Impact of Plasmodium vivax malaria and antimalarial treatment on cytochrome P450 activity in Brazilian patients
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/56898 |
Resumo: | Conselho Nacional de Desenvolvimento Científico e Tecnológico; Departamento de Ciência e Tecnologia, Ministério da Saúde (DECIT) ; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Fundação de Amparo à Pesquisa do Estado de São Paulo; Fundação de Amparo à Pesquisa do Estado do Amazonas. |
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Almeida, Anne CristineElias, Anna Beatriz RibeiroMarques, Maria PaulaMelo, Gisely Cardoso deCosta, Allyson Guimarães daFigueiredo, Erick Frota GomesBrasil, Larissa WanderleyRodrigues-Soares, FernandaMonteiro, Wuelton MarceloLacerda, Marcus Vinicius Guimarães deLanchote, Vera LuciaSuarez-Kurtz, Guilherme2023-02-06T19:08:54Z2023-02-06T19:08:54Z2020ALMEIDA, Anne Cristine et al. Impact of Plasmodium vivax malaria and antimalarial treatment on cytochrome P450 activity in Brazilian patients. British Pharmacological Society, London, v. 87, n. 4, p. 1859-1868, 2020.0306-5251https://www.arca.fiocruz.br/handle/icict/5689810.1111/bcp.14574Conselho Nacional de Desenvolvimento Científico e Tecnológico; Departamento de Ciência e Tecnologia, Ministério da Saúde (DECIT) ; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Fundação de Amparo à Pesquisa do Estado de São Paulo; Fundação de Amparo à Pesquisa do Estado do Amazonas.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Gerência de Malária. Manaus, AM, Brasil.Instituto Nacional de Câncer. Coordenação de Pesquisa. Rio de Janeiro, RJ, Brasil.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Ribeirão Preto, SP, Brasil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Gerência de Malária. Manaus, AM, Brasil.Universidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Manaus, AM, Brasil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Gerência de Malária. Manaus, AM, Brasil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Gerência de Malária. Manaus, AM, Brasil.Universidade Federal do Triângulo Mineiro. Departamento de Patologia, Genética e Evolução. Uberaba, BH, Brasil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Gerência de Malária. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brasil.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Ribeirão Preto, SP, Brasil.Instituto Nacional de Câncer. Coordenação de Pesquisa. Rio de Janeiro, RJ, Brasil.Aims: To investigate the impact of Plasmodium vivax malaria and chloroquine primaquine chemotherapy on CYP2D6 and CYP2C19 activity in patients from the Brazilian Amazon. Methods: Adult patients (n = 30) were given subtherapeutic doses of CYP2D6 and CYP2C19 phenotypic probes metoprolol (10 mg) and omeprazole (2 mg) in three different stages of vivax malaria illness: acute disease (study phase 1), post chemo therapy (phase 2) and convalescence (stage 3). Plasma concentrations of probes and CYP-hydroxylated metabolites (α-OH metoprolol and 5-OH omeprazole) were measured using LC/MS/MS. Two pharmacokinetic metrics were used to estimate CYP activity: (a) ratio of plasma concentrations of probe/metabolite at 240 minutes after administration of the probes and (b) ratio of areas under the time-concentration curves for probe/metabolite (AUC0-12h). For statistical analysis, the pharmacokinetic metrics were normalized to the respective values in phase 3. Taqman assays were used for CYP2D6 and CYP2C19 genotyping. Cytokines levels were measured using cytometric bead array. Results: Both pharmacokinetic metrics for metoprolol and omeprazole, and plasma concentrations of cytokines IL-6, IL-8 and IL-10 varied significantly across the three study phases (ANOVA P < 0.0001). Post hoc tests showed greater metoprolol:α-OH metoprolol ratios in phases 1 and 2 compared to phase 3, larger omeprazole:5-OH omeprazole ratios in phase 1 than in phases 2 and 3, and higher circulating IL-6, IL-8 and IL-10 in phase 1 than in phases 2 and 3. Conclusion: P. vivax malaria and treatment altered CYP2D6 and CYP2C19 metabolic phenotypes. CYP2C19 inhibition is attributed to a higher level of circulating proinflammatory cytokines, while suppression of CYP2D6 is ascribed mainly to chloroquine exposure.engImpact of Plasmodium vivax malaria and antimalarial treatment on cytochrome P450 activity in Brazilian patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBrazilian AmazonChloroquineCYP2C19CYP2D6CytokinesPlasmodium vivax malariaPrimaquineinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/56898/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAlmeida_Anne_etal_ILMD_2021.pdfAlmeida_Anne_etal_ILMD_2021.pdfapplication/pdf2980250https://www.arca.fiocruz.br/bitstream/icict/56898/2/Almeida_Anne_etal_ILMD_2021.pdf42705450f57fe32f465b0bb4cf034172MD52icict/568982023-02-08 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| dc.title.en_US.fl_str_mv |
