Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study

Reyes, Luis Felipe; Murthy, Srinivas; Garcia-Gallo, Esteban; Merson, Laura; Ibáñez-Prada, Elsa D.; Rello, Jordi; Fuentes, Yuli V.; Martin-Loeches, Ignacio; Bozza, Fernando; Duque, Sara; Taccone, Fabio S.; Fowler, Robert A.; Kartsonaki, Christiana; Gonçalves, Bronner P.; Citarella, Barbara Wanjiru; Aryal, Diptesh; Burhan, Erlina; Cummings, Matthew J.; Delmas, Christelle; Diaz, Rodrigo; Figueiredo-Mello, Claudia; Hashmi, Madiha; Panda, Prasan Kumar; Jiménez, Miguel Pedrera; Rincon, Diego Fernando Bautista; Thomson, David; Nichol, Alistair; Marshall, John C.; Olliaro, Piero L.

Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study

Detalhes bibliográficos
Autor(a) principal:	Reyes, Luis Felipe
Data de Publicação:	2022
Outros Autores:	Murthy, Srinivas, Garcia-Gallo, Esteban, Merson, Laura, Ibáñez-Prada, Elsa D., Rello, Jordi, Fuentes, Yuli V., Martin-Loeches, Ignacio, Bozza, Fernando, Duque, Sara, Taccone, Fabio S., Fowler, Robert A., Kartsonaki, Christiana, Gonçalves, Bronner P., Citarella, Barbara Wanjiru, Aryal, Diptesh, Burhan, Erlina, Cummings, Matthew J., Delmas, Christelle, Diaz, Rodrigo, Figueiredo-Mello, Claudia, Hashmi, Madiha, Panda, Prasan Kumar, Jiménez, Miguel Pedrera, Rincon, Diego Fernando Bautista, Thomson, David, Nichol, Alistair, Marshall, John C., Olliaro, Piero L.
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/55747
Resumo:	University of Oxford. Pandemic Sciences Institute. Oxford, UK / Universidad de La Sabana. Infectious Diseases Department. Chía, Colombia / Clínica Universidad de La Sabana. Critical Care Department. Chía, Colombia.

