Erythema multiforme in leprosy

Detalhes bibliográficos
Autor(a) principal: Miranda, Alice Machado
Data de Publicação: 2012
Outros Autores: Antunes, Sérgio Luiz Gomes, Nery, José Augusto Costa, Salles, Ana Maria, Pereira, Mario José dos Santos, Sarno, Euzenir Nunes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/16770
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.
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spelling Miranda, Alice MachadoAntunes, Sérgio Luiz GomesNery, José Augusto CostaSalles, Ana MariaPereira, Mario José dos SantosSarno, Euzenir Nunes2017-01-10T11:03:13Z2017-01-10T11:03:13Z2012MIRANDA, Alice Machado; et al. Erythema multiforme in leprosy. Mem Inst Oswaldo Cruz,v.107, Suppl. I, p.34-42, 2012.0074-0276https://www.arca.fiocruz.br/handle/icict/167701678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzHanseníaseEritema MultiformeEritema Nodosoleprosyerythema multiformeerythema nodosum leprosumErythema multiforme in leprosyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.Universidade do Estado do Rio de Janeiro. Departamento de Fisiologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.The clinical course of leprosy is often interrupted by reactions, which are acute inflammatory episodes that can be classified as type I or type II. Type II reactions can present as cutaneous lesions that resemble erythema multiforme (EM). EM is classically associated with drug allergies or pre-existing viral infections. However, the differential diagnostic criteria of the diverse causative agents remain controversial. The aim of this study was to determine both the clinical relevance and the morphological and immunohistochemical characteristics of the EM-like lesions during the course of type II leprosy reactions. Twenty-seven skin biopsies were taken from typical EM-like lesions of multibacillary patients and reviewed; their histological features were correlated to their clinical aspects. Then, a computer-assisted morphometric analysis was performed to measure the extent of angiogenesis during these acute episodes. The histopathological and immunohistochemical analysis of the EM lesions revealed that they shared the same features that have been previously described for ENL, including immunopositivity in the identical cell-mediated immune markers. Our results point to leprosy as the cause of the EM-like lesions in our patients. Therefore, leprosy should be considered in the differential diagnosis of EM.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16770/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALalice_miranda_etal_IOC_2012.pdfalice_miranda_etal_IOC_2012.pdfapplication/pdf1531709https://www.arca.fiocruz.br/bitstream/icict/16770/2/alice_miranda_etal_IOC_2012.pdfcbf740a62e208ad77b0e8ecd3622d50bMD52TEXTalice_miranda_etal_IOC_2012.pdf.txtalice_miranda_etal_IOC_2012.pdf.txtExtracted texttext/plain41934https://www.arca.fiocruz.br/bitstream/icict/16770/3/alice_miranda_etal_IOC_2012.pdf.txte8660f8784aa75ed72d364579b287df9MD53icict/167702018-08-15 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dc.title.pt_BR.fl_str_mv Erythema multiforme in leprosy
title Erythema multiforme in leprosy
spellingShingle Erythema multiforme in leprosy
Miranda, Alice Machado
Hanseníase
Eritema Multiforme
Eritema Nodoso
leprosy
erythema multiforme
erythema nodosum leprosum
title_short Erythema multiforme in leprosy
title_full Erythema multiforme in leprosy
title_fullStr Erythema multiforme in leprosy
title_full_unstemmed Erythema multiforme in leprosy
title_sort Erythema multiforme in leprosy
author Miranda, Alice Machado
author_facet Miranda, Alice Machado
Antunes, Sérgio Luiz Gomes
Nery, José Augusto Costa
Salles, Ana Maria
Pereira, Mario José dos Santos
Sarno, Euzenir Nunes
author_role author
author2 Antunes, Sérgio Luiz Gomes
Nery, José Augusto Costa
Salles, Ana Maria
Pereira, Mario José dos Santos
Sarno, Euzenir Nunes
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Miranda, Alice Machado
Antunes, Sérgio Luiz Gomes
Nery, José Augusto Costa
Salles, Ana Maria
Pereira, Mario José dos Santos
Sarno, Euzenir Nunes
dc.subject.other.pt_BR.fl_str_mv Hanseníase
Eritema Multiforme
Eritema Nodoso
topic Hanseníase
Eritema Multiforme
Eritema Nodoso
leprosy
erythema multiforme
erythema nodosum leprosum
dc.subject.en.pt_BR.fl_str_mv leprosy
erythema multiforme
erythema nodosum leprosum
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2017-01-10T11:03:13Z
dc.date.available.fl_str_mv 2017-01-10T11:03:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MIRANDA, Alice Machado; et al. Erythema multiforme in leprosy. Mem Inst Oswaldo Cruz,v.107, Suppl. I, p.34-42, 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/16770
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv MIRANDA, Alice Machado; et al. Erythema multiforme in leprosy. Mem Inst Oswaldo Cruz,v.107, Suppl. I, p.34-42, 2012.
0074-0276
1678-8060
url https://www.arca.fiocruz.br/handle/icict/16770
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/16770/1/license.txt
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https://www.arca.fiocruz.br/bitstream/icict/16770/3/alice_miranda_etal_IOC_2012.pdf.txt
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