Impact of Plasmodium vivax malaria and antimalarial treatment on cytochrome P450 activity in Brazilian patients |
| title |
Impact of Plasmodium vivax malaria and antimalarial treatment on cytochrome P450 activity in Brazilian patients |
| spellingShingle |
Impact of Plasmodium vivax malaria and antimalarial treatment on cytochrome P450 activity in Brazilian patients Almeida, Anne Cristine Brazilian Amazon Chloroquine CYP2C19 CYP2D6 Cytokines Plasmodium vivax malaria Primaquine |
| title_short |
Impact of Plasmodium vivax malaria and antimalarial treatment on cytochrome P450 activity in Brazilian patients |
| title_full |
Impact of Plasmodium vivax malaria and antimalarial treatment on cytochrome P450 activity in Brazilian patients |
| title_fullStr |
Impact of Plasmodium vivax malaria and antimalarial treatment on cytochrome P450 activity in Brazilian patients |
| title_full_unstemmed |
Impact of Plasmodium vivax malaria and antimalarial treatment on cytochrome P450 activity in Brazilian patients |
| title_sort |
Impact of Plasmodium vivax malaria and antimalarial treatment on cytochrome P450 activity in Brazilian patients |
| author |
Almeida, Anne Cristine |
| author_facet |
Almeida, Anne Cristine Elias, Anna Beatriz Ribeiro Marques, Maria Paula Melo, Gisely Cardoso de Costa, Allyson Guimarães da Figueiredo, Erick Frota Gomes Brasil, Larissa Wanderley Rodrigues-Soares, Fernanda Monteiro, Wuelton Marcelo Lacerda, Marcus Vinicius Guimarães de Lanchote, Vera Lucia Suarez-Kurtz, Guilherme |
| author_role |
author |
| author2 |
Elias, Anna Beatriz Ribeiro Marques, Maria Paula Melo, Gisely Cardoso de Costa, Allyson Guimarães da Figueiredo, Erick Frota Gomes Brasil, Larissa Wanderley Rodrigues-Soares, Fernanda Monteiro, Wuelton Marcelo Lacerda, Marcus Vinicius Guimarães de Lanchote, Vera Lucia Suarez-Kurtz, Guilherme |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Almeida, Anne Cristine Elias, Anna Beatriz Ribeiro Marques, Maria Paula Melo, Gisely Cardoso de Costa, Allyson Guimarães da Figueiredo, Erick Frota Gomes Brasil, Larissa Wanderley Rodrigues-Soares, Fernanda Monteiro, Wuelton Marcelo Lacerda, Marcus Vinicius Guimarães de Lanchote, Vera Lucia Suarez-Kurtz, Guilherme |
| dc.subject.en.en_US.fl_str_mv |
Brazilian Amazon Chloroquine CYP2C19 CYP2D6 Cytokines Plasmodium vivax malaria Primaquine |
| topic |
Brazilian Amazon Chloroquine CYP2C19 CYP2D6 Cytokines Plasmodium vivax malaria Primaquine |
| description |
Conselho Nacional de Desenvolvimento Científico e Tecnológico; Departamento de Ciência e Tecnologia, Ministério da Saúde (DECIT) ; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Fundação de Amparo à Pesquisa do Estado de São Paulo; Fundação de Amparo à Pesquisa do Estado do Amazonas. |
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2020 |
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2020 |
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2023-02-06T19:08:54Z |
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2023-02-06T19:08:54Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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ALMEIDA, Anne Cristine et al. Impact of Plasmodium vivax malaria and antimalarial treatment on cytochrome P450 activity in Brazilian patients. British Pharmacological Society, London, v. 87, n. 4, p. 1859-1868, 2020. |
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https://www.arca.fiocruz.br/handle/icict/56898 |
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0306-5251 |
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10.1111/bcp.14574 |
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ALMEIDA, Anne Cristine et al. Impact of Plasmodium vivax malaria and antimalarial treatment on cytochrome P450 activity in Brazilian patients. British Pharmacological Society, London, v. 87, n. 4, p. 1859-1868, 2020. 0306-5251 10.1111/bcp.14574 |
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