic |
HTLV-1 Tuberculose Co-infecção Resposta imune HTLV-1 Tuberculosis Co-infection Immune response |
| dc.subject.en.pt_BR.fl_str_mv |
HTLV-1 Tuberculosis Co-infection Immune response |
| description |
CNPq (473459/2012-4), Ministry of Science and Technology (573839/2008-5), CAPES (573839/2008-5), and Maria Emília Pedreira Freire de Carvalho Foundation (160067). |
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2018 |
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2018-04-17T16:21:37Z |
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2018-04-17T16:21:37Z |
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2018 |
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CARVALHO, N. B. et al. Impaired TNF, IL-1β, and IL-17 production and increased susceptibility to Mycobacterium tuberculosis infection in HTLV-1 infected individuals. Tuberculosis, v. 108, p. 35–40, 2018. |
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https://www.arca.fiocruz.br/handle/icict/25909 |
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1472-9792 |
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10.1016/j.tube.2017.10.004 |
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CARVALHO, N. B. et al. Impaired TNF, IL-1β, and IL-17 production and increased susceptibility to Mycobacterium tuberculosis infection in HTLV-1 infected individuals. Tuberculosis, v. 108, p. 35–40, 2018. 1472-9792 10.1016/j.tube.2017.10.004 |
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