Effects of centrally acting antihypertensive drugs on the microcirculation of spontaneously hypertensive rats

Detalhes bibliográficos
Autor(a) principal: Estato, V.
Data de Publicação: 2010
Outros Autores: Araújo, C. V., Bousquet, P., Tibiriçá, E.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/30434
Resumo: Fundação Oswaldo cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil.
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spelling Estato, V.Araújo, C. V.Bousquet, P.Tibiriçá, E.2018-12-08T12:53:06Z2018-12-08T12:53:06Z2010ESTATO, V. et al. Effects of centrally acting antihypertensive drugs on the microcirculation of spontaneously hypertensive rats. Brazilian Journal of Medical and Biological Research, v.37, n.10, p.1541-1549, 2004.0100-879Xhttps://www.arca.fiocruz.br/handle/icict/304341414-431XengAssociação Brasileira de Divulgação CientíficaMicrocirculação mesentéricaHipertensão arterialCkinidinaRilmenidinaBaclofenoMesenteric microcirculationArterial hypertensionClonidineRilmenidineBaclofenLNP 509Effects of centrally acting antihypertensive drugs on the microcirculation of spontaneously hypertensive ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil.Université Louis Pasteur. Faculté de Médecine. Laboratoire de Neurobiologie et Pharmacologie Cardiovasculaire. Strasbourg, France.Fundação Oswaldo cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil.We investigated the acute effects of centrally acting antihypertensive drugs on the microcirculation of pentobarbital-anesthetized spontaneously hypertensive rats (SHR). The effects of the sympatho-inhibitory agents clonidine and rilmenidine, known to activate both α2-adrenoceptors and nonadrenergic I1-imidazoline binding sites (I1BS) in the central nervous system, were compared to those of dicyclopropylmethyl-(4,5-dimethyl-4,5-dihydro-3H-pyrrol-2-yl)-amine hydrochloride (LNP 509), which selectively binds to the I1BS. Terminal mesenteric arterioles were observed by intravital microscopy. Activation of the central sympathetic system with L-glutamate (125 µg, ic) induced marked vasoconstriction of the mesenteric microcirculation (27 ± 3%; N = 6, P < 0.05). In contrast, the marked hypotensive and bradycardic effects elicited by intracisternal injection of clonidine (1 µg), rilmenidine (7 µg) and LNP 509 (60 µg) were accompanied by significant increases in arteriolar diameter (12 ± 1, 25 ± 10 and 21 ± 4%, respectively; N = 6, P < 0.05). The vasodilating effects of rilmenidine and LNP 509 were two-fold higher than those of clonidine, although they induced an identical hypotensive effect. Central sympathetic inhibition elicited by baclofen (1 µg, ic), a GABAB receptor agonist, also resulted in vasodilation of the SHR microvessels. The acute administration of clonidine, rilmenidine and LNP 509 also induced a significant decrease of cardiac output, whereas a decrease in systemic vascular resistance was observed only after rilmenidine and LNP 509. We conclude that the normalization of blood pressure in SHR induced by centrally acting antihypertensive agents is paralleled by important vasodilation of the mesenteric microcirculation. This effect is more pronounced with substances acting preferentially (rilmenidine) or exclusively (LNP 509) upon I1BS than with those presenting important α2-adrenergic activity (clonidine).info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/30434/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALvanessa_estato_etal_IOC_2010.pdfvanessa_estato_etal_IOC_2010.pdfapplication/pdf483607https://www.arca.fiocruz.br/bitstream/icict/30434/2/vanessa_estato_etal_IOC_2010.pdf0b1e979a20cd14b3d85ada4e43e9f990MD52TEXTvanessa_estato_etal_IOC_2010.pdf.txtvanessa_estato_etal_IOC_2010.pdf.txtExtracted texttext/plain34160https://www.arca.fiocruz.br/bitstream/icict/30434/3/vanessa_estato_etal_IOC_2010.pdf.txt4ec421d64a1d17b11f86083befe652a8MD53icict/304342018-12-09 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dc.title.pt_BR.fl_str_mv Effects of centrally acting antihypertensive drugs on the microcirculation of spontaneously hypertensive rats
title Effects of centrally acting antihypertensive drugs on the microcirculation of spontaneously hypertensive rats
spellingShingle Effects of centrally acting antihypertensive drugs on the microcirculation of spontaneously hypertensive rats
Estato, V.
Microcirculação mesentérica
Hipertensão arterial
Ckinidina
Rilmenidina
Baclofeno
Mesenteric microcirculation
Arterial hypertension
Clonidine
Rilmenidine
Baclofen
LNP 509
title_short Effects of centrally acting antihypertensive drugs on the microcirculation of spontaneously hypertensive rats
title_full Effects of centrally acting antihypertensive drugs on the microcirculation of spontaneously hypertensive rats
title_fullStr Effects of centrally acting antihypertensive drugs on the microcirculation of spontaneously hypertensive rats
title_full_unstemmed Effects of centrally acting antihypertensive drugs on the microcirculation of spontaneously hypertensive rats
title_sort Effects of centrally acting antihypertensive drugs on the microcirculation of spontaneously hypertensive rats
author Estato, V.
author_facet Estato, V.
Araújo, C. V.
Bousquet, P.
Tibiriçá, E.
author_role author
author2 Araújo, C. V.
Bousquet, P.
Tibiriçá, E.
author2_role author
author
author
dc.contributor.author.fl_str_mv Estato, V.
Araújo, C. V.
Bousquet, P.
Tibiriçá, E.
dc.subject.other.pt_BR.fl_str_mv Microcirculação mesentérica
Hipertensão arterial
Ckinidina
Rilmenidina
Baclofeno
topic Microcirculação mesentérica
Hipertensão arterial
Ckinidina
Rilmenidina
Baclofeno
Mesenteric microcirculation
Arterial hypertension
Clonidine
Rilmenidine
Baclofen
LNP 509
dc.subject.en.pt_BR.fl_str_mv Mesenteric microcirculation
Arterial hypertension
Clonidine
Rilmenidine
Baclofen
LNP 509
description Fundação Oswaldo cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil.
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2018-12-08T12:53:06Z
dc.date.available.fl_str_mv 2018-12-08T12:53:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ESTATO, V. et al. Effects of centrally acting antihypertensive drugs on the microcirculation of spontaneously hypertensive rats. Brazilian Journal of Medical and Biological Research, v.37, n.10, p.1541-1549, 2004.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/30434
dc.identifier.issn.pt_BR.fl_str_mv 0100-879X
dc.identifier.eissn.none.fl_str_mv 1414-431X
identifier_str_mv ESTATO, V. et al. Effects of centrally acting antihypertensive drugs on the microcirculation of spontaneously hypertensive rats. Brazilian Journal of Medical and Biological Research, v.37, n.10, p.1541-1549, 2004.
0100-879X
1414-431X
url https://www.arca.fiocruz.br/handle/icict/30434
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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