Metadados do item

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network_acronym_str	CRUZ
network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str	2135
spelling	Reyes, Luis FelipeMurthy, SrinivasGarcia-Gallo, EstebanMerson, LauraIbáñez-Prada, Elsa D.Rello, JordiFuentes, Yuli V.Martin-Loeches, IgnacioBozza, FernandoDuque, SaraTaccone, Fabio S.Fowler, Robert A.Kartsonaki, ChristianaGonçalves, Bronner P.Citarella, Barbara WanjiruAryal, DipteshBurhan, ErlinaCummings, Matthew J.Delmas, ChristelleDiaz, RodrigoFigueiredo-Mello, ClaudiaHashmi, MadihaPanda, Prasan KumarJiménez, Miguel PedreraRincon, Diego Fernando BautistaThomson, DavidNichol, AlistairMarshall, John C.Olliaro, Piero L.2022-11-22T12:58:26Z2022-11-22T12:58:26Z2022REYES, Luis Felipe et al. Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study. Critical care, v. 26, n. 1, p. 1-16, 2022.1574-4280https://www.arca.fiocruz.br/handle/icict/5574710.1186/s13054-022-04155-1engBMCRespiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity of Oxford. Pandemic Sciences Institute. Oxford, UK / Universidad de La Sabana. Infectious Diseases Department. Chía, Colombia / Clínica Universidad de La Sabana. Critical Care Department. Chía, Colombia.University of British Columbia. Department of Pediatrics. Vancouver, Canada.Universidad de La Sabana. Infectious Diseases Department. Chía, Colombia.University of Oxford. Pandemic Sciences Institute. Oxford, UK.Universidad de La Sabana. Infectious Diseases Department. Chía, Colombia / Clínica Universidad de La Sabana. Critical Care Department. Chía, Colombia.Vall d'Hebron Institute of Research. Clinical Research Epidemiology in Pneumonia & Sepsis. Barcelona, Spain / Instituto de Salud Carlos III. Centro de Investigación Biomédica En Red de Enfermedades Respiratorias. Madrid, Spain.Universidad de La Sabana. Infectious Diseases Department. Chía, Colombia / Clínica Universidad de La Sabana. Critical Care Department. Chía, Colombia.Multidisciplinary Intensive Care Research Organization. Department of Clinical Medicine, St James's Hospital. Dublin, Ireland.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Brazilian Research in Intensive Care Network. Rio de Janeiro, RJ, Brazil.Universidad de La Sabana. Infectious Diseases Department. Chía, Colombia.Université Libre de Bruxelles. Department of Intensive Care. Brussels, Belgium / Hôpital Erasme. Department of Intensive Care. Laboratoire de Recherche Experimentale. Brussels, Belgium.University of Toronto. Interdepartmental Division of Critical Care Medicine. Toronto, ON, Canada.University of Oxford. Pandemic Sciences Institute. Oxford, UK.University of Oxford. Pandemic Sciences Institute. Oxford, UK.University of Oxford. Pandemic Sciences Institute. Oxford, UK.Nepal Mediciti Hospital. Lalitpur, Nepal.Universitas Indonesia. Department of Pulmonology and Respiratory Medicine. Infection Division. Depok, Indonesia.Columbia University Vagelos College of Physicians and Surgeons. Department of Medicine. Division of Pulmonary, Allergy, and Critical Care Medicine. New York, NY, USA.INSERM. IAME. Paris, France.Clinica Las Condes. Intensive Care Unit. Santiago, Chile.Instituto de Infectologia Emílio Ribas. São Paulo, SP, Brasil.Critical Care Asia and Ziauddin University. Karachi, Pakistan.All India Institute of Medical Sciences. Rishikesh, India.Hospital 12 de Octubre. Madrid, Spain.Fundación Valle del Lili. Department of Intensive Care. Cali, Colombia.University of Cape Town and Groote Schuur Hospital. Division of Critical Care. Cape Town, South Africa.University College Dublin Clinical Research Centre at St Vincent's University Hospital. Dublin, Ireland.St Michael's Hospital. Unity Health Toronto. Li Ka Shing Knowledge Institute. Toronto, ON, Canada.University of Oxford. Pandemic Sciences Institute. Oxford, UK.Background: Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (IMV). We aimed to describe the clinical characteristics, outcomes and risk factors for failing non-invasive respiratory support in patients treated with severe COVID-19 during the first two years of the pandemic in high-income countries (HICs) and low middle-income countries (LMICs). Methods: This is a multinational, multicentre, prospective cohort study embedded in the ISARIC-WHO COVID-19 Clinical Characterisation Protocol. Patients with laboratory-confirmed SARS-CoV-2 infection who required hospital admission were recruited prospectively. Patients treated with HFNC, NIV, or IMV within the first 24 h of hospital admission were included in this study. Descriptive statistics, random forest, and logistic regression analyses were used to describe clinical characteristics and compare clinical outcomes among patients treated with the different types of advanced respiratory support. Results: A total of 66,565 patients were included in this study. Overall, 82.6% of patients were treated in HIC, and 40.6% were admitted to the hospital during the first pandemic wave. During the first 24 h after hospital admission, patients in HICs were more frequently treated with HFNC (48.0%), followed by NIV (38.6%) and IMV (13.4%). In contrast, patients admitted in lower- and middle-income countries (LMICs) were less frequently treated with HFNC (16.1%) and the majority received IMV (59.1%). The failure rate of non-invasive respiratory support (i.e. HFNC or NIV) was 15.5%, of which 71.2% were from HIC and 28.8% from LMIC. The variables most strongly associated with non-invasive ventilation failure, defined as