The Imidazoline receptors and the central regulation of the arterial blood pressure: a minireview

Detalhes bibliográficos
Autor(a) principal: Tibiriçá, Eduardo
Data de Publicação: 1993
Outros Autores: Bricca, Giampiero, Dontenwill, Monique, Feldman, Josiane, Greney, Hugues, Belcourt, Alain, Stutzmann, Jeanne, Bosquet, Pascal
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33532
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ. Brasil.
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spelling Tibiriçá, EduardoBricca, GiampieroDontenwill, MoniqueFeldman, JosianeGreney, HuguesBelcourt, AlainStutzmann, JeanneBosquet, Pascal2019-06-18T12:00:00Z2019-06-18T12:00:00Z1993TIBIRIÇÁ, Eduardo et al. The imidazoline receptors and the central regulation of the arterial blood pressure: a minireview. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 88, n. 2, p. 317-325, Apr./Jun. 1993.0074-0276https://www.arca.fiocruz.br/handle/icict/3353210.1590/S0074-027619930002000241678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzClonidinaSistema nervoso centralRilmenidinaReceptores preferidos da imidazolinaHipotensão arterialNúcleo reticular lateralMedicamentos anti-hipertensivosClonidineRilmenidineImidazoline-preferring receptorsNucleus reticularis lateralisArterial hypotensionAntihypertensive drugsCentral nervous systemThe Imidazoline receptors and the central regulation of the arterial blood pressure: a minireviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ. Brasil.Université Louis Pasteur. Faculté de Médecine. CNRS URA 589. Laboratoire de Pharmacologie Cardiovasculaire et Rénale. Strasbourg, France.Université Louis Pasteur. Faculté de Médecine. CNRS URA 589. Laboratoire de Pharmacologie Cardiovasculaire et Rénale. Strasbourg, France.Université Louis Pasteur. Faculté de Médecine. CNRS URA 589. Laboratoire de Pharmacologie Cardiovasculaire et Rénale. Strasbourg, France.Université Louis Pasteur. Faculté de Médecine. CNRS URA 589. Laboratoire de Pharmacologie Cardiovasculaire et Rénale. Strasbourg, France.Université Louis Pasteur. Faculté de Médecine. CNRS URA 589. Laboratoire de Pharmacologie Cardiovasculaire et Rénale. Strasbourg, France.Université Louis Pasteur. Faculté de Médecine. CNRS URA 589. Laboratoire de Pharmacologie Cardiovasculaire et Rénale. Strasbourg, France.Université Louis Pasteur. Faculté de Médecine. CNRS URA 589. Laboratoire de Pharmacologie Cardiovasculaire et Rénale. Strasbourg, France.Recently, we proposed the hypothesis according to wich the central hypotensive effect of clonidine and related substances could be related to an action upon specific receptors, requiring the imidazoline or imidazoline-like structures, rather than α2-adrenoceptors. Since then, direct evidences have been accumulated to confirm the existence of a population of imidazoline specific binding sites in the brainstem of animals and man, more precisely in the Nucleus Reticularis Lateralis (NRL) region of the ventrolateral medulla (VLM), site of the antihypertensive action of clonidine. The purification of the putative endogenous ligand of the imidazoline receptors - named endazoline - is currently being attempted from human brain extracts. This new concept might at last lead to the expected dissociation of the pharmacological mechanisms involved, on the one hand, in the therapeutic antihypertensive effect, and on the other, in their major side-effect, which is sedation. In fact, it has been recently confirmed that hypotension is mediated by the activation of imidazoline preferring receptors (IPR) within the NRL region, while sedation is attributed to the inhibition of α2-adrenergic mechanisms in the locus coeruleus, which is involved in the control of the sleep-waking cycle. The IPRmay constitute on interesting target for new drugs in the treatment of arterial hypertension. Finally, dysfunctions of this modulatory system which could be involved in the pathophysiologyof some forms of the hypertensive disease are under investigation.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/33532/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALEduardoTibirca_PascalBouquet_etal_IOC_1993.pdfEduardoTibirca_PascalBouquet_etal_IOC_1993.pdfapplication/pdf510735https://www.arca.fiocruz.br/bitstream/icict/33532/2/EduardoTibirca_PascalBouquet_etal_IOC_1993.pdf8c8cac8b6dacb0d31fe947109f0202f9MD52TEXTEduardoTibirca_PascalBouquet_etal_IOC_1993.pdf.txtEduardoTibirca_PascalBouquet_etal_IOC_1993.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv The Imidazoline receptors and the central regulation of the arterial blood pressure: a minireview
