Drugging the schistosome zinc-dependent HDACs: current progress and future perspectives.

Detalhes bibliográficos
Autor(a) principal: Marek, Martin
Data de Publicação: 2015
Outros Autores: Oliveira, Guilherme Correa de, Pierce, Raymond John, Jung, Manfred, Sippl, Wolfgang, Romier, Christophe
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/15727
Resumo: Université de Strasbourg . Institut de Génétique et Biologie Moléculaire et Cellulaire. Département de Biologie Structurale Intégrative. Lille Cedex, France
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spelling Marek, MartinOliveira, Guilherme Correa dePierce, Raymond JohnJung, ManfredSippl, WolfgangRomier, Christophe2016-09-08T17:12:37Z2016-09-08T17:12:37Z2015MAREK, Martin et al. Drugging the schistosome zinc-dependent HDACs: current progress and future perspectives. Future Med Chem., Vol. 7, n. 6, p.783-800, 20151756-8919https://www.arca.fiocruz.br/handle/icict/1572710.4155/fmc.15.25porFuture ScienceDrugging the schistosome zinc-dependent HDACs: current progress and future perspectives.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversité de Strasbourg . Institut de Génétique et Biologie Moléculaire et Cellulaire. Département de Biologie Structurale Intégrative. Lille Cedex, FranceFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Grupo de Genomica e Biologia Computacional. Belo Horizonte, MG, BrasilUniversité de Lille. Institut Pasteur de Lille.Center for Infection & Immunity of Lille.Lille Cedex, FranceAlbert-Ludwigs-Universität Freiburg.Institute of Pharmaceutical Sciences. Freiburg, GermanyMartin-Luther-Universität Halle-Wittenberg. Institute of Pharmacy. Wolfgang-Langenbeck, GermanyUniversité de Strasbourg . Institut de Génétique et Biologie Moléculaire et Cellulaire. Département de Biologie Structurale Intégrative. Lille Cedex, FranceSchistosomes, like many eukaryotic pathogens, typically display morphologically distinct stages during their life cycles. Epigenetic mechanisms underlie the pathogens' morphological transformations, and the targeting of epigenetics-driven cellular programs therefore represents an Achilles' heel of parasites. To speed up the search for new antiparasitic agents, drugs validated for other diseases can be rationally optimized into antiparasitic therapeutics. Specifically, zinc-dependent histone deacetylases (HDACs) are the most explored targets for epigenetic therapies, notably for anticancer treatments. This review focuses on the development of drug-leads inhibiting HDACs from schistosomes. More precisely, current progress on Schistosoma mansoni HDAC8 (smHDAC8) provided a proof of concept that targeting epigenetic enzymes is a valid approach to treat diseases caused by schistosomes, and possibly other eukaryotic pathogensAnthelmintics/chemistryHelminth Proteins/antagonists & inhibitorsSchistosoma/drug effectsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15727/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALfmc.15.pdffmc.15.pdfapplication/pdf11289158https://www.arca.fiocruz.br/bitstream/icict/15727/2/fmc.15.pdfba78c0a2cc7fb48469eb5b5dc4553723MD52TEXTfmc.15.pdf.txtfmc.15.pdf.txtExtracted texttext/plain4371https://www.arca.fiocruz.br/bitstream/icict/15727/3/fmc.15.pdf.txta074a1e11107a7acced058814ec2bfd9MD53icict/157272022-02-01 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dc.title.pt_BR.fl_str_mv Drugging the schistosome zinc-dependent HDACs: current progress and future perspectives.
title Drugging the schistosome zinc-dependent HDACs: current progress and future perspectives.
spellingShingle Drugging the schistosome zinc-dependent HDACs: current progress and future perspectives.
Marek, Martin
Anthelmintics/chemistry
Helminth Proteins/antagonists & inhibitors
Schistosoma/drug effects
title_short Drugging the schistosome zinc-dependent HDACs: current progress and future perspectives.
title_full Drugging the schistosome zinc-dependent HDACs: current progress and future perspectives.
title_fullStr Drugging the schistosome zinc-dependent HDACs: current progress and future perspectives.
title_full_unstemmed Drugging the schistosome zinc-dependent HDACs: current progress and future perspectives.
title_sort Drugging the schistosome zinc-dependent HDACs: current progress and future perspectives.
author Marek, Martin
author_facet Marek, Martin
Oliveira, Guilherme Correa de
Pierce, Raymond John
Jung, Manfred
Sippl, Wolfgang
Romier, Christophe
author_role author
author2 Oliveira, Guilherme Correa de
Pierce, Raymond John
Jung, Manfred
Sippl, Wolfgang
Romier, Christophe
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Marek, Martin
Oliveira, Guilherme Correa de
Pierce, Raymond John
Jung, Manfred
Sippl, Wolfgang
Romier, Christophe
dc.subject.en.pt_BR.fl_str_mv Anthelmintics/chemistry
Helminth Proteins/antagonists & inhibitors
Schistosoma/drug effects
topic Anthelmintics/chemistry
Helminth Proteins/antagonists & inhibitors
Schistosoma/drug effects
description Université de Strasbourg . Institut de Génétique et Biologie Moléculaire et Cellulaire. Département de Biologie Structurale Intégrative. Lille Cedex, France
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-09-08T17:12:37Z
dc.date.available.fl_str_mv 2016-09-08T17:12:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MAREK, Martin et al. Drugging the schistosome zinc-dependent HDACs: current progress and future perspectives. Future Med Chem., Vol. 7, n. 6, p.783-800, 2015
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/15727
dc.identifier.issn.pt_BR.fl_str_mv 1756-8919
dc.identifier.doi.none.fl_str_mv 10.4155/fmc.15.25
identifier_str_mv MAREK, Martin et al. Drugging the schistosome zinc-dependent HDACs: current progress and future perspectives. Future Med Chem., Vol. 7, n. 6, p.783-800, 2015
1756-8919
10.4155/fmc.15.25
url https://www.arca.fiocruz.br/handle/icict/15727
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Future Science
publisher.none.fl_str_mv Future Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/15727/2/fmc.15.pdf
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