Potential of triterpenic natural compound betulinic acid for neglected tropical diseases new treatments

Detalhes bibliográficos
Autor(a) principal: Rocha, Vinícius
Data de Publicação: 2022
Outros Autores: Quadros, Helenita, Meira, Cássio, Silva, Laís, Carvalho, Dahara, Hodel, Katharine, Moreira, Diogo, Soares, Milena
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.3390/biomedicines10040831
Texto Completo: https://www.arca.fiocruz.br/handle/icict/54933
Resumo: Fundação Oswaldo Cruz (Fiocruz) / Instituto Gonçalo Moniz (IGM). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).
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spelling Rocha, ViníciusQuadros, HelenitaMeira, CássioSilva, LaísCarvalho, DaharaHodel, KatharineMoreira, DiogoSoares, Milena2022-09-29T14:52:47Z2022-09-29T14:52:47Z2022ROCHA, Vinícius et al. Potential of Triterpenic Natural Compound Betulinic Acid for Neglected Tropical Diseases New Treatments. Biomedicines, v. 10, n. 831, p. 1-16, 2022.2227-9059https://www.arca.fiocruz.br/handle/icict/5493310.3390/biomedicines10040831Fundação Oswaldo Cruz (Fiocruz) / Instituto Gonçalo Moniz (IGM). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).Instituto de Tecnologia em Saúde (SENAI / CIMATEC / ITS). Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Instituto de Tecnologia em Saúde (SENAI / CIMATEC / ITS). Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Instituto de Tecnologia em Saúde (SENAI / CIMATEC / ITS). Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Instituto de Tecnologia em Saúde (SENAI / CIMATEC / ITS). Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Neglected tropical diseases are one of the most important public health problems in many countries around the world. Among them are leishmaniasis, Chagas disease, and malaria, which contribute to more than 250 million infections worldwide. There is no validated vaccine to prevent these infections and the treatments available are obsolete, highly toxic, and non-effective due to parasitic drug resistance. Additionally, there is a high incidence of these diseases, and they may require hospitalization, which is expensive to the public health systems. Therefore, there is an urgent need to develop new treatments to improve the management of infected people, control the spread of resistant strains, and reduce health costs. Betulinic acid (BA) is a triterpene natural product which has shown antiparasitic activity against Leishmania, Trypanosoma cruzi, and Plasmodium. Here, we review the main results regarding the in vitro and in vivo pharmacological activity of BA and its derivatives against these parasites. Some chemical modifications of BA have been shown to improve its activities against the parasites. Further improvement on studies of drug-derived, as well as structure–activity relationship, are necessary for the development of new betulinic acid-based treatments.engMDPILeishmaniasisChagas diseaseMalariaNeglected diseasesBetulinic acidTherapeuticsLeishmanioseDoença de ChagasMaláriaDoenças tropicais negligenciadasÁcido betulínicoTratamentoLeishmaniasisChagas diseaseMalariaNeglected tropical diseasesBetulinic acidTreatmentLeishmanioseDoença de chagasMaláriaDoenças negligenciadasPotential of triterpenic natural compound betulinic acid for neglected tropical diseases new treatmentsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/54933/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRocha, Vinicius - Potential of Triterpenic Natural Compound Betulinic ....pdfRocha, Vinicius - Potential of Triterpenic Natural Compound Betulinic ....pdfapplication/pdf1320043https://www.arca.fiocruz.br/bitstream/icict/54933/2/Rocha%2c%20Vinicius%20-%20Potential%20of%20Triterpenic%20Natural%20Compound%20Betulinic%20....pdfad5b70629c637fe3017e83f5f6807ea9MD52icict/549332023-03-15 14:32:52.991oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:52Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.en_US.fl_str_mv Potential of triterpenic natural compound betulinic acid for neglected tropical diseases new treatments
title Potential of triterpenic natural compound betulinic acid for neglected tropical diseases new treatments
spellingShingle Potential of triterpenic natural compound betulinic acid for neglected tropical diseases new treatments
Rocha, Vinícius
Leishmaniasis
Chagas disease
Malaria
Neglected diseases
Betulinic acid
Therapeutics
Leishmaniose
Doença de Chagas
Malária
Doenças tropicais negligenciadas
Ácido betulínico
Tratamento
Leishmaniasis
Chagas disease
Malaria
Neglected tropical diseases
Betulinic acid
Treatment
Leishmaniose
Doença de chagas
Malária
Doenças negligenciadas
title_short Potential of triterpenic natural compound betulinic acid for neglected tropical diseases new treatments
title_full Potential of triterpenic natural compound betulinic acid for neglected tropical diseases new treatments
title_fullStr Potential of triterpenic natural compound betulinic acid for neglected tropical diseases new treatments
title_full_unstemmed Potential of triterpenic natural compound betulinic acid for neglected tropical diseases new treatments
title_sort Potential of triterpenic natural compound betulinic acid for neglected tropical diseases new treatments
author Rocha, Vinícius
author_facet Rocha, Vinícius
Quadros, Helenita
Meira, Cássio
Silva, Laís
Carvalho, Dahara
Hodel, Katharine
Moreira, Diogo
Soares, Milena
author_role author
author2 Quadros, Helenita
Meira, Cássio
Silva, Laís
Carvalho, Dahara
Hodel, Katharine
Moreira, Diogo
Soares, Milena
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rocha, Vinícius
Quadros, Helenita
Meira, Cássio
Silva, Laís
Carvalho, Dahara
Hodel, Katharine
Moreira, Diogo
Soares, Milena
dc.subject.mesh.en_US.fl_str_mv Leishmaniasis
Chagas disease
Malaria
Neglected diseases
Betulinic acid
Therapeutics
topic Leishmaniasis
Chagas disease
Malaria
Neglected diseases
Betulinic acid
Therapeutics
Leishmaniose
Doença de Chagas
Malária
Doenças tropicais negligenciadas
Ácido betulínico
Tratamento
Leishmaniasis
Chagas disease
Malaria
Neglected tropical diseases
Betulinic acid
Treatment
Leishmaniose
Doença de chagas
Malária
Doenças negligenciadas
dc.subject.other.en_US.fl_str_mv Leishmaniose
Doença de Chagas
Malária
Doenças tropicais negligenciadas
Ácido betulínico
Tratamento
dc.subject.en.en_US.fl_str_mv Leishmaniasis
Chagas disease
Malaria
Neglected tropical diseases
Betulinic acid
Treatment
dc.subject.decs.en_US.fl_str_mv Leishmaniose
Doença de chagas
Malária
Doenças negligenciadas
description Fundação Oswaldo Cruz (Fiocruz) / Instituto Gonçalo Moniz (IGM). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-09-29T14:52:47Z
dc.date.available.fl_str_mv 2022-09-29T14:52:47Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv ROCHA, Vinícius et al. Potential of Triterpenic Natural Compound Betulinic Acid for Neglected Tropical Diseases New Treatments. Biomedicines, v. 10, n. 831, p. 1-16, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/54933
dc.identifier.issn.en_US.fl_str_mv 2227-9059
dc.identifier.doi.none.fl_str_mv 10.3390/biomedicines10040831
identifier_str_mv ROCHA, Vinícius et al. Potential of Triterpenic Natural Compound Betulinic Acid for Neglected Tropical Diseases New Treatments. Biomedicines, v. 10, n. 831, p. 1-16, 2022.
2227-9059
10.3390/biomedicines10040831
url https://www.arca.fiocruz.br/handle/icict/54933
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/54933/1/license.txt
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