SARS-CoV-2 shifting transmission dynamics and hidden reservoirs potentially limit efficacy of public health interventions in Italy

Giovanetti, Marta; Cella, Eleonora; Benedetti, Francesca; Magalis, Brittany Rife; Fonseca, Vagner; Fabris, Silvia; Campisi, Giovanni; Ciccozzi, Alessandra; Angeletti, Silvia; Borsetti, Alessandra; Tambone, Vittoradolfo; Sagnelli, Caterina; Pascarella, Stefano; Riva, Alberto; Ceccarelli, Giancarlo; Marcello, Alessandro; Azarian, Taj; Wilkinson, Eduan; Oliveira, Tulio de; Alcantara, Luiz Carlos Junior; Cauda, Roberto; Caruso, Arnaldo; Dean, Natalie E.; Browne, Cameron; Lourenço, Jose; Salemi, Marco; Zella, Davide; Ciccozzi, Massimo

SARS-CoV-2 shifting transmission dynamics and hidden reservoirs potentially limit efficacy of public health interventions in Italy

Detalhes bibliográficos
Autor(a) principal:	Giovanetti, Marta
Data de Publicação:	2021
Outros Autores:	Cella, Eleonora, Benedetti, Francesca, Magalis, Brittany Rife, Fonseca, Vagner, Fabris, Silvia, Campisi, Giovanni, Ciccozzi, Alessandra, Angeletti, Silvia, Borsetti, Alessandra, Tambone, Vittoradolfo, Sagnelli, Caterina, Pascarella, Stefano, Riva, Alberto, Ceccarelli, Giancarlo, Marcello, Alessandro, Azarian, Taj, Wilkinson, Eduan, Oliveira, Tulio de, Alcantara, Luiz Carlos Junior, Cauda, Roberto, Caruso, Arnaldo, Dean, Natalie E., Browne, Cameron, Lourenço, Jose, Salemi, Marco, Zella, Davide, Ciccozzi, Massimo
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/48691
Resumo:	Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivirus. Rio de Janeiro, RJ, Brasil / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Genética Celular e Molecular. Belo Horizonte, MG, Brasil / Medical Statistic and Molecular Epidemiology Unit, University of Biomedical Campus, Rome, Italy.

