Why Did ZIKV Perinatal Outcomes Differ in Distinct Regions of Brazil? An Exploratory Study of Two Cohorts

Detalhes bibliográficos
Autor(a) principal: Damasceno, Luana
Data de Publicação: 2021
Outros Autores: Terzian, Ana Carolina Bernardes, Fuller, Trevon, Estofolete, Cassia F, Andrade, Adriana, Kroon, Erna Geessien, Zin, Andrea A, Vasconcelos, Zilton, Pereira Junior, Jose P, Castilho, Márcia C, Piaulino, Isa Cristina R, Vasilakis, Nikos, Moreira, Maria E, Nielsen-Saines, Karin, Espinosa, Flor E Martinez, Nogueira, Maurício L, Brasil, Patricia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/55942
Resumo: Acute Febrile Illnesses Laboratory. National Institute of Infectious Diseases. Oswaldo Cruz Foundation. Rio de Janeiro, RJ, Brazil.
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spelling Damasceno, LuanaTerzian, Ana Carolina BernardesFuller, TrevonEstofolete, Cassia FAndrade, AdrianaKroon, Erna GeessienZin, Andrea AVasconcelos, ZiltonPereira Junior, Jose PCastilho, Márcia CPiaulino, Isa Cristina RVasilakis, NikosMoreira, Maria ENielsen-Saines, KarinEspinosa, Flor E MartinezNogueira, Maurício LBrasil, Patricia2022-12-14T18:37:02Z2022-12-14T18:37:02Z2021DAMASCENO, Luana et al. Why Did ZIKV Perinatal Outcomes Differ in Distinct Regions of Brazil? An Exploratory Study of Two Cohorts. Viruses, v. 13, n. 5, 736, 2021. doi: 10.3390/v13050736.1999-4915https://www.arca.fiocruz.br/handle/icict/55942engMDPIWhy Did ZIKV Perinatal Outcomes Differ in Distinct Regions of Brazil? An Exploratory Study of Two Cohortsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAcute Febrile Illnesses Laboratory. National Institute of Infectious Diseases. Oswaldo Cruz Foundation. Rio de Janeiro, RJ, Brazil.René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil.Acute Febrile Illnesses Laboratory. National Institute of Infectious Diseases. Oswaldo Cruz Foundation. Rio de Janeiro, RJ, Brazil.Laboratory of Virology. School of Medicine. São José do Rio Preto, SP, Brazil.Institute of Biological Sciences. Federal University of Minas Gerais .Belo Horizonte, MG, Brazil.Institute of Biological Sciences. Federal University of Minas Gerais .Belo Horizonte, MG, Brazil.Fernandes Figueira Institute. Oswaldo Cruz Foundation. Rio de Janeiro, RJ, Brazil.Fernandes Figueira Institute. Oswaldo Cruz Foundation. Rio de Janeiro, RJ, Brazil.Fernandes Figueira Institute. Oswaldo Cruz Foundation. Rio de Janeiro, RJ, Brazil.Department of Virology. Dr. Heitor Vieira Dourado Tropical Medicine Foundation. Manaus, AM, Brazil.Postgraduate Program in Tropical Medicine. Amazonas State University. Manaus, AM, Brazil.Department of Pathology. University of Texas Medical Branch. Galveston, TX, USA.Fernandes Figueira Institute. Oswaldo Cruz Foundation. Rio de Janeiro, RJ, Brazil.Department of Pediatrics. David Geffen School of Medicine. University of California. Los Angeles, CA, USA.Laboratory of Territory, Environment, Health, and Sustainability. Leônidas & Maria Deane Institute. Oswaldo Cruz Foundation., Manaus, AM, Brazil/Department of Malaria. Dr. Heitor Vieira Dourado Tropical Medicine Foundation. Manaus, AM, Brazil.Laboratory of Virology. School of Medicine. São José do Rio Preto, SP, Brazil.Acute Febrile Illnesses Laboratory. National Institute of Infectious Diseases. Oswaldo Cruz Foundation. Rio de Janeiro, RJ, Brazil.The Zika virus (ZIKV) epidemic in Brazil occurred in regions where dengue viruses (DENV) are historically endemic. We investigated the differences in adverse pregnancy/infant outcomes in two cohorts comprising 114 pregnant women with PCR-confirmed ZIKV infection in Rio de Janeiro, Southeastern Brazil (n = 50) and Manaus, in the north region of the country (n = 64). Prior exposure to DENV was evaluated through plaque reduction neutralizing antibody assays (PRNT 80) and DENV IgG serologies. Potential associations between pregnancy outcomes and Zika attack rates in the two cities were explored. Overall, 31 women (27%) had adverse pregnancy/infant outcomes, 27 in Rio (54%) and 4 in Manaus (6%), p < 0.001. This included 4 pregnancy losses (13%) and 27 infants with abnormalities at birth (24%). A total of 93 women (82%) had evidence of prior DENV exposure, 45 in Rio (90%) and 48 in Manaus (75%). Zika attack rates differed; the rate in Rio was 10.28 cases/10,000 and in Manaus, 0.6 cases/10,000, p < 0.001. Only Zika attack rates (Odds Ratio: 17.6, 95% Confidence Interval 5.6-55.9, p < 