Pore forming channels as a drug delivery system for photodynamic therapy in cancer associated with nanoscintillators

Detalhes bibliográficos
Autor(a) principal: Alves, Luiz Anastacio
Data de Publicação: 2018
Outros Autores: Ferreira, Leonardo Braga, Pacheco, Paulo Furtado, Mendivelso, Edith Alejandra Carreño, Teixeira, Pedro Celso Nogueira, Faria, Robson Xavier
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/29347
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ. Brasil.
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spelling Alves, Luiz AnastacioFerreira, Leonardo BragaPacheco, Paulo FurtadoMendivelso, Edith Alejandra CarreñoTeixeira, Pedro Celso NogueiraFaria, Robson Xavier2018-10-04T16:07:48Z2018-10-04T16:07:48Z2018ALVES, Luiz Anastacio; et al. Pore forming channels as a drug delivery system for photodynamic therapy in cancer associated with nanoscintillators. Oncotarget, v.9, n.38, p.25342-25354, 2018.1949-2553https://www.arca.fiocruz.br/handle/icict/29347engImpact JournalsCanais formadores de porossistema de administração de medicamentosCâncerterapia fotodinâmicananocintiladorescancerphotodynamic therapynanoscintillatorsPore forming channelsdrug delivery systemPore forming channels as a drug delivery system for photodynamic therapy in cancer associated with nanoscintillatorsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxoplasmose. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxoplasmose. Rio de Janeiro, RJ. Brasil.According to the World Health Organization (WHO), cancer is one of main causes of death worldwide, with 8.2 million people dying from this disease in 2012. Because of this, new forms of treatments or improvement of current treatments are crucial. In this regard, Photodynamic therapy (PDT) has been used to successfully treat cancers that can be easily accessed externally or by fibre-optic endoscopes, such as skin, bladder and esophagus cancers. In addition, this therapy can used alongside radiotherapy and chemotherapy in order to kill cancer cells. The main problem in implementing PDT is penetration of visible light deeper than 10 mm in tissues, due to scattering and absorption by tissue chromophores. Unfortunately, this excludes several internal organs affected by cancer. Another issue in this regard is the use of a selective cancer cell-photosensitizing compound. Nevertheless, several groups have recently developed scintillation nanoparticles, which can be stimulated by X-rays, thereby making this a possible solution for light production in deeper tissues. Alternative approaches have also been developed, such as photosensitizer structure modifications and cell membrane permeabilizing agents. In this context, certain channels lead to transitory plasma membrane permeability changes, such as pannexin, connexin hemmichannels, TRPV1-4 and P2X7, which allow for the non-selective passage of molecules up to 1,000 Da. Herein, we discuss the particular case of the P2X7 receptor-associated pore as a drug delivery system for hydrophilic substances to be applied in PDT, which could also be carried out with other channels. Methylene blue (MB) is a low cost dye used as a prototype photosensitizer, approved for clinical use in several other clinical conditions, as well as photodynamic therapy for fungi infections.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/29347/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALluisanastacio_alves_etal_IOC_2018.pdfluisanastacio_alves_etal_IOC_2018.pdfapplication/pdf2069935https://www.arca.fiocruz.br/bitstream/icict/29347/2/luisanastacio_alves_etal_IOC_2018.pdfc9ca649baa729b2ee959700776d974d6MD52TEXTluisanastacio_alves_etal_IOC_2018.pdf.txtluisanastacio_alves_etal_IOC_2018.pdf.txtExtracted texttext/plain59114https://www.arca.fiocruz.br/bitstream/icict/29347/3/luisanastacio_alves_etal_IOC_2018.pdf.txt5df1fd12d1026a7309f160d5afe1cdadMD53icict/293472018-10-05 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dc.title.pt_BR.fl_str_mv Pore forming channels as a drug delivery system for photodynamic therapy in cancer associated with nanoscintillators
title Pore forming channels as a drug delivery system for photodynamic therapy in cancer associated with nanoscintillators
spellingShingle Pore forming channels as a drug delivery system for photodynamic therapy in cancer associated with nanoscintillators
Alves, Luiz Anastacio
Canais formadores de poros
sistema de administração de medicamentos
Câncer
terapia fotodinâmica
nanocintiladores
cancer
photodynamic therapy
nanoscintillators
Pore forming channels
drug delivery system
title_short Pore forming channels as a drug delivery system for photodynamic therapy in cancer associated with nanoscintillators
title_full Pore forming channels as a drug delivery system for photodynamic therapy in cancer associated with nanoscintillators
title_fullStr Pore forming channels as a drug delivery system for photodynamic therapy in cancer associated with nanoscintillators
title_full_unstemmed Pore forming channels as a drug delivery system for photodynamic therapy in cancer associated with nanoscintillators
title_sort Pore forming channels as a drug delivery system for photodynamic therapy in cancer associated with nanoscintillators
author Alves, Luiz Anastacio
author_facet Alves, Luiz Anastacio
Ferreira, Leonardo Braga
Pacheco, Paulo Furtado
Mendivelso, Edith Alejandra Carreño
Teixeira, Pedro Celso Nogueira
Faria, Robson Xavier
author_role author
author2 Ferreira, Leonardo Braga
Pacheco, Paulo Furtado
Mendivelso, Edith Alejandra Carreño
Teixeira, Pedro Celso Nogueira
Faria, Robson Xavier
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Alves, Luiz Anastacio
Ferreira, Leonardo Braga
Pacheco, Paulo Furtado
Mendivelso, Edith Alejandra Carreño
Teixeira, Pedro Celso Nogueira
Faria, Robson Xavier
dc.subject.other.pt_BR.fl_str_mv Canais formadores de poros
sistema de administração de medicamentos
Câncer
terapia fotodinâmica
nanocintiladores
topic Canais formadores de poros
sistema de administração de medicamentos
Câncer
terapia fotodinâmica
nanocintiladores
cancer
photodynamic therapy
nanoscintillators
Pore forming channels
drug delivery system
dc.subject.en.pt_BR.fl_str_mv cancer
photodynamic therapy
nanoscintillators
Pore forming channels
drug delivery system
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ. Brasil.
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-10-04T16:07:48Z
dc.date.available.fl_str_mv 2018-10-04T16:07:48Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ALVES, Luiz Anastacio; et al. Pore forming channels as a drug delivery system for photodynamic therapy in cancer associated with nanoscintillators. Oncotarget, v.9, n.38, p.25342-25354, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/29347
dc.identifier.issn.pt_BR.fl_str_mv 1949-2553
identifier_str_mv ALVES, Luiz Anastacio; et al. Pore forming channels as a drug delivery system for photodynamic therapy in cancer associated with nanoscintillators. Oncotarget, v.9, n.38, p.25342-25354, 2018.
1949-2553
url https://www.arca.fiocruz.br/handle/icict/29347
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Impact Journals
publisher.none.fl_str_mv Impact Journals
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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