Metadados do item

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network_acronym_str	CRUZ
network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str	2135
spelling	Giovanetti, MartaCella, EleonoraBenedetti, FrancescaMagalis, Brittany RifeFonseca, VagnerFabris, SilviaCampisi, GiovanniCiccozzi, AlessandraAngeletti, SilviaBorsetti, AlessandraTambone, VittoradolfoSagnelli, CaterinaPascarella, StefanoRiva, AlbertoCeccarelli, GiancarloMarcello, AlessandroAzarian, TajWilkinson, EduanOliveira, Tulio deAlcantara, Luiz Carlos JuniorCauda, RobertoCaruso, ArnaldoDean, Natalie E.Browne, CameronLourenço, JoseSalemi, MarcoZella, DavideCiccozzi, Massimo2021-08-20T18:02:20Z2021-08-20T18:02:20Z2021GIOVANETTI, Marta et al. SARS-CoV-2 shifting transmission dynamics and hidden reservoirs potentially limit efficacy of public health interventions in Italy. Communications Biology, v. 4, n. 489, p. 1-9, 2021.2399-3642https://www.arca.fiocruz.br/handle/icict/4869110.1038/s42003-021-02025-0engNatureSARS-CoV-2Dinâmica de transmissãoReservatórios ocultosEficáciaSaúde PúblicaItáliaCOVID-19SARS-CoV-2Shifting transmission dynamicsHidden reservoirsPotentially limit efficacyPublic healthItalyCOVID-19SARS-CoV-2 shifting transmission dynamics and hidden reservoirs potentially limit efficacy of public health interventions in Italyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivirus. Rio de Janeiro, RJ, Brasil / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Genética Celular e Molecular. Belo Horizonte, MG, Brasil / Medical Statistic and Molecular Epidemiology Unit, University of Biomedical Campus, Rome, Italy.University of Central Florida. Burnett School of Biomedical Sciences. Orlando, FL, USA.Institute of Human Virology and Global Virus Network Center, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA.Emerging Pathogens Institute & Department of Pathology, College of Medicine, University of Florida, Gainesville, FL, USA.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Genética Celular e Molecular. Belo Horizonte, MG, Brasil / KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa. / Ministério da Saúde. Secretaria de Vigilância em Saúde. Coordenação dos Laboratórios de Saúde Pública. Brasília, DF, Brasil.Medical Statistic and Molecular Epidemiology Unit, University of Biomedical Campus. Rome, Italy.Department of Molecular and Translational Medicine, Section of Microbiology, University of Brescia. Brescia, Italy.Medical Statistic and Molecular Epidemiology Unit, University of Biomedical Campus. Rome, Italy.Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome. Rome, Italy.National HIV/AIDS Researh Center, Istituto Superiore di Sanità. Rome, Italy.Anthropology, and Applied Ethics, Campus Bio-Medico University. Rome, Italy.Department of Mental Health and Public Medicine, University of Campania “Luigi Vanvitelli”. Naples, Italy.Department of Biochemical Sciences “A. Rossi Fanelli”, University of Rome “La Sapienza”. Rome, Italy.ICBR, University of Florida, Gainesville. FL, USA..Department of Public Health and Infectious Diseases, Policlinico Umberto I Università ‘Sapienza’. Rome, Italy.Laboratory of Molecular Virology, International Centre for Genetic Engineering and Biotechnology (ICGEB). Trieste, Italy.Burnett School of Biomedical Sciences, University of Central Florida. Orlando, FL, USA.KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivirus. Rio de Janeiro, RJ, Brasil / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Genética Celular e Molecular. Belo Horizonte, MG, Brasil.Department Infectious Diseases – Fondazione Policlinico Universitario “A. Gemelli” IRCCS. Rome, Italy.Department of Molecular and Translational Medicine, Section of Microbiology, University of Brescia. Brescia, Italy.Department of Epidemiology, College of Public Health and Health Professions, University of Florida. Gainesville, FL, USA.Department of Mathematics, University of Lafayette. Lafayette, LA, USA.Department of Zoology, University of Oxford. Oxford, UK.Emerging Pathogens Institute & Department of Pathology, College of Medicine, University of Florida. Gainesville, FL, USAInstitute of Human Virology and Global Virus Network Center, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine. Baltimore, MD, USA.Medical Statistic and Molecular Epidemiology Unit, University of Biomedical Campus. Rome, Italy..We investigated SARS-CoV-2 transmission dynamics in Italy, one of the countries hit hardest by the pandemic, using phylodynamic analysis of viral genetic and epidemiological data. We observed the co-circulation of multiple SARS-CoV-2 lineages over time, which were linked to multiple importations and characterized by large transmission clusters concomitant with a high number of infections. Subsequent implementation of a three-phase nationwide lockdown strategy greatly reduced infection numbers and hospitalizations. Yet we present evidence of sustained viral spread among sporadic clusters acting as “hidden reservoirs” during summer 2020. Mathematical modelling shows that increased mobility among residents eventually catalyzed the coalescence of such clusters, thus driving up the number of infections and initiating a new epidemic wave. Our results suggest that the efficacy of public health inter ventions is, ultimately, limited by the size and structure of epidemic reservoirs, which may warrant prioritization during vaccine deployment.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/48691/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMarta_Giovaneti__etal_IOC_2021.pdfMarta_Giovaneti__etal_IOC_2021.pdfapplication/pdf13590332https://www.arca.fiocruz.br/bitstream/icict/48691/2/Marta_Giovaneti__etal_IOC_2021.pdf38de2f168e4f45533ef63621002c5194MD52TEXTMarta_Giovaneti__etal_IOC_2021.pdf.txtMarta_Giovaneti__etal_IOC_2021.pdf.txtExtracted texttext/plain57318https://www.arca.fiocruz.br/bitstream/icict/48691/3/Marta_Giovaneti__etal_IOC_2021.pdf.txtae903a004981a98db77ca272ff4e08acMD53icict/486912023-09-05 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dc.title.pt_BR.fl_str_mv	SARS-CoV-2 shifting transmission dynamics and hidden reservoirs potentially limit efficacy of public health interventions in Italy