progression to IMV, were high leukocyte counts at hospital admission (OR [95%CI]; 5.86 [4.83-7.10]), treatment in an LMIC (OR [95%CI]; 2.04 [1.97-2.11]), and tachypnoea at hospital admission (OR [95%CI]; 1.16 [1.14-1.18]). Patients who failed HFNC/NIV had a higher 28-day fatality ratio (OR [95%CI]; 1.27 [1.25-1.30]). Conclusions: In the present international cohort, the most frequently used advanced respiratory support was the HFNC. However, IMV was used more often in LMIC. Higher leucocyte count, tachypnoea, and treatment in LMIC were risk factors for HFNC/NIV failure. HFNC/NIV failure was related to worse clinical outcomes, such as 28-day mortality. Trial registration This is a prospective observational study; therefore, no health care interventions were applied to participants, and trial registration is not applicable.COVID-19Critical careHigh flow nasal cannulaInvasive mechanical ventilationinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/55747/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRespiratory_Fernando_Bozza_etal_INI_2022_COVID-19.pdfRespiratory_Fernando_Bozza_etal_INI_2022_COVID-19.pdfapplication/pdf3129500https://www.arca.fiocruz.br/bitstream/icict/55747/2/Respiratory_Fernando_Bozza_etal_INI_2022_COVID-19.pdf5f6a5f8bf7e11528b7012db3d5f3d08dMD52icict/557472022-11-22 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dc.title.en_US.fl_str_mv	Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study
title	Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study
spellingShingle	Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study Reyes, Luis Felipe COVID-19 Critical care High flow nasal cannula Invasive mechanical ventilation
title_short	Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study
title_full	Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study
title_fullStr	Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study
title_full_unstemmed	Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study
title_sort	Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study
author	Reyes, Luis Felipe
author_facet	Reyes, Luis Felipe Murthy, Srinivas Garcia-Gallo, Esteban Merson, Laura Ibáñez-Prada, Elsa D. Rello, Jordi Fuentes, Yuli V. Martin-Loeches, Ignacio Bozza, Fernando Duque, Sara Taccone, Fabio S. Fowler, Robert A. Kartsonaki, Christiana Gonçalves, Bronner P. Citarella, Barbara Wanjiru Aryal, Diptesh Burhan, Erlina Cummings, Matthew J. Delmas, Christelle Diaz, Rodrigo Figueiredo-Mello, Claudia Hashmi, Madiha Panda, Prasan Kumar Jiménez, Miguel Pedrera Rincon, Diego Fernando Bautista Thomson, David Nichol, Alistair Marshall, John C. Olliaro, Piero L.
author_role	author
author2	Murthy, Srinivas Garcia-Gallo, Esteban Merson, Laura Ibáñez-Prada, Elsa D. Rello, Jordi Fuentes, Yuli V. Martin-Loeches, Ignacio Bozza, Fernando Duque, Sara Taccone, Fabio S. Fowler, Robert A. Kartsonaki, Christiana Gonçalves, Bronner P. Citarella, Barbara Wanjiru Aryal, Diptesh Burhan, Erlina Cummings, Matthew J. Delmas, Christelle Diaz, Rodrigo Figueiredo-Mello, Claudia Hashmi, Madiha Panda, Prasan Kumar Jiménez, Miguel Pedrera Rincon, Diego Fernando Bautista Thomson, David Nichol, Alistair Marshall, John C. Olliaro, Piero L.
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Reyes, Luis Felipe Murthy, Srinivas Garcia-Gallo, Esteban Merson, Laura Ibáñez-Prada, Elsa D. Rello, Jordi Fuentes, Yuli V. Martin-Loeches, Ignacio Bozza, Fernando Duque, Sara Taccone, Fabio S. Fowler, Robert A. Kartsonaki, Christiana Gonçalves, Bronner P. Citarella, Barbara Wanjiru Aryal, Diptesh Burhan, Erlina Cummings, Matthew J. Delmas, Christelle Diaz, Rodrigo Figueiredo-Mello, Claudia Hashmi, Madiha Panda, Prasan Kumar Jiménez, Miguel Pedrera Rincon, Diego Fernando Bautista Thomson, David Nichol, Alistair Marshall, John C. Olliaro, Piero L.
dc.subject.en.en_US.fl_str_mv	COVID-19 Critical care High flow nasal cannula Invasive mechanical ventilation
topic	COVID-19 Critical care High flow nasal cannula Invasive mechanical ventilation
description	University of Oxford. Pandemic Sciences Institute. Oxford, UK / Universidad de La Sabana. Infectious Diseases Department. Chía, Colombia / Clínica Universidad de La Sabana. Critical Care Department. Chía, Colombia.
publishDate	2022
dc.date.accessioned.fl_str_mv	2022-11-22T12:58:26Z
dc.date.available.fl_str_mv	2022-11-22T12:58:26Z
dc.date.issued.fl_str_mv	2022
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	REYES, Luis Felipe et al. Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study. Critical care, v. 26, n. 1, p. 1-16, 2022.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/55747
dc.identifier.issn.en_US.fl_str_mv	1574-4280
dc.identifier.doi.none.fl_str_mv	10.1186/s13054-022-04155-1
identifier_str_mv	REYES, Luis Felipe et al. Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study. Critical care, v. 26, n. 1, p. 1-16, 2022. 1574-4280 10.1186/s13054-022-04155-1
url	https://www.arca.fiocruz.br/handle/icict/55747
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	BMC
publisher.none.fl_str_mv	BMC
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/55747/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/55747/2/Respiratory_Fernando_Bozza_etal_INI_2022_COVID-19.pdf
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repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
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Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study

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