title The Imidazoline receptors and the central regulation of the arterial blood pressure: a minireview
spellingShingle The Imidazoline receptors and the central regulation of the arterial blood pressure: a minireview
Tibiriçá, Eduardo
Clonidina
Sistema nervoso central
Rilmenidina
Receptores preferidos da imidazolina
Hipotensão arterial
Núcleo reticular lateral
Medicamentos anti-hipertensivos
Clonidine
Rilmenidine
Imidazoline-preferring receptors
Nucleus reticularis lateralis
Arterial hypotension
Antihypertensive drugs
Central nervous system
title_short The Imidazoline receptors and the central regulation of the arterial blood pressure: a minireview
title_full The Imidazoline receptors and the central regulation of the arterial blood pressure: a minireview
title_fullStr The Imidazoline receptors and the central regulation of the arterial blood pressure: a minireview
title_full_unstemmed The Imidazoline receptors and the central regulation of the arterial blood pressure: a minireview
title_sort The Imidazoline receptors and the central regulation of the arterial blood pressure: a minireview
author Tibiriçá, Eduardo
author_facet Tibiriçá, Eduardo
Bricca, Giampiero
Dontenwill, Monique
Feldman, Josiane
Greney, Hugues
Belcourt, Alain
Stutzmann, Jeanne
Bosquet, Pascal
author_role author
author2 Bricca, Giampiero
Dontenwill, Monique
Feldman, Josiane
Greney, Hugues
Belcourt, Alain
Stutzmann, Jeanne
Bosquet, Pascal
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Tibiriçá, Eduardo
Bricca, Giampiero
Dontenwill, Monique
Feldman, Josiane
Greney, Hugues
Belcourt, Alain
Stutzmann, Jeanne
Bosquet, Pascal
dc.subject.other.pt_BR.fl_str_mv Clonidina
Sistema nervoso central
Rilmenidina
Receptores preferidos da imidazolina
Hipotensão arterial
Núcleo reticular lateral
Medicamentos anti-hipertensivos
topic Clonidina
Sistema nervoso central
Rilmenidina
Receptores preferidos da imidazolina
Hipotensão arterial
Núcleo reticular lateral
Medicamentos anti-hipertensivos
Clonidine
Rilmenidine
Imidazoline-preferring receptors
Nucleus reticularis lateralis
Arterial hypotension
Antihypertensive drugs
Central nervous system
dc.subject.en.pt_BR.fl_str_mv Clonidine
Rilmenidine
Imidazoline-preferring receptors
Nucleus reticularis lateralis
Arterial hypotension
Antihypertensive drugs
Central nervous system
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ. Brasil.
publishDate 1993
dc.date.issued.fl_str_mv 1993
dc.date.accessioned.fl_str_mv 2019-06-18T12:00:00Z
dc.date.available.fl_str_mv 2019-06-18T12:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv TIBIRIÇÁ, Eduardo et al. The imidazoline receptors and the central regulation of the arterial blood pressure: a minireview. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 88, n. 2, p. 317-325, Apr./Jun. 1993.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33532
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.pt_BR.fl_str_mv 10.1590/S0074-02761993000200024
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv TIBIRIÇÁ, Eduardo et al. The imidazoline receptors and the central regulation of the arterial blood pressure: a minireview. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 88, n. 2, p. 317-325, Apr./Jun. 1993.
0074-0276
10.1590/S0074-02761993000200024
1678-8060
url https://www.arca.fiocruz.br/handle/icict/33532
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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