Synthesis and biological evaluation against Mycobacterium tuberculosis and Leishmania amazonensis of a series of diaminated terpenoids

Detalhes bibliográficos
Autor(a) principal: Reis, Dijovani Batista dos
Data de Publicação: 2016
Outros Autores: Souza, Thalita Cristina Alves, Lourenço, Maria Cristina S., Almeida, Mauro Vieira de, Barbosa, Adriano, Eger, Iriane, Saraiva, Mauricio Frota
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/32397
Resumo: 2020-04-05
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spelling Reis, Dijovani Batista dosSouza, Thalita Cristina AlvesLourenço, Maria Cristina S.Almeida, Mauro Vieira deBarbosa, AdrianoEger, IrianeSaraiva, Mauricio Frota2019-04-05T15:01:08Z2019-04-05T15:01:08Z2016REIS, Dijovani Batista dos et al. Synthesis and biological evaluation against Mycobacterium tuberculosis and Leishmania amazonensis of a series of diaminated terpenoids. Biomedicine and Pharmacotherapy, v. 84, p. 1739-1747, 2016.0753-3322https://www.arca.fiocruz.br/handle/icict/3239710.1016/j.biopha.2016.10.112engElsevierSynthesis and biological evaluation against Mycobacterium tuberculosis and Leishmania amazonensis of a series of diaminated terpenoidsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-04-05Universidade Federal de Itajubá. Instituto de Física e Química. Itajubá, MG, Brasil.Universidade Federal de Itajubá. Instituto de Física e Química. Itajubá, MG, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisas Clínicas Evandro Chagas. Departamento de Bacteriologia. Rio de Janeiro, RJ, Brasil.Universidade Federal de Juiz de Fora. Instituto de Ciências Exatas. Departamento de Química. Juiz de Fora, MG, Brasil.Universidade Estadual de Ponta Grossa. Departamento de Biologia Geral. Ponta Grossa, PR, Brasil.Universidade Estadual de Ponta Grossa. Departamento de Biologia Geral. Ponta Grossa, PR, Brasil.Universidade Federal de Itajubá. Instituto de Física e Química. Itajubá, MG, Brasil.We report the synthesis of a series of diaminated terpenoids containing, as side-chain of the diamine core, the "head-to-tail" prenyl derivatives, with amino amino spacers of variable length. In vitro biological activity of these compounds was evaluated against Mycobacterium tuberculosis and Leishmania amazonensis, and the structure-activity relationships are discussed. Different biological results were observed depending on the terpenic side-chain length. The best results were obtained for trans,trans-farnesol derivatives. Moreover, these results demonstrated that the stereochemistry of the double bond could play an important role in determining antitubercular and antileishmanial activities of these compounds.TuberculosisLeishmaniasisDiamineTerpenoidinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/32397/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALve_Reis_Dijovani_etal_INI_2016.pdfve_Reis_Dijovani_etal_INI_2016.pdfapplication/pdf1084053https://www.arca.fiocruz.br/bitstream/icict/32397/2/ve_Reis_Dijovani_etal_INI_2016.pdf43dfbdaf7046490dd9a8e67d5dff5f9dMD52TEXTve_Reis_Dijovani_etal_INI_2016.pdf.txtve_Reis_Dijovani_etal_INI_2016.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Synthesis and biological evaluation against Mycobacterium tuberculosis and Leishmania amazonensis of a series of diaminated terpenoids
title Synthesis and biological evaluation against Mycobacterium tuberculosis and Leishmania amazonensis of a series of diaminated terpenoids
spellingShingle Synthesis and biological evaluation against Mycobacterium tuberculosis and Leishmania amazonensis of a series of diaminated terpenoids
Reis, Dijovani Batista dos
Tuberculosis
Leishmaniasis
Diamine
Terpenoid
title_short Synthesis and biological evaluation against Mycobacterium tuberculosis and Leishmania amazonensis of a series of diaminated terpenoids
title_full Synthesis and biological evaluation against Mycobacterium tuberculosis and Leishmania amazonensis of a series of diaminated terpenoids
title_fullStr Synthesis and biological evaluation against Mycobacterium tuberculosis and Leishmania amazonensis of a series of diaminated terpenoids
title_full_unstemmed Synthesis and biological evaluation against Mycobacterium tuberculosis and Leishmania amazonensis of a series of diaminated terpenoids
title_sort Synthesis and biological evaluation against Mycobacterium tuberculosis and Leishmania amazonensis of a series of diaminated terpenoids
author Reis, Dijovani Batista dos
author_facet Reis, Dijovani Batista dos
Souza, Thalita Cristina Alves
Lourenço, Maria Cristina S.
Almeida, Mauro Vieira de
Barbosa, Adriano
Eger, Iriane
Saraiva, Mauricio Frota
author_role author
author2 Souza, Thalita Cristina Alves
Lourenço, Maria Cristina S.
Almeida, Mauro Vieira de
Barbosa, Adriano
Eger, Iriane
Saraiva, Mauricio Frota
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Reis, Dijovani Batista dos
Souza, Thalita Cristina Alves
Lourenço, Maria Cristina S.
Almeida, Mauro Vieira de
Barbosa, Adriano
Eger, Iriane
Saraiva, Mauricio Frota
dc.subject.en.pt_BR.fl_str_mv Tuberculosis
Leishmaniasis
Diamine
Terpenoid
topic Tuberculosis
Leishmaniasis
Diamine
Terpenoid
description 2020-04-05
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2019-04-05T15:01:08Z
dc.date.available.fl_str_mv 2019-04-05T15:01:08Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv REIS, Dijovani Batista dos et al. Synthesis and biological evaluation against Mycobacterium tuberculosis and Leishmania amazonensis of a series of diaminated terpenoids. Biomedicine and Pharmacotherapy, v. 84, p. 1739-1747, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/32397
dc.identifier.issn.pt_BR.fl_str_mv 0753-3322
dc.identifier.doi.none.fl_str_mv 10.1016/j.biopha.2016.10.112
identifier_str_mv REIS, Dijovani Batista dos et al. Synthesis and biological evaluation against Mycobacterium tuberculosis and Leishmania amazonensis of a series of diaminated terpenoids. Biomedicine and Pharmacotherapy, v. 84, p. 1739-1747, 2016.
0753-3322
10.1016/j.biopha.2016.10.112
url https://www.arca.fiocruz.br/handle/icict/32397
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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