title	SARS-CoV-2 shifting transmission dynamics and hidden reservoirs potentially limit efficacy of public health interventions in Italy
spellingShingle	SARS-CoV-2 shifting transmission dynamics and hidden reservoirs potentially limit efficacy of public health interventions in Italy Giovanetti, Marta SARS-CoV-2 Dinâmica de transmissão Reservatórios ocultos Eficácia Saúde Pública Itália COVID-19 SARS-CoV-2 Shifting transmission dynamics Hidden reservoirs Potentially limit efficacy Public health Italy COVID-19
title_short	SARS-CoV-2 shifting transmission dynamics and hidden reservoirs potentially limit efficacy of public health interventions in Italy
title_full	SARS-CoV-2 shifting transmission dynamics and hidden reservoirs potentially limit efficacy of public health interventions in Italy
title_fullStr	SARS-CoV-2 shifting transmission dynamics and hidden reservoirs potentially limit efficacy of public health interventions in Italy
title_full_unstemmed	SARS-CoV-2 shifting transmission dynamics and hidden reservoirs potentially limit efficacy of public health interventions in Italy
title_sort	SARS-CoV-2 shifting transmission dynamics and hidden reservoirs potentially limit efficacy of public health interventions in Italy
author	Giovanetti, Marta
author_facet	Giovanetti, Marta Cella, Eleonora Benedetti, Francesca Magalis, Brittany Rife Fonseca, Vagner Fabris, Silvia Campisi, Giovanni Ciccozzi, Alessandra Angeletti, Silvia Borsetti, Alessandra Tambone, Vittoradolfo Sagnelli, Caterina Pascarella, Stefano Riva, Alberto Ceccarelli, Giancarlo Marcello, Alessandro Azarian, Taj Wilkinson, Eduan Oliveira, Tulio de Alcantara, Luiz Carlos Junior Cauda, Roberto Caruso, Arnaldo Dean, Natalie E. Browne, Cameron Lourenço, Jose Salemi, Marco Zella, Davide Ciccozzi, Massimo
author_role	author
author2	Cella, Eleonora Benedetti, Francesca Magalis, Brittany Rife Fonseca, Vagner Fabris, Silvia Campisi, Giovanni Ciccozzi, Alessandra Angeletti, Silvia Borsetti, Alessandra Tambone, Vittoradolfo Sagnelli, Caterina Pascarella, Stefano Riva, Alberto Ceccarelli, Giancarlo Marcello, Alessandro Azarian, Taj Wilkinson, Eduan Oliveira, Tulio de Alcantara, Luiz Carlos Junior Cauda, Roberto Caruso, Arnaldo Dean, Natalie E. Browne, Cameron Lourenço, Jose Salemi, Marco Zella, Davide Ciccozzi, Massimo
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Giovanetti, Marta Cella, Eleonora Benedetti, Francesca Magalis, Brittany Rife Fonseca, Vagner Fabris, Silvia Campisi, Giovanni Ciccozzi, Alessandra Angeletti, Silvia Borsetti, Alessandra Tambone, Vittoradolfo Sagnelli, Caterina Pascarella, Stefano Riva, Alberto Ceccarelli, Giancarlo Marcello, Alessandro Azarian, Taj Wilkinson, Eduan Oliveira, Tulio de Alcantara, Luiz Carlos Junior Cauda, Roberto Caruso, Arnaldo Dean, Natalie E. Browne, Cameron Lourenço, Jose Salemi, Marco Zella, Davide Ciccozzi, Massimo
dc.subject.other.pt_BR.fl_str_mv	SARS-CoV-2 Dinâmica de transmissão Reservatórios ocultos Eficácia Saúde Pública Itália COVID-19
topic	SARS-CoV-2 Dinâmica de transmissão Reservatórios ocultos Eficácia Saúde Pública Itália COVID-19 SARS-CoV-2 Shifting transmission dynamics Hidden reservoirs Potentially limit efficacy Public health Italy COVID-19
dc.subject.en.pt_BR.fl_str_mv	SARS-CoV-2 Shifting transmission dynamics Hidden reservoirs Potentially limit efficacy Public health Italy COVID-19
description	Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivirus. Rio de Janeiro, RJ, Brasil / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Genética Celular e Molecular. Belo Horizonte, MG, Brasil / Medical Statistic and Molecular Epidemiology Unit, University of Biomedical Campus, Rome, Italy.
publishDate	2021
dc.date.accessioned.fl_str_mv	2021-08-20T18:02:20Z
dc.date.available.fl_str_mv	2021-08-20T18:02:20Z
dc.date.issued.fl_str_mv	2021
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	GIOVANETTI, Marta et al. SARS-CoV-2 shifting transmission dynamics and hidden reservoirs potentially limit efficacy of public health interventions in Italy. Communications Biology, v. 4, n. 489, p. 1-9, 2021.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/48691
dc.identifier.issn.pt_BR.fl_str_mv	2399-3642
dc.identifier.doi.none.fl_str_mv	10.1038/s42003-021-02025-0
identifier_str_mv	GIOVANETTI, Marta et al. SARS-CoV-2 shifting transmission dynamics and hidden reservoirs potentially limit efficacy of public health interventions in Italy. Communications Biology, v. 4, n. 489, p. 1-9, 2021. 2399-3642 10.1038/s42003-021-02025-0
url	https://www.arca.fiocruz.br/handle/icict/48691
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Nature
publisher.none.fl_str_mv	Nature
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
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repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
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SARS-CoV-2 shifting transmission dynamics and hidden reservoirs potentially limit efficacy of public health interventions in Italy

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