Functionalized hydrogels for cartilage repair: the value of secretome-instructive signaling

Detalhes bibliográficos
Autor(a) principal: Barisón, María Julia
Data de Publicação: 2022
Outros Autores: Nogoceke, Rodrigo, Josino, Raphaella, Horinouchi, Cintia Delai da Silva, Marcon, Bruna Hilzendeger, Correa, Alejandro, Stimamiglio, Marco Augusto, Robert, Anny Waloski
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/54664
Resumo: Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.
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spelling Barisón, María JuliaNogoceke, RodrigoJosino, RaphaellaHorinouchi, Cintia Delai da SilvaMarcon, Bruna HilzendegerCorrea, AlejandroStimamiglio, Marco AugustoRobert, Anny Waloski2022-08-16T17:31:31Z2022-08-16T17:31:31Z2022BARISÓN, María Julia et al. Functionalized hydrogels for cartilage repair: the value of secretome-instructive signaling. Int. J. Mol. Sci, v. 23, n. 6010, p. 1–22, 2022.1422-0067https://www.arca.fiocruz.br/handle/icict/5466410. https:// doi.org/10.3390/ijms23116010porMDPIFunctionalized hydrogels for cartilage repair: the value of secretome-instructive signalinginfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.Cartilage repair has been a challenge in the medical field for many years. Although treatments that alleviate pain and injury are available, none can effectively regenerate the cartilage. Currently, regenerative medicine and tissue engineering are among the developed strategies to treat cartilage injury. The use of stem cells, associated or not with scaffolds, has shown potential in cartilage regeneration. However, it is currently known that the effect of stem cells occurs mainly through the secretion of paracrine factors that act on local cells. In this review, we will address the use of the secretome—a set of bioactive factors (soluble factors and extracellular vesicles) secreted by the cells—of mesenchymal stem cells as a treatment for cartilage regeneration. We will also discuss methodologies for priming the secretome to enhance the chondroregenerative potential. In addition, considering the difficulty of delivering therapies to the injured cartilage site, we will address works that use hydrogels functionalized with growth factors and secretome components. We aim to show that secretome-functionalized hydrogels can be an exciting approach to cell-free cartilage repair therapy.CartilageSecretomeHydrogelsConnective Tissue Growth FactorExtracellular VesiclesCartílagoHidrogelesFactor de Crecimiento del Tejido ConjuntivoVesículas ExtracelularesCartilagemSecretomaHidrogéisFator de Crescimento do Tecido ConjuntivoVesículas Extracelularesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/54664/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINALijms-23-06010ok.pdfijms-23-06010ok.pdfapplication/pdf1044153https://www.arca.fiocruz.br/bitstream/icict/54664/2/ijms-23-06010ok.pdf413840007e30aacc64b7f924e0fa6faeMD52icict/546642022-08-16 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dc.title.pt_BR.fl_str_mv Functionalized hydrogels for cartilage repair: the value of secretome-instructive signaling
title Functionalized hydrogels for cartilage repair: the value of secretome-instructive signaling
spellingShingle Functionalized hydrogels for cartilage repair: the value of secretome-instructive signaling
Barisón, María Julia
Cartilage
Secretome
Hydrogels
Connective Tissue Growth Factor
Extracellular Vesicles
Cartílago
Hidrogeles
Factor de Crecimiento del Tejido Conjuntivo
Vesículas Extracelulares
Cartilagem
Secretoma
Hidrogéis
Fator de Crescimento do Tecido Conjuntivo
Vesículas Extracelulares
title_short Functionalized hydrogels for cartilage repair: the value of secretome-instructive signaling
title_full Functionalized hydrogels for cartilage repair: the value of secretome-instructive signaling
title_fullStr Functionalized hydrogels for cartilage repair: the value of secretome-instructive signaling
title_full_unstemmed Functionalized hydrogels for cartilage repair: the value of secretome-instructive signaling
title_sort Functionalized hydrogels for cartilage repair: the value of secretome-instructive signaling
author Barisón, María Julia
author_facet Barisón, María Julia
Nogoceke, Rodrigo
Josino, Raphaella
Horinouchi, Cintia Delai da Silva
Marcon, Bruna Hilzendeger
Correa, Alejandro
Stimamiglio, Marco Augusto
Robert, Anny Waloski
author_role author
author2 Nogoceke, Rodrigo
Josino, Raphaella
Horinouchi, Cintia Delai da Silva
Marcon, Bruna Hilzendeger
Correa, Alejandro
Stimamiglio, Marco Augusto
Robert, Anny Waloski
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Barisón, María Julia
Nogoceke, Rodrigo
Josino, Raphaella
Horinouchi, Cintia Delai da Silva
Marcon, Bruna Hilzendeger
Correa, Alejandro
Stimamiglio, Marco Augusto
Robert, Anny Waloski
dc.subject.en.pt_BR.fl_str_mv Cartilage
Secretome
Hydrogels
Connective Tissue Growth Factor
Extracellular Vesicles
topic Cartilage
Secretome
Hydrogels
Connective Tissue Growth Factor
Extracellular Vesicles
Cartílago
Hidrogeles
Factor de Crecimiento del Tejido Conjuntivo
Vesículas Extracelulares
Cartilagem
Secretoma
Hidrogéis
Fator de Crescimento do Tecido Conjuntivo
Vesículas Extracelulares
dc.subject.es.pt_BR.fl_str_mv Cartílago
Hidrogeles
Factor de Crecimiento del Tejido Conjuntivo
Vesículas Extracelulares
dc.subject.decs.pt_BR.fl_str_mv Cartilagem
Secretoma
Hidrogéis
Fator de Crescimento do Tecido Conjuntivo
Vesículas Extracelulares
description Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-08-16T17:31:31Z
dc.date.available.fl_str_mv 2022-08-16T17:31:31Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BARISÓN, María Julia et al. Functionalized hydrogels for cartilage repair: the value of secretome-instructive signaling. Int. J. Mol. Sci, v. 23, n. 6010, p. 1–22, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/54664
dc.identifier.issn.pt_BR.fl_str_mv 1422-0067
dc.identifier.doi.none.fl_str_mv 10. https:// doi.org/10.3390/ijms23116010
identifier_str_mv BARISÓN, María Julia et al. Functionalized hydrogels for cartilage repair: the value of secretome-instructive signaling. Int. J. Mol. Sci, v. 23, n. 6010, p. 1–22, 2022.
1422-0067
10. https:// doi.org/10.3390/ijms23116010
url https://www.arca.fiocruz.br/handle/icict/54664
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/54664/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/54664/2/ijms-23-06010ok.pdf
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