0.001) and infection in the first trimester of pregnancy (OR: 4.26, 95% CI 1.4-12.9, p = 0.011) were associated with adverse pregnancy and infant outcomes. Pre-existing immunity to DENV was not associated with outcomes (normal or abnormal) in patients with ZIKV infection during pregnancy.Zikaarbovirusesdengueobstetricspregnancyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/55942/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALWhy Did ZIKV Perinatal Outcomes Differ in Distinct Regions of Brazil.pdfWhy Did ZIKV Perinatal Outcomes Differ in Distinct Regions of Brazil.pdfapplication/pdf609860https://www.arca.fiocruz.br/bitstream/icict/55942/2/Why%20Did%20ZIKV%20Perinatal%20Outcomes%20Differ%20in%20Distinct%20Regions%20of%20Brazil.pdf8cc02fe12e1308206cbba54d13767f49MD52icict/559422022-12-14 15:37:03.178oai:www.arca.fiocruz.br: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ório 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dc.title.en_US.fl_str_mv Why Did ZIKV Perinatal Outcomes Differ in Distinct Regions of Brazil? An Exploratory Study of Two Cohorts
title Why Did ZIKV Perinatal Outcomes Differ in Distinct Regions of Brazil? An Exploratory Study of Two Cohorts
spellingShingle Why Did ZIKV Perinatal Outcomes Differ in Distinct Regions of Brazil? An Exploratory Study of Two Cohorts
Damasceno, Luana
Zika
arboviruses
dengue
obstetrics
pregnancy
title_short Why Did ZIKV Perinatal Outcomes Differ in Distinct Regions of Brazil? An Exploratory Study of Two Cohorts
title_full Why Did ZIKV Perinatal Outcomes Differ in Distinct Regions of Brazil? An Exploratory Study of Two Cohorts
title_fullStr Why Did ZIKV Perinatal Outcomes Differ in Distinct Regions of Brazil? An Exploratory Study of Two Cohorts
title_full_unstemmed Why Did ZIKV Perinatal Outcomes Differ in Distinct Regions of Brazil? An Exploratory Study of Two Cohorts
title_sort Why Did ZIKV Perinatal Outcomes Differ in Distinct Regions of Brazil? An Exploratory Study of Two Cohorts
author Damasceno, Luana
author_facet Damasceno, Luana
Terzian, Ana Carolina Bernardes
Fuller, Trevon
Estofolete, Cassia F
Andrade, Adriana
Kroon, Erna Geessien
Zin, Andrea A
Vasconcelos, Zilton
Pereira Junior, Jose P
Castilho, Márcia C
Piaulino, Isa Cristina R
Vasilakis, Nikos
Moreira, Maria E
Nielsen-Saines, Karin
Espinosa, Flor E Martinez
Nogueira, Maurício L
Brasil, Patricia
author_role author
author2 Terzian, Ana Carolina Bernardes
Fuller, Trevon
Estofolete, Cassia F
Andrade, Adriana
Kroon, Erna Geessien
Zin, Andrea A
Vasconcelos, Zilton
Pereira Junior, Jose P
Castilho, Márcia C
Piaulino, Isa Cristina R
Vasilakis, Nikos
Moreira, Maria E
Nielsen-Saines, Karin
Espinosa, Flor E Martinez
Nogueira, Maurício L
Brasil, Patricia
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Damasceno, Luana
Terzian, Ana Carolina Bernardes
Fuller, Trevon
Estofolete, Cassia F
Andrade, Adriana
Kroon, Erna Geessien
Zin, Andrea A
Vasconcelos, Zilton
Pereira Junior, Jose P
Castilho, Márcia C
Piaulino, Isa Cristina R
Vasilakis, Nikos
Moreira, Maria E
Nielsen-Saines, Karin
Espinosa, Flor E Martinez
Nogueira, Maurício L
Brasil, Patricia
dc.subject.en.en_US.fl_str_mv Zika
arboviruses
dengue
obstetrics
pregnancy
topic Zika
arboviruses
dengue
obstetrics
pregnancy
description Acute Febrile Illnesses Laboratory. National Institute of Infectious Diseases. Oswaldo Cruz Foundation. Rio de Janeiro, RJ, Brazil.
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2022-12-14T18:37:02Z
dc.date.available.fl_str_mv 2022-12-14T18:37:02Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv DAMASCENO, Luana et al. Why Did ZIKV Perinatal Outcomes Differ in Distinct Regions of Brazil? An Exploratory Study of Two Cohorts. Viruses, v. 13, n. 5, 736, 2021. doi: 10.3390/v13050736.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/55942
dc.identifier.issn.en_US.fl_str_mv 1999-4915
identifier_str_mv DAMASCENO, Luana et al. Why Did ZIKV Perinatal Outcomes Differ in Distinct Regions of Brazil? An Exploratory Study of Two Cohorts. Viruses, v. 13, n. 5, 736, 2021. doi: 10.3390/v13050736.
1999-4915
url https://www.arca.fiocruz.br/handle/icict/55942
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/55942/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/55942/2/Why%20Did%20ZIKV%20Perinatal%20Outcomes%20Differ%20in%20Distinct%20Regions%20of%20Brazil.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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