“Ab initio” ulcerated erythema multiforme-like type 2 reaction: an atypical presentation of leprosy in the lepromatous range

• Autor(a) principal: Contin, Letícia Arsie
• Data de Publicação: 2008
• Outros Autores: Delanina, Wladimir F. B., Barreto, Jaison Antônio, Nogueira, Maria Esther S. Nogueira, Souza, Suzi O. T. Berbert de
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Hansenologia Internationalis (Online)
• Texto Completo: https://periodicos.saude.sp.gov.br/hansenologia/article/view/35177
• topic: Hanseníase virchowiana; Eritema nodoso hansênico; Poliquimioterapia; Lepromatous leprosy; Erythema nodosum leprosum; Multidrug therapy

A 49 years old white man comes from a city of the inner part of the state of São Paulo with the diagnosis of multibacillary leprosy under treatment for 2 months. He reported that 2 years before he noted loss of sensitivity on his left foot which was associated with several red and hypopigmented macules with disturbance of skin sensitivity. The disease evolved with axillary and inguinal lymphadenopathy, as well as tender sharp borders’ plaques and ill-defined nodules, some of then ulcerated, and high degree fever also occurred. He was then admitted into a general hospital, and empirical antibiotics were started, without improvement of symptoms. An evaluation by an infectologist was requested, and the diagnosis of reactional multibacillary leprosy was made after skin smears and skin biopsy were performed. Multibacillary multidrug therapy (MDT-MB) was started,as well as prednisone, with clinical improvement, but diabetes mellitus induced by prednisone occurred, and the patient was referred to the “Instituto Lauro de souza Lima” (ILSL). At admission, on the physical examination, other than the plaques, nodules and mild inguinal and axillary lymphadenopathy, the patient did not present classical findings of lepromatous leprosy, i.e., madarosis, difuse infiltration of skin, saddle nose, well-defined enlargement of periferal nerve trunks or even important disturbance of sensitivity on his limbs. Histopathologic examination of a skin biopsy collected from the border of a plaque showed leprosy on the lepromatous range with Type 2 reation, and the infiltrate was distributed mainly in the superficial dermis (erythema multiforme-like ENL), bacilloscopy 5+ (fragmented bacilli). Bacilloscopy of skin smears collected from index points was positive in all the 6 points, showing 3-4 +, with fragmented bacilli. ELISA for IgM anti-PGL-1 (phenolic glycolipid-1) was 0,241 and ML-Flow test (lateral flux test for M. leprae) was 4+. Hemogram showed severe anemia (Ht=26%), leucocytosis with left deviation with toxic granules inside the neutrophils, and the ESR=101mm. Bacteriological examinationof a swab collected from an ulcerated lesion showed S. aureus coagulase negative. Prednisone was reduced and thalidomide 300mg/day was added, with fast involution of the lesions. It is discussed the delay in the diagnosis despite the initial clinical findings, as well as the typical type 2 reactional features, the therapeutic procedures, and the pathogenesis of the type 2 reaction occurred before the begining of Multidrug therapy (MDT).